RGD Reference Report - The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. - Rat Genome Database

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The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma.

Authors: Tsai, HW  Chow, NH  Lin, CP  Chan, SH  Chou, CY  Ho, CL 
Citation: Tsai HW, etal., Hum Pathol. 2006 Feb;37(2):198-204. Epub 2005 Dec 20.
RGD ID: 2292398
Pubmed: PMID:16426920   (View Abstract at PubMed)
DOI: DOI:10.1016/j.humpath.2005.10.012   (Journal Full-text)

To examine the importance of prohibitin 1 and c-Met/hepatocyte growth factor receptor (HGFR) expression in human cervical adenocarcinomas, 85 patients (69 with invasive adenocarcinoma [ACA] and 16 with adenocarcinoma in situ [AIS]) were studied using immunohistochemistry. High prohibitin 1 expression was found in 51 (73.9%) of the 69 ACAs and 11 (68.7%) of the 16 AIS lesions. Prohibitin 1 overexpression was significantly higher in ACA and AIS than in adjacent nonneoplastic glandular epithelium (P < .001 for both comparisons). Prohibitin 1 expression was also positively related to tumor size (P = .019) or parametrial involvement (P = .027) in ACA. c-Met was expressed in 21 ACAs (30.4%) and was positively correlated with the Federation Internationale de Gynecologie et d'Obstetrique (International Federation of Gynecology and Obstetrics) stage classification (P = .007) or nodal metastasis (P = .047). Nodal metastasis (P = .028) and c-Met expression (P = .022) were independent predictors for the overall survival of patients in multivariate analysis using the Cox regression method. Prohibitin 1 activation seems to be an early event, whereas c-Met overexpression may be important for the progression of cervical adenocarcinomas. Evaluation of c-Met expression status may identify a subset of patients with cervical adenocarcinoma who require more intensive treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervix uteri carcinoma in situ  IEP 2292398protein:increased expression:uterine cervixRGD 
cervix uteri carcinoma in situ  ISOPHB1 (Homo sapiens)2292398; 2292398protein:increased expression:uterine cervixRGD 
Uterine Cervical Neoplasms disease_progressionIEP 2292398protein:increased expression:uterine cervixRGD 
Uterine Cervical Neoplasms disease_progressionISOPHB1 (Homo sapiens)2292398; 2292398protein:increased expression:uterine cervixRGD 

Objects Annotated

Genes (Rattus norvegicus)
Phb1  (prohibitin 1)

Genes (Mus musculus)
Phb1  (prohibitin 1)

Genes (Homo sapiens)
PHB1  (prohibitin 1)


Additional Information