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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67394
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eln
Name: elastin
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Elndecreases expressionEXP 6480464CTDOkadaic Acid results in decreased expression of ELN mRNA; Okadaic Acid results in decreased expression of ELN protein modified formPMID:8997264
Elnmultiple interactionsEXP 6480464CTD[IL1B protein co-treated with Okadaic Acid] results in decreased expression of ELN mRNA; [Okadaic Acid co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ELN mRNA; Cycloheximide inhibits the reaction [Okadaic Acid results in decreased expression of ELN mRNA]PMID:8997264
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