Arg2 (arginase 2) - Rat Genome Database

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Gene: Arg2 (arginase 2) Rattus norvegicus
Symbol: Arg2
Name: arginase 2
RGD ID: 2151
Description: Enables arginase activity and nitric-oxide synthase binding activity. Involved in several processes, including arginine catabolic process to ornithine; cellular response to cytokine stimulus; and cellular response to lipid. Located in mitochondrion. Used to study hypertension. Biomarker of acute kidney failure; end stage renal disease; hypertension; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2); PARTICIPATES IN urea cycle pathway; arginine and proline metabolic pathway; Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
Previously known as: AII type II arginase; AII, type II arginase; arginase II; arginase type II; arginase-2, mitochondrial; kidney-type arginase; non-hepatic arginase; type II arginase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Uae22
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr86103,669,001 - 103,694,375 (+)NCBIGRCr8
mRatBN7.2697,936,002 - 97,961,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,936,002 - 97,961,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,365,491 - 98,390,838 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,664,639 - 98,689,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0698,050,802 - 98,076,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,311,097 - 102,338,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,311,116 - 102,338,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06114,998,810 - 115,025,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,901,653 - 101,928,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16101,905,108 - 101,931,737 (+)NCBI
Celera696,321,210 - 96,346,531 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
irinotecan  (EXP)
isoflavones  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
menadione  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
neomycin  (EXP)
nickel sulfate  (ISO)
organophosphorus compound  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
poly(I:C)  (EXP)
pravastatin  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urea  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
arginine catabolic process to ornithine  (IBA,IDA,IEA,TAS)
arginine metabolic process  (IEA,IMP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to interleukin-4  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to type II interferon  (IEP)
lung development  (IEP)
maternal process involved in female pregnancy  (IEP)
midgut development  (IEP)
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process  (IEA,ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
negative regulation of chemokine (C-C motif) ligand 4 production  (IEA,ISO)
negative regulation of chemokine (C-C motif) ligand 5 production  (IEA,ISO)
negative regulation of defense response to bacterium  (IEA,ISO)
negative regulation of interleukin-13 production  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of macrophage inflammatory protein 1 alpha production  (IEA,ISO)
negative regulation of nitric-oxide synthase activity  (IMP)
negative regulation of striated muscle contraction  (IMP)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type 2 immune response  (IEA,ISO)
positive regulation of cellular senescence  (IEA,ISO)
regulation of interleukin-1 beta production  (IEA,ISO)
regulation of L-arginine import across plasma membrane  (IDA)
regulation of nitric oxide biosynthetic process  (IEP)
regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
response to amine  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to cadmium ion  (IEP)
response to glucose  (IEP)
response to herbicide  (IEP)
response to hormone  (IEP)
response to hypoxia  (IEP)
response to mercury ion  (IEP)
response to nutrient  (IEP)
response to selenium ion  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
striated muscle contraction  (IEA,ISO)
urea cycle  (IEA)
ureteric bud development  (IEA,ISO)

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. Bagnost T, etal., J Hypertens. 2008 Jun;26(6):1110-8.
2. Developmental changes in arginase expression and activity in the lung. Belik J, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L498-504. Epub 2008 Jan 11.
3. Differential expression of arginase and iNOS in the lung in sepsis. Carraway MS, etal., Exp Lung Res. 1998 May-Jun;24(3):253-68.
4. Time course of vascular arginase expression and activity in spontaneously hypertensive rats. Demougeot C, etal., Life Sci. 2007 Feb 27;80(12):1128-34. Epub 2006 Dec 14.
5. Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury. Erbas H, etal., Pharmacol Res. 2004 Nov;50(5):523-7.
6. Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid. Erisir M, etal., Cell Biochem Funct. 2003 Dec;21(4):331-5.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Modulation of intestinal urea cycle by dietary spermine in suckling rat. Gharbi M, etal., Biochem Biophys Res Commun. 2005 Nov 4;336(4):1119-24.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Involvement of arginase in regulating myometrial contractions during gestation in the rat. Hirata M, etal., Mol Hum Reprod. 2006 Aug;12(8):513-8. Epub 2006 May 30.
11. High glucose augments arginase activity and nitric oxide production in the renal cortex. Ishii N, etal., Metabolism. 2004 Jul;53(7):868-74.
12. Decreased expression of arginase II in the kidneys of Dahl salt-sensitive rats. Iwata S, etal., Hypertens Res. 2002 May;25(3):411-8.
13. The human arginases and arginase deficiency. Iyer R, etal., J Inherit Metab Dis 1998;21 Suppl 1:86-100.
14. Cloning and characterization of the mouse and rat type II arginase genes. Iyer RK, etal., Mol Genet Metab 1998 Mar;63(3):168-75.
15. Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock. Johnson RA, etal., J Trauma. 2010 Aug;69(2):384-91.
16. Downregulation of arginase II and renal apoptosis by inorganic mercury: overexpression of arginase II reduces its apoptosis. Kanda H, etal., Arch Toxicol. 2008 Feb;82(2):67-73. Epub 2007 Sep 14.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages. Klasen S, etal., Br J Pharmacol. 2001 Mar;132(6):1349-57.
19. Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II. Levillain O, etal., Am J Physiol Renal Physiol 2004 Apr;286(4):F727-38. Epub 2004 Feb 10.
20. Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells. Li H, etal., Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E75-82.
21. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. Li H, etal., J Allergy Clin Immunol. 2006 Jan;117(1):119-26. Epub 2005 Nov 28.
22. Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts. Lindemann D and Racke K, Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):546-50. Epub 2003 Nov 15.
23. Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway. Liu H, etal., Am J Transplant. 2005 Jun;5(6):1256-63.
24. Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: a link to deficits in object recognition? Liu P, etal., J Vestib Res. 2004;14(6):411-7.
25. Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia. Lopez V, etal., High Alt Med Biol. 2009 Winter;10(4):373-81.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. Moradi H, etal., Am J Nephrol. 2006;26(3):310-8. Epub 2006 Jun 29.
28. Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells. Moran JM, etal., Nitric Oxide. 2010 Apr 11.
29. Arginase-2 mediates diabetic renal injury. Morris SM Jr, etal., Diabetes. 2011 Nov;60(11):3015-22. Epub 2011 Sep 16.
30. Arginase: an emerging key player in the mammalian immune system. Munder M Br J Pharmacol. 2009 Oct;158(3):638-51. Epub 2009 Sep 17.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver. Nissim I, et al., J Biol Chem. 2005 May 6;280(18):17715-24. Epub 2005 Mar 7.
33. Expression of arginase II and related enzymes in the rat small intestine and kidney. Ozaki M, etal., J Biochem. 1999 Mar;125(3):586-93.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. Induction of arginase isoforms in the lung during hyperoxia. Que LG, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102.
36. Effects of arginase isoforms on NO Production by nNOS. Que LG, etal., Nitric Oxide 2002 Feb;6(1):1-8.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo. Schnorr O, etal., Arch Biochem Biophys. 2008 Aug 15;476(2):211-5. Epub 2008 Mar 6.
40. Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats. Schwartz IF, etal., Kidney Blood Press Res. 2008;31(3):210-6. Epub 2008 Jun 14.
41. L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats. Schwartz IF, etal., Kidney Int 2002 Nov;62(5):1700-6.
42. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Steppan J, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64. Epub 2006 Mar 13.
43. Oral administration of orthovanadate and Trigonella foenum graecum seed power restore the activities of mitochondrial enzymes in tissues of alloxan-induced diabetic rats. Thakran S, etal., Mol Cell Biochem. 2003 May;247(1-2):45-53.
44. Inhibition of rat liver and kidney arginase by cadmium ion. Tormanen CD J Enzyme Inhib Med Chem. 2006 Feb;21(1):119-23.
45. Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat. van Balkom BW, etal., Am J Physiol Renal Physiol. 2004 Feb;286(2):F216-24. Epub 2003 Oct 7.
46. Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. Vonk JM, etal., Pharmacogenet Genomics. 2010 Mar;20(3):179-86.
47. Induction of arginase II in livers of bile duct-ligated rats. Wei CL, etal., Biochem Pharmacol. 2002 Mar 15;63(6):1043-50.
48. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. Zimmermann N, etal., J Clin Invest. 2003 Jun;111(12):1863-74.
Additional References at PubMed
PMID:8898077   PMID:12859189   PMID:14651853   PMID:16128822   PMID:16545622   PMID:16794538   PMID:18614015   PMID:19763131   PMID:20981735   PMID:21281730   PMID:21408057   PMID:21952491  
PMID:21975054   PMID:22160208   PMID:22182949   PMID:22507752   PMID:22928666   PMID:23665321   PMID:25009204   PMID:25490411   PMID:26140333   PMID:27074721   PMID:27214549   PMID:27745970  
PMID:28614294   PMID:29627571  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr86103,669,001 - 103,694,375 (+)NCBIGRCr8
mRatBN7.2697,936,002 - 97,961,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,936,002 - 97,961,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,365,491 - 98,390,838 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,664,639 - 98,689,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0698,050,802 - 98,076,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,311,097 - 102,338,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,311,116 - 102,338,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06114,998,810 - 115,025,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,901,653 - 101,928,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16101,905,108 - 101,931,737 (+)NCBI
Celera696,321,210 - 96,346,531 (+)NCBICelera
Cytogenetic Map6q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381467,619,920 - 67,651,708 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,619,920 - 67,651,708 (+)EnsemblGRCh38hg38GRCh38
GRCh371468,086,637 - 68,118,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361467,156,332 - 67,188,190 (+)NCBINCBI36Build 36hg18NCBI36
Build 341467,156,331 - 67,188,190NCBI
Celera1448,145,655 - 48,177,498 (+)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1448,256,285 - 48,288,134 (+)NCBIHuRef
CHM1_11468,025,216 - 68,057,216 (+)NCBICHM1_1
T2T-CHM13v2.01461,827,050 - 61,858,841 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391279,177,562 - 79,203,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1279,177,551 - 79,203,075 (+)EnsemblGRCm39 Ensembl
GRCm381279,130,788 - 79,156,301 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1279,130,777 - 79,156,301 (+)EnsemblGRCm38mm10GRCm38
MGSCv371280,231,775 - 80,257,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361280,049,665 - 80,075,136 (+)NCBIMGSCv36mm8
Celera1280,595,209 - 80,620,745 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554662,549,557 - 2,577,060 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,549,557 - 2,577,060 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21568,728,161 - 68,761,716 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,944,743 - 67,978,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01448,197,831 - 48,231,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11467,075,941 - 67,109,962 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1467,075,941 - 67,109,962 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1841,588,051 - 41,619,406 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,588,150 - 41,619,402 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,281,436 - 41,312,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,816,768 - 41,848,126 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,816,756 - 41,848,129 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,435,619 - 41,467,086 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,509,266 - 41,540,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,868,759 - 41,900,077 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864063,146,234 - 63,187,387 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649511,004,176 - 11,045,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649511,004,296 - 11,045,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl791,343,988 - 91,385,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,343,987 - 91,385,911 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,650,711 - 97,693,055 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12444,851,139 - 44,884,118 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,851,175 - 44,883,853 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605333,080,857 - 33,116,479 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473433,321,295 - 33,352,277 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,321,161 - 33,352,306 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Arg2
174 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:280
Count of miRNA genes:189
Interacting mature miRNAs:220
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,956,532 - 97,956,728 (+)MAPPERmRatBN7.2
Rnor_6.06102,333,560 - 102,333,755NCBIRnor6.0
Rnor_5.06115,020,454 - 115,020,649UniSTSRnor5.0
RGSC_v3.46101,923,436 - 101,923,631UniSTSRGSC3.4
Celera696,341,687 - 96,341,882UniSTS
RH 3.4 Map6691.6UniSTS
Cytogenetic Map6q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,958,174 - 97,958,391 (+)MAPPERmRatBN7.2
Rnor_6.06102,335,202 - 102,335,418NCBIRnor6.0
Rnor_5.06115,022,096 - 115,022,312UniSTSRnor5.0
RGSC_v3.46101,925,078 - 101,925,294UniSTSRGSC3.4
Celera696,343,329 - 96,343,545UniSTS
RH 3.4 Map6692.3UniSTS
Cytogenetic Map6q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.46101,928,292 - 101,928,470UniSTSRGSC3.4
Celera696,346,541 - 96,346,719UniSTS
RH 3.4 Map6691.09UniSTS
Cytogenetic Map6q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,961,023 - 97,961,210 (+)MAPPERmRatBN7.2
Rnor_6.06102,338,051 - 102,338,237NCBIRnor6.0
Rnor_5.06115,024,945 - 115,025,131UniSTSRnor5.0
RGSC_v3.46101,927,927 - 101,928,113UniSTSRGSC3.4
Celera696,346,176 - 96,346,362UniSTS
Cytogenetic Map6q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 64 35 28
Low 1 15 32 16 19 16 8 11 10 13 11 8
Below cutoff 22 9 9 9


RefSeq Acc Id: ENSRNOT00000083433   ⟹   ENSRNOP00000073568
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl697,936,002 - 97,961,378 (+)Ensembl
Rnor_6.0 Ensembl6102,311,116 - 102,338,520 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097140   ⟹   ENSRNOP00000093599
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl697,936,105 - 97,961,378 (+)Ensembl
RefSeq Acc Id: NM_019168   ⟹   NP_062041
Rat AssemblyChrPosition (strand)Source
GRCr86103,669,001 - 103,694,375 (+)NCBI
mRatBN7.2697,936,002 - 97,961,379 (+)NCBI
Rnor_6.06102,311,097 - 102,338,406 (+)NCBI
Rnor_5.06114,998,810 - 115,025,300 (+)NCBI
RGSC_v3.46101,901,653 - 101,928,282 (+)RGD
Celera696,321,210 - 96,346,531 (+)RGD
Protein Sequences
Protein RefSeqs NP_062041 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC22580 (Get FASTA)   NCBI Sequence Viewer  
  AAM34681 (Get FASTA)   NCBI Sequence Viewer  
  BAA13183 (Get FASTA)   NCBI Sequence Viewer  
  EDM03719 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073568
GenBank Protein O08701 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062041   ⟸   NM_019168
- Peptide Label: precursor
- UniProtKB: P97539 (UniProtKB/Swiss-Prot),   O08701 (UniProtKB/Swiss-Prot),   G3V7H6 (UniProtKB/TrEMBL),   A6HCG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073568   ⟸   ENSRNOT00000083433
RefSeq Acc Id: ENSRNOP00000093599   ⟸   ENSRNOT00000097140

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08701-F1-model_v2 AlphaFold O08701 1-354 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694691
Promoter ID:EPDNEW_R5215
Type:multiple initiation site
Description:arginase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.06102,311,140 - 102,311,200EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2151 AgrOrtholog
BioCyc Gene G2FUF-36973 BioCyc
BioCyc Pathway ARG-PRO-PWY [L-arginine degradation VI (arginase 2 pathway)] BioCyc
  ARGASEDEG-PWY [L-arginine degradation I (arginase pathway)] BioCyc
  CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  PWY-46 [putrescine biosynthesis III] BioCyc
  PWY-4984 [urea cycle] BioCyc
BioCyc Pathway Image ARG-PRO-PWY BioCyc
  PWY-46 BioCyc
  PWY-4984 BioCyc
Ensembl Genes ENSRNOG00000053811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083433 ENTREZGENE
  ENSRNOT00000083433.2 UniProtKB/TrEMBL
  ENSRNOT00000097140.1 UniProtKB/TrEMBL
Gene3D-CATH Ureohydrolase domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_Mn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29215 UniProtKB/Swiss-Prot
  PTHR43782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arg2 PhenoGen
PIRSF Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARGINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053811 RatGTEx
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AM02_RAT UniProtKB/TrEMBL
  ARGI2_RAT UniProtKB/Swiss-Prot
UniProt Secondary P97539 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Arg2  arginase 2  Arg2  arginase type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Arg2  arginase type II  Arg2  arginase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Arg2  arginase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the hydrolysis of arginine to ornithine and urea 634667
gene_process may regulate nitric oxide production 634667