Arg2 (arginase 2) - Rat Genome Database

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Gene: Arg2 (arginase 2) Heterocephalus glaber
Analyze
Symbol: Arg2
Name: arginase 2
RGD ID: 18916475
Description: ENCODES a protein that exhibits arginase activity (ortholog); nitric-oxide synthase binding (ortholog); INVOLVED IN arginine catabolic process to ornithine (ortholog); arginine metabolic process (ortholog); cellular response to dexamethasone stimulus (ortholog); PARTICIPATES IN urea cycle pathway; ASSOCIATED WITH acute kidney failure (ortholog); asthma (ortholog); congestive heart failure (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Arginase-2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,321,295 - 33,352,277 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,321,161 - 33,352,306 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arginine catabolic process to ornithine  (IEA,ISO)
arginine metabolic process  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to interleukin-4  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to type II interferon  (ISO)
lung development  (ISO)
maternal process involved in female pregnancy  (ISO)
midgut development  (ISO)
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process  (ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
negative regulation of chemokine (C-C motif) ligand 4 production  (ISO)
negative regulation of chemokine (C-C motif) ligand 5 production  (ISO)
negative regulation of defense response to bacterium  (ISO)
negative regulation of interleukin-13 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of macrophage inflammatory protein 1 alpha production  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of striated muscle contraction  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type 2 immune response  (ISO)
positive regulation of cellular senescence  (ISO)
regulation of interleukin-1 beta production  (ISO)
regulation of L-arginine import across plasma membrane  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of reactive oxygen species biosynthetic process  (ISO)
response to amine  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to glucose  (ISO)
response to herbicide  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to mercury ion  (ISO)
response to nutrient  (ISO)
response to selenium ion  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
striated muscle contraction  (ISO)
urea cycle  (IEA)
ureteric bud development  (ISO)

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Arg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,321,295 - 33,352,277 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,321,161 - 33,352,306 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ARG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,619,920 - 67,651,708 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,619,920 - 67,651,708 (+)EnsemblGRCh38hg38GRCh38
GRCh371468,086,637 - 68,118,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361467,156,332 - 67,188,190 (+)NCBINCBI36Build 36hg18NCBI36
Build 341467,156,331 - 67,188,190NCBI
Celera1448,145,655 - 48,177,498 (+)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1448,256,285 - 48,288,134 (+)NCBIHuRef
CHM1_11468,025,216 - 68,057,216 (+)NCBICHM1_1
T2T-CHM13v2.01461,827,050 - 61,858,841 (+)NCBIT2T-CHM13v2.0
Arg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391279,177,562 - 79,203,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1279,177,551 - 79,203,075 (+)EnsemblGRCm39 Ensembl
GRCm381279,130,788 - 79,156,301 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1279,130,777 - 79,156,301 (+)EnsemblGRCm38mm10GRCm38
MGSCv371280,231,775 - 80,257,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361280,049,665 - 80,075,136 (+)NCBIMGSCv36mm8
Celera1280,595,209 - 80,620,745 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
Arg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,669,001 - 103,694,375 (+)NCBIGRCr8
mRatBN7.2697,936,002 - 97,961,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,936,002 - 97,961,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,365,491 - 98,390,838 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,664,639 - 98,689,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0698,050,802 - 98,076,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,311,097 - 102,338,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,311,116 - 102,338,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06114,998,810 - 115,025,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,901,653 - 101,928,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16101,905,108 - 101,931,737 (+)NCBI
Celera696,321,210 - 96,346,531 (+)NCBICelera
Cytogenetic Map6q24NCBI
Arg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,549,557 - 2,577,060 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,549,557 - 2,577,060 (-)NCBIChiLan1.0ChiLan1.0
ARG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,728,161 - 68,761,716 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,944,743 - 67,978,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01448,197,831 - 48,231,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11467,075,941 - 67,109,962 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1467,075,941 - 67,109,962 (+)Ensemblpanpan1.1panPan2
ARG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,588,051 - 41,619,406 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,588,150 - 41,619,402 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,281,436 - 41,312,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,816,768 - 41,848,126 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,816,756 - 41,848,129 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,435,619 - 41,467,086 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,509,266 - 41,540,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,868,759 - 41,900,077 (+)NCBIUU_Cfam_GSD_1.0
Arg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,146,234 - 63,187,387 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649511,004,176 - 11,045,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649511,004,296 - 11,045,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,343,988 - 91,385,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,343,987 - 91,385,911 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,650,711 - 97,693,055 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,851,139 - 44,884,118 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,851,175 - 44,883,853 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605333,080,857 - 33,116,479 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Ensembl Acc Id: ENSHGLT00000017104   ⟹   ENSHGLP00000016933
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473433,321,295 - 33,352,277 (-)Ensembl
RefSeq Acc Id: XM_004837347   ⟹   XP_004837404
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473433,321,161 - 33,352,306 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004837404 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB17637 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016933
GenBank Protein JAN96635 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004837404   ⟸   XM_004837347
- UniProtKB: A0A0P6J8J1 (UniProtKB/TrEMBL),   G5C7X6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016933   ⟸   ENSHGLT00000017104


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012107 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000017104 ENTREZGENE
Gene3D-CATH Ureohydrolase domain UniProtKB/TrEMBL
InterPro Arginase UniProtKB/TrEMBL
  Ureohydrolase UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_Mn_BS UniProtKB/TrEMBL
KEGG Report hgl:101717125 UniProtKB/TrEMBL
NCBI Gene Arg2 ENTREZGENE
PANTHER ARGINASE-2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR43782 UniProtKB/TrEMBL
Pfam Arginase UniProtKB/TrEMBL
PIRSF Arginase UniProtKB/TrEMBL
PRINTS ARGINASE UniProtKB/TrEMBL
PROSITE ARGINASE_1 UniProtKB/TrEMBL
  ARGINASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt A0A0P6J8J1 ENTREZGENE, UniProtKB/TrEMBL
  G5C7X6 ENTREZGENE, UniProtKB/TrEMBL