Srsf2 (serine and arginine rich splicing factor 2) - Rat Genome Database

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Gene: Srsf2 (serine and arginine rich splicing factor 2) Rattus norvegicus
Analyze
Symbol: Srsf2
Name: serine and arginine rich splicing factor 2
RGD ID: 1359422
Description: Enables protein kinase C binding activity. Involved in mitotic cell cycle and response to vitamin E. Located in interchromatin granule; nuclear speck; and perichromatin fibrils. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to human SRSF2 (serine and arginine rich splicing factor 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC73009; SC-35; serine/arginine-rich splicing factor 2; Sfrs2; similar to splicing factor, arginine/serine-rich 2; splicing component, 35 kDa; splicing factor SC35; splicing factor, arginine/serine-rich 2; splicing factor, arginine/serine-rich 2 (SC-35)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210102,052,158 - 102,055,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,052,314 - 102,055,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10107,156,134 - 107,159,309 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010106,619,223 - 106,622,399 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010101,972,989 - 101,976,169 (-)NCBIRnor_WKY
Rnor_6.010105,792,779 - 105,795,986 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,792,779 - 105,795,958 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,451,332 - 105,454,538 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,954,365 - 106,956,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,968,870 - 106,971,311 (-)NCBI
Celera10100,620,618 - 100,623,797 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic UMP  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
artesunate  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butan-2-one  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress. Bryantsev AL, etal., Exp Cell Res. 2007 Jan 1;313(1):195-209. Epub 2006 Oct 13.
2. Effect of hypoxia and aging on PKC delta-mediated SC-35 phosphorylation in rat myocardial tissue. Cataldi A, etal., Anat Rec (Hoboken). 2009 Aug;292(8):1135-42. doi: 10.1002/ar.20936.
3. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
4. A new function of the splicing factor SRSF2 in the control of E2F1-mediated cell cycle progression in neuroendocrine lung tumors. Edmond V, etal., Cell Cycle. 2013 Apr 15;12(8):1267-78. doi: 10.4161/cc.24363. Epub 2013 Mar 21.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma. Gout S, etal., PLoS One. 2012;7(10):e46539. doi: 10.1371/journal.pone.0046539. Epub 2012 Oct 10.
8. Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors. Je EM, etal., Int J Cancer. 2013 Jul;133(1):260-5. doi: 10.1002/ijc.28011. Epub 2013 Feb 5.
9. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
10. SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Luo C, etal., Cancer Res. 2017 Mar 1;77(5):1168-1178. doi: 10.1158/0008-5472.CAN-16-1919. Epub 2017 Jan 12.
11. Aging and vitamin E deficiency are responsible for altered RNA pathways. Malatesta M, etal., Ann N Y Acad Sci. 2004 Jun;1019:379-82.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: immunocytochemical evidence for differential distribution during changes in functional states. Sahlas DJ, etal., J Cell Sci. 1993 Jun;105 ( Pt 2):347-57.
18. Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells. Sharma S, etal., Mol Cancer Ther. 2011 Sep;10(9):1751-9. doi: 10.1158/1535-7163.MCT-11-0248. Epub 2011 Jul 15.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Serine/arginine rich splicing factor 2 expression and clinic pathological features indicating a prognostic factor in human hepatocellular carcinoma patients. Wang P, etal., Cancer Biomark. 2018 Feb 14;21(3):681-687. doi: 10.3233/CBM-170770.
21. Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Zaidi SK, etal., Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14852-7. Epub 2003 Dec 1.
22. Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development. Zara S, etal., J Biol Regul Homeost Agents. 2009 Jan-Mar;23(1):45-54.
23. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice. Zhang C, etal., Commun Biol. 2020 May 5;3(1):210. doi: 10.1038/s42003-020-0893-5.
24. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Zhang SJ, etal., Blood. 2012 May 10;119(19):4480-5. doi: 10.1182/blood-2011-11-390252. Epub 2012 Mar 19.
Additional References at PubMed
PMID:11641275   PMID:11683997   PMID:11739632   PMID:11827461   PMID:12799190   PMID:15489334   PMID:15564382   PMID:15652350   PMID:15798186   PMID:15988025   PMID:16376875   PMID:16854843  
PMID:17494991   PMID:19734146   PMID:20356838   PMID:21117027   PMID:21470964   PMID:21653549   PMID:21984414   PMID:22658674   PMID:22681889   PMID:22840402   PMID:23376485   PMID:23512658  
PMID:23562910   PMID:25896510   PMID:26013685   PMID:31505169  


Genomics

Comparative Map Data
Srsf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210102,052,158 - 102,055,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,052,314 - 102,055,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10107,156,134 - 107,159,309 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010106,619,223 - 106,622,399 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010101,972,989 - 101,976,169 (-)NCBIRnor_WKY
Rnor_6.010105,792,779 - 105,795,986 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,792,779 - 105,795,958 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,451,332 - 105,454,538 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,954,365 - 106,956,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,968,870 - 106,971,311 (-)NCBI
Celera10100,620,618 - 100,623,797 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
SRSF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,734,115 - 76,737,411 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1776,734,115 - 76,737,333 (-)EnsemblGRCh38hg38GRCh38
GRCh371774,730,197 - 74,733,493 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361772,241,792 - 72,245,007 (-)NCBINCBI36Build 36hg18NCBI36
Build 341772,241,793 - 72,245,007NCBI
Celera1771,322,570 - 71,325,785 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1770,157,912 - 70,161,208 (-)NCBIHuRef
CHM1_11774,795,009 - 74,798,305 (-)NCBICHM1_1
T2T-CHM13v2.01777,631,102 - 77,634,398 (-)NCBIT2T-CHM13v2.0
Srsf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,740,723 - 116,744,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,740,727 - 116,743,920 (-)EnsemblGRCm39 Ensembl
GRCm3811116,849,897 - 116,853,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,849,901 - 116,853,094 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,711,211 - 116,714,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,665,997 - 116,669,172 (-)NCBIMGSCv36mm8
Celera11128,590,379 - 128,593,569 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.49NCBI
Srsf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,569,302 - 5,570,120 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,569,280 - 5,572,164 (+)NCBIChiLan1.0ChiLan1.0
SRSF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11776,375,957 - 76,379,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1776,375,957 - 76,379,759 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01770,809,931 - 70,813,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SRSF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,028,414 - 4,032,371 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,028,482 - 4,030,793 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,709,901 - 4,713,865 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,704,238 - 4,708,205 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,704,294 - 4,708,202 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,730,113 - 4,734,075 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.094,849,750 - 4,853,714 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.094,930,800 - 4,934,764 (+)NCBIUU_Cfam_GSD_1.0
Srsf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,633,549 - 4,636,547 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365941,775,412 - 1,778,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl124,800,624 - 4,801,675 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1124,800,578 - 4,803,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,652,818 - 4,653,543 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11644,945,193 - 44,948,496 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1644,945,200 - 44,946,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607715,682,841 - 15,686,671 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srsf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,575,325 - 6,578,468 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248016,575,322 - 6,578,429 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srsf2
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:98
Interacting mature miRNAs:111
Transcripts:ENSRNOT00000067739
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
D11Wsu175e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,052,252 - 102,052,476 (+)MAPPERmRatBN7.2
Rnor_6.010105,792,874 - 105,793,097NCBIRnor6.0
Rnor_5.010105,451,427 - 105,451,650UniSTSRnor5.0
RGSC_v3.410106,953,723 - 106,953,946UniSTSRGSC3.4
Celera10100,620,713 - 100,620,936UniSTS
Cytogenetic Map10q32.3UniSTS
D4S2570E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,055,017 - 102,055,124 (+)MAPPERmRatBN7.2
Rnor_6.010105,795,638 - 105,795,744NCBIRnor6.0
Rnor_5.010105,454,191 - 105,454,297UniSTSRnor5.0
RGSC_v3.410106,956,487 - 106,956,593UniSTSRGSC3.4
Celera10100,623,477 - 100,623,583UniSTS
Cytogenetic Map10q32.3UniSTS
RH139654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,051,833 - 102,052,049 (+)MAPPERmRatBN7.2
Rnor_6.010105,792,455 - 105,792,670NCBIRnor6.0
Rnor_5.010105,451,008 - 105,451,223UniSTSRnor5.0
RGSC_v3.410106,953,304 - 106,953,519UniSTSRGSC3.4
Celera10100,620,294 - 100,620,509UniSTS
Cytogenetic Map10q32.3UniSTS
UniSTS:275635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,052,885 - 102,053,630 (+)MAPPERmRatBN7.2
Rnor_6.010105,793,507 - 105,794,250NCBIRnor6.0
Rnor_5.010105,452,060 - 105,452,803UniSTSRnor5.0
RGSC_v3.410106,954,356 - 106,955,099UniSTSRGSC3.4
Celera10100,621,346 - 100,622,089UniSTS
Cytogenetic Map10q32.3UniSTS
UniSTS:479265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,054,314 - 102,055,148 (+)MAPPERmRatBN7.2
Rnor_6.010105,794,935 - 105,795,768NCBIRnor6.0
Rnor_5.010105,453,488 - 105,454,321UniSTSRnor5.0
RGSC_v3.410106,955,784 - 106,956,617UniSTSRGSC3.4
Celera10100,622,774 - 100,623,607UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000067739   ⟹   ENSRNOP00000059012
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10102,052,314 - 102,055,338 (-)Ensembl
Rnor_6.0 Ensembl10105,792,779 - 105,795,958 (-)Ensembl
RefSeq Acc Id: NM_001009720   ⟹   NP_001009720
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210102,052,158 - 102,055,338 (-)NCBI
Rnor_6.010105,792,779 - 105,795,958 (-)NCBI
Rnor_5.010105,451,332 - 105,454,538 (-)NCBI
RGSC_v3.410106,954,365 - 106,956,807 (-)RGD
Celera10100,620,618 - 100,623,797 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247813   ⟹   XP_006247875
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
Rnor_6.010105,792,794 - 105,795,986 (-)NCBI
Rnor_5.010105,451,332 - 105,454,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768382   ⟹   XP_008766604
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
Rnor_6.010105,792,794 - 105,795,985 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005489900
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
RefSeq Acc Id: XR_005489901
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
RefSeq Acc Id: XR_005489902
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
RefSeq Acc Id: XR_358012
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
Rnor_6.010105,792,794 - 105,795,986 (-)NCBI
Rnor_5.010105,451,332 - 105,454,538 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001009720   ⟸   NM_001009720
- UniProtKB: Q6PDU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247875   ⟸   XM_006247813
- Peptide Label: isoform X1
- UniProtKB: Q6PDU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008766604   ⟸   XM_008768382
- Peptide Label: isoform X1
- UniProtKB: Q6PDU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059012   ⟸   ENSRNOT00000067739
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PDU1-F1-model_v2 AlphaFold Q6PDU1 1-221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697927
Promoter ID:EPDNEW_R8452
Type:single initiation site
Name:Srsf2_1
Description:serine and arginine rich splicing factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010105,795,957 - 105,796,017EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359422 AgrOrtholog
BioCyc Gene G2FUF-22579 BioCyc
Ensembl Genes ENSRNOG00000000248 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000059012 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067739 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889746 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
  RRM_dom_euk UniProtKB/Swiss-Prot
  SRSF2-like UniProtKB/Swiss-Prot
KEGG Report rno:494445 UniProtKB/Swiss-Prot
MGC_CLONE MGC:73009 IMAGE-MGC_LOAD
NCBI Gene 494445 ENTREZGENE
PANTHER PTHR23147:SF119 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Srsf2 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
  RRM_1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt Q6PDU1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Srsf2  serine and arginine rich splicing factor 2  Srsf2  serine/arginine-rich splicing factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Srsf2  serine/arginine-rich splicing factor 2  Sfrs2  splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Sfrs2  splicing factor, arginine/serine-rich 2  Srsf2  serine/arginine-rich splicing factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srsf2  serine/arginine-rich splicing factor 2  Sfrs2  splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Sfrs2  splicing factor, arginine/serine-rich 2  Srsf2  serine/arginine-rich splicing factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-14 Srsf2  serine/arginine-rich splicing factor 2  Sfrs2  splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Sfrs2  splicing factor, arginine/serine-rich 2  Sfrs2  splicing factor, arginine/serine-rich 2 (SC-35)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Sfrs2  splicing factor, arginine/serine-rich 2 (SC-35)  Sfrs2  similar to splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED