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Gene: Phb (prohibitin) Mus musculus
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Symbol: Phb
Name: prohibitin
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in DNA biosynthetic process and negative regulation of transcription by RNA polymerase II. Localizes to cell surface; mitochondrial inner membrane; and nucleus. Is expressed in ectoplacental cone; embryo; and extraembryonic ectoderm. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB (prohibitin); INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-cell receptor-associated protein 32; BAP32
Orthologs:
Homo sapiens (human) : PHB (prohibitin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Phb (prohibitin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phb (prohibitin)
Pan paniscus (bonobo/pygmy chimpanzee) : PHB (prohibitin)
Canis lupus familiaris (dog) : PHB (prohibitin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phb (prohibitin)
Sus scrofa (pig) : PHB (prohibitin)
Chlorocebus sabaeus (African green monkey) : PHB (prohibitin)
Heterocephalus glaber (naked mole-rat) : Phb (prohibitin)
more info ...
Related Pseudogenes: Gm11383   Gm14834   Gm15078   Gm4773   Gm4996   Gm7542   Gm7666   Gm8855   Gm9673  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1195,666,957 - 95,680,773 (+)EnsemblGRCm38mm10GRCm38
GRCm381195,666,957 - 95,680,773 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371195,528,271 - 95,542,087 (+)NCBIGRCm37mm9NCBIm37
MGSCv361195,483,105 - 95,496,855 (+)NCBImm8
Celera11105,306,168 - 105,322,388 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Phb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11096
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.