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Gene: NOS1 (nitric oxide synthase 1) Homo sapiens
Symbol: NOS1
Name: nitric oxide synthase 1
Description: Exhibits nitric-oxide synthase activity. Involved in several processes, including multicellular organismal response to stress; positive regulation of peptidyl-serine phosphorylation; and vasodilation. Localizes to the nucleoplasm; sarcolemma; and sarcoplasmic reticulum. Predicted to colocalize with the ryanodine receptor complex. Implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Biomarker of Duchenne muscular dystrophy; chronic obstructive pulmonary disease; cystic fibrosis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bNOS; constitutive NOS; IHPS1; N-NOS; NC-NOS; neuronal NOS; nitric oxide synthase 1 (neuronal); nitric oxide synthase, brain; nNOS; NOS; NOS type I; peptidyl-cysteine S-nitrosylase NOS1
Mus musculus (house mouse) : Nos1 (nitric oxide synthase 1, neuronal)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nos1 (nitric oxide synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nos1 (nitric oxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOS1 (nitric oxide synthase 1)
Canis lupus familiaris (dog) : NOS1 (nitric oxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nos1 (nitric oxide synthase 1)
Sus scrofa (pig) : NOS1 (nitric oxide synthase 1)
Heterocephalus glaber (naked mole-rat) : Nos1 (nitric oxide synthase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12117,208,142 - 117,452,170 (-)Ensembl
GRCh3812117,208,142 - 117,361,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712117,645,921 - 117,799,607 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBINCBI36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBI
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NOS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619551
Created: 2002-07-23
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.