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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:38725
Term: mevinphos
Definition: An organophosphate insecticide that has formula C7H13O6P.
Chemical ID: MESH:D008799
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1increases activityEXP 6480464CTDMevinphos results in increased activity of NOS1 proteinPMID:15617736
Nos1increases expressionEXP 6480464CTDMevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 proteinPMID:15111025 PMID:17150954 PMID:17395621 PMID:17438462 PMID:21390240 PMID:24462917 PMID:28601397
Nos1multiple interactionsEXP 6480464CTDARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]PMID:17150954 PMID:17395621 PMID:17438462 PMID:21390240
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