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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:17833
Term: gentamycin
Definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
Chemical ID: MESH:D005839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases cleavageEXP 6480464CTDGentamicins results in increased cleavage of NOS2 proteinPMID:22526374
Nos2increases expressionEXP 6480464CTDGentamicins results in increased expression of NOS2 proteinPMID:15936777 PMID:16925772 PMID:17312373 PMID:18441258 PMID:19535489 PMID:30458643
Nos2multiple interactionsEXP 6480464CTD[Gentamicins results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; Cholecalciferol inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]PMID:16925772 PMID:17312373 PMID:22526374 PMID:30458643
Nos2increases expressionISONos2 (Mus musculus)6480464CTDGentamicins results in increased expression of NOS2 mRNA; Gentamicins results in increased expression of NOS2 proteinPMID:29751043
Nos2multiple interactionsISONos2 (Mus musculus)6480464CTDGentamicins promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of NOS2 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]PMID:17442725 PMID:29751043
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