Phb1 (prohibitin 1) - Rat Genome Database

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Gene: Phb1 (prohibitin 1) Rattus norvegicus
Analyze
Symbol: Phb1
Name: prohibitin 1
RGD ID: 3322
Description: Predicted to enable several functions, including complement binding activity; histone deacetylase binding activity; and protein heterodimerization activity. Involved in several processes, including female gonad development; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of smooth muscle cell proliferation. Located in mitochondrial outer membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of presynaptic active zone membrane. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1); INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Phb; prohibitin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Phb1-ps1   Phb1-ps21  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21080,605,268 - 80,618,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,605,251 - 80,618,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,553,897 - 85,566,665 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,051,939 - 85,064,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,444,228 - 80,456,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,476,107 - 83,488,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,284,048 - 83,296,819 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1199,127,730 - 9,128,666 (+)NCBI
Celera1079,373,802 - 79,386,571 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
7,12-dimethyltetraphene  (EXP,IEP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
busulfan  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
choline  (EXP)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diuron  (EXP)
dopamine  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eurycomanone  (ISO)
finasteride  (EXP)
flavone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (EXP)
geraniol  (EXP,ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (EXP,ISO)
malathion  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
ochratoxin A  (EXP,ISO)
ozone  (EXP)
paracetamol  (ISO)
paraoxon  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
PhIP  (EXP,IEP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
pyrogallol  (ISO)
quinomethionate  (ISO)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
thapsigargin  (ISO)
Tributyltin oxide  (ISO)
triciribine  (EXP)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
antiviral innate immune response  (ISO)
B cell activation  (ISO,ISS)
CD40 signaling pathway  (ISO,ISS)
cellular response to interleukin-6  (ISO)
DNA biosynthetic process  (ISO)
epigenetic regulation of gene expression  (ISO)
mitochondrion organization  (IBA,ISO)
modulation by host of viral RNA genome replication  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IMP,ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of glucocorticoid receptor signaling pathway  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by competitive promoter binding  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
ovarian follicle atresia  (IEP)
ovarian follicle development  (IEP)
positive regulation of complement activation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO,ISS)
positive regulation of interleukin-17 production  (ISO,ISS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
progesterone receptor signaling pathway  (ISO)
protein stabilization  (ISO)
regulation of DNA-templated transcription  (ISO)
response to cytokine  (IEP)
response to ethanol  (IEP)
response to immobilization stress  (IEP)
response to peptide hormone  (IEP)
response to xenobiotic stimulus  (IEP)
RIG-I signaling pathway  (ISO)
T-helper 17 type immune response  (ISO,ISS)
viral entry into host cell  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Regions of evolutionary conservation between the rat and human prohibitin-encoding genes. Altus MS, etal., Gene 1995 Jun 9;158(2):291-4.
2. Prohibitin gene is overexpressed but not mutated in rat bladder carcinomas and cell lines. Asamoto M and Cohen SM, Cancer Lett. 1994 Aug 15;83(1-2):201-7.
3. S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. Bailey SM, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G857-67. Epub 2006 Jul 6.
4. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
5. Two-dimensional gel analysis of human endometrial proteins: characterization of proteins with increased expression in hyperplasia and adenocarcinoma. Byrjalsen I, etal., Mol Hum Reprod. 1999 Aug;5(8):748-56.
6. Prohibitin 3' untranslated region polymorphism and breast cancer risk. Campbell IG, etal., Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1273-4.
7. Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats. Cao YY, etal., Life Sci. 2020 Jun 1;250:117548. doi: 10.1016/j.lfs.2020.117548. Epub 2020 Mar 12.
8. Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin. Chowdhury I, etal., Endocrinology. 2007 Jan;148(1):206-17. Epub 2006 Oct 12.
9. Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin. Dixit VD, etal., Endocrinology. 2003 Apr;144(4):1496-505.
10. Composition of the synaptic PSD-95 complex. Dosemeci A, etal., Mol Cell Proteomics. 2007 Oct;6(10):1749-60. doi: 10.1074/mcp.M700040-MCP200. Epub 2007 Jul 9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-beta1. Guo W, etal., Mol Cell Biochem. 2007 Jan;295(1-2):167-77. Epub 2006 Oct 17.
14. Prohibitin, an antiproliferative protein, is localized to mitochondria. Ikonen E, etal., FEBS Lett. 1995 Jan 30;358(3):273-7.
15. Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. Jupe ER, etal., Lancet. 2001 May 19;357(9268):1588-9.
16. Proteomic characterization of the effects of clofibrate on protein expression in rat liver. Leonard JF, etal., Proteomics. 2006 Mar;6(6):1915-33.
17. Proteomic analysis of mitochondrial proteins in cardiomyocytes from chronic stressed rat. Liu XH, etal., Proteomics. 2004 Oct;4(10):3167-76.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Nuell MJ, etal., Mol Cell Biol 1991 Mar;11(3):1372-81.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury. Opii WO, etal., J Neurotrauma. 2007 May;24(5):772-89.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. Sato T, etal., Cancer Res. 1992 Mar 15;52(6):1643-6.
28. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
29. A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. Smalla KH, etal., Mol Psychiatry. 2008 Sep;13(9):878-96. doi: 10.1038/mp.2008.60. Epub 2008 May 27.
30. The prohibitin 3' untranslated region polymorphism is not associated with risk of ovarian cancer. Spurdle AB, etal., Gynecol Oncol. 2003 Jul;90(1):145-9.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Prohibitin expression is decreased in the regenerating liver but not in chemically induced hepatic tumors in rats. Tanno S, etal., Jpn J Cancer Res. 1997 Dec;88(12):1155-64.
33. Regulation of prohibitin expression during follicular development and atresia in the mammalian ovary. Thompson WE, etal., Biol Reprod. 2004 Jul;71(1):282-90. Epub 2004 Mar 17.
34. The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. Tsai HW, etal., Hum Pathol. 2006 Feb;37(2):198-204. Epub 2005 Dec 20.
35. Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer. Ummanni R, etal., Cancer Lett. 2008 Mar 31;.
36. Prohibitin in the pathogenesis of transitional cell bladder cancer. Wu TF, etal., Anticancer Res. 2007 Mar-Apr;27(2):895-900.
Additional References at PubMed
PMID:11302691   PMID:11884367   PMID:12065415   PMID:12466959   PMID:12566959   PMID:12865426   PMID:14500729   PMID:14651853   PMID:15274632   PMID:15489334   PMID:16210410   PMID:16854843  
PMID:16964284   PMID:17008324   PMID:17070910   PMID:17324931   PMID:17597094   PMID:17634366   PMID:18480465   PMID:18487222   PMID:18614015   PMID:18958584   PMID:19906925   PMID:19946888  
PMID:20030709   PMID:20403401   PMID:20458337   PMID:20832420   PMID:20833797   PMID:20959514   PMID:21179762   PMID:21256116   PMID:21914039   PMID:22238093   PMID:22417827   PMID:22711522  
PMID:23254195   PMID:23376485   PMID:23921388   PMID:23992168   PMID:24096434   PMID:24185039   PMID:24204768   PMID:24625528   PMID:24732013   PMID:25031298   PMID:25463519   PMID:26048717  
PMID:26310625   PMID:26316108   PMID:26623724   PMID:27044659   PMID:27854077   PMID:28376086   PMID:29476059   PMID:29867124   PMID:30967257   PMID:34219469   PMID:36453777  


Genomics

Comparative Map Data
Phb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21080,605,268 - 80,618,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,605,251 - 80,618,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,553,897 - 85,566,665 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,051,939 - 85,064,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,444,228 - 80,456,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,476,107 - 83,488,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,284,048 - 83,296,819 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1199,127,730 - 9,128,666 (+)NCBI
Celera1079,373,802 - 79,386,571 (+)NCBICelera
Cytogenetic Map10q26NCBI
PHB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,404,052 - 49,414,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,404,049 - 49,414,905 (-)EnsemblGRCh38hg38GRCh38
GRCh371747,481,414 - 47,492,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,836,419 - 44,847,241 (-)NCBINCBI36Build 36hg18NCBI36
Build 341744,836,418 - 44,847,241NCBI
Celera1743,936,440 - 43,947,262 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1742,846,458 - 42,857,310 (-)NCBIHuRef
CHM1_11747,546,565 - 47,557,421 (-)NCBICHM1_1
T2T-CHM13v2.01750,267,083 - 50,277,908 (-)NCBIT2T-CHM13v2.0
Phb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,557,783 - 95,571,599 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,557,783 - 95,571,599 (+)EnsemblGRCm39 Ensembl
GRCm381195,666,957 - 95,680,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,666,957 - 95,680,773 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,528,271 - 95,542,087 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,483,105 - 95,496,855 (+)NCBIMGSCv36mm8
Celera11105,306,168 - 105,322,388 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Phb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,110,290 - 12,120,124 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,110,290 - 12,119,870 (+)NCBIChiLan1.0ChiLan1.0
PHB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11717,718,717 - 17,728,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,189,555 - 8,200,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,175,912 - 8,186,790 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,175,968 - 8,186,790 (+)Ensemblpanpan1.1panPan2
PHB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,525,711 - 25,536,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,526,649 - 25,536,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,985,397 - 24,996,403 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,321,934 - 26,332,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,185,622 - 26,347,114 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,089,828 - 25,100,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,349,147 - 25,360,155 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,478,042 - 25,489,037 (-)NCBIUU_Cfam_GSD_1.0
Phb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,936,269 - 24,948,093 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649012,127,065 - 12,138,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,596,523 - 25,609,706 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,596,520 - 25,609,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,535,912 - 25,549,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,805,968 - 69,816,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,806,923 - 69,816,754 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,910,348 - 40,921,223 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,556,450 - 5,565,988 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,556,728 - 5,565,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phb1
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:367
Count of miRNA genes:197
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000075733
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat

Markers in Region
RH127963  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19p13UniSTS
Cytogenetic MapXq14UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map6q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075733   ⟹   ENSRNOP00000066502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1080,605,251 - 80,618,042 (+)Ensembl
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)Ensembl
RefSeq Acc Id: NM_031851   ⟹   NP_114039
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21080,605,268 - 80,618,042 (+)NCBI
Rnor_6.01083,476,107 - 83,488,878 (+)NCBI
Rnor_5.01083,284,048 - 83,296,819 (+)NCBI
Celera1079,373,802 - 79,386,571 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085263   ⟹   XP_038941191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21080,605,318 - 80,618,043 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_114039   ⟸   NM_031851
- UniProtKB: Q4V8M6 (UniProtKB/Swiss-Prot),   P67779 (UniProtKB/Swiss-Prot),   A6HIA7 (UniProtKB/TrEMBL),   A6HHC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066502   ⟸   ENSRNOT00000075733
RefSeq Acc Id: XP_038941191   ⟸   XM_039085263
- Peptide Label: isoform X1
- UniProtKB: P67779 (UniProtKB/Swiss-Prot),   Q4V8M6 (UniProtKB/Swiss-Prot),   A6HIA7 (UniProtKB/TrEMBL),   A6HHC9 (UniProtKB/TrEMBL)
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P67779-F1-model_v2 AlphaFold P67779 1-272 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3322 AgrOrtholog
BioCyc Gene G2FUF-23537 BioCyc
Ensembl Genes ENSRNOG00000046799 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066502 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075733 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105633 IMAGE-MGC_LOAD
  IMAGE:7441791 IMAGE-MGC_LOAD
InterPro Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prohibitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25344 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114298 IMAGE-MGC_LOAD
  MGC:91613 IMAGE-MGC_LOAD
NCBI Gene 25344 ENTREZGENE
PANTHER PROHIBITIN UniProtKB/Swiss-Prot
  PROHIBITIN UniProtKB/TrEMBL
  PROHIBITIN UniProtKB/TrEMBL
  PTHR23222 UniProtKB/Swiss-Prot
Pfam Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phb1 PhenoGen
PRINTS PROHIBITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Band 7/SPFH domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HHC9 ENTREZGENE, UniProtKB/TrEMBL
  A6HIA7 ENTREZGENE, UniProtKB/TrEMBL
  P67779 ENTREZGENE, UniProtKB/Swiss-Prot
  Q4V8M6 ENTREZGENE
UniProt Secondary P24142 UniProtKB/Swiss-Prot
  Q4V8M6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-11 Phb1  prohibitin 1  Phb  prohibitin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Phb  Prohibitin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has homology to the Drosophila Cc gene 729436