RGD Reference Report - Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children. - Rat Genome Database

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Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children.

Authors: Li, Jun  Zhai, Xiao-Wen  Wang, Hong-Sheng  Qian, Xiao-Wen  Miao, Hui  Zhu, Xiao-Hua 
Citation: Li J, etal., Med Sci Monit. 2016 Dec 19;22:4992-5002. doi: 10.12659/msm.897417.
RGD ID: 41404643
Pubmed: PMID:27991481   (View Abstract at PubMed)
PMCID: PMC5198749   (View Article at PubMed Central)
DOI: DOI:10.12659/msm.897417   (Journal Full-text)

BACKGROUND The aim of this study was to investigate the diagnostic and prognostic value of microRNA (miRNA)-21, miRNA-23a, and miRNA-125b in Burkitt lymphoma (BL) in children. MATERIAL AND METHODS We recruited 41 children with BL for the case group, 56 children with lymph node inflammation for the positive control group, and 60 healthy children for the negative control group. Real-time fluorescent quantitative polymerase chain reaction (RT-qPCR) was conducted for detection of circulating miRNA-21, miRNA-23a, and miRNA-125b. A receiver operating characteristic (ROC) curve was drawn to compare the diagnostic value of miRNA-21, miRNA-23a, and miRNA-125b. Kaplan-Meier method and log-rank test were used for prognostic analyses. RESULTS MiRNA-21 and miRNA-23a had significantly higher expression in cases than in positive and negative controls (all P<0.05). Overexpression of miRNA-21 and miRNA-23a were associated with staging, WBC, upregulated serum lactate dehydrogenase (LDH) level, presence of lymphoma size >=6 cm, and cluster of differentiation 10 (CD10) expression, while miRNA-125b expression had an association with staging and upregulated serum LDH level (both P<0.05). ROC curves of miRNA-21, miRNA-23a, and miRNA-125b presented an area under curve (AUC) of 0.759, 0.853 and 0.615, respectively. MiRNA-21 and miRNA-23a in combination had an AUC of 0.869. After treatment, both miRNA-21 and miRNA-23a expression were significantly decreased (both P<0.05). Advanced clinical stage, upregulated LDH, and lymphoma size of ³6 cm were related to low complete remission rate (all P<0.05). CONCLUSIONS Patients with high expression of miRNA-21 and miRNA-23a had significantly lower complete remission rates and survival rates than those with low expression. Expression of miRNA-21 and miRNA-23a may serve as useful diagnostic and prognostic biomarkers in children with BL.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR21HumanBurkitt lymphoma treatmentIEP  RGD 
MIR23BHumanBurkitt lymphoma treatmentIEP  RGD 
Mir21RatBurkitt lymphoma treatmentISOMIR21 (Homo sapiens) RGD 
Mir21aMouseBurkitt lymphoma treatmentISOMIR21 (Homo sapiens) RGD 
Mir23bMouseBurkitt lymphoma treatmentISOMIR23B (Homo sapiens) RGD 
Mir23bRatBurkitt lymphoma treatmentISOMIR23B (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir21  (microRNA 21)
Mir23b  (microRNA 23b)

Genes (Mus musculus)
Mir21a  (microRNA 21a)
Mir23b  (microRNA 23b)

Genes (Homo sapiens)
MIR21  (microRNA 21)
MIR23B  (microRNA 23b)


Additional Information