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Gene: Tob1 (transducer of ErbB-2.1) Rattus norvegicus
Symbol: Tob1
Name: transducer of ErbB-2.1
Description: Predicted to have SMAD binding activity; receptor tyrosine kinase binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of osteoblast differentiation; regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to CCR4-NOT complex; cytoplasm; and nucleus. Orthologous to human TOB1 (transducer of ERBB2, 1); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: transducer of ERBB2, 1
Homo sapiens (human) : TOB1 (transducer of ERBB2, 1)  HGNC  Alliance
Mus musculus (house mouse) : Tob1 (transducer of ErbB-2.1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tob1 (transducer of ERBB2, 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TOB1 (transducer of ERBB2, 1)
Canis lupus familiaris (dog) : TOB1 (transducer of ERBB2, 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tob1 (transducer of ERBB2, 1)
Sus scrofa (pig) : TOB1 (transducer of ERBB2, 1)
Chlorocebus sabaeus (African green monkey) : TOB1 (transducer of ERBB2, 1)
Heterocephalus glaber (naked mole-rat) : Tob1 (transducer of ERBB2, 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01081,913,689 - 81,915,727 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,913,689 - 81,915,716 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,746,516 - 81,748,554 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,852,405 - 82,854,443 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11082,866,780 - 82,868,808 (+)NCBI
Celera1077,952,276 - 77,954,314 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tob1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621126
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.