Nos1 (nitric oxide synthase 1) - Rat Genome Database

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Gene: Nos1 (nitric oxide synthase 1) Chinchilla lanigera
Analyze
Symbol: Nos1
Name: nitric oxide synthase 1
RGD ID: 8804517
Description: ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN arginine catabolic process (ortholog); behavioral response to cocaine (ortholog); calcium ion transport (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN neuron projection terminus; perikaryon; azurophil granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nitric oxide synthase 1 (neuronal); nitric oxide synthase, brain
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (ISO)
acute kidney failure  (ISO)
acute necrotizing pancreatitis  (ISO)
alcoholic cardiomyopathy  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
Carbon Monoxide Poisoning  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cerebellar disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
cystic fibrosis  (ISO)
Dehydration  (ISO)
depressive disorder  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of mental health  (ISO)
Duchenne muscular dystrophy  (ISO)
End Stage Liver Disease  (ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Radiation Injuries  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Hypoxia  (ISO)
Fever  (ISO)
Heat Stroke  (ISO)
hepatic encephalopathy  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypertrophic pyloric stenosis  (ISO)
Hypoxia  (ISO)
impotence  (ISO)
Infantile Hypertrophic Pyloric Stenosis 1  (ISO)
intestinal perforation  (ISO)
intracranial aneurysm  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
morphine dependence  (ISO)
motor neuron disease  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Nervous System Trauma  (ISO)
Neuralgia  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
portal hypertension  (ISO)
Prehypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
temporal lobe epilepsy  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urethral obstruction  (ISO)
Urination Disorders  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arginine catabolic process  (ISO)
behavioral response to cocaine  (ISO)
calcium ion transport  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
establishment of localization in cell  (ISO)
establishment of protein localization  (ISO)
female pregnancy  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of hepatic stellate cell contraction  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of potassium ion transport  (ISO)
negative regulation of serotonin uptake  (ISO)
negative regulation of vasoconstriction  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide metabolic process  (ISO)
nitric oxide-cGMP-mediated signaling  (ISO)
peptidyl-cysteine S-nitrosylation  (ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of sodium ion transmembrane transport  (ISO)
positive regulation of the force of heart contraction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
potassium ion transport  (ISO)
regulation of neurogenesis  (ISO)
regulation of postsynaptic membrane potential  (ISO)
regulation of sodium ion transport  (ISO)
response to activity  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to nitric oxide  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
response to vitamin B3  (ISO)
response to vitamin E  (ISO)
striated muscle contraction  (ISO)
synaptic signaling by nitric oxide  (ISO)
vasodilation  (ISO)
xenobiotic catabolic process  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Morphology and immunohistochemical characteristics of the pterygopalatine ganglion in the chinchilla (Chinchilla laniger, Molina). Szczurkowski A, etal., Pol J Vet Sci. 2013;16(2):359-68.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
NOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812117,208,142 - 117,361,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12117,208,142 - 117,452,170 (-)EnsemblGRCh38hg38GRCh38
GRCh3712117,645,947 - 117,799,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBICelera
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
T2T-CHM13v2.012117,189,186 - 117,342,679 (-)NCBIT2T-CHM13v2.0
Nos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,004,904 - 118,096,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,919,097 - 118,096,905 (+)EnsemblGRCm39 Ensembl
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBIMGSCv36mm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
Nos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,276,011 - 44,456,371 (-)NCBIGRCr8
mRatBN7.21238,615,111 - 38,795,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,802,061 - 39,886,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,415,854 - 40,500,100 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,468,822 - 39,553,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
Celera1240,283,655 - 40,368,674 (-)NCBICelera
RH 3.4 Map12718.8RGD
RH 3.4 Map12717.0RGD
Cytogenetic Map12q16NCBI
NOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210125,268,855 - 125,423,277 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112125,265,237 - 125,419,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012114,784,232 - 114,938,385 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112118,163,655 - 118,314,005 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,163,655 - 118,314,005 (-)Ensemblpanpan1.1panPan2
NOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,787,341 - 13,895,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,786,309 - 13,962,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,781,845 - 13,865,309 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02614,042,033 - 14,222,209 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2614,044,400 - 14,151,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12614,009,781 - 14,093,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02614,087,144 - 14,170,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02614,122,943 - 14,206,510 (-)NCBIUU_Cfam_GSD_1.0
Nos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118154,176,906 - 154,267,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365585,233,459 - 5,301,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1435,113,184 - 35,295,944 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11435,112,898 - 35,299,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,401,967 - 37,515,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,642,374 - 112,673,882 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037132,411,769 - 132,561,385 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nos1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474716,003,969 - 16,113,165 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474715,940,614 - 16,118,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000025513   ⟹   ENSCLAP00000025266
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000025514   ⟹   ENSCLAP00000025267
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545513,860,954 - 13,972,566 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000025515   ⟹   ENSCLAP00000025268
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545513,860,954 - 13,972,566 (+)Ensembl
RefSeq Acc Id: XM_005396543   ⟹   XP_005396600
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520392   ⟹   XP_013375846
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,861,132 - 13,978,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520393   ⟹   XP_013375847
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,860,292 - 13,978,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520394   ⟹   XP_013375848
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005396600   ⟸   XM_005396543
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375848   ⟸   XM_013520394
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YUZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375847   ⟸   XM_013520393
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375846   ⟸   XM_013520392
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUZ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000025268   ⟸   ENSCLAT00000025515
Ensembl Acc Id: ENSCLAP00000025267   ⟸   ENSCLAT00000025514
Ensembl Acc Id: ENSCLAP00000025266   ⟸   ENSCLAT00000025513
Protein Domains
FAD-binding FR-type   Flavodoxin-like   PDZ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017357 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025513 ENTREZGENE
  ENSCLAT00000025513.1 UniProtKB/TrEMBL
  ENSCLAT00000025514 ENTREZGENE
  ENSCLAT00000025514.1 UniProtKB/TrEMBL
  ENSCLAT00000025515 ENTREZGENE
  ENSCLAT00000025515.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.360 UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/TrEMBL
  3.90.440.10 UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/TrEMBL
  NOS UniProtKB/TrEMBL
  NOS_dom_1 UniProtKB/TrEMBL
  NOS_dom_2 UniProtKB/TrEMBL
  NOS_dom_3 UniProtKB/TrEMBL
  NOS_euk UniProtKB/TrEMBL
  NOS_N UniProtKB/TrEMBL
  NOS_N_sf UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/TrEMBL
NCBI Gene Nos1 ENTREZGENE
PANTHER NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
Pfam FAD_binding_1 UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/TrEMBL
  NO_synthase UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PIRSF NOS UniProtKB/TrEMBL
PRINTS FLAVODOXIN UniProtKB/TrEMBL
  FPNCR UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/TrEMBL
  FLAVODOXIN_LIKE UniProtKB/TrEMBL
  NOS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/TrEMBL
  SSF52218 UniProtKB/TrEMBL
  SSF52343 UniProtKB/TrEMBL
  SSF56512 UniProtKB/TrEMBL
  SSF63380 UniProtKB/TrEMBL
UniProt A0A8C2YUZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YUZ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nos1  nitric oxide synthase 1    nitric oxide synthase 1 (neuronal)  Symbol and/or name change 5135510 APPROVED