Nos1 (nitric oxide synthase 1) - Rat Genome Database
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Gene: Nos1 (nitric oxide synthase 1) Ictidomys tridecemlineatus
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Symbol: Nos1
Name: nitric oxide synthase 1
RGD ID: 12566457
Description: ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN aging (ortholog); arginine catabolic process (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Necrotizing Pancreatitis (ortholog); alcoholic cardiomyopathy (ortholog); FOUND IN azurophil granule (ortholog); calyx of Held (ortholog); caveola (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: nitric oxide synthase, brain
Orthologs:
Homo sapiens (human) : NOS1 (nitric oxide synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Nos1 (nitric oxide synthase 1, neuronal)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nos1 (nitric oxide synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nos1 (nitric oxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOS1 (nitric oxide synthase 1)
Canis lupus familiaris (dog) : NOS1 (nitric oxide synthase 1)
Sus scrofa (pig) : NOS1 (nitric oxide synthase 1)
Heterocephalus glaber (naked mole-rat) : Nos1 (nitric oxide synthase 1)
more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
alcoholic cardiomyopathy  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
Carbon Monoxide Poisoning  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cerebellar disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
cystic fibrosis  (ISO)
Dehydration  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of mental health  (ISO)
Duchenne muscular dystrophy  (ISO)
End Stage Liver Disease  (ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Hypoxia  (ISO)
Fever  (ISO)
Heat Stroke  (ISO)
hepatic encephalopathy  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
impotence  (ISO)
intestinal perforation  (ISO)
intracranial aneurysm  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
morphine dependence  (ISO)
motor neuron disease  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Nervous System Trauma  (ISO)
Neuralgia  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonian Disorders  (ISO)
portal hypertension  (ISO)
Prehypertension  (ISO)
Pyloric Stenosis, Infantile Hypertrophic 1  (ISO)
Radiation Injuries, Experimental  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
temporal lobe epilepsy  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urethral obstruction  (ISO)
Urination Disorders  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
arginine catabolic process  (ISO)
behavioral response to cocaine  (ISO)
brain development  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
establishment of protein localization  (ISO)
exogenous drug catabolic process  (ISO)
female pregnancy  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of heart contraction  (ISO)
negative regulation of hepatic stellate cell contraction  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of potassium ion transport  (ISO)
negative regulation of serotonin uptake  (ISO)
negative regulation of vasoconstriction  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide mediated signal transduction  (ISO)
obsolete positive regulation of blood vessel diameter  (ISO)
peptidyl-cysteine S-nitrosylation  (ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (ISO)
positive regulation of histone acetylation  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of sodium ion transmembrane transport  (ISO)
positive regulation of the force of heart contraction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of heart contraction  (ISO)
regulation of neurogenesis  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of sodium ion transport  (ISO)
response to activity  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to nitric oxide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
response to vitamin E  (ISO)
retrograde trans-synaptic signaling by nitric oxide  (ISO)
striated muscle contraction  (ISO)
synaptic signaling by nitric oxide  (ISO)
vasodilation  (ISO)

References

Genomics

Comparative Map Data
Nos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12117,208,142 - 117,452,170 (-)EnsemblGRCh38hg38GRCh38
GRCh3812117,208,142 - 117,361,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712117,645,921 - 117,799,607 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBINCBI36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBI
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
Nos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,004,904 - 118,096,905 (+)NCBI
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIGRCm37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBImm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
Nos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
Celera1240,283,655 - 40,368,674 (-)NCBICelera
Cytogenetic Map12q16NCBI
RH 3.4 Map12718.8RGD
RH 3.4 Map12717.0RGD
Nos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
NOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112118,163,655 - 118,314,005 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,163,655 - 118,314,005 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012114,784,232 - 114,938,385 (-)NCBIMhudiblu_PPA_v0panPan3
NOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2613,786,309 - 13,962,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12613,787,341 - 13,895,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
NOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1435,113,184 - 35,295,972 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11435,112,898 - 35,299,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,401,967 - 37,515,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nos1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474715,940,614 - 16,118,051 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013360437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGTP01058656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGTP01058675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_013360437   ⟹   XP_013215891
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013215891 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013215891   ⟸   XM_013360437
- Sequence:
Protein Domains
Flavodoxin-like   PDZ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028824 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000023013 UniProtKB/TrEMBL
  ENSSTOP00000023214 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000029576 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000025993 UniProtKB/TrEMBL
  ENSSTOT00000027339 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOT00000038179 UniProtKB/TrEMBL
Gene3D-CATH 1.20.990.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  3.40.50.360 UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/TrEMBL
  NOS_euk UniProtKB/TrEMBL
  NOS_N UniProtKB/TrEMBL
  NOS_N_sf UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/TrEMBL
NCBI Gene Nos1 ENTREZGENE
Pfam FAD_binding_1 UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/TrEMBL
  NO_synthase UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PIRSF NOS UniProtKB/TrEMBL
PRINTS FLAVODOXIN UniProtKB/TrEMBL
  FPNCR UniProtKB/TrEMBL
PROSITE FLAVODOXIN_LIKE UniProtKB/TrEMBL
  NOS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/TrEMBL
  SSF52218 UniProtKB/TrEMBL
  SSF52343 UniProtKB/TrEMBL
  SSF56512 UniProtKB/TrEMBL
  SSF63380 UniProtKB/TrEMBL
UniProt A0A287D7T4_ICTTR UniProtKB/TrEMBL
  I3NF66_ICTTR UniProtKB/TrEMBL
  I3NFR7_ICTTR UniProtKB/TrEMBL