RGD Reference Report - Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. - Rat Genome Database
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Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke.

Authors: Raza, SS  Khan, MM  Ahmad, A  Ashafaq, M  Khuwaja, G  Tabassum, R  Javed, H  Siddiqui, MS  Safhi, MM  Islam, F 
Citation: Raza SS, etal., Brain Res. 2011 Aug 27.
RGD ID: 5508751
Pubmed: (View Article at PubMed) PMID:21959178
DOI: Full-text: DOI:10.1016/j.brainres.2011.08.047

Incidence of stroke is considered to be a major cause of death throughout the world. The middle cerebral artery occlusion (MCAO) for 2h followed by 22h of reperfusion model was used in male Wistar rats to study the protection of stroke by hesperidin. Hesperidin administration (50mg/kg b.wt.) once daily for 15days has improved the infarct size, reduced the neurological deficits in terms of behaviors, and protected the elevated level of thiobarbituric acid reactive species (TBARS). A significantly depleted activity of antioxidant enzymes, glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT) and superoxide dismutase (SOD) and content of glutathione (GSH) in MCAO group were protected significantly in MCAO group pretreated with hesperidin. Moreover, inflammatory mediators like TNF-alpha, IL-1beta levels, expression of iNOS and glial fibrillary acidic protein (GFAP) were significantly attenuated in H+MCAO group as compared to MCAO group. In conclusion, prophylactic treatment with hesperidin ameliorated the functional and histological outcomes with elevated endogenous antioxidants status as well as reduced induction of proinflammatory cytokines in MCA occluded rat. We theorized that hesperidin is among the pharmacological agents that reduce free radicals and its associated inflammation and have been found to limit the extent of brain damage following stroke.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Nos2  (nitric oxide synthase 2)

Genes (Mus musculus)
Nos2  (nitric oxide synthase 2, inducible)

Genes (Homo sapiens)
NOS2  (nitric oxide synthase 2)


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