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[Apoptosis related genes--Bcl-2, bax and iNOS, expressed in the olfactory epithelium of mice infected with influenza virus].

Authors: Chen, Z  Ni, D  Gao, Y  Lin, J 
Citation: Chen Z, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Jun;21(11):510-2.
Pubmed: (View Article at PubMed) PMID:17674769

OBJECTIVE: To study the expression of apoptosis related genes, Bcl-2, bax, and iNOS in the olfactory epithelium of mice infected with influenza virus, and to discuss how they regulate apoptosis of the olfactory sensory neurons. METHOD: The expression levels of apoptosis related genes were detected with semi-quantity RT-PCR. RESULT: (1) The expression levels of Bcl-2 mRNA remain relatively constant after virus inoculation; (2) The expression levels of bax mRNA increased massively, and decreased gradually; (3) The expression levels of iNOS mRNA increased significantly in a short period, and then fell down to the undetectable level gradually. CONCLUSION: The apoptosis related genes, Bcl-2, bax, and iNOS may play important roles in regulation of apoptosis of olfactory sensory neurons of mice infected with influenza virus.

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RGD Object Information
RGD ID: 4891919
Created: 2011-01-21
Species: All species
Last Modified: 2011-01-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.