Eln (elastin) - Rat Genome Database

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Gene: Eln (elastin) Mus musculus
Analyze
Symbol: Eln
Name: elastin
RGD ID: 733666
MGI Page MGI
Description: Enables extracellular matrix binding activity. Acts upstream of or within several processes, including regulation of actin filament polymerization; skeletal muscle tissue development; and stress fiber assembly. Located in elastic fiber. Is expressed in several structures, including alimentary system; cardiovascular system; hindlimb; musculoskeletal system; and respiratory system. Used to study aortic valve disease; essential hypertension; and supravalvular aortic stenosis. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI385707; AI480567; E030024M20Rik; tropoelastin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,731,449 - 134,776,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,731,447 - 134,776,177 (-)EnsemblGRCm39 Ensembl
GRCm385134,702,595 - 134,747,368 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,702,593 - 134,747,323 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,178,466 - 135,223,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,987,223 - 135,031,881 (-)NCBIMGSCv36mm8
Celera5131,710,617 - 131,755,279 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Anetoderma  (ISO)
aortic aneurysm  (ISO)
aortic valve disease  (IAGP)
aortic valve stenosis  (ISO)
atrioventricular septal defect  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autosomal dominant cutis laxa  (ISO)
autosomal dominant cutis laxa 1  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
bladder neck obstruction  (ISO)
Buschke-Ollendorff syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (ISO)
cutis laxa  (ISO)
dermatitis herpetiformis  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
essential hypertension  (IAGP)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
facioscapulohumeral muscular dystrophy  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
inguinal hernia  (ISO)
intestinal volvulus  (ISO)
intracranial aneurysm  (ISO)
Kawasaki disease  (IEP)
Kuhnt-Junius degeneration  (ISO)
Lichen Sclerosus et Atrophicus  (ISO)
liver cirrhosis  (ISO)
macular degeneration  (ISO)
melanoma  (ISO)
Myocardial Ischemia  (ISO)
Neurodevelopmental Disorders  (ISO)
photosensitivity disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polyarteritis nodosa  (ISO)
polymyositis  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
primary open angle glaucoma  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Stroke  (ISO)
Sunburn  (ISO)
Supravalvar Aortic Stenosis, Eisenberg Type  (ISO)
supravalvular aortic stenosis  (IAGP,ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
thoracic aortic aneurysm  (ISO)
thromboangiitis obliterans  (ISO)
Urinary Incontinence, Stress  (ISO)
varicose veins  (ISO)
Volvulus Of Midgut  (ISO)
Williams-Beuren syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
alachlor  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
beta-aminopropionitrile  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
C60 fullerene  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloroprene  (ISO)
choline  (EXP)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
cycloheximide  (ISO)
D-penicillamine  (ISO)
dexamethasone  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
enilconazole  (ISO)
fenamidone  (EXP)
flurbiprofen  (EXP)
folic acid  (EXP)
furan  (ISO)
griseofulvin  (EXP)
hydralazine  (ISO)
hydrogen sulfide  (EXP)
isoprenaline  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP)
losartan  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP)
nitrofen  (ISO)
nitroglycerin  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
radicicol  (ISO)
rotenone  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thiacloprid  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
Trapidil  (ISO)
tremolite asbestos  (EXP)
triclosan  (ISO)
triptonide  (EXP)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Inhibition of transforming growth factor beta worsens elastin degradation in a murine model of Kawasaki disease. Alvira CM, etal., Am J Pathol. 2011 Mar;178(3):1210-20. doi: 10.1016/j.ajpath.2010.11.054.
2. Immunochemical identification of abnormal constituents in the dermis of pseudoxanthoma elasticum patients. Baccarani-Contri M, etal., Eur J Histochem. 1994;38(2):111-23.
3. Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. Bernstein EF, etal., J Invest Dermatol. 1994 Aug;103(2):182-6.
4. Dermatitis herpetiformis--an autoimmune disease due to cross-reaction between dietary glutenin and dermal elastin? Bodvarsson S, etal., Scand J Immunol. 1993 Dec;38(6):546-50.
5. Elastin degradation in systemic vasculitis. Bokarewa M, etal., Pathol Biol (Paris). 1996 Apr;44(4):254-8.
6. Abnormalities of serum antielastin antibodies in connective tissue diseases. Colburn KK, etal., J Investig Med. 2003 Mar;51(2):104-9.
7. Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. DeSilva U, etal., Genome Res 1999 May;9(5):428-36.
8. Skin elastic fibers in Williams syndrome. Dridi SM, etal., Am J Med Genet. 1999 Nov 19;87(2):134-8.
9. Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. Ewart AK, etal., J Clin Invest. 1994 Mar;93(3):1071-7.
10. Alterations in fibrillin as well as collagens I and III and elastin occur in vulval lichen sclerosus. Farrell AM, etal., J Eur Acad Dermatol Venereol. 2001 May;15(3):212-7.
11. Relationship of tumorigenic malignant melanomas to dermal elastin: an expression of tumor/stromal interaction that may be related to prognosis. Feinmesser M, etal., Am J Dermatopathol. 2002 Apr;24(2):108-17.
12. Elastase derived elastin peptides: putative autoimmune targets in giant cell arteritis. Gillot JM, etal., J Rheumatol. 1997 Apr;24(4):677-82.
13. Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture. Giro MG, etal., J Invest Dermatol. 1992 Aug;99(2):129-37.
14. Time-dependent alterations of select genes in streptozotocin-induced diabetic rat bladder. Gray MA, etal., Urology. 2008 Jun;71(6):1214-9. doi: 10.1016/j.urology.2007.11.054. Epub 2008 Feb 15.
15. Effect of mechanical ventilation on the pulmonary expression and production of elastin in nitrofen-induced diaphragmatic hernia in rats. Guarino N, etal., J Pediatr Surg. 2002 Sep;37(9):1253-7.
16. Twenty patients including 7 probands with autosomal dominant cutis laxa confirm clinical and molecular homogeneity. Hadj-Rabia S, etal., Orphanet J Rare Dis. 2013 Feb 25;8:36. doi: 10.1186/1750-1172-8-36.
17. Ultrastructural immunocytochemical analysis of elastin in the human lamina cribrosa. Changes in elastic fibers in primary open-angle glaucoma. Hernandez MR Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2891-903.
18. Serum elastin-derived peptides and anti-elastin antibody in patients with systemic sclerosis. Hong YJ, etal., J Korean Med Sci. 2012 May;27(5):484-8. doi: 10.3346/jkms.2012.27.5.484. Epub 2012 Apr 25.
19. The use of elastin immunostain improves the evaluation of melanomas associated with nevi. Kamino H, etal., J Cutan Pathol. 2009 Aug;36(8):845-52. doi: 10.1111/j.1600-0560.2008.01170.x. Epub 2008 Nov 19.
20. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Kelleher CM, etal., Am J Respir Cell Mol Biol. 2005 Oct;33(4):355-62. Epub 2005 Aug 4.
21. Elastin gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Kondo N, etal., Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1101-5. doi: 10.1167/iovs.07-1145.
22. Phenotype of the Williams-Beuren syndrome associated with hemizygosity at the elastin locus. Kotzot D, etal., Eur J Pediatr. 1995 Jun;154(6):477-82.
23. Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences. Krex D, etal., Cerebrovasc Dis. 2004;18(2):104-10. Epub 2004 Jun 22.
24. Altered bladder function in transgenic mice expressing rat elastin. Lemack GE, etal., Neurourol Urodyn 1999;18(1):55-68.
25. Novel arterial pathology in mice and humans hemizygous for elastin. Li DY, etal., J Clin Invest 1998 Nov 15;102(10):1783-7.
26. Elastin rs2301995 polymorphism is not associated with polypoidal choroidal vasculopathy in caucasians. Lima LH, etal., Ophthalmic Genet. 2011 Jun;32(2):80-2. doi: 10.3109/13816810.2010.544362. Epub 2011 Mar 10.
27. Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Lin G, etal., Cytotherapy. 2010;12(1):88-95. doi: 10.3109/14653240903350265.
28. [Expressions of fibrillin-1, elastin and matrix metalloproteinase-1 and -9 in chronic actinic dermatitis in elderly patients]. Liu P, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1354-7.
29. Increased elastin production in experimental granulomatous lung disease. Mariani TJ, etal., Am J Pathol. 1995 Oct;147(4):988-1000.
30. Elastin: mutational spectrum in supravalvular aortic stenosis. Metcalfe K, etal., Eur J Hum Genet. 2000 Dec;8(12):955-63.
31. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
32. MGDs mouse GO annotations MGD data from the GO Consortium
33. Elastosis of the lamina cribrosa in pseudoexfoliation syndrome with glaucoma. Netland PA, etal., Ophthalmology. 1995 Jun;102(6):878-86.
34. Aortic stiffness is associated with vascular calcification and remodeling in a chronic kidney disease rat model. Ng K, etal., Am J Physiol Renal Physiol. 2011 Jun;300(6):F1431-6. doi: 10.1152/ajprenal.00079.2011. Epub 2011 Apr 6.
35. An association of anti-elastin IgA antibodies with development of retinopathy in diabetic children. Nicoloff G, etal., Gen Pharmacol. 2000 Aug;35(2):83-7.
36. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. Ogata T, etal., J Vasc Surg. 2005 Jun;41(6):1036-42.
37. Anetoderma: biochemical and ultrastructural demonstration of an elastin defect in the skin of three patients. Oikarinen AI, etal., J Am Acad Dermatol. 1984 Jul;11(1):64-72.
38. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. Pellicoro A, etal., Hepatology. 2012 Jun;55(6):1965-75. doi: 10.1002/hep.25567. Epub 2012 Apr 18.
41. Mouse MP Annotation Import Pipeline RGD automated import pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa. Rodriguez-Revenga L, etal., Arch Dermatol. 2004 Sep;140(9):1135-9.
45. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
46. Elastase digestion of normal and pseudoxanthoma elasticum lesional skin elastins. Schwartz E, etal., Exp Mol Pathol. 1991 Oct;55(2):190-5.
47. Heterogeneity of elastin expression in cutis laxa fibroblast strains. Sephel GC, etal., J Invest Dermatol. 1989 Jul;93(1):147-53.
48. Serum elastin-derived peptides in age-related macular degeneration. Sivaprasad S, etal., Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3046-51.
49. Aortic aneurysmal disease and cutis laxa caused by defects in the elastin gene. Szabo Z, etal., J Med Genet. 2006 Mar;43(3):255-8. Epub 2005 Aug 5.
50. Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. Tanaka K, etal., Mol Vis. 2011;17:2751-8. Epub 2011 Oct 22.
51. Autosomal dominant cutis laxa with severe lung disease: synthesis and matrix deposition of mutant tropoelastin. Urban Z, etal., J Invest Dermatol. 2005 Jun;124(6):1193-9.
52. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, etal., Genomics 2000 Oct 1;69(1):1-13.
53. Mechanism of abnormal elastin gene expression in the pinguecular part of pterygia. Wang IJ, etal., Am J Pathol. 2000 Oct;157(4):1269-76.
54. Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and tested in the elastase model of abdominal aortic aneurysm in rats. Xiong J, etal., J Vasc Surg. 2008 Oct;48(4):965-73. doi: 10.1016/j.jvs.2008.04.016. Epub 2008 Jun 30.
55. Elastic tissue changes in skin following PUVA therapy. Zelickson AS, etal., J Am Acad Dermatol. 1980 Aug;3(2):186-92.
56. Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN). Zhang MC, etal., J Biol Chem. 1999 Jan 8;274(2):981-6.
Additional References at PubMed
PMID:1981051   PMID:2014796   PMID:7829060   PMID:8096378   PMID:9374392   PMID:9382709   PMID:9607766   PMID:10349636   PMID:10544250   PMID:10552047   PMID:10600892   PMID:10613847  
PMID:10675334   PMID:10848613   PMID:10861287   PMID:10970822   PMID:11042159   PMID:11076861   PMID:11082275   PMID:11217851   PMID:11431694   PMID:11514592   PMID:11779826   PMID:11970905  
PMID:12466207   PMID:12477932   PMID:12592609   PMID:12626514   PMID:12909585   PMID:12952863   PMID:14499643   PMID:14597767   PMID:14614988   PMID:15018818   PMID:15615710   PMID:15710889  
PMID:15863465   PMID:15900406   PMID:16141072   PMID:16141073   PMID:16192629   PMID:16236725   PMID:16251195   PMID:16602821   PMID:16783635   PMID:16830225   PMID:16982180   PMID:16989802  
PMID:17099216   PMID:17142349   PMID:17400710   PMID:17626896   PMID:17656671   PMID:18083765   PMID:18173368   PMID:18258849   PMID:18311803   PMID:18321928   PMID:18441095   PMID:18479957  
PMID:18487037   PMID:18495804   PMID:18506002   PMID:18554416   PMID:18591670   PMID:18614015   PMID:18635823   PMID:18651661   PMID:18667463   PMID:18757743   PMID:18772328   PMID:19185580  
PMID:19372465   PMID:19850904   PMID:19897741   PMID:19915155   PMID:20019329   PMID:20356956   PMID:20495146   PMID:20498044   PMID:20576933   PMID:20595636   PMID:20847053   PMID:20926892  
PMID:21267068   PMID:21281809   PMID:21305018   PMID:21438071   PMID:21490399   PMID:21513708   PMID:21536846   PMID:21707943   PMID:21730037   PMID:21778429   PMID:21856305   PMID:21873635  
PMID:21979435   PMID:21985298   PMID:22049077   PMID:22096492   PMID:22159717   PMID:22238283   PMID:22265892   PMID:22331032   PMID:22573328   PMID:22682244   PMID:22685574   PMID:22899851  
PMID:23011393   PMID:23261250   PMID:23273220   PMID:23322300   PMID:23493289   PMID:23696835   PMID:23723064   PMID:23817199   PMID:23857752   PMID:23895934   PMID:23938297   PMID:23994172  
PMID:24036114   PMID:24131868   PMID:24262428   PMID:24282586   PMID:24291458   PMID:24322348   PMID:24368172   PMID:24414067   PMID:24777781   PMID:24793170   PMID:24886827   PMID:25086405  
PMID:25131766   PMID:25166724   PMID:25395457   PMID:25428696   PMID:25535917   PMID:25539853   PMID:25652465   PMID:25670798   PMID:25701072   PMID:25771258   PMID:25923353   PMID:26027930  
PMID:26167199   PMID:26232234   PMID:26439735   PMID:26711913   PMID:26743624   PMID:26858344   PMID:26878215   PMID:26932671   PMID:26982166   PMID:27062406   PMID:27183603   PMID:27364009  
PMID:27412481   PMID:27527664   PMID:27645581   PMID:28071719   PMID:28237967   PMID:28254817   PMID:28684544   PMID:28751568   PMID:28754555   PMID:29251627   PMID:29366776   PMID:29498532  
PMID:29665133   PMID:29802129   PMID:29956664   PMID:30346946   PMID:30348760   PMID:30389913   PMID:30578393   PMID:30713523   PMID:31282949   PMID:31366218   PMID:31590613   PMID:31624071  
PMID:31634485   PMID:31691186   PMID:31844321   PMID:32046118   PMID:32151560   PMID:32412588   PMID:32460513   PMID:32533648   PMID:32882513   PMID:33035438   PMID:33108351   PMID:33153107  
PMID:33372189   PMID:33707239   PMID:34323105   PMID:34790711   PMID:34990407   PMID:34997665   PMID:35247391   PMID:35364055   PMID:35681537   PMID:35831318   PMID:35964009  


Genomics

Comparative Map Data
Eln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,731,449 - 134,776,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,731,447 - 134,776,177 (-)EnsemblGRCm39 Ensembl
GRCm385134,702,595 - 134,747,368 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,702,593 - 134,747,323 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,178,466 - 135,223,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,987,223 - 135,031,881 (-)NCBIMGSCv36mm8
Celera5131,710,617 - 131,755,279 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.76NCBI
ELN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,028,173 - 74,069,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl774,027,789 - 74,069,907 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,442,503 - 73,484,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,080,363 - 73,122,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 34772,887,168 - 72,927,681NCBI
Celera768,923,491 - 68,963,674 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,326,571 - 69,367,012 (+)NCBIHuRef
CHM1_1773,587,503 - 73,629,630 (+)NCBICHM1_1
T2T-CHM13v2.0775,231,309 - 75,273,042 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,775,191 - 72,817,309 (+)NCBI
Eln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21221,968,544 - 22,011,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,109,255 - 23,152,934 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01223,721,589 - 23,765,283 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01222,789,694 - 22,833,151 (+)NCBIRnor_WKY
Rnor_6.01224,978,478 - 25,021,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,978,483 - 25,021,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,978,748 - 27,022,485 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,033,657 - 23,077,043 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,892,500 - 22,934,907 (+)NCBI
Celera1223,732,827 - 23,776,213 (+)NCBICelera
RH 3.4 Map12345.7RGD
RH 3.4 Map12344.2RGD
Cytogenetic Map12q12NCBI
Eln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545613,788,992 - 13,818,836 (-)NCBIChiLan1.0ChiLan1.0
ELN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1781,177,699 - 81,218,306 (+)NCBIpanpan1.1PanPan1.1panPan2
ELN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,299,524 - 6,331,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,300,727 - 6,331,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,997,308 - 8,029,192 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,114,552 - 6,146,504 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,114,583 - 6,146,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,104,697 - 6,136,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,052,537 - 6,084,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,216,223 - 6,248,126 (-)NCBIUU_Cfam_GSD_1.0
Eln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,871,544 - 130,901,273 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365433,135,169 - 3,165,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,214,205 - 11,244,897 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,214,194 - 11,245,891 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,929,464 - 10,935,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ELN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,999,164 - 9,048,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660707,474,714 - 7,540,034 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474013,856,932 - 13,886,266 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D5Mit282  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,746,693 - 134,746,794UniSTSGRCm38
MGSCv375135,222,563 - 135,222,664UniSTSGRCm37
Celera5131,754,718 - 131,754,819UniSTS
Cytogenetic Map5G2UniSTS
cM Map574.0UniSTS
Whitehead Genetic564.5UniSTS
Whitehead/MRC_RH51635.74UniSTS
Whitehead_YAC5 UniSTS
AI385707  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,702,945 - 134,703,068UniSTSGRCm38
MGSCv375135,178,815 - 135,178,938UniSTSGRCm37
Celera5131,710,966 - 131,711,089UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Whitehead/MRC_RH51637.05UniSTS
Whitehead/MRC_RH51635.74UniSTS
G48109  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,738,648 - 134,738,776UniSTSGRCm38
MGSCv375135,214,518 - 135,214,646UniSTSGRCm37
Celera5131,746,673 - 131,746,801UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
G48111  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,726,444 - 134,726,664UniSTSGRCm38
MGSCv375135,202,314 - 135,202,534UniSTSGRCm37
Celera5131,734,465 - 131,734,685UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
G48112  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,706,238 - 134,706,373UniSTSGRCm38
MGSCv375135,182,108 - 135,182,243UniSTSGRCm37
Celera5131,714,259 - 131,714,394UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
G48151  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,728,439 - 134,728,580UniSTSGRCm38
MGSCv375135,204,309 - 135,204,450UniSTSGRCm37
Celera5131,736,460 - 131,736,601UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Eln  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375135,204,288 - 135,205,017UniSTSGRCm37
MGSCv375135,178,734 - 135,178,980UniSTSGRCm37
MGSCv375135,178,985 - 135,179,606UniSTSGRCm37
Celera5131,711,136 - 131,711,757UniSTS
Celera5131,736,439 - 131,737,168UniSTS
Celera5131,710,885 - 131,711,131UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
cM Map575.0UniSTS
D12Mgh12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,718,043 - 134,718,149UniSTSGRCm38
MGSCv375135,193,913 - 135,194,019UniSTSGRCm37
Celera5131,726,064 - 131,726,170UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Eln  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,703,727 - 134,704,572UniSTSGRCm38
Celera5131,711,748 - 131,712,593UniSTS
Cytogenetic Map5G2UniSTS
Eln  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,703,115 - 134,703,736UniSTSGRCm38
MGSCv375135,178,985 - 135,179,606UniSTSGRCm37
Celera5131,711,136 - 131,711,757UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Eln  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,728,418 - 134,729,147UniSTSGRCm38
MGSCv375135,204,288 - 135,205,017UniSTSGRCm37
Celera5131,736,439 - 131,737,168UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Eln  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
Eln  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,702,864 - 134,703,110UniSTSGRCm38
MGSCv375135,178,734 - 135,178,980UniSTSGRCm37
Celera5131,710,885 - 131,711,131UniSTS
Cytogenetic Map5G2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir497mmu-miR-497-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI21305018
Mir15ammu-miR-15a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI21305018
Mir29ammu-miR-29a-3pMirecordsexternal_infoNANA18723672

Predicted Target Of
Summary Value
Count of predictions:169
Count of miRNA genes:147
Interacting mature miRNAs:165
Transcripts:ENSMUST00000015138
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015138   ⟹   ENSMUSP00000015138
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,731,447 - 134,776,177 (-)Ensembl
GRCm38.p6 Ensembl5134,702,593 - 134,747,323 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201399
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,773,580 - 134,776,107 (-)Ensembl
GRCm38.p6 Ensembl5134,744,726 - 134,747,253 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201856   ⟹   ENSMUSP00000144555
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,731,692 - 134,776,100 (-)Ensembl
GRCm38.p6 Ensembl5134,702,838 - 134,747,246 (-)Ensembl
RefSeq Acc Id: ENSMUST00000202570
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,731,692 - 134,754,154 (-)Ensembl
GRCm38.p6 Ensembl5134,702,838 - 134,725,300 (-)Ensembl
RefSeq Acc Id: ENSMUST00000202620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,754,457 - 134,757,960 (-)Ensembl
GRCm38.p6 Ensembl5134,725,603 - 134,729,106 (-)Ensembl
RefSeq Acc Id: NM_007925   ⟹   NP_031951
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,731,449 - 134,776,177 (-)NCBI
GRCm385134,702,595 - 134,747,323 (-)NCBI
MGSCv375135,178,466 - 135,223,124 (-)RGD
Celera5131,710,617 - 131,755,279 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240855   ⟹   XP_011239157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,731,692 - 134,776,300 (-)NCBI
GRCm385134,702,838 - 134,747,368 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031951   ⟸   NM_007925
- Peptide Label: precursor
- UniProtKB: Q8C9L8 (UniProtKB/Swiss-Prot),   P54320 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011239157   ⟸   XM_011240855
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000015138   ⟸   ENSMUST00000015138
RefSeq Acc Id: ENSMUSP00000144555   ⟸   ENSMUST00000201856

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54320-F1-model_v2 AlphaFold P54320 1-860 view protein structure

Promoters
RGD ID:6888272
Promoter ID:EPDNEW_M7587
Type:initiation region
Name:Eln_1
Description:Mus musculus elastin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385134,747,254 - 134,747,314EPDNEW
RGD ID:6847905
Promoter ID:MM_ACW:39757
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ELN.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,205,116 - 135,205,616 (-)MPROMDB
RGD ID:6837411
Promoter ID:MM_KWN:44316
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_007925
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,222,571 - 135,223,071 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95317 AgrOrtholog
Ensembl Genes ENSMUSG00000029675 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000015138 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000144555.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015138 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000201856.2 UniProtKB/TrEMBL
InterPro Tropoelastin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13717 UniProtKB/Swiss-Prot
MGD MGI:95317 ENTREZGENE
NCBI Gene 13717 ENTREZGENE
PANTHER PTHR24018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eln PhenoGen
UniProt A0A0J9YV95_MOUSE UniProtKB/TrEMBL
  ELN_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C9L8 ENTREZGENE
UniProt Secondary Q8C9L8 UniProtKB/Swiss-Prot