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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:90721
Term: N-[3-(aminomethyl)benzyl]acetamidine
Definition: An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase.
Chemical ID: MESH:C104820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2decreases activityEXP 6480464CTDN-3-aminomethylbenzylacetamidine results in decreased activity of NOS2 protein

PMID:16461118 PMID:23061969
Nos2multiple interactionsEXP 6480464CTD[N-3-aminomethylbenzylacetamidine results in decreased activity of NOS2 protein] which results in increased susceptibility to endothelium-dependent hyperpolarization factor N-3-aminomethylbenzylacetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] N-3-aminomethylbenzylacetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2] N-3-aminomethylbenzylacetamidine inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]

PMID:16933320 PMID:19951519 PMID:20035746 PMID:20497644 PMID:20549418
Nos2decreases activityISORGD:109966480464CTDN-3-aminomethylbenzylacetamidine results in decreased activity of NOS2 protein

PMID:11134894
Nos2multiple interactionsISORGD:109966480464CTD[N-3-aminomethylbenzylacetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species] [N-3-aminomethylbenzylacetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]

PMID:19442826
Nos2multiple interactionsISORGD:7309516480464CTD[N-3-aminomethylbenzylacetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide] N-3-aminomethylbenzylacetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]

PMID:11076874 PMID:24964743
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