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Gene: Hrk (harakiri, BCL2 interacting protein) Rattus norvegicus
Symbol: Hrk
Name: harakiri, BCL2 interacting protein
Description: Involved in apoptotic process; cellular response to potassium ion starvation; and positive regulation of neuron apoptotic process. Predicted to localize to mitochondrion. Orthologous to human HRK (harakiri, BCL2 interacting protein); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activator of apoptosis harakiri; BH3 interacting (with BCL2 family) domain apoptosis agonist; BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3 interacting domain 3; BH3-interacting domain-containing protein 3; Bid3; Dp5; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5
Homo sapiens (human) : HRK (harakiri, BCL2 interacting protein)  HGNC  Alliance
Mus musculus (house mouse) : Hrk (harakiri, BCL2 interacting protein (contains only BH3 domain))  MGI  Alliance
Canis lupus familiaris (dog) : HRK (harakiri, BCL2 interacting protein)
Sus scrofa (pig) : HRK (harakiri, BCL2 interacting protein)
Chlorocebus sabaeus (African green monkey) : HRK (harakiri, BCL2 interacting protein)
Heterocephalus glaber (naked mole-rat) : Hrk (harakiri, BCL2 interacting protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly; Note: NM_057130.4 is based on transcript and protein alignment data, and may not be a true representation of the structure of GeneID 117271 due to the incomplete nature of the assembly in this region of the genome. [10 Oct 2014]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01244,008,879 - 44,029,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,839,708 - 45,861,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,520,265 - 39,543,901 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11239,383,652 - 39,407,289 (-)NCBI
Celera1240,046,737 - 40,068,164 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hrk
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70549
Created: 2002-05-20
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.