Nos1 (nitric oxide synthase 1) - Rat Genome Database

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Gene: Nos1 (nitric oxide synthase 1) Chinchilla lanigera
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Symbol: Nos1
Name: nitric oxide synthase 1
RGD ID: 8804517
Description: ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN aging (ortholog); arginine catabolic process (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Necrotizing Pancreatitis (ortholog); alcoholic cardiomyopathy (ortholog); FOUND IN neuron projection terminus; perikaryon; azurophil granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: nitric oxide synthase 1 (neuronal); nitric oxide synthase, brain
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
alcoholic cardiomyopathy  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
Carbon Monoxide Poisoning  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cerebellar disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
cystic fibrosis  (ISO)
Dehydration  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of mental health  (ISO)
Duchenne muscular dystrophy  (ISO)
End Stage Liver Disease  (ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Hypoxia  (ISO)
Fever  (ISO)
Heat Stroke  (ISO)
hepatic encephalopathy  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
impotence  (ISO)
intestinal perforation  (ISO)
intracranial aneurysm  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
morphine dependence  (ISO)
motor neuron disease  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Nervous System Trauma  (ISO)
Neuralgia  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
portal hypertension  (ISO)
Prehypertension  (ISO)
Pyloric Stenosis, Infantile Hypertrophic 1  (ISO)
Radiation Injuries, Experimental  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
temporal lobe epilepsy  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urethral obstruction  (ISO)
Urination Disorders  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
arginine catabolic process  (ISO)
behavioral response to cocaine  (ISO)
brain development  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
establishment of protein localization  (ISO)
exogenous drug catabolic process  (ISO)
female pregnancy  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of heart contraction  (ISO)
negative regulation of hepatic stellate cell contraction  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of potassium ion transport  (ISO)
negative regulation of serotonin uptake  (ISO)
negative regulation of vasoconstriction  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide mediated signal transduction  (ISO)
peptidyl-cysteine S-nitrosylation  (ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (ISO)
positive regulation of histone acetylation  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of sodium ion transmembrane transport  (ISO)
positive regulation of the force of heart contraction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of heart contraction  (ISO)
regulation of neurogenesis  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of sodium ion transport  (ISO)
response to activity  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to nitric oxide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
response to vitamin E  (ISO)
retrograde trans-synaptic signaling by nitric oxide  (ISO)
striated muscle contraction  (ISO)
synaptic signaling by nitric oxide  (ISO)
vasodilation  (ISO)

References


Genomics

Comparative Map Data
Nos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
NOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12117,208,142 - 117,452,170 (-)EnsemblGRCh38hg38GRCh38
GRCh3812117,208,142 - 117,361,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712117,645,947 - 117,799,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBINCBI36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBI
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
Nos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,004,904 - 118,096,905 (+)NCBIGRCm39mm39
GRCm39 Ensembl5117,919,097 - 118,096,905 (+)Ensembl
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIGRCm37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBImm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
Nos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21238,615,111 - 38,795,492 (-)NCBI
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
Celera1240,283,655 - 40,368,674 (-)NCBICelera
RH 3.4 Map12717.0RGD
RH 3.4 Map12718.8RGD
Cytogenetic Map12q16NCBI
NOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112118,163,655 - 118,314,005 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,163,655 - 118,314,005 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012114,784,232 - 114,938,385 (-)NCBIMhudiblu_PPA_v0panPan3
NOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,787,341 - 13,895,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,786,309 - 13,962,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,781,845 - 13,865,309 (-)NCBI
ROS_Cfam_1.02614,042,033 - 14,222,209 (-)NCBI
UMICH_Zoey_3.12614,009,781 - 14,093,258 (-)NCBI
UNSW_CanFamBas_1.02614,087,144 - 14,170,688 (-)NCBI
UU_Cfam_GSD_1.02614,122,943 - 14,206,510 (-)NCBI
Nos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118154,176,906 - 154,267,437 (-)NCBI
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1435,113,184 - 35,295,972 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11435,112,898 - 35,299,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,401,967 - 37,515,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,642,374 - 112,673,882 (-)NCBI
Vero_WHO_p1.0NW_023666037132,411,769 - 132,561,385 (+)NCBI
Nos1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474715,940,614 - 16,118,051 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000025513   ⟹   ENSCLAP00000025266
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000025514   ⟹   ENSCLAP00000025267
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545513,860,954 - 13,972,566 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000025515   ⟹   ENSCLAP00000025268
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545513,860,954 - 13,972,566 (+)Ensembl
RefSeq Acc Id: XM_005396543   ⟹   XP_005396600
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520392   ⟹   XP_013375846
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,861,132 - 13,978,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520393   ⟹   XP_013375847
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,860,292 - 13,978,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520394   ⟹   XP_013375848
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005396600 (Get FASTA)   NCBI Sequence Viewer  
  XP_013375846 (Get FASTA)   NCBI Sequence Viewer  
  XP_013375847 (Get FASTA)   NCBI Sequence Viewer  
  XP_013375848 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005396600   ⟸   XM_005396543
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013375848   ⟸   XM_013520394
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013375847   ⟸   XM_013520393
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013375846   ⟸   XM_013520392
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000025268   ⟸   ENSCLAT00000025515
RefSeq Acc Id: ENSCLAP00000025267   ⟸   ENSCLAT00000025514
RefSeq Acc Id: ENSCLAP00000025266   ⟸   ENSCLAT00000025513


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017357 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000025266 ENTREZGENE
  ENSCLAP00000025267 ENTREZGENE
  ENSCLAP00000025268 ENTREZGENE
Ensembl Transcript ENSCLAT00000025513 ENTREZGENE
  ENSCLAT00000025514 ENTREZGENE
  ENSCLAT00000025515 ENTREZGENE
NCBI Gene Nos1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nos1  nitric oxide synthase 1    nitric oxide synthase 1 (neuronal)  Symbol and/or name change 5135510 APPROVED