GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of NOS2 mRNA; Ethanol results in increased expression of NOS2 protein | PMID:18037914 PMID:19615717 PMID:22257724 PMID:22525864 PMID:26460608 PMID:26522475 PMID:30372842 | Nos2 | multiple interactions | EXP | | 6480464 | CTD | [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 protein; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 protein; [Dietary Fats co-treated with Ethanol] results in increased expression of NOS2 mRNA; [Ethanol results in decreased expression of and results in decreased activity of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Quercetin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]; Ethanol results in decreased expression of and results in decreased activity of NOS2 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; Plant Extracts inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; Plant Extracts inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]] | PMID:10231168 PMID:11173986 PMID:22257724 PMID:22525864 PMID:26460608 PMID:26522475 PMID:26747958 PMID:30372842 | Nos2 | increases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Ethanol results in increased expression of NOS2 mRNA; Ethanol results in increased expression of NOS2 protein | PMID:19063909 PMID:20016022 PMID:23500890 PMID:23832548 PMID:26970604 PMID:27984176 PMID:35526736 PMID:35639301 | Nos2 | increases expression | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Ethanol results in increased expression of NOS2 protein | PMID:18845238 | Nos2 | multiple interactions | ISO | Nos2 (Mus musculus) | 6480464 | CTD | 5-aminoisoquinolinone inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; [Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in increased expression of NOS2 protein; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein; [Ethanol co-treated with Thioacetamide] results in increased expression of NOS2 mRNA; [ethylene dichloride co-treated with Ethanol] results in increased expression of NOS2 protein; allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of NOS2 protein]; CNR1 gene mutant form affects the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of NOS2 mRNA]; costunolide inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Ethanol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of NOS2 protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in increased expression of NOS2 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of NOS2 mRNA]; SOD2 protein affects the reaction [Ethanol results in increased expression of NOS2 protein]; SOD2 protein inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; sodium propionate inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; TLR4 gene mutant form inhibits the reaction [Ethanol results in increased expression of NOS2 protein] | PMID:18281171 PMID:19063909 PMID:20016022 PMID:21863215 PMID:23500890 PMID:26970604 PMID:27984176 PMID:33516661 PMID:35526736 PMID:35639301 PMID:37054933 PMID:37150348 | Nos2 | multiple interactions | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | [Ethanol results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide | PMID:18845238 | | ||||||||||||||||||||||
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