Ervfrd-1 (endogenous retrovirus group FRD member 1, envelope) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ervfrd-1 (endogenous retrovirus group FRD member 1, envelope) Rattus norvegicus
Analyze
Symbol: Ervfrd-1
Name: endogenous retrovirus group FRD member 1, envelope
RGD ID: 1563240
Description: Predicted to be involved in syncytium formation by plasma membrane fusion. Predicted to act upstream of or within labyrinthine layer development and myoblast fusion. Predicted to be located in membrane. Orthologous to human ERVFRD-1 (endogenous retrovirus group FRD member 1, envelope); INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: endogenous retrovirus group FRD member 1; envelope glycoprotein syncytin-A; Gm52; Syna; syncytin a
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,787,680 - 27,794,732 (+)NCBIGRCr8
mRatBN7.21222,151,211 - 22,158,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,151,211 - 22,158,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,294,443 - 23,301,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,905,524 - 23,912,428 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,972,115 - 22,979,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,161,130 - 25,168,182 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,161,130 - 25,168,182 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,161,524 - 27,168,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,220,471 - 23,222,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1223,915,041 - 23,922,023 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 63 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ervfrd-1Rat(25R)-cholest-5-ene-3beta,26-diol decreases expressionISORGD:1606632648046427-hydroxycholesterol results in decreased expression of ERVFRD-1 proteinCTDPMID:38180513
Ervfrd-1Rat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISORGD:160663264804642-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in decreased expression of ERVFRD-1 protein]CTDPMID:38180513
Ervfrd-1Rat1,2-dichloroethane increases expressionISORGD:16157136480464ethylene dichloride results in increased expression of SYNA mRNACTDPMID:28960355
Ervfrd-1Rat17beta-estradiol increases expressionISORGD:16066326480464Estradiol results in increased expression of ERVFRD-1 mRNACTDPMID:31278978
Ervfrd-1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:160663264804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of ERVFRD-1 proteinCTDPMID:31675489
Ervfrd-1Rat2,4,6-tribromophenol increases expressionISORGD:160663264804642,4,6-tribromophenol results in increased expression of ERVFRD-1 mRNACTDPMID:31675489
Ervfrd-1Rat2-hydroxypropanoic acid increases expressionISORGD:16066326480464Lactic Acid results in increased expression of ERVFRD-1 mRNACTDPMID:30851411
Ervfrd-1Rat26-hydroxycholesterol multiple interactionsISORGD:160663264804642-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in decreased expression of ERVFRD-1 protein]CTDPMID:38180513
Ervfrd-1Rat26-hydroxycholesterol decreases expressionISORGD:1606632648046427-hydroxycholesterol results in decreased expression of ERVFRD-1 proteinCTDPMID:38180513
Ervfrd-1Rat3,3',5,5'-tetrabromobisphenol A increases expressionISORGD:16066326480464tetrabromobisphenol A results in increased expression of ERVFRD-1 proteinCTDPMID:31675489
Ervfrd-1Rat3,7-dihydropurine-6-thione decreases expressionEXP 6480464Mercaptopurine results in decreased expression of ERVFRD-1 mRNACTDPMID:23358152
Ervfrd-1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of SYNA mRNACTDPMID:25825206
Ervfrd-1Ratall-trans-retinoic acid multiple interactionsISORGD:16157136480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of SYNA mRNACTDPMID:36189433
Ervfrd-1Ratalpha-naphthoflavone multiple interactionsISORGD:16066326480464alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]CTDPMID:24361490
Ervfrd-1RatAM-251 multiple interactionsISORGD:16066326480464AM 251 affects the reaction [Dronabinol results in decreased expression of ERVFRD-1 mRNA]CTDPMID:26070387
Ervfrd-1Ratanandamide decreases expressionISORGD:16066326480464anandamide results in decreased expression of ERVFRD-1 mRNACTDPMID:30610963
Ervfrd-1Ratbenzo[a]pyrene increases expressionISORGD:16066326480464Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNACTDPMID:24361490
Ervfrd-1Ratbenzo[a]pyrene multiple interactionsISORGD:160663264804642-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]; AHR more ...CTDPMID:24361490
Ervfrd-1Ratbis(2-ethylhexyl) phthalate increases expressionISORGD:16066326480464Diethylhexyl Phthalate results in increased expression of ERVFRD-1 mRNACTDPMID:31163220
Ervfrd-1Ratbis(2-ethylhexyl) phthalate increases expressionISORGD:16157136480464Diethylhexyl Phthalate results in increased expression of SYNA mRNACTDPMID:34319233

1 to 20 of 63 rows

Biological Process
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ervfrd-1Ratlabyrinthine layer development acts_upstream_of_or_withinISORGD:16157131624291MGI:3852417 PMID:19564597RGDPMID:19564597
Ervfrd-1Ratlabyrinthine layer development acts_upstream_of_or_withinIEAUniProtKB:Q5G5D5|ensembl:ENSMUSP000001164371600115GO_REF:0000107EnsemblGO_REF:0000107
Ervfrd-1Ratmyoblast fusion acts_upstream_of_or_withinISORGD:16066321624291 PMID:27589388RGDPMID:27589388
Ervfrd-1Ratmyoblast fusion acts_upstream_of_or_withinIEAUniProtKB:Q5G5D5|ensembl:ENSMUSP000001164371600115GO_REF:0000107EnsemblGO_REF:0000107
Ervfrd-1Ratmyoblast fusion acts_upstream_of_or_withinISORGD:16157131624291 PMID:27589388RGDPMID:27589388
Ervfrd-1Ratsyncytium formation involved_inISORGD:16066321624291 PMID:23492904RGDPMID:23492904
Ervfrd-1Ratsyncytium formation by plasma membrane fusion involved_inISORGD:16066321624291 PMID:14557543RGDPMID:14557543
Ervfrd-1Ratsyncytium formation by plasma membrane fusion acts_upstream_of_or_withinISORGD:16157131624291MGI:3852417 PMID:15644441, PMID:19564597RGDPMID:15644441|PMID:19564597
Ervfrd-1Ratsyncytium formation by plasma membrane fusion acts_upstream_of_or_withinIEAUniProtKB:Q5G5D5|ensembl:ENSMUSP000001164371600115GO_REF:0000107EnsemblGO_REF:0000107
Ervfrd-1Ratsyncytium formation by plasma membrane fusion involved_inIBAMGI:2684898|PANTHER:PTN0013115561600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 10 of 10 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ervfrd-1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ervfrd-1Ratprotein binding enablesISORGD:16066321624291UniProtKB:O95183|UniProtKB:P09466|UniProtKB:P30301|UniProtKB:Q01453|UniProtKB:Q03518|UniProtKB:Q06432|UniProtKB:Q08426|UniProtKB:Q7Z2K6|UniProtKB:Q86YW7|UniProtKB:Q8IWU4|UniProtKB:Q8NHW4|UniProtKB:Q8WWP7|UniProtKB:Q92520|UniProtKB:Q92843|UniProtKB:Q969Y0|UniProtKB:Q96IW7|UniProtKB:Q96JW4|UniProtKB:Q9H2L4|UniProtKB:Q9NRS4|UniProtKB:Q9NZG7 PMID:32296183RGDPMID:32296183


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:14557543   PMID:15644441   PMID:19564597   PMID:23492904   PMID:27589388  



Ervfrd-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,787,680 - 27,794,732 (+)NCBIGRCr8
mRatBN7.21222,151,211 - 22,158,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,151,211 - 22,158,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,294,443 - 23,301,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,905,524 - 23,912,428 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,972,115 - 22,979,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,161,130 - 25,168,182 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,161,130 - 25,168,182 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,161,524 - 27,168,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,220,471 - 23,222,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1223,915,041 - 23,922,023 (+)NCBICelera
Cytogenetic Map12q12NCBI
ERVFRD-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38611,102,489 - 11,111,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl611,102,324 - 11,111,845 (-)EnsemblGRCh38hg38GRCh38
GRCh37611,102,722 - 11,111,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36611,210,708 - 11,219,945 (-)NCBINCBI36Build 36hg18NCBI36
Celera612,331,189 - 12,340,538 (-)NCBICelera
Cytogenetic Map6p24.2NCBI
HuRef611,034,168 - 11,043,517 (-)NCBIHuRef
CHM1_1611,104,822 - 11,114,171 (-)NCBICHM1_1
T2T-CHM13v2.0610,970,408 - 10,979,644 (-)NCBIT2T-CHM13v2.0
Syna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,586,108 - 134,605,891 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,587,000 - 134,589,025 (-)EnsemblGRCm39 Ensembl
GRCm385134,557,254 - 134,577,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,558,146 - 134,560,171 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,034,110 - 135,035,963 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,842,867 - 134,844,720 (-)NCBIMGSCv36mm8
Celera5131,565,945 - 131,567,798 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.67NCBI
ERVFRD-1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,749,397 - 25,758,717 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,739,431 - 21,748,751 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,940,832 - 10,950,152 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1611,216,488 - 11,225,808 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl611,217,693 - 11,219,309 (-)Ensemblpanpan1.1panPan2
LOC119881605
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.0918,735,394 - 18,791,155 (-)NCBIROS_Cfam_1.0
ERVFRD-1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,033,479 - 61,042,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1761,039,949 - 61,041,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604411,133,315 - 11,142,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Ervfrd-1
62 total Variants

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:97
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000074788
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat

1 to 10 of 54 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 1 4 30 33 41 19 18 19 2 81 29 23 23 18 22



Ensembl Acc Id: ENSRNOT00000074788   ⟹   ENSRNOP00000067387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,151,211 - 22,158,264 (+)Ensembl
Rnor_6.0 Ensembl1225,161,130 - 25,168,182 (+)Ensembl
RefSeq Acc Id: NM_001014771   ⟹   NP_001014771
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,787,680 - 27,794,732 (+)NCBI
mRatBN7.21222,151,211 - 22,158,264 (+)NCBI
Rnor_6.01225,161,130 - 25,168,182 (+)NCBI
Rnor_5.01227,161,524 - 27,168,576 (+)NCBI
RGSC_v3.41223,220,471 - 23,222,327 (+)RGD
Celera1223,915,041 - 23,922,023 (+)NCBI
Sequence:
Protein RefSeqs NP_001014771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAW62447 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067387
  ENSRNOP00000067387.1
RefSeq Acc Id: NP_001014771   ⟸   NM_001014771
- Peptide Label: precursor
- UniProtKB: Q5G5D4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067387   ⟸   ENSRNOT00000074788

Name Modeler Protein Id AA Range Protein Structure
AF-Q5G5D4-F1-model_v2 AlphaFold Q5G5D4 1-618 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 15 of 15 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19575 BioCyc
Ensembl Genes ENSRNOG00000050672 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074788 ENTREZGENE
  ENSRNOT00000074788.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.210 UniProtKB/TrEMBL
InterPro TLV/ENV_coat_polyprotein UniProtKB/TrEMBL
KEGG Report rno:288602 UniProtKB/TrEMBL
NCBI Gene 288602 ENTREZGENE
PANTHER HERV-H_2Q24.1 PROVIRUS ANCESTRAL ENV POLYPROTEIN-RELATED UniProtKB/TrEMBL
  PTHR10424 UniProtKB/TrEMBL
Pfam TLV_coat UniProtKB/TrEMBL
PhenoGen Ervfrd-1 PhenoGen
RatGTEx ENSRNOG00000050672 RatGTEx
Superfamily-SCOP Virus ectodomain UniProtKB/TrEMBL
UniProt Q5G5D4 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-05 Ervfrd-1  endogenous retrovirus group FRD member 1, envelope  Ervfrd-1  endogenous retrovirus group FRD member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Ervfrd-1  endogenous retrovirus group FRD member 1  Syna  syncytin a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-21 Syna  syncytin a  Gm52  envelope glycoprotein syncytin-A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gm52  envelope glycoprotein syncytin-A   Gm52_predicted  envelope glycoprotein syncytin-A (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 Gm52_predicted  envelope glycoprotein syncytin-A (predicted)  Gm52  envelope glycoprotein syncytin-A  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Gm52  envelope glycoprotein syncytin-A      Symbol and Name status set to provisional 70820 PROVISIONAL