Mir21a (microRNA 21a) - Rat Genome Database

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Gene: Mir21a (microRNA 21a) Mus musculus
Analyze
Symbol: Mir21a
Name: microRNA 21a
RGD ID: 1608349
MGI Page MGI
Description: Enables mRNA 3'-UTR binding activity. Involved in miRNA-mediated gene silencing. Acts upstream of or within several processes, including cellular response to cytokine stimulus; cellular response to dexamethasone stimulus; and regulation of gene expression. Part of RISC complex. Is expressed in lung.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: Mir; Mir21; Mirn21; mmu-mir-; mmu-mir-21; mmu-mir-21a
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,474,893 - 86,474,984 (-)NCBIGRCm39mm39
GRCm39 Ensembl1186,474,893 - 86,474,984 (-)Ensembl
GRCm381186,584,067 - 86,584,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,584,067 - 86,584,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,397,569 - 86,397,660 (-)NCBIGRCm37mm9NCBIm37
Celera1196,199,974 - 96,200,065 (-)NCBICelera
Cytogenetic Map11CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
allergic contact dermatitis  (ISO)
Angina Pectoris  (ISO)
atherosclerosis  (ISO)
Atrial Remodeling  (ISO)
autoimmune uveitis  (IMP)
brain glioma  (ISO)
breast cancer  (ISO)
Burkitt lymphoma  (ISO)
Cardio-Renal Syndrome  (ISO)
Cardiomegaly  (IEP,ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
cervicitis  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (IEP)
cholangiocarcinoma  (ISO)
Cholangiofibrosis  (ISO)
Chronic Hepatitis  (ISO)
chronic lymphocytic leukemia  (ISO)
colon cancer  (ISO)
colorectal cancer  (IEP,IMP,ISO)
congestive heart failure  (IEP,IMP,ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cryptosporidiosis  (IEP)
dengue disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
esophageal cancer  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Colitis  (IMP)
Fibrosis  (ISO)
Fusobacterium Infections  (ISO)
glioblastoma  (ISO)
Haemophilus Infections  (IMP)
heart disease  (ISO)
hepatitis C  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertensive heart disease  (ISO)
Inflammation  (ISO)
influenza  (IMP)
intestinal obstruction  (ISO)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
irritable bowel syndrome  (ISO)
Joubert syndrome  (ISO)
kidney disease  (ISO)
listeriosis  (IMP)
liver cirrhosis  (IEP,ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (IEP,ISO)
lung adenoma  (IEP)
lung cancer  (HEP,IEP,ISO)
lung carcinoma  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Microsatellite Instability  (ISO)
Myocardial Reperfusion Injury  (IMP,ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
non-alcoholic steatohepatitis  (IMP,ISO)
obesity  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (ISO)
peritonitis  (IMP)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (IMP)
sciatic neuropathy  (ISO)
skin melanoma  (ISO)
skin papilloma  (IMP)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
thyroid gland anaplastic carcinoma  (ISO)
thyroid gland cancer  (ISO)
toxic shock syndrome  (IMP)
Varicose Ulcer  (ISO)
Viral Myocarditis  (IDA,IMP)
visceral leishmaniasis  (IEP)
Weight Gain  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(R)-lipoic acid  (ISO)
1,2-dichloroethane  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,5-hexanedione  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
acetic acid  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antigen  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
baicalein  (ISO)
Bandrowski's base  (ISO)
benomyl  (ISO)
berberine  (ISO)
bicalutamide  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon atom  (ISO)
carbon monoxide  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
cobalt atom  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental carbon  (ISO)
Enterolactone  (ISO)
fenhexamid  (ISO)
ferulic acid  (ISO)
fludioxonil  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (ISO)
graphene oxide  (ISO)
halothane  (EXP)
hydrogen peroxide  (ISO)
icariin  (EXP)
isoprenaline  (ISO)
lamotrigine  (ISO)
lipoic acid  (ISO)
LY294002  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (ISO)
methapyrilene  (ISO)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
myo-inositol hexakisphosphate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (EXP,ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
piperacillin  (ISO)
potassium bromate  (ISO)
progesterone  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
solasodine  (ISO)
sporidesmin A  (ISO)
stattic  (ISO)
sulfamethoxazole  (ISO)
sulfur dioxide  (ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
Tungsten carbide  (EXP)
tyrphostin AG 1478  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
BMP signaling pathway  (ISO)
cellular response to angiotensin  (ISO)
cellular response to decreased oxygen levels  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to gamma radiation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEP)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-6  (IEP)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
endothelial tube morphogenesis  (ISO)
epithelial to mesenchymal transition involved in cardiac fibroblast development  (ISO)
female pregnancy  (IDA)
inflammatory response to antigenic stimulus  (IDA)
miRNA-mediated gene silencing  (IDA,IEP)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of aortic smooth muscle cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cartilage development  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chondrocyte proliferation  (ISO)
negative regulation of cytokine-mediated signaling pathway  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (IMP,ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
negative regulation of hydrogen sulfide biosynthetic process  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of interleukin-1-mediated signaling pathway  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-21 production  (ISO)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myofibroblast cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of regulatory T cell differentiation  (ISO)
negative regulation of stress fiber assembly  (ISO)
negative regulation of superoxide dismutase activity  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
negative regulation of type I interferon production  (ISO)
negative regulation of type I interferon-mediated signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
phenotypic switching  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell growth  (IDA,IGI)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of potassium ion export across plasma membrane  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of replicative senescence  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of type II interferon production  (IMP)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle contraction  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of wound healing  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of cell migration  (ISO)
regulation of cell shape  (ISO)
regulation of epidermal growth factor receptor signaling pathway  (ISO)
regulation of gene expression  (IDA)
regulation of mesenchymal stem cell differentiation  (ISO)
response to bacterium  (IEP)
response to hypoxia  (ISO)
response to muscle activity  (IDA)
response to oxygen levels  (IDA)
wound healing  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Adams AT, etal., Inflamm Bowel Dis. 2014 Oct;20(10):1784-93. doi: 10.1097/MIB.0000000000000179.
2. Anti-inflammatory effects of miR-21 in the macrophage response to peritonitis. Barnett RE, etal., J Leukoc Biol. 2016 Feb;99(2):361-71. doi: 10.1189/jlb.4A1014-489R. Epub 2015 Sep 17.
3. MicroRNA-21 protects neurons from ischemic death. Buller B, etal., FEBS J. 2010 Oct;277(20):4299-307. doi: 10.1111/j.1742-4658.2010.07818.x. Epub 2010 Sep 14.
4. Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. Bumrungthai S, etal., PLoS One. 2015 May 26;10(5):e0127109. doi: 10.1371/journal.pone.0127109. eCollection 2015.
5. Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia. Chen N, etal., Oncol Rep. 2018 Jun;39(6):3064-3072. doi: 10.3892/or.2018.6367. Epub 2018 Apr 12.
6. MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Chuppa S, etal., Kidney Int. 2018 Feb;93(2):375-389. doi: 10.1016/j.kint.2017.05.014. Epub 2017 Jul 29.
7. Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein. Clément S, etal., Liver Int. 2019 Jul;39(7):1226-1236. doi: 10.1111/liv.14112. Epub 2019 Apr 16.
8. Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. Correa-Gallego C, etal., PLoS One. 2016 Sep 29;11(9):e0163699. doi: 10.1371/journal.pone.0163699. eCollection 2016.
9. Upregulation of miR-21 by Ras in vivo and its role in tumor growth. Frezzetti D, etal., Oncogene. 2011 Jan 20;30(3):275-86. doi: 10.1038/onc.2010.416. Epub 2010 Oct 18.
10. miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen-/- Immunization. Gannavaram S, etal., Front Immunol. 2019 Sep 24;10:2273. doi: 10.3389/fimmu.2019.02273. eCollection 2019.
11. MicroRNA-21 contributes to high glucose-induced fibrosis in peritoneal mesothelial cells in rat models by activation of the Ras-MAPK signaling pathway via Sprouty-1. Gao Q, etal., J Cell Physiol. 2019 May;234(5):5915-5925. doi: 10.1002/jcp.26941. Epub 2018 Dec 4.
12. CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice. Guesdon W, etal., J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.
13. MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis. He J, etal., Clin Invest Med. 2013 Apr 1;36(2):E103-11. doi: 10.25011/cim.v36i2.19573.
14. Methyl helicterte ameliorates liver fibrosis by regulating miR-21-mediated ERK and TGF-β1/Smads pathways. Huang Q, etal., Int Immunopharmacol. 2019 Jan;66:41-51. doi: 10.1016/j.intimp.2018.11.006. Epub 2018 Nov 9.
15. Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer. Iseki Y, etal., Anticancer Res. 2016 Oct;36(10):5145-5151. doi: 10.21873/anticanres.11084.
16. MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis. Jia P, etal., Crit Care Med. 2017 Jul;45(7):e703-e710. doi: 10.1097/CCM.0000000000002363.
17. Serum miR-21 and miR-26a Levels Negatively Correlate with Severity of Cirrhosis in Patients with Chronic Hepatitis B. Jiang S, etal., Microrna. 2019;8(1):86-92. doi: 10.2174/2211536607666180821162850.
18. Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. Jiao J, etal., J Int Med Res. 2015 Oct;43(5):672-8. doi: 10.1177/0300060515583707. Epub 2015 Jul 6.
19. MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection. Johnston DGW, etal., Front Cell Infect Microbiol. 2017 May 23;7:201. doi: 10.3389/fcimb.2017.00201. eCollection 2017.
20. Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer. Kabakov AV, etal., Bull Exp Biol Med. 2020 Feb;168(4):500-502. doi: 10.1007/s10517-020-04740-w. Epub 2020 Mar 10.
21. Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes. Kim G, etal., J Control Release. 2020 Jan 10;317:273-281. doi: 10.1016/j.jconrel.2019.11.009. Epub 2019 Nov 12.
22. Therapeutic efficacy of modified anti-miR21 in metastatic prostate cancer. Kim K, etal., Biochem Biophys Res Commun. 2020 Aug 27;529(3):707-713. doi: 10.1016/j.bbrc.2020.05.215. Epub 2020 Jul 18.
23. MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2. Kim RY, etal., J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10.
24. Associations Between miRNAs and Two Different Cancers: Breast and Colon. Kundaktepe BP, etal., Cancer Manag Res. 2020 Feb 7;12:871-879. doi: 10.2147/CMAR.S227628. eCollection 2020.
25. MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression. Kunita A, etal., Sci Rep. 2018 Jun 11;8(1):8838. doi: 10.1038/s41598-018-27128-3.
26. Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children. Li J, etal., Med Sci Monit. 2016 Dec 19;22:4992-5002. doi: 10.12659/msm.897417.
27. MicroRNA-21-Mediated Inhibition of Mast Cell Degranulation Involved in the Protective Effect of Berberine on 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Rats via p38 Pathway. Li W, etal., Inflammation. 2018 Mar;41(2):689-699. doi: 10.1007/s10753-017-0723-1.
28. LncRNA RUNX1-IT1 is Downregulated in Endometrial Cancer and Binds to miR-21 Precursor to Suppress Its Maturation. Liang M, etal., Cancer Manag Res. 2020 Dec 30;12:13451-13459. doi: 10.2147/CMAR.S272165. eCollection 2020.
29. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. Liu C, etal., J Hepatol. 2010 Jul;53(1):98-107. doi: 10.1016/j.jhep.2010.02.021. Epub 2010 Apr 4.
30. Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer. Liu Q, etal., J BUON. 2018 Jan-Feb;23(1):29-35.
31. Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study. Liu W, etal., Pediatr Surg Int. 2016 Nov;32(11):1059-1065. doi: 10.1007/s00383-016-3960-8. Epub 2016 Sep 6.
32. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. Liu X, etal., J Clin Invest. 2010 Apr;120(4):1298-309. doi: 10.1172/JCI39566. Epub 2010 Mar 8.
33. MicroRNA-21 and -146b are involved in the pathogenesis of murine viral myocarditis by regulating TH-17 differentiation. Liu YL, etal., Arch Virol. 2013 Sep;158(9):1953-63. doi: 10.1007/s00705-013-1695-6. Epub 2013 Apr 16.
34. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Liu ZL, etal., Mol Cell Biochem. 2013 Jan;372(1-2):35-45. doi: 10.1007/s11010-012-1443-3. Epub 2012 Sep 6.
35. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression. Loyer X, etal., Gut. 2016 Nov;65(11):1882-1894. doi: 10.1136/gutjnl-2014-308883. Epub 2015 Sep 3.
36. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Lu JM, etal., Exp Eye Res. 2020 Jan;190:107886. doi: 10.1016/j.exer.2019.107886. Epub 2019 Nov 21.
37. MicroRNA-21-Regulated Activation of the Akt Pathway Participates in the Protective Effects of H2S against Liver Ischemia-Reperfusion Injury. Lu M, etal., Biol Pharm Bull. 2018 Feb 1;41(2):229-238. doi: 10.1248/bpb.b17-00769. Epub 2017 Nov 30.
38. Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability. Lü Y, etal., Oncol Lett. 2018 Apr;15(4):5971-5976. doi: 10.3892/ol.2018.7997. Epub 2018 Feb 8.
39. Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Ma X, etal., Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10144-9. doi: 10.1073/pnas.1103735108. Epub 2011 Jun 6.
40. Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Marquez RT, etal., Lab Invest. 2010 Dec;90(12):1727-36. doi: 10.1038/labinvest.2010.126. Epub 2010 Jul 12.
41. MicroRNA MIR21 and T Cells in Colorectal Cancer. Mima K, etal., Cancer Immunol Res. 2016 Jan;4(1):33-40. doi: 10.1158/2326-6066.CIR-15-0084. Epub 2015 Sep 29.
42. MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival. Mima K, etal., Clin Cancer Res. 2016 Aug 1;22(15):3841-8. doi: 10.1158/1078-0432.CCR-15-2173. Epub 2016 Mar 8.
43. NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression. Okayama H, etal., Int J Cancer. 2013 Jan 1;132(1):9-18. doi: 10.1002/ijc.27644. Epub 2012 Jun 13.
44. Dysregulated Serum MiRNA Profile and Promising Biomarkers in Dengue-infected Patients. Ouyang X, etal., Int J Med Sci. 2016 Feb 18;13(3):195-205. doi: 10.7150/ijms.13996. eCollection 2016.
45. Induction of specific microRNAs inhibits cutaneous wound healing. Pastar I, etal., J Biol Chem. 2012 Aug 24;287(35):29324-35. doi: 10.1074/jbc.M112.382135. Epub 2012 Jul 6.
46. Mouse MP Annotation Import Pipeline RGD automated import pipeline
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus. Risbud RM, etal., Brain Res. 2011 Nov 18;1424:53-9. doi: 10.1016/j.brainres.2011.09.039. Epub 2011 Sep 24.
49. Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson's Disease. Sancandi M, etal., Int J Mol Sci. 2020 Apr 15;21(8). pii: ijms21082743. doi: 10.3390/ijms21082743.
50. MicroRNA-21 knockout improve the survival rate in DSS induced fatal colitis through protecting against inflammation and tissue injury. Shi C, etal., PLoS One. 2013 Jun 24;8(6):e66814. doi: 10.1371/journal.pone.0066814. Print 2013.
51. Adenovirus-mediated down-regulation of miR-21-5p alleviates experimental autoimmune uveoretinitis in mice. Shi L, etal., Int Immunopharmacol. 2019 Sep;74:105698. doi: 10.1016/j.intimp.2019.105698. Epub 2019 Jun 19.
52. [Effects of microRNA-21 inhibitor on apoptosis of type II alveolar epithelial cells in rats with hyperoxia-induced acute lung injury]. Shi L, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 Mar;29(3):244-248. doi: 10.3760/cma.j.issn.2095-4352.2017.03.010.
53. Urinary microRNA-192 and microRNA-21 as potential indicators for liver fluke-associated cholangiocarcinoma risk group. Silakit R, etal., Parasitol Int. 2017 Aug;66(4):479-485. doi: 10.1016/j.parint.2015.10.001. Epub 2015 Oct 9.
54. Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection. Su Y, etal., Clin Epigenetics. 2016 Oct 19;8:109. doi: 10.1186/s13148-016-0275-5. eCollection 2016.
55. Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer. Sun M, etal., Dis Markers. 2016;2016:3823121. doi: 10.1155/2016/3823121. Epub 2016 Jan 11.
56. Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts. Sun NN, etal., Sci Rep. 2017 Oct 30;7(1):14369. doi: 10.1038/s41598-017-13305-3.
57. MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease. Takeuchi-Yorimoto A, etal., Toxicol Lett. 2016 Sep 6;258:159-167. doi: 10.1016/j.toxlet.2016.06.012. Epub 2016 Jun 15.
58. Targeting of microRNA-21-5p protects against seizure damage in a kainic acid-induced status epilepticus model via PTEN-mTOR. Tang C, etal., Epilepsy Res. 2018 Aug;144:34-42. doi: 10.1016/j.eplepsyres.2018.05.001. Epub 2018 May 4.
59. MicroRNA-21 promotes cell metastasis in cervical cancer through modulating epithelial-mesenchymal transition. Tang Y, etal., Oncol Lett. 2020 Apr;19(4):3289-3295. doi: 10.3892/ol.2020.11438. Epub 2020 Mar 3.
60. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Thum T, etal., Nature. 2008 Dec 18;456(7224):980-4. doi: 10.1038/nature07511. Epub 2008 Nov 30.
61. Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice. Toldo S, etal., Circ Cardiovasc Genet. 2014 Jun;7(3):311-20. doi: 10.1161/CIRCGENETICS.113.000381. Epub 2014 May 13.
62. Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. Tomimaru Y, etal., J Hepatol. 2012 Jan;56(1):167-75. doi: 10.1016/j.jhep.2011.04.026. Epub 2011 Jul 13.
63. The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors. Wang B and Zhang Q, J Cancer Res Clin Oncol. 2012 Oct;138(10):1659-66. doi: 10.1007/s00432-012-1244-9. Epub 2012 May 26.
64. Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. Wang H, etal., Biomed Res Int. 2014;2014:864894. doi: 10.1155/2014/864894. Epub 2014 May 18.
65. MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. Wang X, etal., PLoS One. 2017 Sep 8;12(9):e0184292. doi: 10.1371/journal.pone.0184292. eCollection 2017.
66. Ski-related novel protein suppresses the development of diabetic nephropathy by modulating transforming growth factor-β signaling and microRNA-21 expression. Wang Y, etal., J Cell Physiol. 2019 Aug;234(10):17925-17936. doi: 10.1002/jcp.28425. Epub 2019 Mar 7.
67. The association between microRNA-21 and hypertension-induced cardiac remodeling. Watanabe K, etal., PLoS One. 2020 Feb 10;15(2):e0226053. doi: 10.1371/journal.pone.0226053. eCollection 2020.
68. Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer. Winther M, etal., Acta Oncol. 2015;54(9):1582-91. doi: 10.3109/0284186X.2015.1064161.
69. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Wu YR, etal., Tumour Biol. 2016 Sep;37(9):12061-12070. doi: 10.1007/s13277-016-5074-2. Epub 2016 May 17.
70. miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock. Xue Z, etal., Cell Death Dis. 2019 Jun 12;10(6):461. doi: 10.1038/s41419-019-1713-z.
71. MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3). Yang CH, etal., J Biol Chem. 2014 Sep 5;289(36):25079-87. doi: 10.1074/jbc.M114.593863. Epub 2014 Jul 24.
72. Effect of Corilagin on the miR-21/smad7/ERK signaling pathway in a schistosomiasis-induced hepatic fibrosis mouse model. Yang F, etal., Parasitol Int. 2016 Aug;65(4):308-15. doi: 10.1016/j.parint.2016.03.001. Epub 2016 Mar 2.
73. Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4. Yang Y, etal., Cancer Gene Ther. 2015 Jan;22(1):23-9. doi: 10.1038/cgt.2014.66. Epub 2014 Dec 5.
74. Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21. Yang Y, etal., Gastroenterology. 2017 Mar;152(4):851-866.e24. doi: 10.1053/j.gastro.2016.11.018. Epub 2016 Nov 19.
75. Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats. Yao L, etal., Chin J Nat Med. 2020 Apr;18(4):308-320. doi: 10.1016/S1875-5364(20)30038-8.
76. CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. Yuan Y, etal., Biochem Biophys Res Commun. 2018 Sep 5;503(2):870-875. doi: 10.1016/j.bbrc.2018.06.089. Epub 2018 Jun 23.
77. Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression. Zhang CC, etal., Bioengineered. 2021 Dec;12(1):414-425. doi: 10.1080/21655979.2021.1872191.
78. MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Zhang JG, etal., Clin Chim Acta. 2010 Jun 3;411(11-12):846-52. doi: 10.1016/j.cca.2010.02.074. Epub 2010 Mar 16.
79. Beneficial effects of tolvaptan on atrial remodeling induced by chronic intermittent hypoxia in rats. Zhang K, etal., Cardiovasc Ther. 2018 Dec;36(6):e12466. doi: 10.1111/1755-5922.12466. Epub 2018 Sep 29.
80. MicroRNA-21 is upregulated during intestinal barrier dysfunction induced by ischemia reperfusion. Zhang L, etal., Kaohsiung J Med Sci. 2018 Oct;34(10):556-563. doi: 10.1016/j.kjms.2018.05.006. Epub 2018 Jun 7.
81. [Effect of overexpression of microRNA-21-5p on early apoptosis of type II alveolar epithelial cells in rats with hyperoxic acute lung injury]. Zhang W, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Aug;31(8):978-982. doi: 10.3760/cma.j.issn.2095-4352.2019.08.013.
82. [Clinicopathological significance of microRNA-21 and miR-125 expression in colorectal cancer]. Zhang Y, etal., Zhonghua Wei Chang Wai Ke Za Zhi. 2009 Nov;12(6):623-6.
83. MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury. Zhou S, etal., Neurosci Lett. 2015 Jan 23;586:43-9. doi: 10.1016/j.neulet.2014.12.006. Epub 2014 Dec 4.
84. Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis. Zhou X, etal., Biomed Pharmacother. 2019 Jul;115:108818. doi: 10.1016/j.biopha.2019.108818. Epub 2019 May 16.
85. Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients. Zhu GF, etal., J Interv Cardiol. 2019 Dec 1;2019:9723129. doi: 10.1155/2019/9723129. eCollection 2019.
86. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Zhu S, etal., Cell Res. 2008 Mar;18(3):350-9. doi: 10.1038/cr.2008.24.
87. MicroRNA-21 inhibits lipopolysaccharide-induced acute lung injury by targeting nuclear factor-κB. Zhu WD, etal., Exp Ther Med. 2018 Dec;16(6):4616-4622. doi: 10.3892/etm.2018.6789. Epub 2018 Sep 24.
Additional References at PubMed
PMID:12007417   PMID:12554860   PMID:12919684   PMID:15538371   PMID:16381832   PMID:16766679   PMID:16882971   PMID:17369397   PMID:17604727   PMID:17687032   PMID:18372920   PMID:18452032  
PMID:18508928   PMID:18556655   PMID:18723672   PMID:19014979   PMID:19147652   PMID:19342679   PMID:19450585   PMID:19559694   PMID:19578358   PMID:19946272   PMID:20086200   PMID:20167875  
PMID:20215419   PMID:20357270   PMID:20378849   PMID:20413612   PMID:20439489   PMID:20643828   PMID:20651252   PMID:20693987   PMID:20739651   PMID:20832755   PMID:20884876   PMID:20978354  
PMID:21037258   PMID:21267068   PMID:21273303   PMID:21295561   PMID:21347332   PMID:21371421   PMID:21494432   PMID:21613227   PMID:21617699   PMID:21730150   PMID:21768389   PMID:21775484  
PMID:21822254   PMID:21849676   PMID:21852586   PMID:21853131   PMID:21882343   PMID:21940630   PMID:21987635   PMID:22001440   PMID:22067035   PMID:22087031   PMID:22113163   PMID:22210724  
PMID:22213800   PMID:22227207   PMID:22326957   PMID:22344686   PMID:22357537   PMID:22367207   PMID:22371328   PMID:22503104   PMID:22508494   PMID:22511778   PMID:22517757   PMID:22570807  
PMID:22614019   PMID:22666537   PMID:22710123   PMID:22931209   PMID:22956257   PMID:22960625   PMID:23072816   PMID:23159215   PMID:23185045   PMID:23238710   PMID:23238785   PMID:23239859  
PMID:23248281   PMID:23272133   PMID:23355454   PMID:23385064   PMID:23390194   PMID:23395552   PMID:23416424   PMID:23443810   PMID:23469132   PMID:23527070   PMID:23533623   PMID:23578931  
PMID:23597671   PMID:23637774   PMID:23793828   PMID:23797704   PMID:23891589   PMID:23902531   PMID:23988020   PMID:24063588   PMID:24098402   PMID:24196965   PMID:24205035   PMID:24291840  
PMID:24342610   PMID:24356956   PMID:24391219   PMID:24497637   PMID:24497923   PMID:24502419   PMID:24574341   PMID:24577093   PMID:24722419   PMID:24732886   PMID:24743145   PMID:24887517  
PMID:24891504   PMID:24967703   PMID:24980967   PMID:24983504   PMID:25000291   PMID:25069679   PMID:25087183   PMID:25118289   PMID:25141837   PMID:25222661   PMID:25263593   PMID:25277076  
PMID:25322693   PMID:25415439   PMID:25457879   PMID:25501551   PMID:25504627   PMID:25546547   PMID:25564252   PMID:25642768   PMID:25658689   PMID:25704079   PMID:25738901   PMID:25769721  
PMID:25771247   PMID:25815684   PMID:25844699   PMID:25861727   PMID:25868368   PMID:25892183   PMID:25903305   PMID:25917529   PMID:25979949   PMID:25990308   PMID:26086742   PMID:26146062  
PMID:26149640   PMID:26154133   PMID:26183619   PMID:26209818   PMID:26259139   PMID:26371058   PMID:26460584   PMID:26619149   PMID:26655730   PMID:26677864   PMID:26689812   PMID:26744142  
PMID:26806551   PMID:26865549   PMID:26924493   PMID:26990296   PMID:26996129   PMID:27030384   PMID:27033308   PMID:27115417   PMID:27171163   PMID:27210794   PMID:27345200   PMID:27347933  
PMID:27391071   PMID:27430527   PMID:27545313   PMID:27565813   PMID:27596748   PMID:27775690   PMID:28109960   PMID:28129112   PMID:28240263   PMID:28270521   PMID:28317237   PMID:28346427  
PMID:28379062   PMID:28395721   PMID:28396121   PMID:28406477   PMID:28448534   PMID:28627440   PMID:28674080   PMID:28677811   PMID:28714020   PMID:28737660   PMID:28760826   PMID:28771630  
PMID:28802862   PMID:28817807   PMID:28844616   PMID:28943430   PMID:29091291   PMID:29113828   PMID:29154818   PMID:29176651   PMID:29229992   PMID:29238035   PMID:29329959   PMID:29361523  
PMID:29445851   PMID:29483836   PMID:29503197   PMID:29507336   PMID:29519942   PMID:29540832   PMID:29543496   PMID:29608690   PMID:29656516   PMID:29660503   PMID:29694248   PMID:29695199  
PMID:29698635   PMID:29780331   PMID:29883711   PMID:29884447   PMID:29884767   PMID:29923218   PMID:29925181   PMID:29925839   PMID:29936495   PMID:29968904   PMID:30153065   PMID:30174317  
PMID:30206377   PMID:30256395   PMID:30257106   PMID:30302012   PMID:30455267   PMID:30455689   PMID:30537729   PMID:30587001   PMID:30711569   PMID:30809283   PMID:30840288   PMID:31033484  
PMID:31039423   PMID:31078118   PMID:31090056   PMID:31106445   PMID:31306658   PMID:31393787   PMID:31497013   PMID:31512783   PMID:31533034   PMID:31638173   PMID:31655195   PMID:31660076  
PMID:31680453   PMID:31704554   PMID:31707083   PMID:31710308   PMID:31713930   PMID:31878977   PMID:31914380   PMID:31974197   PMID:32016444   PMID:32093031   PMID:32297634   PMID:32314840  
PMID:32357909   PMID:32397166   PMID:32409593   PMID:32414810   PMID:32619670   PMID:32634115   PMID:32667078   PMID:32808325   PMID:32846020   PMID:32855524   PMID:33082517   PMID:33115604  
PMID:33254626   PMID:33310519   PMID:33332077   PMID:33426313   PMID:33481270   PMID:33495831   PMID:33501624   PMID:33504420   PMID:33550817   PMID:33552064   PMID:33601867   PMID:33604680  
PMID:33604775   PMID:33739023   PMID:33757404   PMID:33881417   PMID:33882443   PMID:33902001   PMID:34039637   PMID:34099844   PMID:34137511   PMID:34164910   PMID:34233454   PMID:34301845  
PMID:34341171   PMID:34345208   PMID:34350954   PMID:34411594   PMID:34484568   PMID:34522205   PMID:34610416   PMID:34679210   PMID:34685526   PMID:34758342   PMID:34818056   PMID:34854397  
PMID:34858422   PMID:34900520   PMID:35039434   PMID:35064305   PMID:35177192   PMID:35257356   PMID:35322738   PMID:35412442   PMID:35511299   PMID:35729232  


Genomics

Comparative Map Data
Mir21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,474,893 - 86,474,984 (-)NCBIGRCm39mm39
GRCm39 Ensembl1186,474,893 - 86,474,984 (-)Ensembl
GRCm381186,584,067 - 86,584,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,584,067 - 86,584,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,397,569 - 86,397,660 (-)NCBIGRCm37mm9NCBIm37
Celera1196,199,974 - 96,200,065 (-)NCBICelera
Cytogenetic Map11CNCBI
MIR21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1759,841,266 - 59,841,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBINCBI36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBI
Mir21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21071,405,257 - 71,405,348 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1071,405,257 - 71,405,348 (-)Ensembl
Rnor_6.01073,902,210 - 73,902,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,902,210 - 73,902,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,197,081 - 76,197,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1070,326,375 - 70,326,466 (-)NCBICelera
Cytogenetic Map10q26NCBI
MIR21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,340,550 - 34,340,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,340,533 - 34,340,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha933,572,293 - 33,572,352 (+)NCBI
ROS_Cfam_1.0935,150,885 - 35,150,944 (+)NCBI
ROS_Cfam_1.0 Ensembl935,150,868 - 35,150,959 (+)Ensembl
UMICH_Zoey_3.1933,934,637 - 33,934,696 (+)NCBI
UNSW_CanFamBas_1.0934,220,122 - 34,220,181 (+)NCBI
UU_Cfam_GSD_1.0934,306,261 - 34,306,320 (+)NCBI
MIR21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,065,267 - 36,065,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,065,267 - 36,065,358 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,340,385 - 37,340,476 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
UniSTS:236684  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,584,842 - 86,585,045UniSTSGRCm38
MGSCv371186,398,344 - 86,398,547UniSTSGRCm37
Celera1196,200,749 - 96,200,952UniSTS
Cytogenetic Map11CUniSTS
AA859070  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,584,762 - 86,584,916UniSTSGRCm38
MGSCv371186,398,264 - 86,398,418UniSTSGRCm37
Celera1196,200,669 - 96,200,823UniSTS
Cytogenetic Map11CUniSTS
AI787464  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,585,015 - 86,585,094UniSTSGRCm38
GRCm38529,831,765 - 29,831,872UniSTSGRCm38
MGSCv37530,158,305 - 30,158,412UniSTSGRCm37
MGSCv371186,398,517 - 86,398,596UniSTSGRCm37
Celera1196,200,922 - 96,201,001UniSTS
Celera527,348,534 - 27,348,641UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map5B1UniSTS
Whitehead/MRC_RH111117.4UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Faslmmu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Northern Functional MTI20404348
Peli1mmu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;qRT-PCR;Functional MTI20167875
Pdcd4mmu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18372920
Pdcd4mmu-miR-21a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21273303
Pdcd4mmu-miR-21a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21295561
Pdcd4mmu-miR-21a-5pMirtarbaseexternal_infoWestern blotFunctional MTI20404348
Spry2mmu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI18508928
Ptenmmu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19147652
Ptenmmu-miR-21a-5pMirtarbaseexternal_infoReporter assayFunctional MTI20167875
Reckmmu-miR-21a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18372920
Reckmmu-miR-21a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18508928
Spry1mmu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19043405
Spry1mmu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
Tgfbimmu-miR-21a-5pMirtarbaseexternal_infoELISA//FACS//Luciferase reporter assay//qRT-PCR//WFunctional MTI21494432
Spry4mmu-miR-21a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19043405
Pias3mmu-miR-21a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI22517757

Predicted Targets
Summary Value
Count of predictions:19768
Count of gene targets:8434
Count of transcripts:13784
Interacting mature miRNAs:mmu-miR-21a-3p, mmu-miR-21a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083521
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,474,893 - 86,474,984 (-)Ensembl
GRCm38.p6 Ensembl1186,584,067 - 86,584,158 (-)Ensembl
RefSeq Acc Id: NR_029738
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391186,474,893 - 86,474,984 (-)NCBI
GRCm381186,584,067 - 86,584,158 (-)ENTREZGENE
MGSCv371186,397,569 - 86,397,660 (-)RGD
Celera1196,199,974 - 96,200,065 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Promoters
RGD ID:8676020
Promoter ID:EPDNEW_M16041
Type:single initiation site
Name:Mir21a_1
Description:Mus musculus microRNA 21a , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381186,584,080 - 86,584,140EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSMUSG00000065455 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083521 ENTREZGENE
MGD MGI:2676885 ENTREZGENE
miRBase MI0000569 ENTREZGENE
NCBI Gene 387140 ENTREZGENE
PhenoGen Mir21a PhenoGen
RNAcentral URS000015930E RNACentral
  URS000039ED8D RNACentral
  URS000075A91E RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-27 Mir21a  microRNA 21a  Mir21  microRNA 21  Symbol and/or name change 5135510 APPROVED
2011-08-17 Mir21  microRNA 21  Mir21  microRNA 21  Symbol and/or name change 5135510 APPROVED