Serpine1 (serpin family E member 1) - Rat Genome Database

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Gene: Serpine1 (serpin family E member 1) Rattus norvegicus
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Symbol: Serpine1
Name: serpin family E member 1
RGD ID: 3249
Description: Exhibits protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Localizes to chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; muscular atrophy; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; INTERACTS WITH (S)-colchicine; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; Pai1; PAI1A; Pai1aa; Planh; Plasminogen activator inhibitor; plasminogen activator inhibitor 1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,601,272 - 19,611,657 (+)NCBI
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP)
Acquired Protein C Deficiency  (IEP)
Acute Lung Injury  (IDA,IEP)
Acute Necrotizing Pancreatitis  (IEP,ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (IEP)
alcoholic liver cirrhosis  (ISO)
allergic rhinitis  (ISO)
amyloidosis  (ISO)
Animal Disease Models  (ISO)
anterolateral myocardial infarction  (ISO)
aortic aneurysm  (IMP)
Aortic Remodeling  (IDA)
Arterial Thrombosis  (IEP)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
brain ischemia  (IDA)
breast cancer  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Fibrosis  (IDA,IEP)
Carotid Artery Injuries  (IEP)
Central Serous Chorioretinopathy  (ISO)
cerebral infarction  (IDA)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Choroidal Neovascularization, Experimental  (IDA,ISO)
Chronic Allograft Nephropathy  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISS)
Dermal Fibrosis  (ISO)
diabetes mellitus  (IDA)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IDA,IEP,ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (IDA,IEP)
end stage renal disease  (IDA,ISO)
Endotoxemia  (IDA,IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
fibrosarcoma  (ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (IDA,IEP)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematopoietic system disease  (IDA)
Hemorrhage  (IDA,IEP)
hemorrhagic disease  (ISO)
high grade glioma  (ISO)
Hyaline Membrane Disease  (ISO)
hypertension  (IDA,IEP,ISO)
hyperthyroidism  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin Resistance  (IDA,IEP)
interstitial lung disease  (ISO)
Intestinal Polyps  (ISO)
Intestinal Reperfusion Injury  (IDA)
ischemic colitis  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (IEP)
lung disease  (ISO)
Lung Reperfusion Injury  (IDA,ISO)
macular degeneration  (ISO)
Metabolic Syndrome  (IDA)
middle cerebral artery infarction  (IEP)
Multiple Organ Failure  (IDA)
Multiple Trauma  (IEP)
muscular atrophy  (IEP)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
Neointima  (IMP,ISO)
Neovascularization, Pathologic  (ISO)
nephrotic syndrome  (ISO)
nervous system disease  (ISO)
neurilemmoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Oxygen-Induced Retinopathy  (IEP,ISO)
peripheral artery disease  (ISO)
Peritoneal Adhesions  (IDA,IEP)
Peritoneal Fibrosis  (ISO)
placental insufficiency  (ISO)
Plasminogen Activator Inhibitor-1 Deficiency  (ISO)
platelet-type bleeding disorder 10  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
polycythemia  (IEP)
polyneuropathy  (ISO)
portal vein thrombosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy Complications  (ISO)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
pulmonary hypertension  (IDA,ISO)
Radiation Nephropathy  (IEP)
relapsing-remitting multiple sclerosis  (ISO)
renal fibrosis  (IDA,IEP)
respiratory allergy  (ISO)
retinal vein occlusion  (ISO)
retinopathy of prematurity  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (IDA,ISO)
sleep apnea  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (IDA,IEP,ISO)
ureteral obstruction  (IDA,IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
Vascular Depression  (IDA)
Vascular Remodeling  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (IEP,IMP,ISO)
Ventilator-Induced Lung Injury  (IEP)
Wounds, Penetrating  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (ISO)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (EXP,ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apocynin  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspalathin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
Aurin  (ISO)
azathioprine  (ISO)
barium chloride  (EXP)
benazepril  (EXP,ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
busulfan  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
Clofop  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
emodin  (ISO)
enalapril  (EXP)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
eplerenone  (EXP)
eprosartan  (EXP)
Ethyl icosapentate  (EXP)
ethyl methanesulfonate  (ISO)
famotidine  (EXP)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
geldanamycin  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gestodene  (ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
guanethidine  (ISO)
GW 501516  (ISO)
heparin  (EXP)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (EXP)
Honokiol  (EXP)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxychloroquine  (ISO)
hydroxyl  (ISO)
hypochlorous acid  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
iron(III) citrate  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
LY 364947  (ISO)
magnesium atom  (ISO)
magnesium dichloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
meglumine amidotrizoate  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metaproterenol  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
mitoxantrone  (EXP)
monocrotaline  (ISO)
N-acetylsphingosine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nonanedioic acid  (ISO)
Nonidet P-40  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
orciprenaline  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
paricalcitol  (ISO)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Phenelzine  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chloride  (EXP)
potassium dichromate  (ISO)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
saralasin  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiacloprid  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
tibolone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
trans-caffeic acid  (ISO)
triadimefon  (ISO)
triamterene  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
undecane  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc molecular entity  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
cellular response to aldosterone  (IEP)
cellular response to angiotensin  (IEP)
cellular response to ATP  (IEP)
cellular response to cAMP  (IEP)
cellular response to cGMP  (IEP)
cellular response to cycloheximide  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to drug  (IDA)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gravity  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-1  (IDA)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to metal ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to nicotine  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to potassium ion  (IEP)
cellular response to resveratrol  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP,ISO)
decidualization  (IEP)
defense response to Gram-negative bacterium  (IEA,ISO)
dentinogenesis  (IEA,ISO)
female gonad development  (IDA)
glucose homeostasis  (IEP)
mast cell activation  (IEP)
negative regulation of cell adhesion mediated by integrin  (IEA,ISO)
negative regulation of cell migration  (IDA,IMP,ISO)
negative regulation of endopeptidase activity  (IBA,IC,IDA,IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of fibrinolysis  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of plasminogen activation  (IBA,IEA,ISO)
negative regulation of smooth muscle cell migration  (IEA,ISO)
negative regulation of smooth muscle cell-matrix adhesion  (IEA,ISO)
negative regulation of vascular wound healing  (IBA,IEA,ISO)
placenta development  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of calcium ion import  (IMP)
positive regulation of coagulation  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of epithelium regeneration  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of keratinocyte migration  (IMP)
positive regulation of leukotriene production involved in inflammatory response  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IEA,ISO)
positive regulation of odontoblast differentiation  (IEA,ISO)
positive regulation of receptor-mediated endocytosis  (IEA,IMP,ISO)
regulation of angiogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of signaling receptor activity  (IEA,ISO)
replicative senescence  (IEA,ISO,ISS)
response to cytokine  (IEP)
response to epidermal growth factor  (IEP)
response to estrogen  (IEP)
response to hyperoxia  (IEP)
response to laminar fluid shear stress  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to reactive oxygen species  (IEP)
response to starvation  (IEP)
response to transforming growth factor beta  (IEP)
tissue regeneration  (IEP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
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Additional References at PubMed
PMID:1601887   PMID:1632457   PMID:1695900   PMID:2298740   PMID:2503541   PMID:8508955   PMID:8837777   PMID:9207454   PMID:9386191   PMID:10902815   PMID:11776323   PMID:11818362  
PMID:11866539   PMID:12114510   PMID:12192306   PMID:12600825   PMID:12777947   PMID:14610081   PMID:15201552   PMID:15328353   PMID:15728787   PMID:15808835   PMID:15853774   PMID:16862142  
PMID:17394767   PMID:17396111   PMID:17655862   PMID:17953365   PMID:18367662   PMID:18471418   PMID:18554148   PMID:18636553   PMID:18664599   PMID:18761555   PMID:18835034   PMID:18974388  
PMID:19246637   PMID:19306296   PMID:19403340   PMID:19625379   PMID:19718486   PMID:19855083   PMID:19887897   PMID:19916862   PMID:20538356   PMID:21036181   PMID:21119013   PMID:21193004  
PMID:21276792   PMID:21355198   PMID:21412817   PMID:21613793   PMID:21752621   PMID:21829547   PMID:22071631   PMID:22556277   PMID:23016136   PMID:23021499   PMID:23218127   PMID:23979707  
PMID:24006456   PMID:24913911   PMID:25106729   PMID:25342286   PMID:26415098   PMID:27046084   PMID:27456456   PMID:28337441   PMID:28722352   PMID:29278662   PMID:29644896   PMID:30449218  
PMID:30982977   PMID:31257474  


Genomics

Comparative Map Data
Serpine1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,601,272 - 19,611,657 (+)NCBI
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
SERPINE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7101,127,089 - 101,139,266 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl7101,127,104 - 101,139,247 (+)EnsemblGRCh38hg38GRCh38
GRCh387101,127,104 - 101,139,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,770,385 - 100,782,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,557,172 - 100,569,026 (+)NCBINCBI36hg18NCBI36
Build 347100,363,886 - 100,375,741NCBI
Celera795,778,744 - 95,790,926 (+)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,363,553 - 95,375,745 (+)NCBIHuRef
CHM1_17100,700,705 - 100,712,867 (+)NCBICHM1_1
CRA_TCAGchr7v27100,128,757 - 100,140,934 (+)NCBI
Serpine1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,090,358 - 137,101,126 (-)NCBIGRCm39mm39
GRCm39 Ensembl5137,090,358 - 137,101,122 (-)Ensembl
GRCm385137,061,504 - 137,072,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,061,504 - 137,072,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,537,374 - 137,548,142 (-)NCBIGRCm37mm9NCBIm37
MGSCv365137,346,135 - 137,356,886 (-)NCBImm8
Celera5134,078,340 - 134,089,224 (-)NCBICelera
Cytogenetic Map5G2NCBI
Serpine1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,145,944 - 16,157,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,147,523 - 16,157,040 (-)NCBIChiLan1.0ChiLan1.0
SERPINE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17106,511,539 - 106,518,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,510,130 - 106,518,450 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0793,267,517 - 93,279,728 (+)NCBIMhudiblu_PPA_v0panPan3
SERPINE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,719,547 - 8,727,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,720,825 - 8,726,301 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,418,147 - 10,423,482 (-)NCBI
ROS_Cfam_1.068,538,810 - 8,546,429 (-)NCBI
UMICH_Zoey_3.168,500,159 - 8,505,509 (-)NCBI
UNSW_CanFamBas_1.068,470,611 - 8,475,963 (-)NCBI
UU_Cfam_GSD_1.068,635,341 - 8,640,693 (-)NCBI
Serpine1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,997,052 - 133,003,714 (-)NCBI
SpeTri2.0NW_0049365431,032,543 - 1,040,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,863,695 - 8,871,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,863,738 - 8,871,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SERPINE1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,047,520 - 12,060,662 (-)NCBI
ChlSab1.1 Ensembl2812,047,529 - 12,060,202 (-)Ensembl
Vero_WHO_p1.0NW_0236660704,295,672 - 4,308,796 (+)NCBI
Serpine1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474016,128,145 - 16,136,696 (-)NCBI

Position Markers
D12Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,870 - 19,611,091 (+)MAPPER
Rnor_6.01222,650,702 - 22,650,918NCBIRnor6.0
Rnor_5.01224,662,983 - 24,663,199UniSTSRnor5.0
RGSC_v3.41220,932,560 - 20,932,776UniSTSRGSC3.4
RGSC_v3.41220,932,559 - 20,932,776RGDRGSC3.4
RGSC_v3.11220,922,171 - 20,922,388RGD
Celera1221,386,630 - 21,386,846UniSTS
RH 3.4 Map12280.3RGD
RH 3.4 Map12280.3UniSTS
RH 2.0 Map12205.1RGD
SHRSP x BN Map1222.7RGD
FHH x ACI Map129.01RGD
Cytogenetic Map12q11-q12UniSTS
D12Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,886 - 19,611,090 (+)MAPPER
Rnor_6.01222,650,718 - 22,650,917NCBIRnor6.0
Rnor_5.01224,662,999 - 24,663,198UniSTSRnor5.0
RGSC_v3.41220,932,561 - 20,932,760UniSTSRGSC3.4
RGSC_v3.41220,932,560 - 20,932,760RGDRGSC3.4
RGSC_v3.11220,922,172 - 20,922,372RGD
Celera1221,386,646 - 21,386,845UniSTS
RH 3.4 Map12277.7UniSTS
RH 3.4 Map12277.7RGD
RH 2.0 Map12206.8RGD
Cytogenetic Map12q11-q12UniSTS
D12Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,889 - 19,611,095 (+)MAPPER
Rnor_6.01222,650,721 - 22,650,922NCBIRnor6.0
Rnor_5.01224,663,002 - 24,663,203UniSTSRnor5.0
RGSC_v3.41220,932,556 - 20,932,757UniSTSRGSC3.4
RGSC_v3.41220,932,555 - 20,932,757RGDRGSC3.4
RGSC_v3.11220,922,167 - 20,922,369RGD
Celera1221,386,649 - 21,386,850UniSTS
RH 3.4 Map12277.5UniSTS
RH 3.4 Map12277.5RGD
RH 2.0 Map12197.1RGD
Cytogenetic Map12q11-q12UniSTS
D12Arb4   No map positions available.
RH129692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,611,385 - 19,611,585 (+)MAPPER
Rnor_6.01222,651,211 - 22,651,410NCBIRnor6.0
Rnor_5.01224,663,492 - 24,663,691UniSTSRnor5.0
RGSC_v3.41220,932,068 - 20,932,267UniSTSRGSC3.4
Celera1221,387,139 - 21,387,338UniSTS
RH 3.4 Map12277.5UniSTS
Cytogenetic Map12q11-q12UniSTS
RH142420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,381 - 19,610,594 (+)MAPPER
Rnor_6.01222,650,213 - 22,650,425NCBIRnor6.0
Rnor_5.01224,662,494 - 24,662,706UniSTSRnor5.0
RGSC_v3.41220,933,053 - 20,933,265UniSTSRGSC3.4
Celera1221,386,141 - 21,386,353UniSTS
RH 3.4 Map12277.5UniSTS
Cytogenetic Map12q11-q12UniSTS
RH94577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,611,229 - 19,611,407 (+)MAPPER
Rnor_6.01222,651,055 - 22,651,232NCBIRnor6.0
Rnor_5.01224,663,336 - 24,663,513UniSTSRnor5.0
RGSC_v3.41220,932,246 - 20,932,423UniSTSRGSC3.4
Celera1221,386,983 - 21,387,160UniSTS
Cytogenetic Map12q11-q12UniSTS
PMC15197P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,609,566 - 19,610,072 (+)MAPPER
Rnor_6.01222,649,398 - 22,649,903NCBIRnor6.0
Rnor_5.01224,661,679 - 24,662,184UniSTSRnor5.0
RGSC_v3.41220,933,575 - 20,934,080UniSTSRGSC3.4
Celera1221,385,326 - 21,385,831UniSTS
Cytogenetic Map12q11-q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12122650917Rat
10450854Stl34Serum triglyceride level QTL 343.50.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)12122853017Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12123035872Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123758197Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12130749723Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12136919844Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12138334225Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)1215081045150810Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1215081045150810Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)1249257845492578Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12247568747475687Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12251344247513442Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12251344247513442Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12421005149210051Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12895459327911196Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6922362652716770Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922363052716770Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12978983452716770Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121017588931975590Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)121025689031723732Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)121176499537522089Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121312721127285590Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121312721131723688Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121312721150320041Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121441977552716770Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121502198652716770Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121571460935964508Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121571460941291738Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121590890052716770Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121590890052716770Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121711477023839390Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121718558044098244Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121796086538409001Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121834247752716770Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121834247752716770Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121872904352716770Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121875259352716770Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101875259352716770Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)122265070227190240Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122265070245946937Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122265070248598906Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)122265070252716770Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122265072141291738Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:814
Count of miRNA genes:305
Interacting mature miRNAs:394
Transcripts:ENSRNOT00000001916
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 16 3 3 9 5
Low 2 27 48 35 19 35 8 11 66 32 32 6 8
Below cutoff 6 6 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001916   ⟹   ENSRNOP00000001916
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)Ensembl
RefSeq Acc Id: NM_012620   ⟹   NP_036752
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21219,601,272 - 19,611,657 (+)NCBI
Rnor_6.01222,641,104 - 22,651,482 (+)NCBI
Rnor_5.01224,653,385 - 24,663,763 (+)NCBI
RGSC_v3.41220,931,996 - 20,942,374 (-)RGD
Celera1221,377,028 - 21,387,410 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036752 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41796 (Get FASTA)   NCBI Sequence Viewer  
  AAA56856 (Get FASTA)   NCBI Sequence Viewer  
  EDM13286 (Get FASTA)   NCBI Sequence Viewer  
  P20961 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036752   ⟸   NM_012620
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000001916   ⟸   ENSRNOT00000001916
Protein Domains
SERPIN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698524
Promoter ID:EPDNEW_R9049
Type:multiple initiation site
Name:Serpine1_1
Description:serpin family E member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,641,079 - 22,641,139EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)