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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionEXP 6480464CTDNicotine results in increased expression of NOS2 mRNA; Nicotine results in increased expression of NOS2 proteinPMID:19673871
Nos2multiple interactionsEXP 6480464CTDNicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]PMID:27984197
Nos2decreases expressionISONos2 (Mus musculus)6480464CTDNicotine results in decreased expression of NOS2 mRNA; Nicotine results in decreased expression of NOS2 proteinPMID:17135361
Nos2increases expressionISONos2 (Mus musculus)6480464CTDNicotine results in increased expression of NOS2 mRNAPMID:16254210 PMID:21237301
Nos2increases expressionISONOS2 (Homo sapiens)6480464CTDNicotine results in increased expression of NOS2 mRNA; Nicotine results in increased expression of NOS2 proteinPMID:16927020 PMID:18247414
Nos2multiple interactionsISONos2 (Mus musculus)6480464CTD[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]; [Nicotine results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]PMID:17135361 PMID:21237301 PMID:23933227
Nos2multiple interactionsISONOS2 (Homo sapiens)6480464CTDNicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]PMID:16927020
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