Phb (prohibitin) - Rat Genome Database

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Gene: Phb (prohibitin) Ictidomys tridecemlineatus
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Symbol: Phb
Name: prohibitin
RGD ID: 12499907
Description: ENCODES a protein that exhibits complement component C3a binding (ortholog); complement component C3b binding (ortholog); enzyme binding (ortholog); INVOLVED IN activation of phospholipase C activity (ortholog); activation of protein kinase C activity (ortholog); animal organ regeneration (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); Brain Injuries (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: prohibitin, transcript variant X1; prohibitin, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,936,269 - 24,948,093 (-)NCBI
SpeTri2.0NW_00493649012,127,065 - 12,138,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (ISO)
activation of protein kinase C activity  (ISO)
animal organ regeneration  (ISO)
antiviral innate immune response  (ISO)
B cell activation  (ISO)
CD40 signaling pathway  (ISO)
cellular response to interleukin-6  (ISO)
DNA biosynthetic process  (ISO)
histone deacetylation  (ISO)
mitochondrion organization  (ISO)
modulation by host of viral RNA genome replication  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of glucocorticoid receptor signaling pathway  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by competitive promoter binding  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
ovarian follicle atresia  (ISO)
ovarian follicle development  (ISO)
positive regulation of cell death  (ISO)
positive regulation of complement activation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
progesterone receptor signaling pathway  (ISO)
protein stabilization  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to ethanol  (ISO)
response to immobilization stress  (ISO)
response to peptide hormone  (ISO)
RIG-I signaling pathway  (ISO)
T-helper 17 type immune response  (ISO)
viral entry into host cell  (ISO)

References

Genomics

Comparative Map Data
Phb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,936,269 - 24,948,093 (-)NCBI
SpeTri2.0NW_00493649012,127,065 - 12,138,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1749,404,052 - 49,414,901 (-)EnsemblGRCh38hg38GRCh38
GRCh381749,404,052 - 49,414,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371747,481,414 - 47,492,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,836,419 - 44,847,241 (-)NCBINCBI36hg18NCBI36
Build 341744,836,418 - 44,847,241NCBI
Celera1743,936,440 - 43,947,262 (-)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1742,846,458 - 42,857,310 (-)NCBIHuRef
CHM1_11747,546,565 - 47,557,421 (-)NCBICHM1_1
Phb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,557,783 - 95,571,599 (+)NCBIGRCm39mm39
GRCm39 Ensembl1195,557,783 - 95,571,599 (+)Ensembl
GRCm381195,666,957 - 95,680,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,666,957 - 95,680,773 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,528,271 - 95,542,087 (+)NCBIGRCm37mm9NCBIm37
MGSCv361195,483,105 - 95,496,855 (+)NCBImm8
Celera11105,306,168 - 105,322,388 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Phb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21080,605,268 - 80,618,043 (+)NCBI
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01083,476,107 - 83,488,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01083,284,048 - 83,296,819 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1199,127,730 - 9,128,666 (+)NCBI
Celera1079,373,802 - 79,386,571 (+)NCBICelera
Cytogenetic Map10q26NCBI
Phb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,110,290 - 12,120,124 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,110,290 - 12,119,870 (+)NCBIChiLan1.0ChiLan1.0
PHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1178,175,912 - 8,186,790 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,175,968 - 8,186,790 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0178,189,555 - 8,200,491 (+)NCBIMhudiblu_PPA_v0panPan3
PHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,525,711 - 25,536,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,526,649 - 25,536,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,985,397 - 24,996,403 (-)NCBI
ROS_Cfam_1.0926,321,934 - 26,332,949 (-)NCBI
UMICH_Zoey_3.1925,089,828 - 25,100,839 (-)NCBI
UNSW_CanFamBas_1.0925,349,147 - 25,360,155 (-)NCBI
UU_Cfam_GSD_1.0925,478,042 - 25,489,037 (-)NCBI
PHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,584,443 - 25,609,656 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,596,520 - 25,609,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,535,912 - 25,549,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,805,968 - 69,816,792 (-)NCBI
ChlSab1.1 Ensembl1669,806,923 - 69,816,754 (-)Ensembl
Vero_WHO_p1.0NW_02366607740,910,348 - 40,921,223 (-)NCBI
Phb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247955,556,728 - 5,565,969 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005321694   ⟹   XP_005321751
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560224,936,269 - 24,948,093 (-)NCBI
SpeTri2.0NW_00493649012,127,065 - 12,138,870 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013357106   ⟹   XP_013212560
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493649012,127,803 - 12,138,870 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321751 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3269202 (Get FASTA)   NCBI Sequence Viewer  
  KAG3269203 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321751   ⟸   XM_005321694
- UniProtKB: I3NCT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013212560   ⟸   XM_013357106
- Sequence:
Protein Domains
PHB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000019929 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000022181 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028529 UniProtKB/TrEMBL
InterPro Band_7 UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/TrEMBL
  Prohibitin UniProtKB/TrEMBL
NCBI Gene Phb ENTREZGENE
PANTHER PTHR23222 UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/TrEMBL
PRINTS PROHIBITIN UniProtKB/TrEMBL
SMART PHB UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/TrEMBL
UniProt I3NCT4 ENTREZGENE, UniProtKB/TrEMBL