GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | increases expression | EXP | | 6480464 | CTD | Diclofenac results in increased expression of NOS2 mRNA | PMID:15135310 PMID:16944022 PMID:17275683 PMID:29027214 | Nos2 | multiple interactions | EXP | | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; sodium nitrate inhibits the reaction [Diclofenac results in increased expression of NOS2 mRNA] | PMID:17275683 PMID:19393675 PMID:23395999 PMID:23939143 | Nos2 | decreases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Diclofenac results in decreased expression of NOS2 mRNA | PMID:35537566 | Nos2 | decreases expression | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Diclofenac results in decreased expression of NOS2 mRNA | PMID:29027214 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |