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Gene: Nos1 (nitric oxide synthase 1, neuronal) Mus musculus
Symbol: Nos1
Name: nitric oxide synthase 1, neuronal
Description: Exhibits nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of nitrogen compound metabolic process; and regulation of ion transport. Localizes to several cellular components, including T-tubule; Z disc; and calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (S)-amphetamine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310005C01Rik; bNOS; constitutive NOS; N-NOS; NC-NOS; neuronal nitric oxide synthase; neuronal NOS; nitric oxide synthase, brain; nNOS; NO; NOS; NOS type I; Nos-1; NOS-I; peptidyl-cysteine S-nitrosylase NOS1; RIKEN cDNA 2310005C01 gene
Homo sapiens (human) : NOS1 (nitric oxide synthase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nos1 (nitric oxide synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nos1 (nitric oxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOS1 (nitric oxide synthase 1)
Canis lupus familiaris (dog) : NOS1 (nitric oxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nos1 (nitric oxide synthase 1)
Sus scrofa (pig) : NOS1 (nitric oxide synthase 1)
Heterocephalus glaber (naked mole-rat) : Nos1 (nitric oxide synthase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)EnsemblGRCm38mm10GRCm38
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIGRCm37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBImm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Nos1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10991
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.