Imported Disease Annotations - ClinVarObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | NOS1 | Human | Infantile Hypertrophic Pyloric Stenosis 1 | | IAGP | (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Pyloric stenosis more ... | ClinVar | PMID:14757827 and PMID:19851341 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Altered Contractile Response due to Increased beta3-Adrenoceptor Stimulation in Diabetic Cardiomyopathy: The Role of Nitric Oxide Synthase 1-derived Nitric Oxide. | Amour J, etal., Anesthesiology. 2007 Sep;107(3):452-460. |
| 2. | Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. | Aoki T, etal., Lab Invest. 2011 Apr;91(4):619-26. Epub 2011 Feb 14. |
| 3. | Renoprotective effect of pioglitazone by the prevention of glomerular hyperfiltration through the possible restoration of altered macula densa signaling in rats with type 2 diabetic nephropathy. | Asakura J, etal., Nephron Exp Nephrol. 2012;122(3-4):83-94. doi: 10.1159/000348661. Epub 2013 Mar 29. |
| 4. | Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease. | Barreiro E, etal., Am J Respir Cell Mol Biol. 2003 Dec;29(6):771-8. Epub 2003 Jun 19. |
| 5. | Reduced neuronal nitric oxide synthase (NOS1) antigen in sacral motor neurones in motor neurone disease. | Baxter RG, etal., Acta Neuropathol. 2002 Oct;104(4):391-7. Epub 2002 Jun 26. |
| 6. | Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat. | Bendall JK, etal., Circulation. 2004 Oct 19;110(16):2368-75. Epub 2004 Oct 4. |
| 7. | Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. | Brindicci C, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):21-30. Epub 2009 Sep 24. |
| 8. | Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. | Cheng BC, etal., Neuropharmacology. 2007 Feb;52(2):297-305. Epub 2006 Sep 6. |
| 9. | Spinal cord transection significantly influences nNOS-IR in neuronal circuitry that underlies the tail-flick reflex activity. | Davidova A, etal., Cell Mol Neurobiol. 2009 Sep;29(6-7):879-86. Epub 2009 Mar 17. |
| 10. | [Effects of electroacupuncture on the expressions of neuroal nitric oxide synthase and astrocyte in dentate gyrus of rats with Parkinson's disease]. | Ding YX, etal., Zhongguo Zhen Jiu. 2013 Jun;33(6):533-7. |
| 11. | Reduction of neuronal and inducible nitric oxide synthase gene expression in patients with cystic fibrosis. | Dotsch J, etal., Eur Arch Otorhinolaryngol. 2002 Apr;259(4):222-6. |
| 12. | Human influenza viral infection in utero increases nNOS expression in hippocampi of neonatal mice. | Fatemi SH, etal., Synapse. 1998 May;29(1):84-8. |
| 13. | Differential expression of nNOS mRNA and protein in the nucleus tractus solitarii of young and aged Wistar-Kyoto and spontaneously hypertensive rats. | Ferrari MF and Fior-Chadi DR, J Hypertens. 2005 Sep;23(9):1683-90. |
| 14. | Association of a NOS1 promoter repeat with Alzheimer's disease. | Galimberti D, etal., Neurobiol Aging. 2008 Sep;29(9):1359-65. doi: 10.1016/j.neurobiolaging.2007.03.003. Epub 2007 Apr 6. |
| 15. | Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. | Gangula PR, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G725-33. |
| 16. | Variants of NOS1, NOS2, and NOS3 genes in asthmatics. | Gao PS, etal., Biochem Biophys Res Commun. 2000 Jan 27;267(3):761-3. |
| 17. | Nitric oxide synthase and nitric oxide alterations in chronically stressed rats: a model for nitric oxide in major depressive disorder. | Gao SF, etal., Psychoneuroendocrinology. 2014 Sep;47:136-40. doi: 10.1016/j.psyneuen.2014.05.009. Epub 2014 May 22. |
| 18. | Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease. | Gatto EM, etal., Nitric Oxide. 2000 Oct;4(5):534-9. |
| 19. | GOAs Human GO annotations | GOA_HUMAN data from the GO Consortium |
| 20. | Caveolin-3 and nitric oxide synthase I in healthy and diseased skeletal muscle. | Gossrau R, Acta Histochem. 1998 Feb;100(1):99-112. doi: 10.1016/S0065-1281(98)80009-3. |
| 21. | A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma. | Grasemann H, etal., Biochem Biophys Res Commun. 2000 Jun 7;272(2):391-4. |
| 22. | Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism. | Grasemann H, etal., Nitric Oxide. 2002 Mar;6(2):236-41. |
| 23. | Expression of nitric oxide synthase isoforms in hypothalamo-pituitary-adrenal axis during the development of spontaneous hypertension in rats. | Hauser W, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):198-204. |
| 24. | Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. | Hsu CN, etal., Int J Mol Sci. 2019 Sep 6;20(18):4382. doi: 10.3390/ijms20184382. |
| 25. | Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide. | Huang CF, etal., Eur J Pharmacol. 2013 Jan 15;699(1-3):233-40. doi: 10.1016/j.ejphar.2012.11.034. Epub 2012 Nov 28. |
| 26. | Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. | Hugyecz M, etal., Brain Res. 2011 Aug 2;1404:31-8. Epub 2011 Jun 12. |
| 27. | Combined therapeutic effect of udenafil and adipose-derived stem cell (ADSC)/brain-derived neurotrophic factor (BDNF)-membrane system in a rat model of cavernous nerve injury. | Jeong HH, etal., Urology. 2013 May;81(5):1108.e7-14. doi: 10.1016/j.urology.2013.01.022. Epub 2013 Mar 22. |
| 28. | Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms. | Jiang J, etal., Br J Pharmacol. 2013 Aug 2. doi: 10.1111/bph.12326. |
| 29. | Early and sharp nitric oxide production and anoxic depolarization in the rat hippocampus during transient forebrain ischemia. | Jiang MH and Hada J, Eur J Pharmacol. 2007 Jul 12;567(1-2):83-8. Epub 2007 Mar 24. |
| 30. | KEGG: Kyoto Encyclopedia of Genes and Genomes | KEGG |
| 31. | Triamcinolone acetonide prevents enhancement of hypoxia-induced neuronal and inducible nitric oxide synthases in the retinas of rats with oxygen-induced retinopathy. | Kim SJ, etal., Korean J Ophthalmol. 2012 Dec;26(6):455-61. doi: 10.3341/kjo.2012.26.6.455. Epub 2012 Nov 12. |
| 32. | Effect of detrusor overactivity on the expression of aquaporins and nitric oxide synthase in rat urinary bladder following bladder outlet obstruction. | Kim SO, etal., Can Urol Assoc J. 2013 May-Jun;7(5-6):E268-74. doi: 10.5489/cuaj.993. |
| 33. | Plasticity of basal ganglia neurocircuitries following perinatal asphyxia: effect of nicotinamide. | Klawitter V, etal., Exp Brain Res. 2007 Jun;180(1):139-52. Epub 2007 Feb 20. |
| 34. | Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes. | Komers R, etal., Am J Physiol Renal Physiol. 2000 Sep;279(3):F573-83. doi: 10.1152/ajprenal.2000.279.3.F573. |
| 35. | Atheroprotective effects of neuronal nitric oxide synthase in apolipoprotein e knockout mice. | Kuhlencordt PJ, etal., Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1539-44. Epub 2006 Apr 20. |
| 36. | Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats. | Li D, etal., Hypertension. 2013 Jan;61(1):202-7. doi: 10.1161/HYPERTENSIONAHA.111.00105. Epub 2012 Nov 19. |
| 37. | Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin. | Li Z, etal., Kidney Int. 2005 Dec;68(6):2766-72. |
| 38. | [Antidepressant effect of microinjection of neuropeptide Y into the hippocampus is mediated by decreased expression of nitric oxide synthase]. | Lian T and An SC, Sheng Li Xue Bao. 2010 Jun 25;62(3):237-46. |
| 39. | Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats. | Liu J, etal., Int J Mol Sci. 2013 May 21;14(5):10661-73. doi: 10.3390/ijms140510661. |
| 40. | The dynamic detection of NO during stroke and reperfusion in vivo. | Liu K, etal., Brain Inj. 2009 May;23(5):450-8. |
| 41. | Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats. | Liu ZW, etal., Neurochem Res. 2007 Jun 5;. |
| 42. | 5'-flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan. | Lo HS, etal., J Neurol Sci 2002 Feb 15;194(1):11-3. |
| 43. | 17{beta} estradiol regulates constitutive nitric oxide synthase expression differentially in the myocardium in response to pressure overload. | Loyer X, etal., Endocrinology. 2007 Aug 2;. |
| 44. | Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation. | Lüth HJ, etal., Brain Res. 2002 Oct 25;953(1-2):135-43. |
| 45. | Bladder outlet obstruction triggers neural plasticity in sensory pathways and contributes to impaired sensitivity in erectile dysfunction. | Malykhina AP, etal., Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R837-45. doi: 10.1152/ajpregu.00558.2012. Epub 2013 Mar 27. |
| 46. | Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat. | Mulvey C, etal., Eur J Cell Biol. 2005 Nov;84(11):867-83. |
| 47. | Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria. | Ni Z and Vaziri ND, Biochim Biophys Acta. 2003 Jul 14;1638(2):129-37. |
| 48. | Oxidative stress in the rats brain capillaries in sepsis--the influence of 7-nitroindazole. | Ninkovic M, etal., Acta Physiol Hung. 2006 Dec;93(4):315-23. |
| 49. | Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. | North ML, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L911-20. Epub 2009 Mar 13. |
| 50. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 51. | Phosphorylation of neuronal nitric oxide synthase at Ser in the dentate gyrus of rat brain after transient forebrain ischemia. | Osuka K, etal., Neurochem Int. 2013 Jun 24;63(4):269-274. doi: 10.1016/j.neuint.2013.06.011. |
| 52. | Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia. | Palsson E, etal., Psychopharmacology (Berl). 2010 Dec;212(4):643-51. Epub 2010 Aug 28. |
| 53. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 54. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 55. | [Effects of shenshuai II recipe on the protein expressions of Ang II and nNOS in chronic renal failure rats' nephridial tissue]. | Qin JY, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Sep;32(9):1280-4. |
| 56. | Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohort. | Reif A, etal., J Alzheimers Dis. 2011;23(2):327-33. doi: 10.3233/JAD-2010-101491. |
| 57. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 58. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 59. | RGD HPO Phenotype Annotation Pipeline | RGD automated import pipeline for human HPO-to-gene-to-disease annotations |
| 60. | Neuronal nitric oxide synthase within paraventricular nucleus: blood pressure and baroreflex in two-kidney, one-clip hypertensive rats. | Rossi NF, etal., Exp Physiol. 2010 Aug;95(8):845-57. Epub 2010 May 21. |
| 61. | Linkage and association of childhood asthma with the chromosome 12 genes. | Shao C, etal., J Hum Genet. 2004;49(3):115-22. Epub 2004 Feb 7. |
| 62. | A combination of tumor necrosis factor-alpha and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat. | Sharma HS Ann N Y Acad Sci. 2010 Jun;1199:175-85. |
| 63. | Angiotensin II-mediated post-translational modification of nNOS in the PVN of rats with CHF: Role for PIN. | Sharma NM, etal., Am J Physiol Heart Circ Physiol. 2013 Jul 5. |
| 64. | nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease. | Simic G, etal., Exp Neurol. 2000 Sep;165(1):12-26. doi: 10.1006/exnr.2000.7448. |
| 65. | Intrauterine growth restriction and shallower implantation site in rats with maternal hyperinsulinemia are associated with altered NOS expression. | Skarzinski G, etal., Placenta. 2009 Oct;30(10):898-906. Epub 2009 Aug 25. |
| 66. | Induction of NOS and nitrotyrosine expression in the rat striatum following experimental hepatic encephalopathy. | Suarez I, etal., Metab Brain Dis. 2009 Sep;24(3):395-408. |
| 67. | The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy. | Suarez I, etal., Neuropathol Appl Neurobiol. 2006 Dec;32(6):594-604. |
| 68. | Renal neuronal nitric oxide synthase protein expression as a marker of renal injury. | Szabo AJ, etal., Kidney Int. 2003 Nov;64(5):1765-71. doi: 10.1046/j.1523-1755.2003.00260.x. |
| 69. | Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. | Tain YL, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1404-10. Epub 2007 Jan 2. |
| 70. | Brain neuronal nitric oxide synthase neuron-mediated sympathoinhibition is enhanced in hypertensive Dahl rats. | Tandai-Hiruma M, etal., J Hypertens. 2005 Apr;23(4):825-34. |
| 71. | Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis. | Texereau J, etal., Thorax. 2004 Feb;59(2):156-8. |
| 72. | Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). | Theilig F, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F987-94. Epub 2006 Jun 20. |
| 73. | Neuronal nitric oxide synthase and N-methyl-D-aspartate neurons in experimental carbon monoxide poisoning. | Thom SR, etal., Toxicol Appl Pharmacol. 2004 Feb 1;194(3):280-95. doi: 10.1016/j.taap.2003.09.017. |
| 74. | Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. | Umar S, etal., Pathol Res Pract. 2007;203(12):863-72. Epub 2007 Oct 29. |
| 75. | Nitricoxide synthase-induced oxidative stress in prolonged alcoholic myopathies of rats. | Wang J, etal., Mol Cell Biochem. 2007 Jul 3;. |
| 76. | The effects of NOS1 gene on asthma and total IgE levels in Taiwanese children, and the interactions with environmental factors. | Wang TN, etal., Pediatr Allergy Immunol. 2010 Nov;21(7):1064-71. doi: 10.1111/j.1399-3038.2009.00981.x. |
| 77. | Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. | Wyneken U, etal., Neuroscience. 2001;102(1):65-74. |
| 78. | [Effect of electroacupuncture on expression of spinal neuronal nitric oxide synthase protein and mRNA in rats with neuropathic pain]. | Yan LP, etal., Zhen Ci Yan Jiu. 2012 Oct;37(5):345-50. |
| 79. | Water deprivation increases the expression of neuronal nitric oxide synthase (nNOS) but not orexin-A in the lateral hypothalamic area of the rat. | Yao ST, etal., J Comp Neurol. 2005 Sep 19;490(2):180-93. doi: 10.1002/cne.20662. |
| 80. | Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract. | Yono M, etal., Life Sci. 2007 Jun 27;81(3):218-22. Epub 2007 May 21. |
| 81. | Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. | Yu Q, etal., J Clin Invest. 2000 Mar;105(6):741-8. doi: 10.1172/JCI7997. |
| 82. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Yuan AH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Apr;27(4):454-7. |
| 83. | Effect of octreotide on enteric motor neurons in experimental acute necrotizing pancreatitis. | Zhou H, etal., PLoS One. 2012;7(12):e52163. doi: 10.1371/journal.pone.0052163. Epub 2012 Dec 26. |
Additional References at PubMed
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| PMID:22008325 | PMID:22095614 | PMID:22227051 | PMID:22374200 | PMID:22448456 | PMID:22457368 | PMID:22486744 | PMID:22560594 | PMID:22579290 | PMID:22589245 | PMID:22613021 | PMID:22797309 |
| PMID:22875507 | PMID:22885173 | PMID:22937753 | PMID:22989585 | PMID:23062293 | PMID:23109339 | PMID:23159936 | PMID:23289611 | PMID:23406356 | PMID:23541953 | PMID:23549614 | PMID:23567464 |
| PMID:23572278 | PMID:23727770 | PMID:23770231 | PMID:23826716 | PMID:23953641 | PMID:24063785 | PMID:24082858 | PMID:24114042 | PMID:24192154 | PMID:24220657 | PMID:24235139 | PMID:24251120 |
| PMID:24573959 | PMID:24622112 | PMID:24666322 | PMID:24668187 | PMID:24691438 | PMID:24710408 | PMID:24713495 | PMID:24740233 | PMID:24801117 | PMID:24897285 | PMID:24917196 | PMID:25126568 |
| PMID:25170949 | PMID:25286850 | PMID:25300364 | PMID:25366612 | PMID:25460324 | PMID:25490993 | PMID:25613138 | PMID:25724429 | PMID:25855559 | PMID:25871004 | PMID:25902315 | PMID:26081147 |
| PMID:26233433 | PMID:26283425 | PMID:26378238 | PMID:26458913 | PMID:26607632 | PMID:26746182 | PMID:26791826 | PMID:26821215 | PMID:26923072 | PMID:26941280 | PMID:27041589 | PMID:27225184 |
| PMID:27481317 | PMID:27487179 | PMID:27603575 | PMID:27739347 | PMID:27749554 | PMID:28013342 | PMID:28061969 | PMID:28089352 | PMID:28126743 | PMID:28195573 | PMID:28235709 | PMID:28465168 |
| PMID:28589541 | PMID:28602747 | PMID:28646032 | PMID:28720408 | PMID:28770971 | PMID:28795310 | PMID:29698501 | PMID:29940959 | PMID:30021884 | PMID:30066461 | PMID:30096361 | PMID:30503614 |
| PMID:30900130 | PMID:31002875 | PMID:31043586 | PMID:31153640 | PMID:31405541 | PMID:31607476 | PMID:31805977 | PMID:31881190 | PMID:32061134 | PMID:32361414 | PMID:32591478 | PMID:32693129 |
| PMID:33228180 | PMID:33347982 | PMID:33434144 | PMID:33501735 | PMID:33709161 | PMID:33771575 | PMID:33961781 | PMID:33964320 | PMID:34299181 | PMID:34719364 | PMID:34944061 | PMID:35041938 |
| PMID:35772285 | PMID:35821897 | PMID:36197968 | PMID:36682419 | PMID:36715280 | PMID:37689310 | PMID:38158677 | PMID:39201459 |
Genomics
Comparative Map Data
| NOS1 (Homo sapiens - human) |
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| Nos1 (Mus musculus - house mouse) |
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| Nos1 (Rattus norvegicus - Norway rat) |
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| Nos1 (Chinchilla lanigera - long-tailed chinchilla) |
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| NOS1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| NOS1 (Canis lupus familiaris - dog) |
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| Nos1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| NOS1 (Sus scrofa - pig) |
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| NOS1 (Chlorocebus sabaeus - green monkey) |
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| Nos1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in NOS1
154 total Variants 
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