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Gene: Mvk (mevalonate kinase) Rattus norvegicus
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Symbol: Mvk
Name: mevalonate kinase
Description: Exhibits several functions, including ATP binding activity; magnesium ion binding activity; and mevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and negative regulation of translation. Localizes to the cytosol and peroxisome. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Lrbp; MK
Orthologs:
Homo sapiens (human) : MVK (mevalonate kinase)  HGNC  Alliance
Mus musculus (house mouse) : Mvk (mevalonate kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mvk (mevalonate kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MVK (mevalonate kinase)
Canis lupus familiaris (dog) : MVK (mevalonate kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mvk (mevalonate kinase)
Sus scrofa (pig) : MVK (mevalonate kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01247,904,266 - 47,920,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01249,695,252 - 49,711,443 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1243,753,220 - 43,770,539 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mvk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621295
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.