Arg2 (arginase 2) - Rat Genome Database

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Gene: Arg2 (arginase 2) Rattus norvegicus
Analyze
Symbol: Arg2
Name: arginase 2
RGD ID: 2151
Description: Enables arginase activity and nitric-oxide synthase binding activity. Involved in several processes, including arginine catabolic process to ornithine; cellular response to cytokine stimulus; and cellular response to lipid. Located in mitochondrion. Used to study hypertension. Biomarker of acute kidney failure; end stage renal disease; hypertension; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2); PARTICIPATES IN urea cycle pathway; arginine and proline metabolic pathway; Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AII type II arginase; AII, type II arginase; arginase II; arginase type II; arginase-2, mitochondrial; kidney-type arginase; non-hepatic arginase; type II arginase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2697,936,002 - 97,961,379 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl697,936,002 - 97,961,378 (+)Ensembl
Rnor_6.06102,311,097 - 102,338,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,311,116 - 102,338,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06114,998,810 - 115,025,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,901,653 - 101,928,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16101,905,108 - 101,931,737 (+)NCBI
Celera696,321,210 - 96,346,531 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
ampicillin  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
irinotecan  (EXP)
isoflavones  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
menadione  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
neomycin  (EXP)
nickel sulfate  (ISO)
organophosphorus compound  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
poly(I:C)  (EXP)
pravastatin  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urea  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
apoptotic process  (IEP)
arginine catabolic process to ornithine  (IBA,IDA,TAS)
arginine metabolic process  (IEA,IMP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to interferon-gamma  (IEP)
cellular response to interleukin-4  (IEP)
cellular response to lipopolysaccharide  (IEP)
lung development  (IEP)
maternal process involved in female pregnancy  (IEP)
midgut development  (IEP)
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process  (IEA,ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
negative regulation of chemokine (C-C motif) ligand 4 production  (IEA,ISO)
negative regulation of chemokine (C-C motif) ligand 5 production  (IEA,ISO)
negative regulation of defense response to bacterium  (IEA,ISO)
negative regulation of interleukin-13 production  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of macrophage inflammatory protein 1 alpha production  (IEA,ISO)
negative regulation of nitric-oxide synthase activity  (IMP)
negative regulation of striated muscle contraction  (IMP)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type 2 immune response  (IEA,ISO)
positive regulation of cellular senescence  (IEA,ISO)
regulation of interleukin-1 beta production  (IEA,ISO)
regulation of L-arginine import across plasma membrane  (IDA)
regulation of nitric oxide biosynthetic process  (IEP)
regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
response to amine  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to cadmium ion  (IEP)
response to glucose  (IEP)
response to herbicide  (IEP)
response to hormone  (IEP)
response to hypoxia  (IEP)
response to mercury ion  (IEP)
response to nutrient  (IEP)
response to selenium ion  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
striated muscle contraction  (IEA,ISO)
urea cycle  (IEA)
ureteric bud development  (IEA,ISO)

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bagnost T, etal., J Hypertens. 2008 Jun;26(6):1110-8.
2. Belik J, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L498-504. Epub 2008 Jan 11.
3. Carraway MS, etal., Exp Lung Res. 1998 May-Jun;24(3):253-68.
4. Demougeot C, etal., Life Sci. 2007 Feb 27;80(12):1128-34. Epub 2006 Dec 14.
5. Erbas H, etal., Pharmacol Res. 2004 Nov;50(5):523-7.
6. Erisir M, etal., Cell Biochem Funct. 2003 Dec;21(4):331-5.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Gharbi M, etal., Biochem Biophys Res Commun. 2005 Nov 4;336(4):1119-24.
9. GOA data from the GO Consortium
10. Hirata M, etal., Mol Hum Reprod. 2006 Aug;12(8):513-8. Epub 2006 May 30.
11. Ishii N, etal., Metabolism. 2004 Jul;53(7):868-74.
12. Iwata S, etal., Hypertens Res. 2002 May;25(3):411-8.
13. Iyer R, etal., J Inherit Metab Dis 1998;21 Suppl 1:86-100.
14. Iyer RK, etal., Mol Genet Metab 1998 Mar;63(3):168-75.
15. Johnson RA, etal., J Trauma. 2010 Aug;69(2):384-91.
16. Kanda H, etal., Arch Toxicol. 2008 Feb;82(2):67-73. Epub 2007 Sep 14.
17. KEGG
18. Klasen S, etal., Br J Pharmacol. 2001 Mar;132(6):1349-57.
19. Levillain O, etal., Am J Physiol Renal Physiol 2004 Apr;286(4):F727-38. Epub 2004 Feb 10.
20. Li H, etal., Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E75-82.
21. Li H, etal., J Allergy Clin Immunol. 2006 Jan;117(1):119-26. Epub 2005 Nov 28.
22. Lindemann D and Racke K, Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):546-50. Epub 2003 Nov 15.
23. Liu H, etal., Am J Transplant. 2005 Jun;5(6):1256-63.
24. Liu P, etal., J Vestib Res. 2004;14(6):411-7.
25. Lopez V, etal., High Alt Med Biol. 2009 Winter;10(4):373-81.
26. MGD data from the GO Consortium
27. Moradi H, etal., Am J Nephrol. 2006;26(3):310-8. Epub 2006 Jun 29.
28. Moran JM, etal., Nitric Oxide. 2010 Apr 11.
29. Morris SM Jr, etal., Diabetes. 2011 Nov;60(11):3015-22. Epub 2011 Sep 16.
30. Munder M Br J Pharmacol. 2009 Oct;158(3):638-51. Epub 2009 Sep 17.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Nissim I, et al., J Biol Chem. 2005 May 6;280(18):17715-24. Epub 2005 Mar 7.
33. Ozaki M, etal., J Biochem. 1999 Mar;125(3):586-93.
34. Pipeline to import KEGG annotations from KEGG into RGD
35. Que LG, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102.
36. Que LG, etal., Nitric Oxide 2002 Feb;6(1):1-8.
37. RGD automated data pipeline
38. RGD automated import pipeline for gene-chemical interactions
39. Schnorr O, etal., Arch Biochem Biophys. 2008 Aug 15;476(2):211-5. Epub 2008 Mar 6.
40. Schwartz IF, etal., Kidney Blood Press Res. 2008;31(3):210-6. Epub 2008 Jun 14.
41. Schwartz IF, etal., Kidney Int 2002 Nov;62(5):1700-6.
42. Steppan J, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64. Epub 2006 Mar 13.
43. Thakran S, etal., Mol Cell Biochem. 2003 May;247(1-2):45-53.
44. Tormanen CD J Enzyme Inhib Med Chem. 2006 Feb;21(1):119-23.
45. van Balkom BW, etal., Am J Physiol Renal Physiol. 2004 Feb;286(2):F216-24. Epub 2003 Oct 7.
46. Vonk JM, etal., Pharmacogenet Genomics. 2010 Mar;20(3):179-86.
47. Wei CL, etal., Biochem Pharmacol. 2002 Mar 15;63(6):1043-50.
48. Zimmermann N, etal., J Clin Invest. 2003 Jun;111(12):1863-74.
Additional References at PubMed
PMID:8898077   PMID:12859189   PMID:14651853   PMID:16128822   PMID:16545622   PMID:16794538   PMID:18614015   PMID:19763131   PMID:20981735   PMID:21281730   PMID:21408057   PMID:21952491  
PMID:21975054   PMID:22160208   PMID:22182949   PMID:22507752   PMID:22928666   PMID:23665321   PMID:25009204   PMID:25490411   PMID:26140333   PMID:27074721   PMID:27214549   PMID:27745970  
PMID:28614294   PMID:29627571  


Genomics

Candidate Gene Status
Arg2 is a candidate Gene for QTL Uae22
Comparative Map Data
Arg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2697,936,002 - 97,961,379 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl697,936,002 - 97,961,378 (+)Ensembl
Rnor_6.06102,311,097 - 102,338,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,311,116 - 102,338,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06114,998,810 - 115,025,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,901,653 - 101,928,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16101,905,108 - 101,931,737 (+)NCBI
Celera696,321,210 - 96,346,531 (+)NCBICelera
Cytogenetic Map6q24NCBI
ARG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1467,619,920 - 67,651,708 (+)EnsemblGRCh38hg38GRCh38
GRCh381467,619,920 - 67,651,708 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371468,086,637 - 68,118,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361467,156,332 - 67,188,190 (+)NCBINCBI36hg18NCBI36
Build 341467,156,331 - 67,188,190NCBI
Celera1448,145,655 - 48,177,498 (+)NCBI
Cytogenetic Map14q24.1NCBI
HuRef1448,256,285 - 48,288,134 (+)NCBIHuRef
CHM1_11468,025,216 - 68,057,216 (+)NCBICHM1_1
Arg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391279,177,562 - 79,203,075 (+)NCBIGRCm39mm39
GRCm39 Ensembl1279,177,551 - 79,203,075 (+)Ensembl
GRCm381279,130,788 - 79,156,301 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1279,130,777 - 79,156,301 (+)EnsemblGRCm38mm10GRCm38
MGSCv371280,231,775 - 80,257,288 (+)NCBIGRCm37mm9NCBIm37
MGSCv361280,049,665 - 80,075,136 (+)NCBImm8
Celera1280,595,209 - 80,620,745 (+)NCBICelera
Cytogenetic Map12C3NCBI
Arg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,549,557 - 2,577,060 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,549,557 - 2,577,060 (-)NCBIChiLan1.0ChiLan1.0
ARG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11467,075,941 - 67,109,962 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1467,075,941 - 67,109,962 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01448,197,831 - 48,231,829 (+)NCBIMhudiblu_PPA_v0panPan3
ARG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,588,051 - 41,619,406 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,588,150 - 41,619,402 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,281,436 - 41,312,716 (+)NCBI
ROS_Cfam_1.0841,816,768 - 41,848,126 (+)NCBI
ROS_Cfam_1.0 Ensembl841,816,756 - 41,848,129 (+)Ensembl
UMICH_Zoey_3.1841,435,619 - 41,467,086 (+)NCBI
UNSW_CanFamBas_1.0841,509,266 - 41,540,499 (+)NCBI
UU_Cfam_GSD_1.0841,868,759 - 41,900,077 (+)NCBI
Arg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,146,234 - 63,187,387 (-)NCBI
SpeTri2.0NW_00493649511,004,296 - 11,045,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,343,987 - 91,385,911 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,343,987 - 91,385,911 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,650,711 - 97,693,055 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,851,139 - 44,884,118 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,851,175 - 44,883,853 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605333,080,857 - 33,116,479 (+)NCBIVero_WHO_p1.0
Arg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473433,321,161 - 33,352,306 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH129742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,956,532 - 97,956,728 (+)MAPPERmRatBN7.2
Rnor_6.06102,333,560 - 102,333,755NCBIRnor6.0
Rnor_5.06115,020,454 - 115,020,649UniSTSRnor5.0
RGSC_v3.46101,923,436 - 101,923,631UniSTSRGSC3.4
Celera696,341,687 - 96,341,882UniSTS
RH 3.4 Map6691.6UniSTS
Cytogenetic Map6q24UniSTS
RH133838  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,958,174 - 97,958,391 (+)MAPPERmRatBN7.2
Rnor_6.06102,335,202 - 102,335,418NCBIRnor6.0
Rnor_5.06115,022,096 - 115,022,312UniSTSRnor5.0
RGSC_v3.46101,925,078 - 101,925,294UniSTSRGSC3.4
Celera696,343,329 - 96,343,545UniSTS
RH 3.4 Map6692.3UniSTS
Cytogenetic Map6q24UniSTS
BF386764  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.46101,928,292 - 101,928,470UniSTSRGSC3.4
Celera696,346,541 - 96,346,719UniSTS
RH 3.4 Map6691.09UniSTS
Cytogenetic Map6q24UniSTS
RH141711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,961,023 - 97,961,210 (+)MAPPERmRatBN7.2
Rnor_6.06102,338,051 - 102,338,237NCBIRnor6.0
Rnor_5.06115,024,945 - 115,025,131UniSTSRnor5.0
RGSC_v3.46101,927,927 - 101,928,113UniSTSRGSC3.4
Celera696,346,176 - 96,346,362UniSTS
Cytogenetic Map6q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:280
Count of miRNA genes:189
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000015083
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 64 35 28
Low 1 15 32 16 19 16 8 11 10 13 11 8
Below cutoff 22 9 9 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083433   ⟹   ENSRNOP00000073568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl697,936,002 - 97,961,378 (+)Ensembl
Rnor_6.0 Ensembl6102,311,116 - 102,338,520 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097140   ⟹   ENSRNOP00000093599
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl697,936,105 - 97,961,378 (+)Ensembl
RefSeq Acc Id: NM_019168   ⟹   NP_062041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2697,936,002 - 97,961,379 (+)NCBI
Rnor_6.06102,311,097 - 102,338,406 (+)NCBI
Rnor_5.06114,998,810 - 115,025,300 (+)NCBI
RGSC_v3.46101,901,653 - 101,928,282 (+)RGD
Celera696,321,210 - 96,346,531 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062041 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC22580 (Get FASTA)   NCBI Sequence Viewer  
  AAM34681 (Get FASTA)   NCBI Sequence Viewer  
  BAA13183 (Get FASTA)   NCBI Sequence Viewer  
  EDM03719 (Get FASTA)   NCBI Sequence Viewer  
  O08701 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062041   ⟸   NM_019168
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000073568   ⟸   ENSRNOT00000083433
RefSeq Acc Id: ENSRNOP00000093599   ⟸   ENSRNOT00000097140

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694691
Promoter ID:EPDNEW_R5215
Type:multiple initiation site
Name:Arg2_1
Description:arginase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06102,311,140 - 102,311,200EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2151 AgrOrtholog
Ensembl Genes ENSRNOG00000053811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073568 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083433 ENTREZGENE, UniProtKB/TrEMBL
InterPro Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_Mn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29215 UniProtKB/Swiss-Prot
NCBI Gene 29215 ENTREZGENE
Pfam Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arg2 PhenoGen
PIRSF Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ARGINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARGINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARGINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs rocF_arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARGI2_RAT UniProtKB/Swiss-Prot
  G3V7H6_RAT UniProtKB/TrEMBL
  O08701 ENTREZGENE
UniProt Secondary P97539 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Arg2  arginase 2  Arg2  arginase type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Arg2  arginase type II  Arg2  arginase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Arg2  arginase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the hydrolysis of arginine to ornithine and urea 634667
gene_process may regulate nitric oxide production 634667