Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of programmed cell death; and positive regulation of signal transduction. Located in extracellular vesicle. Used to study glioblastoma; status epilepticus; and thyroid cancer. Biomarker of several diseases, including cerebral infarction; diabetic retinopathy; pulmonary hypertension; sciatic neuropathy; and status epilepticus. Orthologous to human MIR21 (microRNA 21); INTERACTS WITH (R)-lipoic acid; 17beta-estradiol; 2,5-hexanedione.
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]] and Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]
[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3 and 3-bis(2-aminoethyl)-1-triazene] results in increased expression of MIR21 mRNA
[Dronabinol inhibits the reaction [Antigens results in increased expression of MIR21A mRNA]] which results in decreased expression of IFNG mRNA and Dronabinol inhibits the reaction [Antigens results in increased expression of MIR21A mRNA]
MIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of KCNH2 protein] and MIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of SP1 protein]
baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA] and MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
[Air Pollutants results in increased abundance of [Carbon co-treated with Particulate Matter]] which results in increased expression of MIR21 mRNA more ...
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein] more ...
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]] and Cyclosporine promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] more ...
MIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of KCNH2 protein] and MIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of SP1 protein]
[Air Pollutants results in increased abundance of [Carbon co-treated with Particulate Matter]] which results in increased expression of MIR21 mRNA more ...
[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR21 mRNA and ferulic acid inhibits the reaction [Thioacetamide results in increased expression of MIR21 mRNA]
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]] and Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MIR21 mRNA results in decreased susceptibility to Cisplatin]
Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA] and Acetylcysteine inhibits the reaction [Vehicle Emissions affects the expression of MIR21 mRNA]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIR21 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA] and MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA and [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides]] which results in increased expression of MIR21 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIR21 mRNA
MicroRNA-21 contributes to high glucose-induced fibrosis in peritoneal mesothelial cells in rat models by activation of the Ras-MAPK signaling pathway via Sprouty-1.
CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.
MicroRNA-21-Mediated Inhibition of Mast Cell Degranulation Involved in the Protective Effect of Berberine on 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Rats via p38 Pathway.
Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression.
Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy.
Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson's Disease.
miR-21 enhances the protective effect of loperamide on rat cardiomyocytes against hypoxia/reoxygenation, reactive oxygen species production and apoptosis via regulating Akap8 and Bard1 expression.
Ski-related novel protein suppresses the development of diabetic nephropathy by modulating transforming growth factor-β signaling and microRNA-21 expression.
Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4.
Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.
Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression.