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Strain: DA/OlaHsd

Symbol: DA/OlaHsd
Strain: DA
Substrain: OlaHsd
RGD ID: 734475
Citation ID: RRID:RGD_734475
Ontology ID: RS:0000244
Previously known as: MDC-03-04
Type: inbred
Source: Envigo
Origin: Odell at the Oak Ridge National Laboratory (USA) initiated the inbreeding of these rats which was completed at the Wistar Institute (USA) in 1965.
Coat Color: Agouti
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Sex-specific Genetic Loci for Femoral Neck Bone Mass and Strength Identified in Inbred COP and DA Rats. Alam I, etal., J Bone Miner Res. 2008 Feb 18;.
2. Strain differences in neointimal hyperplasia in the rat. Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252.
3. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
4. Spectrum of aerobic endurance running performance in eleven inbred strains of rats. Barbato JC, etal., J Appl Physiol 1998 Aug;85(2):530-6.
5. The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage. Brenner M, etal., Arthritis Rheum 2005 Jan;52(1):322-32.
6. The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis. Brenner M, etal., J Immunol 2005 Jun 15;174(12):7894-903.
7. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
8. Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. Koch LG, etal., Physiol Genomics 1999 Aug 31;1(2):63-9.
9. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
10. RGD Strain RSO annotation pipeline RGD Automated Pipelines
11. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
12. Genetic loci affecting bone structure and strength in inbred COP and DA rats. Sun Q, etal., Bone. 2008 Mar;42(3):547-53. Epub 2007 Nov 28.
13. A genome scan for Loci associated with aerobic running capacity in rats. Ways JA, etal., Genomics 2002 Jul;80(1):13-20.
14. Congenic Strains Confirm Aerobic Running Capacity Quantitative Trait Loci on Rat Chromosome 16 and Identify Possible Intermediate Phenotypes. Ways JA, etal., Physiol Genomics. 2006 Dec 19;.

Region

Strain QTL Data
Symbol Name Trait
Arunc1 Aerobic running capacity QTL 1 exercise endurance trait   (VT:0002332)    
Arunc2 Aerobic running capacity QTL 2 exercise endurance trait   (VT:0002332)    
Arunc3 Aerobic running capacity QTL 3 exercise endurance trait   (VT:0002332)    
Bmd19 Bone mineral density QTL 19 femur mineral mass   (VT:0010011)    
Bmd20 Bone mineral density QTL 20 femur mineral mass   (VT:0010011)    
Bmd21 Bone mineral density QTL 21 femur mineral mass   (VT:0010011)    
Bmd22 Bone mineral density QTL 22 femur mineral mass   (VT:0010011)    
Bmd23 Bone mineral density QTL 23 femur mineral mass   (VT:0010011)    
Bmd24 Bone mineral density QTL 24 femur mineral mass   (VT:0010011)    
Bmd25 Bone mineral density QTL 25 femur mineral mass   (VT:0010011)    
Bmd26 Bone mineral density QTL 26 femur mineral mass   (VT:0010011)    
Bmd27 Bone mineral density QTL 27 femur mineral mass   (VT:0010011)    
Bmd28 Bone mineral density QTL 28 femur mineral mass   (VT:0010011)    
Bmd29 Bone mineral density QTL 29 femur size trait   (VT:1000369)    
Bmd30 Bone mineral density QTL 30 femur mineral mass   (VT:0010011)    
Bmd31 Bone mineral density QTL 31 femur size trait   (VT:1000369)    
Bmd32 Bone mineral density QTL 32 femur strength trait   (VT:0010010)    
Bmd33 Bone mineral density QTL 33 femur strength trait   (VT:0010010)    
Bmd34 Bone mineral density QTL 34 femur strength trait   (VT:0010010)    
Bmd35 Bone mineral density QTL 35 femur strength trait   (VT:0010010)    
Bmd36 Bone mineral density QTL 36 femur strength trait   (VT:0010010)    
Bmd37 Bone mineral density QTL 37 femur strength trait   (VT:0010010)    
Bmd38 Bone mineral density QTL 38 femur size trait   (VT:1000369)    
Bmd39 Bone mineral density QTL 39 femur strength trait   (VT:0010010)    
Bmd40 Bone mineral density QTL 40 femur mineral mass   (VT:0010011)    
Bmd41 Bone mineral density QTL 41 femur mineral mass   (VT:0010011)    
Bmd42 Bone mineral density QTL 42 lumbar vertebra mineral mass   (VT:0010511)    
Bmd43 Bone mineral density QTL 43 femur mineral mass   (VT:0010011)    
Bmd44 Bone mineral density QTL 44 lumbar vertebra mineral mass   (VT:0010511)    
Bmd45 Bone mineral density QTL 45 lumbar vertebra mineral mass   (VT:0010511)    
Bmd46 Bone mineral density QTL 46 femur mineral mass   (VT:0010011)    
Bmd47 Bone mineral density QTL 47 femur mineral mass   (VT:0010011)    
Bmd48 Bone mineral density QTL 48 femur mineral mass   (VT:0010011)    
Bmd49 Bone mineral density QTL 49 lumbar vertebra mineral mass   (VT:0010511)    
Bmd50 Bone mineral density QTL 50 femur mineral mass   (VT:0010011)    
Bmd51 Bone mineral density QTL 51 femur mineral mass   (VT:0010011)    
Bmd52 Bone mineral density QTL 52 femur mineral mass   (VT:0010011)    
Bmd53 Bone mineral density QTL 53 lumbar vertebra mineral mass   (VT:0010511)    
Bmd54 Bone mineral density QTL 54 femur mineral mass   (VT:0010011)    
Bmd55 Bone mineral density QTL 55 femur mineral mass   (VT:0010011)    
Bmd56 Bone mineral density QTL 56 femur mineral mass   (VT:0010011)    
Bmd57 Bone mineral density QTL 57 femur mineral mass   (VT:0010011)    
Bmd58 Bone mineral density QTL 58 lumbar vertebra mineral mass   (VT:0010511)    
Bmd59 Bone mineral density QTL 59 lumbar vertebra mineral mass   (VT:0010511)    
Bmd60 Bone mineral density QTL 60 femur mineral mass   (VT:0010011)    
Bmd61 Bone mineral density QTL 61 femur mineral mass   (VT:0010011)    
Bmd62 Bone mineral density QTL 62 lumbar vertebra mineral mass   (VT:0010511)    
Bmd63 Bone mineral density QTL 63 femur mineral mass   (VT:0010011)    
Bmd64 Bone mineral density QTL 64 lumbar vertebra mineral mass   (VT:0010511)    
Bmd65 Bone mineral density QTL 65 femur mineral mass   (VT:0010011)    
Bmd66 Bone mineral density QTL 66 lumbar vertebra mineral mass   (VT:0010511)    
Bmd67 Bone mineral density QTL 67 femur mineral mass   (VT:0010011)    
Bmd68 Bone mineral density QTL 68 femur mineral mass   (VT:0010011)    
Bmd88 Bone mineral density QTL 88 femur mineral mass   (VT:0010011)    
Bmd89 Bone mineral density QTL 89 femur strength trait   (VT:0010010)    
Bmd90 Bone mineral density QTL 90 femur size trait   (VT:1000369)    
Bmd91 Bone mineral density QTL 91 femur size trait   (VT:1000369)    
Bss22 Bone structure and strength QTL 22 femur morphology trait   (VT:0000559)    
Bss23 Bone structure and strength QTL 23 femur morphology trait   (VT:0000559)    
Bss24 Bone structure and strength QTL 24 femur morphology trait   (VT:0000559)    
Bss25 Bone structure and strength QTL 25 femur morphology trait   (VT:0000559)    
Bss26 Bone structure and strength QTL 26 femur morphology trait   (VT:0000559)    
Bss27 Bone structure and strength QTL 27 femur morphology trait   (VT:0000559)    
Bss28 Bone structure and strength QTL 28 femur morphology trait   (VT:0000559)    
Bss29 Bone structure and strength QTL 29 femur morphology trait   (VT:0000559)    
Bss30 Bone structure and strength QTL 30 femur strength trait   (VT:0010010)    
Bss31 Bone structure and strength QTL 31 femur strength trait   (VT:0010010)    
Bss32 Bone structure and strength QTL 32 femur strength trait   (VT:0010010)    
Bss33 Bone structure and strength QTL 33 femur strength trait   (VT:0010010)    
Bss34 Bone structure and strength QTL 34 femur strength trait   (VT:0010010)    
Bss35 Bone structure and strength QTL 35 femur strength trait   (VT:0010010)    
Bss36 Bone structure and strength QTL 36 femur strength trait   (VT:0010010)    
Bss37 Bone structure and strength QTL 37 femur strength trait   (VT:0010010)    
Bss38 Bone structure and strength QTL 38 femur strength trait   (VT:0010010)    
Bss39 Bone structure and strength QTL 39 femur strength trait   (VT:0010010)    
Bss40 Bone structure and strength QTL 40 femur strength trait   (VT:0010010)    
Bss41 Bone structure and strength QTL 41 lumbar vertebra size trait   (VT:0010518)    
Bss42 Bone structure and strength QTL 42 lumbar vertebra size trait   (VT:0010518)    
Bss43 Bone structure and strength QTL 43 lumbar vertebra size trait   (VT:0010518)    
Bss44 Bone structure and strength QTL 44 lumbar vertebra morphology trait   (VT:0010494)    
Bss45 Bone structure and strength QTL 45 lumbar vertebra morphology trait   (VT:0010494)    
Bss46 Bone structure and strength QTL 46 lumbar vertebra morphology trait   (VT:0010494)    
Bss47 Bone structure and strength QTL 47 lumbar vertebra size trait   (VT:0010518)    
Bss48 Bone structure and strength QTL 48 lumbar vertebra size trait   (VT:0010518)    
Bss49 Bone structure and strength QTL 49 lumbar vertebra size trait   (VT:0010518)    
Bss50 Bone structure and strength QTL 50 lumbar vertebra size trait   (VT:0010518)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
DA/OlaHsd (2019) 2782
DA/OlaHsd (2019)


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Male rats demonstrate a high aerobic running capacity. 619535
strain_characteristics Male rats demonstrate a high aerobic running capacity. 731241
strain_life_disease These show similar resistance to myocardial ischemia as SS/JrHsdMcwi strain but 2.5 times greater than BN/NHsdMcwi with LEW and WIST/Hsd intermediate in response. 1342469
strain_life_disease These are a suitable model for susceptibility to myocardial ischemia. 1342469
strain_other These are the best performers out of 11 strains tested for the aerobic endurance performance that comprises of maximum running capacity on a treadmill and isolated cardiac performance. 1358977
strain_other On the basis of work, these females performed significantly better than the COP females. 1358977
strain_other These have shortest survival time after controlled hemorrhage whereas BN/HsdMcwiCrl have the longest. 2302114
strain_phys_biochem Have a higher heart weight to body weight ratio as compared to the COP/OlaHsd strain. 731241

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-12 DA/OlaHsd    DA/OlaHsd    Name updated 68913 APPROVED
2015-10-12 DA/OlaHsd    DA/OlaHsd    Name updated 68913 APPROVED