PHB1 (prohibitin 1) - Rat Genome Database

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Gene: PHB1 (prohibitin 1) Canis lupus familiaris
Analyze
Symbol: PHB1
Name: prohibitin 1
RGD ID: 12171845
Description: ENCODES a protein that exhibits complement component C3a binding (ortholog); complement component C3b binding (ortholog); enzyme binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antiviral innate immune response (ortholog); B cell activation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); Brain Injuries (ortholog); FOUND IN exocytic vesicle; cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PHB; prohibitin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC484431  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,525,711 - 25,536,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,526,649 - 25,536,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,985,397 - 24,996,403 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,321,934 - 26,332,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,185,622 - 26,347,114 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,089,828 - 25,100,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,349,147 - 25,360,155 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,478,042 - 25,489,037 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
antiviral innate immune response  (ISO)
B cell activation  (ISO)
CD40 signaling pathway  (ISO)
cellular response to interleukin-6  (ISO)
DNA biosynthetic process  (ISO)
epigenetic regulation of gene expression  (ISO)
mitochondrion organization  (IEA)
modulation by host of viral RNA genome replication  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucocorticoid receptor signaling pathway  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by competitive promoter binding  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
ovarian follicle atresia  (ISO)
ovarian follicle development  (ISO)
positive regulation of complement activation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
progesterone receptor signaling pathway  (ISO)
protein stabilization  (ISO)
regulation of DNA-templated transcription  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to immobilization stress  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
RIG-I signaling pathway  (ISO)
symbiont entry into host cell  (ISO)
T-helper 17 type immune response  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:25312047   PMID:30032202  


Genomics

Comparative Map Data
PHB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,525,711 - 25,536,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,526,649 - 25,536,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,985,397 - 24,996,403 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,321,934 - 26,332,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,185,622 - 26,347,114 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,089,828 - 25,100,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,349,147 - 25,360,155 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,478,042 - 25,489,037 (-)NCBIUU_Cfam_GSD_1.0
PHB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,404,052 - 49,414,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,404,049 - 49,414,905 (-)EnsemblGRCh38hg38GRCh38
GRCh371747,481,414 - 47,492,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,836,419 - 44,847,241 (-)NCBINCBI36Build 36hg18NCBI36
Build 341744,836,418 - 44,847,241NCBI
Celera1743,936,440 - 43,947,262 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1742,846,458 - 42,857,310 (-)NCBIHuRef
CHM1_11747,546,565 - 47,557,421 (-)NCBICHM1_1
T2T-CHM13v2.01750,267,083 - 50,277,908 (-)NCBIT2T-CHM13v2.0
Phb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,557,783 - 95,571,599 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,557,783 - 95,571,599 (+)EnsemblGRCm39 Ensembl
GRCm381195,666,957 - 95,680,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,666,957 - 95,680,773 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,528,271 - 95,542,087 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,483,105 - 95,496,855 (+)NCBIMGSCv36mm8
Celera11105,306,168 - 105,322,388 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Phb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,102,043 - 81,114,815 (+)NCBIGRCr8
mRatBN7.21080,605,268 - 80,618,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,605,251 - 80,618,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,553,897 - 85,566,665 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,051,939 - 85,064,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,444,228 - 80,456,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,476,107 - 83,488,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,284,048 - 83,296,819 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1199,127,730 - 9,128,666 (+)NCBI
Celera1079,373,802 - 79,386,571 (+)NCBICelera
Cytogenetic Map10q26NCBI
Phb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,110,290 - 12,120,124 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,110,290 - 12,119,870 (+)NCBIChiLan1.0ChiLan1.0
PHB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,752,626 - 15,762,789 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,718,717 - 17,728,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,189,555 - 8,200,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,175,912 - 8,186,790 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,175,968 - 8,186,790 (+)Ensemblpanpan1.1panPan2
Phb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,936,269 - 24,948,093 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649012,127,065 - 12,138,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,596,523 - 25,609,706 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,596,520 - 25,609,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,535,912 - 25,549,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,805,968 - 69,816,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,806,923 - 69,816,754 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,910,348 - 40,921,223 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,556,450 - 5,565,988 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,556,728 - 5,565,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PHB1
112 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000026787   ⟹   ENSCAFP00000024890
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl925,526,649 - 25,536,722 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019388   ⟹   ENSCAFP00845015158
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl926,185,622 - 26,329,954 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019426   ⟹   ENSCAFP00845015188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl926,185,622 - 26,329,684 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019490   ⟹   ENSCAFP00845015242
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl926,321,954 - 26,347,114 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019534   ⟹   ENSCAFP00845015285
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl926,321,954 - 26,347,114 (-)Ensembl
RefSeq Acc Id: NM_001110179   ⟹   NP_001103649
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1925,525,711 - 25,536,722 (-)NCBI
Dog10K_Boxer_Tasha924,985,397 - 24,996,403 (-)NCBI
ROS_Cfam_1.0926,321,934 - 26,332,949 (-)NCBI
UMICH_Zoey_3.1925,089,828 - 25,100,839 (-)NCBI
UNSW_CanFamBas_1.0925,349,147 - 25,360,155 (-)NCBI
UU_Cfam_GSD_1.0925,478,042 - 25,489,037 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001103649   ⟸   NM_001110179
- UniProtKB: A8W340 (UniProtKB/TrEMBL),   A0A8P0PG28 (UniProtKB/TrEMBL),   A0A8C0LZX1 (UniProtKB/TrEMBL),   A0A8I3NHA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024890   ⟸   ENSCAFT00000026787
RefSeq Acc Id: ENSCAFP00845015158   ⟸   ENSCAFT00845019388
RefSeq Acc Id: ENSCAFP00845015285   ⟸   ENSCAFT00845019534
RefSeq Acc Id: ENSCAFP00845015242   ⟸   ENSCAFT00845019490
RefSeq Acc Id: ENSCAFP00845015188   ⟸   ENSCAFT00845019426
Protein Domains
Band


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016926 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001269 UniProtKB/TrEMBL
  ENSCAFG00040009453 UniProtKB/TrEMBL
  ENSCAFG00845010966 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026787.4 UniProtKB/TrEMBL
  ENSCAFT00000097662.1 UniProtKB/TrEMBL
  ENSCAFT00000104355.1 UniProtKB/TrEMBL
  ENSCAFT00000107561.1 UniProtKB/TrEMBL
  ENSCAFT00030002280.1 UniProtKB/TrEMBL
  ENSCAFT00030002345.1 UniProtKB/TrEMBL
  ENSCAFT00040017561.1 UniProtKB/TrEMBL
  ENSCAFT00040017648.1 UniProtKB/TrEMBL
  ENSCAFT00040017688.1 UniProtKB/TrEMBL
  ENSCAFT00845019388.1 UniProtKB/TrEMBL
  ENSCAFT00845019426.1 UniProtKB/TrEMBL
  ENSCAFT00845019490.1 UniProtKB/TrEMBL
  ENSCAFT00845019534 ENTREZGENE
  ENSCAFT00845019534.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.30 UniProtKB/TrEMBL
InterPro Band_7 UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/TrEMBL
  Prohibitin UniProtKB/TrEMBL
KEGG Report cfa:480547 UniProtKB/TrEMBL
NCBI Gene PHB ENTREZGENE
PANTHER PROHIBITIN UniProtKB/TrEMBL
  PTHR23222 UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/TrEMBL
PRINTS PROHIBITIN UniProtKB/TrEMBL
SMART PHB UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/TrEMBL
UniProt A0A8C0LZX1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S3L6_CANLF UniProtKB/TrEMBL
  A0A8C0S3P2_CANLF UniProtKB/TrEMBL
  A0A8I3NHA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NHU7_CANLF UniProtKB/TrEMBL
  A0A8I3NJ57_CANLF UniProtKB/TrEMBL
  A0A8P0PG28 ENTREZGENE, UniProtKB/TrEMBL
  A8W340 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:55714 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-08 PHB1  prohibitin 1  PHB  prohibitin  Symbol and/or name change 19259463 PROVISIONAL