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Gene: Serpine1 (serpin family E member 1) Rattus norvegicus
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Symbol: Serpine1
Name: serpin family E member 1
Description: Exhibits protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to lipid; and cellular response to organonitrogen compound. Localizes to the chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal failure; and hematopoietic system disease (multiple). Biomarker of several diseases, including glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; muscular atrophy; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetic angiopathy; eye disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-colchicine; (S)-naringenin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; Pai1; PAI1A; Pai1aa; Planh; Plasminogen activator inhibitor; plasminogen activator inhibitor 1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Orthologs:
Homo sapiens (human) : SERPINE1 (serpin family E member 1)  HGNC  Alliance
Mus musculus (house mouse) : Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpine1 (serpin family E member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINE1 (serpin family E member 1)
Canis lupus familiaris (dog) : SERPINE1 (serpin family E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpine1 (serpin family E member 1)
Sus scrofa (pig) : SERPINE1 (serpin family E member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
Cytogenetic Map12q12NCBI
RH 3.4 Map12277.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
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Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)