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Gene: Socs3 (suppressor of cytokine signaling 3) Rattus norvegicus
Symbol: Socs3
Name: suppressor of cytokine signaling 3
RGD ID: 621087
Description: Predicted to have 1-phosphatidylinositol-3-kinase regulator activity and phosphotyrosine residue binding activity. Involved in several processes, including receptor signaling pathway via JAK-STAT; response to estradiol; and response to steroid hormone. Localizes to cytoplasm. Biomarker of obesity; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3); PARTICIPATES IN erythropoietin signaling pathway; insulin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
Also known as: Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; Socs-3; Ssi-3
Homo sapiens (human) : SOCS3 (suppressor of cytokine signaling 3)  HGNC  Alliance
Mus musculus (house mouse) : Socs3 (suppressor of cytokine signaling 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs3 (suppressor of cytokine signaling 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS3 (suppressor of cytokine signaling 3)
Canis lupus familiaris (dog) : SOCS3 (suppressor of cytokine signaling 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs3 (suppressor of cytokine signaling 3)
Sus scrofa (pig) : SOCS3 (suppressor of cytokine signaling 3)
Chlorocebus sabaeus (African green monkey) : SOCS3 (suppressor of cytokine signaling 3)
Heterocephalus glaber (naked mole-rat) : Socs3 (suppressor of cytokine signaling 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Socs3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621087
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.