Hspb8 (heat shock protein family B (small) member 8) - Rat Genome Database

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Gene: Hspb8 (heat shock protein family B (small) member 8) Rattus norvegicus
Analyze
Symbol: Hspb8
Name: heat shock protein family B (small) member 8
RGD ID: 71003
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein and positive regulation of aggrephagy. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and autosomal dominant distal hereditary motor neuronopathy 2. Orthologous to human HSPB8 (heat shock protein family B (small) member 8); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-crystallin C chain; Cryac; crystallin, alpha C; heat shock 22kDa protein 8; heat shock protein 8; heat shock protein B8; heat shock protein beta-8; Hsp22; LOC108352462; MGC72354; small stress protein-like protein HSP22; uncharacterized LOC108352462
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81245,835,899 - 45,866,449 (+)NCBIGRCr8
mRatBN7.21240,176,405 - 40,205,002 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,176,532 - 40,191,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1241,351,855 - 41,366,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,965,698 - 41,980,331 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,026,095 - 41,040,728 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01245,905,371 - 45,920,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1245,905,371 - 45,920,013 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01247,717,762 - 47,731,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,407,166 - 41,421,565 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,270,553 - 41,284,952 (+)NCBI
Celera1241,813,553 - 41,828,157 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha,alpha-trehalose  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
DDE  (ISO)
deoxycholic acid  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (EXP)
fenofibrate  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
lactulose  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
melibiose  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
Nutlin-3  (ISO)
organoselenium compound  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO,ISS)
protein folding chaperone complex  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27). Benndorf R, etal., J Biol Chem 2001 Jul 20;276(29):26753-61.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14594798   PMID:14985082   PMID:15030316   PMID:15122253   PMID:15489334   PMID:17092938   PMID:18006506   PMID:19464326   PMID:22185499   PMID:22366786   PMID:23546289  
PMID:25904010   PMID:28144995   PMID:29200947   PMID:29266518   PMID:30422312   PMID:33472123   PMID:33478532   PMID:35352799   PMID:36644958   PMID:38319409  


Genomics

Comparative Map Data
Hspb8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81245,835,899 - 45,866,449 (+)NCBIGRCr8
mRatBN7.21240,176,405 - 40,205,002 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,176,532 - 40,191,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1241,351,855 - 41,366,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,965,698 - 41,980,331 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,026,095 - 41,040,728 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01245,905,371 - 45,920,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1245,905,371 - 45,920,013 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01247,717,762 - 47,731,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,407,166 - 41,421,565 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,270,553 - 41,284,952 (+)NCBI
Celera1241,813,553 - 41,828,157 (+)NCBICelera
Cytogenetic Map12q16NCBI
HSPB8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812119,178,931 - 119,194,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12119,171,555 - 119,224,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3712119,616,736 - 119,632,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612118,100,978 - 118,116,934 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412118,079,314 - 118,095,270NCBI
Celera12119,249,740 - 119,265,695 (+)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12116,624,758 - 116,640,724 (+)NCBIHuRef
CHM1_112119,584,428 - 119,600,385 (+)NCBICHM1_1
T2T-CHM13v2.012119,166,359 - 119,182,179 (+)NCBIT2T-CHM13v2.0
Hspb8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395116,546,550 - 116,560,923 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5116,546,550 - 116,560,923 (-)EnsemblGRCm39 Ensembl
GRCm385116,408,491 - 116,422,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5116,408,491 - 116,422,864 (-)EnsemblGRCm38mm10GRCm38
MGSCv375116,858,504 - 116,872,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365116,669,494 - 116,683,863 (-)NCBIMGSCv36mm8
Celera5113,505,586 - 113,520,087 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.41NCBI
Hspb8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545512,290,587 - 12,304,656 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545512,290,884 - 12,304,588 (-)NCBIChiLan1.0ChiLan1.0
HSPB8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210127,244,376 - 127,260,703 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112127,240,755 - 127,257,082 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012116,758,785 - 116,774,883 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112120,136,986 - 120,153,102 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12120,136,986 - 120,153,102 (+)Ensemblpanpan1.1panPan2
HSPB8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12615,337,718 - 15,349,993 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2615,336,864 - 15,355,757 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2615,343,116 - 15,355,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02615,606,043 - 15,618,322 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2615,605,664 - 15,625,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12615,575,862 - 15,588,132 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02615,643,221 - 15,655,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02615,685,151 - 15,697,445 (+)NCBIUU_Cfam_GSD_1.0
Hspb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,997,711 - 147,017,378 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366681,496,600 - 1,505,650 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPB8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1433,626,120 - 33,640,792 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11433,626,125 - 33,639,824 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21435,688,321 - 35,701,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPB8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111114,522,236 - 114,540,186 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11114,522,248 - 114,540,477 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037130,563,295 - 130,581,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspb8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474714,383,421 - 14,397,528 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474714,383,600 - 14,397,440 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hspb8
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:149
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000039275
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

Markers in Region
RH134545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21240,190,911 - 40,191,119 (+)MAPPERmRatBN7.2
Rnor_6.01245,919,738 - 45,919,945NCBIRnor6.0
Rnor_5.01247,731,607 - 47,731,814UniSTSRnor5.0
RGSC_v3.41241,421,289 - 41,421,496UniSTSRGSC3.4
Celera1241,827,881 - 41,828,088UniSTS
Cytogenetic Map12q16UniSTS
RH143808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21240,176,821 - 40,176,927 (+)MAPPERmRatBN7.2
Rnor_6.01245,905,634 - 45,905,739NCBIRnor6.0
Rnor_5.01247,718,025 - 47,718,130UniSTSRnor5.0
RGSC_v3.41241,407,429 - 41,407,534UniSTSRGSC3.4
Celera1241,813,816 - 41,813,921UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000039275   ⟹   ENSRNOP00000033432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1240,176,532 - 40,191,185 (+)Ensembl
Rnor_6.0 Ensembl1245,905,371 - 45,920,013 (+)Ensembl
RefSeq Acc Id: NM_053612   ⟹   NP_446064
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81245,837,308 - 45,851,939 (+)NCBI
mRatBN7.21240,176,559 - 40,191,188 (+)NCBI
Rnor_6.01245,905,371 - 45,920,014 (+)NCBI
Rnor_5.01247,717,762 - 47,731,883 (+)NCBI
RGSC_v3.41241,407,166 - 41,421,565 (+)RGD
Celera1241,813,553 - 41,828,157 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089000   ⟹   XP_038944928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81245,835,899 - 45,866,449 (+)NCBI
mRatBN7.21240,176,405 - 40,205,002 (+)NCBI
RefSeq Acc Id: NP_446064   ⟸   NM_053612
- UniProtKB: Q9EPX0 (UniProtKB/Swiss-Prot),   A6J1Q6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033432   ⟸   ENSRNOT00000039275
RefSeq Acc Id: XP_038944928   ⟸   XM_039089000
- Peptide Label: isoform X1
- UniProtKB: A6J1Q5 (UniProtKB/TrEMBL)
Protein Domains
sHSP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPX0-F1-model_v2 AlphaFold Q9EPX0 1-196 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698679
Promoter ID:EPDNEW_R9204
Type:multiple initiation site
Name:Hspb8_1
Description:heat shock protein family B member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01245,905,344 - 45,905,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71003 AgrOrtholog
BioCyc Gene G2FUF-19032 BioCyc
Ensembl Genes ENSRNOG00000022392 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055002089 UniProtKB/Swiss-Prot
  ENSRNOG00060004361 UniProtKB/Swiss-Prot
  ENSRNOG00065006303 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039275.4 UniProtKB/Swiss-Prot
  ENSRNOT00055003343 UniProtKB/Swiss-Prot
  ENSRNOT00060007314 UniProtKB/Swiss-Prot
  ENSRNOT00065009667 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599613 IMAGE-MGC_LOAD
InterPro A-crystallin/Hsp20_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-crystallin/HSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP20-like_chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSPB8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HspB8_ACD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72354 IMAGE-MGC_LOAD
NCBI Gene 113906 ENTREZGENE
PANTHER HEAT SHOCK PROTEIN BETA-8 UniProtKB/Swiss-Prot
  HEAT SHOCK PROTEIN BETA-8 UniProtKB/TrEMBL
  HEAT SHOCK PROTEIN BETA-8 UniProtKB/TrEMBL
  PTHR46906 UniProtKB/Swiss-Prot
Pfam HSP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspb8 PhenoGen
PRINTS ACRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SHSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022392 RatGTEx
  ENSRNOG00055002089 RatGTEx
  ENSRNOG00060004361 RatGTEx
  ENSRNOG00065006303 RatGTEx
Superfamily-SCOP HSP20-like chaperones UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6J1Q5 ENTREZGENE, UniProtKB/TrEMBL
  A6J1Q6 ENTREZGENE, UniProtKB/TrEMBL
  A6J1Q7_RAT UniProtKB/TrEMBL
  HSPB8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hspb8  heat shock protein family B (small) member 8  LOC108352462  uncharacterized LOC108352462  Data merged from RGD:11481703 737654 PROVISIONAL
2016-08-02 LOC108352462  uncharacterized LOC108352462      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-01-26 Hspb8  heat shock protein family B (small) member 8  Hspb8  heat shock protein B8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-06 Hspb8  heat shock protein B8  Hspb8  heat shock protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Hspb8  heat shock protein 8  Hspb8  heat shock 22kDa protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-05-11 Hspb8  heat shock 22kDa protein 8  Cryac  crystallin, alpha C  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-07-09 Cryac  crystallin, alpha C      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function displays chaperone-like activity preventing DTT-induced aggregation of insulin and heat-induced aggregation of citrate synthase 1358137
gene_function protein has a Mn2+ dependent autokinase activity in vitro 1358137
gene_homology 97.4% homologous to the human mRNA 1358137
gene_other protein degradation during storage is not the result of autocatalytic proteolysis; may be due to the presence of labile Asp-Pro peptide bonds 1358137
gene_physical_interaction unlike other small Hsps, appears to exist in a monomeric form in vitro 1358137
gene_protein predominantly a random coiled secondary structure; lacks the beta-sheet usually seen in the alph-crystallin domain of small Hsps 1358137
gene_regulation highly expressed in kidney after treatment of the immunosuppressive drug, cyclosporine A 634734