Myl10 (myosin light chain 10) - Rat Genome Database

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Gene: Myl10 (myosin light chain 10) Rattus norvegicus
Analyze
Symbol: Myl10
Name: myosin light chain 10
RGD ID: 1561258
Description: Predicted to enable calcium ion binding activity. Predicted to be active in mitochondrion. Orthologous to human MYL10 (myosin light chain 10); INTERACTS WITH trichloroethene; (+)-catechin (ortholog); 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC501831; Myl10-ps1; Mylc2pl; myosin light chain 2, precursor lymphocyte-specific; myosin regulatory light chain 10; myosin, light chain 10, regulatory; myosin, light chain 10, regulatory, pseudogene 1; RGD1561258; similar to myosin light chain 2, precursor lymphocyte-specific; uncharacterized protein LOC501831
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,606,558 - 25,619,270 (-)NCBIGRCr8
mRatBN7.21219,969,174 - 19,982,627 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,970,055 - 19,978,614 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01223,011,817 - 23,075,558 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,011,942 - 23,021,517 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,014,687 - 25,076,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,082,810 - 21,095,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1221,742,549 - 21,805,591 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015  


Genomics

Comparative Map Data
Myl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,606,558 - 25,619,270 (-)NCBIGRCr8
mRatBN7.21219,969,174 - 19,982,627 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,970,055 - 19,978,614 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01223,011,817 - 23,075,558 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,011,942 - 23,021,517 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,014,687 - 25,076,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,082,810 - 21,095,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1221,742,549 - 21,805,591 (-)NCBICelera
Cytogenetic Map12q12NCBI
MYL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,613,330 - 101,629,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,613,330 - 101,629,296 (-)EnsemblGRCh38hg38GRCh38
GRCh377101,256,610 - 101,272,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367101,043,475 - 101,059,118 (-)NCBINCBI36Build 36hg18NCBI36
Celera796,264,670 - 96,280,650 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,845,759 - 95,861,739 (-)NCBIHuRef
CHM1_17101,188,570 - 101,204,545 (-)NCBICHM1_1
T2T-CHM13v2.07102,933,202 - 102,949,180 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,614,992 - 100,630,963 (-)NCBI
Myl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395136,717,749 - 136,730,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5136,722,000 - 136,729,948 (+)EnsemblGRCm39 Ensembl
GRCm385136,688,892 - 136,701,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,693,146 - 136,701,094 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,169,016 - 137,176,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,977,773 - 136,985,721 (+)NCBIMGSCv36mm8
Celera5133,714,303 - 133,722,952 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.03NCBI
Myl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545615,754,234 - 15,763,987 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545615,754,234 - 15,763,987 (+)NCBIChiLan1.0ChiLan1.0
MYL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,623,857 - 119,639,811 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,888,482 - 167,904,436 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,751,255 - 93,767,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,986,547 - 107,002,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,986,697 - 107,002,148 (-)Ensemblpanpan1.1panPan2
MYL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,313,891 - 8,333,518 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,301,401 - 8,333,520 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,011,744 - 10,031,367 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,133,669 - 8,153,299 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,142,574 - 8,153,299 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,089,981 - 8,109,600 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,064,717 - 8,084,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,229,569 - 8,249,192 (+)NCBIUU_Cfam_GSD_1.0
Myl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,641,074 - 132,676,429 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,359,413 - 1,395,611 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,360,101 - 1,368,686 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl39,187,812 - 9,198,493 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.139,187,808 - 9,198,476 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,726,761 - 8,738,595 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12811,559,077 - 11,570,826 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660704,828,432 - 4,845,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474015,773,217 - 15,784,513 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474015,731,519 - 15,784,472 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:85
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000041654
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 1 20 25 28 19 2 19 3 53 11 17 6 25 9

Sequence


Ensembl Acc Id: ENSRNOT00000041654   ⟹   ENSRNOP00000048768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,970,055 - 19,978,614 (-)Ensembl
Rnor_6.0 Ensembl1223,011,942 - 23,021,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100216   ⟹   ENSRNOP00000081000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,970,314 - 19,978,614 (-)Ensembl
RefSeq Acc Id: XM_039089891   ⟹   XP_038945819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,606,558 - 25,619,270 (-)NCBI
mRatBN7.21219,969,174 - 19,982,627 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001418803 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418804 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945819 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13308 (Get FASTA)   NCBI Sequence Viewer  
  EDM13309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048768.6
  ENSRNOP00000081000.1
Ensembl Acc Id: ENSRNOP00000048768   ⟸   ENSRNOT00000041654
RefSeq Acc Id: XP_038945819   ⟸   XM_039089891
Ensembl Acc Id: ENSRNOP00000081000   ⟸   ENSRNOT00000100216
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCI9-F1-model_v2 AlphaFold D3ZCI9 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561258 AgrOrtholog
BioCyc Gene G2FUF-19663 BioCyc
Ensembl Genes ENSRNOG00000028981 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041654.6 UniProtKB/TrEMBL
  ENSRNOT00000100216.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Myosin_RLC UniProtKB/TrEMBL
NCBI Gene 501831 ENTREZGENE
PANTHER MYOSIN REGULATORY LIGHT CHAIN 10 UniProtKB/TrEMBL
  MYOSIN REGULATORY LIGHT CHAIN 2 UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PhenoGen Myl10 PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028981 RatGTEx
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8I5ZS23_RAT UniProtKB/TrEMBL
  A6J069 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCI9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Myl10  myosin light chain 10  Myl10  myosin, light chain 10, regulatory  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-05 Myl10  myosin, light chain 10, regulatory  Myl10-ps1  myosin, light chain 10, regulatory, pseudogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-08 Myl10-ps1  myosin, light chain 10, regulatory, pseudogene 1  Myl10  myosin, light chain 10, regulatory  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-07 Myl10  myosin, light chain 10, regulatory  Mylc2pl  myosin light chain 2, precursor lymphocyte-specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Mylc2pl  myosin light chain 2, precursor lymphocyte-specific  RGD1561258_predicted  similar to myosin light chain 2, precursor lymphocyte-specific (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561258_predicted  similar to myosin light chain 2, precursor lymphocyte-specific (predicted)  LOC501831  similar to myosin light chain 2, precursor lymphocyte-specific  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501831  similar to myosin light chain 2, precursor lymphocyte-specific      Symbol and Name status set to provisional 70820 PROVISIONAL