Serpine1 (serpin family E member 1) - Rat Genome Database

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Gene: Serpine1 (serpin family E member 1) Rattus norvegicus
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Symbol: Serpine1
Name: serpin family E member 1
RGD ID: 3249
Description: Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); metabolic dysfunction and alcohol associated liver disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; INTERACTS WITH (S)-colchicine; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; Pai1; PAI1A; Pai1aa; Planh; Plasminogen activator inhibitor; plasminogen activator inhibitor 1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,237,977 - 25,248,356 (+)NCBIGRCr8
mRatBN7.21219,601,272 - 19,611,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,601,272 - 19,611,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,739,113 - 20,749,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,351,819 - 21,362,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,416,358 - 20,426,756 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP)
Acquired Protein C Deficiency  (IEP)
Acute Lung Injury  (IDA,IEP)
acute necrotizing pancreatitis  (IEP,ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic rhinitis  (ISO)
amyloidosis  (ISO)
Animal Disease Models  (ISO)
anterolateral myocardial infarction  (ISO)
aortic aneurysm  (IMP)
Aortic Remodeling  (IDA)
Arterial Thrombosis  (IEP)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (IDA)
breast cancer  (ISO)
bronchopulmonary dysplasia  (ISO)
Cardiac Fibrosis  (IDA,IEP)
Carotid Artery Injuries  (IEP)
Central Serous Chorioretinopathy  (ISO)
cerebral infarction  (IDA)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Choroidal Neovascularization, Experimental  (IDA,ISO)
Chronic Allograft Nephropathy  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISS)
Dermal Fibrosis  (ISO)
diabetes mellitus  (IDA)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IDA,IEP,ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (IDA,IEP)
end stage renal disease  (IDA,ISO)
Endotoxemia  (IDA,IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
familial Mediterranean fever  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
fibrosarcoma  (ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
Gastrointestinal Hemorrhage  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (IDA,IEP)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematopoietic system disease  (IDA)
Hemorrhage  (IDA,IEP,ISO)
hemorrhagic disease  (ISO)
high grade glioma  (ISO)
Hyaline Membrane Disease  (ISO)
hypertension  (IDA,IEP,ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (IDA,IEP)
interstitial lung disease  (ISO)
Intestinal Polyps  (ISO)
Intestinal Reperfusion Injury  (IDA)
ischemic colitis  (ISO)
Kidney Reperfusion Injury  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (IEP)
lung disease  (ISO)
Lung Reperfusion Injury  (IDA,ISO)
macular degeneration  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IDA)
middle cerebral artery infarction  (IEP)
Multiple Organ Failure  (IDA)
Multiple Trauma  (IEP)
muscular atrophy  (IEP)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
Neointima  (IMP,ISO)
Neovascularization, Pathologic  (ISO)
nephrotic syndrome  (ISO)
nervous system disease  (ISO)
neurilemmoma  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Oxygen-Induced Retinopathy  (IEP,ISO)
Penetrating Wounds  (IEP)
peripheral artery disease  (ISO)
Peritoneal Adhesions  (IDA,IEP)
Peritoneal Fibrosis  (ISO)
placental insufficiency  (ISO)
Plasminogen Activator Inhibitor-1 Deficiency  (ISO)
platelet-type bleeding disorder 10  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
polycythemia  (IEP)
polyneuropathy  (ISO)
portal vein thrombosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy Complications  (ISO)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
pulmonary hypertension  (IDA,ISO)
Radiation Nephropathy  (IEP)
relapsing-remitting multiple sclerosis  (ISO)
renal fibrosis  (IDA,IEP)
respiratory allergy  (ISO)
retinal vein occlusion  (ISO)
retinopathy of prematurity  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (IDA,ISO)
sleep apnea  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (IDA,IEP,ISO)
ureteral obstruction  (IDA,IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
Vascular Depression  (IDA)
Vascular Remodeling  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (IEP,IMP,ISO)
Ventilator-Induced Lung Injury  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2,5-dichlorophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (EXP,ISO)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
aminoguanidine  (EXP,ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
apocynin  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspalathin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
Aurin  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
barium chloride  (EXP)
benazepril  (EXP,ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
busulfan  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (EXP)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
Clofop  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
emodin  (ISO)
enalapril  (EXP)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
eplerenone  (EXP)
eprosartan  (EXP)
Ethyl icosapentate  (EXP)
ethyl methanesulfonate  (ISO)
famotidine  (EXP)
fenofibrate  (EXP,ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gestodene  (ISO)
Gingerenone A  (ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
guanethidine  (ISO)
GW 501516  (ISO)
heparin  (EXP)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (EXP)
Honokiol  (EXP)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxychloroquine  (ISO)
hydroxyl  (ISO)
hypochlorous acid  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
iron(III) citrate  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium atom  (ISO)
magnesium dichloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
meglumine amidotrizoate  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metaproterenol  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metyrapone  (EXP)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N-acetylsphingosine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nonanedioic acid  (ISO)
Nonidet P-40  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
orciprenaline  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pazopanib  (ISO)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
Phenelzine  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phosphane  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Phytolaccoside E  (ISO)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chloride  (EXP)
potassium dichromate  (ISO)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
roflumilast  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salvianolic acid B  (ISO)
saralasin  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiacloprid  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thiram  (ISO)
tibolone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
trametinib  (ISO)
trans-caffeic acid  (ISO)
triadimefon  (ISO)
triamterene  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
undecane  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
cellular response to aldosterone  (IEP)
cellular response to angiotensin  (IEP)
cellular response to ATP  (IEP)
cellular response to cAMP  (IEP)
cellular response to cGMP  (IEP)
cellular response to cycloheximide  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gravity  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-1  (IDA)
cellular response to ionomycin  (IEP)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to metal ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to nicotine  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to potassium ion  (IEP)
cellular response to pyrimidine ribonucleotide  (IEP)
cellular response to resveratrol  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP,ISO)
cellular response to xenobiotic stimulus  (IDA)
decidualization  (IEP)
defense response to Gram-negative bacterium  (IEA,ISO)
dentinogenesis  (IEA,ISO)
female gonad development  (IDA)
mast cell activation  (IEP)
negative regulation of cell adhesion mediated by integrin  (IEA,ISO)
negative regulation of cell migration  (IDA,IMP,ISO)
negative regulation of endopeptidase activity  (IC,IDA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of fibrinolysis  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of plasminogen activation  (IBA,IEA,ISO)
negative regulation of smooth muscle cell migration  (IEA,ISO)
negative regulation of smooth muscle cell-matrix adhesion  (IEA,ISO)
negative regulation of vascular wound healing  (IBA,IEA,ISO)
placenta development  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of calcium ion import  (IMP)
positive regulation of coagulation  (IBA,IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of epithelium regeneration  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of keratinocyte migration  (IMP)
positive regulation of leukotriene production involved in inflammatory response  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IEA,ISO)
positive regulation of odontoblast differentiation  (IEA,ISO)
positive regulation of receptor-mediated endocytosis  (IEA,IMP,ISO)
regulation of angiogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of signaling receptor activity  (ISO)
replicative senescence  (IEA,ISO,ISS)
response to cytokine  (IEP)
response to epidermal growth factor  (IEP)
response to estrogen  (IEP)
response to hyperoxia  (IEP)
response to laminar fluid shear stress  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to reactive oxygen species  (IEP)
response to starvation  (IEP)
response to transforming growth factor beta  (IEP)
tissue regeneration  (IEP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
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2. Modulation of retinal capillary endothelial cells by Muller glial cell-derived factors. Abukawa H, etal., Mol Vis. 2009;15:451-7. Epub 2009 Feb 27.
3. Prevention of aneurysm development and rupture by local overexpression of plasminogen activator inhibitor-1. Allaire E, etal., Circulation. 1998 Jul 21;98(3):249-55.
4. Osteoblasts display receptors for and responses to leukemia-inhibitory factor. Allan EH, etal., J Cell Physiol. 1990 Oct;145(1):110-9.
5. Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model rats. Asakura H, etal., J Thromb Haemost. 2005 May;3(5):1050-5.
6. Elevated plasma procoagulant and fibrinolytic markers in patients with chronic obstructive pulmonary disease. Ashitani J, etal., Intern Med. 2002 Mar;41(3):181-5.
7. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. Askari AT, etal., J Exp Med. 2003 Mar 3;197(5):615-24.
8. Mutant matrix metalloproteinase-9 reduces postoperative peritoneal adhesions in rats. Atta H, etal., Int J Surg. 2016 Feb;26:58-63. doi: 10.1016/j.ijsu.2015.12.065. Epub 2016 Jan 12.
9. Role of COX-2-derived PGE2 on vascular stiffness and function in hypertension. Avendano MS, etal., Br J Pharmacol. 2016 May;173(9):1541-55. doi: 10.1111/bph.13457. Epub 2016 Mar 21.
10. Secretion of cardiac plasminogen activator during hypoxia-induced right ventricular hypertrophy. Bansal DD, etal., J Mol Cell Cardiol. 1997 Nov;29(11):3105-14.
11. Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. Barazzone C, etal., J Clin Invest. 1996 Dec 15;98(12):2666-73.
12. Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy. Basu A, etal., Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4974-81. doi: 10.1167/iovs.09-3619. Epub 2009 May 14.
13. Analysis of inherited thrombophilic mutations and natural anticoagulant deficiency in patients with idiopathic portal hypertension. Bayan K, etal., J Thromb Thrombolysis. 2009 Jul;28(1):57-62. doi: 10.1007/s11239-008-0244-8. Epub 2008 Aug 7.
14. The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population. Benes P, etal., J Mol Med. 2001 Apr;79(2-3):116-20.
15. Plasminogen activator inhibitor-1 gene polymorphism in Iranian Azeri Turkish patients with FMF disease and its association with amyloidosis. Bonyadi M, etal., Eur J Pediatr. 2013 Jan;172(1):91-8. doi: 10.1007/s00431-012-1844-z. Epub 2012 Oct 5.
16. Natriuretic factors and nitric oxide suppress plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Role of cGMP in the regulation of the plasminogen system. Bouchie JL, etal., Arterioscler Thromb Vasc Biol. 1998 Nov;18(11):1771-9.
17. P2Y receptor regulation of PAI-1 expression in vascular smooth muscle cells. Bouchie JL, etal., Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):866-73.
18. Pioglitazone in adult rats reverses immediate postnatal overfeeding-induced metabolic, hormonal, and inflammatory alterations. Boullu-Ciocca S, etal., Endocrine. 2015 Dec;50(3):608-19. doi: 10.1007/s12020-015-0657-z. Epub 2015 Jun 18.
19. The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats. Bouton MC, etal., Arterioscler Thromb Vasc Biol 2003 Jan 1;23(1):142-7.
20. Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors. Braun OO, etal., J Mol Cell Cardiol. 2010 Sep;49(3):362-9. doi: 10.1016/j.yjmcc.2010.05.001. Epub 2010 May 13.
21. Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids. Brims FJ, etal., Thorax. 2009 Dec;64(12):1037-43. Epub 2009 Aug 23.
22. Modulation of plasminogen activator inhibitor type-1 biosynthesis in vitro and in vivo with oligo(nucleoside phosphorothioate)s and related constructs. Buczko W, etal., Pharmacol Ther. 1997 Oct-Dec;76(1-3):161-75.
23. Treatment with oestrogen-receptor agonists or oxytocin in conjunction with exercise protects against post-menopausal myocardial infarction in rats. Bulut EC, etal., Exp Physiol. 2016 Mar 9. doi: 10.1113/EP085708.
24. Fructose-induced inflammation, insulin resistance and oxidative stress: A liver pathological triad effectively disrupted by lipoic acid. Castro MC, etal., Life Sci. 2015 Sep 15;137:1-6. doi: 10.1016/j.lfs.2015.07.010. Epub 2015 Jul 17.
25. Plasminogen activator inhibitor-1 is independently associated with non-alcoholic fatty liver disease whereas leptin and adiponectin vary between genders. Chang ML, etal., J Gastroenterol Hepatol. 2015 Feb;30(2):329-36. doi: 10.1111/jgh.12705.
26. SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin. Chang W, etal., J Biol Chem. 2010 Mar 12;285(11):8196-206. Epub 2010 Jan 8.
27. Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia. Charakida M, etal., Atherosclerosis. 2009 Jun;204(2):532-7. doi: 10.1016/j.atherosclerosis.2008.09.025. Epub 2008 Oct 5.
28. 4G/5G promoter polymorphism of plasminogen activator inhibitor-1, lipid profiles, and ischemic stroke. Chen CH, etal., J Lab Clin Med. 2003 Aug;142(2):100-5.
29. Intravesical administration of plasminogen activator inhibitor type-1 inhibits in vivo bladder tumor invasion and progression.