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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionEXP 6480464CTDHistamine results in increased expression of NOS2 proteinPMID:36565801
Nos2increases phosphorylationISONOS2 (Homo sapiens)6480464CTDHistamine results in increased phosphorylation of NOS2 proteinPMID:21145922
Nos2multiple interactionsISONOS2 (Homo sapiens)6480464CTD[PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein]; Deoxyglucose promotes the reaction [STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]]; STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]; STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]PMID:21145922
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