GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | decreases activity | EXP | | 6480464 | CTD | Manganese results in decreased activity of NOS2 protein | PMID:16488514 | Nos2 | increases expression | EXP | | 6480464 | CTD | Manganese results in increased expression of NOS2 mRNA; Manganese results in increased expression of NOS2 protein | PMID:20224926 PMID:20798247 PMID:24777576 | Nos2 | multiple interactions | EXP | | 6480464 | CTD | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [Manganese results in increased abundance of Reactive Oxygen Species] promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Manganese results in increased expression of and results in increased activity of NOS2 protein; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] | PMID:15010209 PMID:16488514 PMID:17827730 PMID:24777576 | Nos2 | decreases methylation | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Manganese results in decreased methylation of NOS2 exon | PMID:25634431 | Nos2 | increases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Manganese results in increased expression of NOS2 mRNA; Manganese results in increased expression of NOS2 protein | PMID:16168523 PMID:16417967 PMID:16551646 PMID:18335517 PMID:19812365 PMID:23832297 | Nos2 | multiple interactions | ISO | Nos2 (Mus musculus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of NOS2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of NOS2 protein; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 mRNA]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 protein] | PMID:16168523 PMID:16417967 PMID:34018660 | | ||||||||||||||||||||||
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