MIR21 (microRNA 21) - Rat Genome Database

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Gene: MIR21 (microRNA 21) Homo sapiens
Analyze
Symbol: MIR21
Name: microRNA 21
RGD ID: 1349265
HGNC Page HGNC
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and regulation of signal transduction. Acts upstream of or within negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm and extracellular exosome. Part of extracellular vesicle. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); liver cirrhosis (multiple); lymphoma (multiple); and uterine disease (multiple).
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-21; miR-21; MIRN21; miRNA21
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1759,841,266 - 59,841,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBINCBI36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute myocardial infarction  (IEP)
allergic contact dermatitis  (ISO)
Angina Pectoris  (IEP)
atherosclerosis  (IEP)
Atrial Remodeling  (ISO)
autoimmune uveitis  (ISO)
breast cancer  (ISO)
Burkitt lymphoma  (IEP)
Cardio-Renal Syndrome  (ISO)
Cardiomegaly  (EXP,ISO)
cerebral infarction  (ISO)
cervical cancer  (IEP)
cervical squamous cell carcinoma  (IEP)
cervicitis  (IEP)
cervix uteri carcinoma in situ  (IEP)
Chemical and Drug Induced Liver Injury  (EXP)
chlamydia  (ISO)
cholangiocarcinoma  (IEP)
Cholangiofibrosis  (IEP)
Chronic Hepatitis  (IEP)
chronic lymphocytic leukemia  (IEP)
colorectal cancer  (IEP,ISO)
congestive heart failure  (IEP,ISO)
coronary artery disease  (IEP)
Crohn's disease  (IEP)
cryptosporidiosis  (ISO)
dengue disease  (IEP)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (EXP)
endometrial cancer  (IEP)
endometriosis  (EXP)
Esophageal Neoplasms  (EXP)
esophagus adenocarcinoma  (IEP)
Experimental Colitis  (ISO)
Fibrosis  (EXP)
Fusobacterium Infections  (IEP)
glioblastoma  (ISO)
Haemophilus Infections  (ISO)
heart disease  (EXP)
hepatitis C  (IEP)
hepatoblastoma  (IEP)
hepatocellular carcinoma  (IEP)
Hyperoxic Lung Injury  (ISO)
hypertensive heart disease  (IEP)
Inflammation  (EXP)
influenza  (ISO)
intestinal obstruction  (IEP)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (IEP)
irritable bowel syndrome  (IEP)
Joubert syndrome  (IAGP)
kidney disease  (EXP)
listeriosis  (ISO)
liver cirrhosis  (IEP,ISO)
Liver Reperfusion Injury  (ISO)
lung adenoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IEP)
Microsatellite Instability  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
Neoplasm Invasiveness  (EXP)
Neoplastic Cell Transformation  (EXP)
non-alcoholic steatohepatitis  (IEP,ISO)
obesity  (EXP)
papillomavirus infectious disease  (IEP)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (ISO)
peritonitis  (ISO)
primary biliary cholangitis  (IEP)
Prostatic Neoplasms  (EXP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (ISO)
skin papilloma  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
thyroid gland anaplastic carcinoma  (IEP)
thyroid gland cancer  (ISO)
toxic shock syndrome  (ISO)
Varicose Ulcer  (IEP)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (EXP)
(R)-lipoic acid  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,5-hexanedione  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (EXP)
3,7-dihydropurine-6-thione  (ISO)
acetic acid  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
Allylamine  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antigen  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
baicalein  (EXP)
Bandrowski's base  (EXP)
benomyl  (ISO)
bicalutamide  (EXP)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon atom  (EXP)
carbon monoxide  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (EXP)
curcumin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
daunorubicin  (EXP)
DDT  (EXP,ISO)
dehydroepiandrosterone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental carbon  (EXP)
Enterolactone  (EXP)
fenhexamid  (EXP)
ferulic acid  (ISO)
fludioxonil  (EXP)
formaldehyde  (EXP)
fulvestrant  (EXP)
gallic acid  (ISO)
geldanamycin  (EXP)
gentamycin  (ISO)
graphene oxide  (EXP)
halothane  (ISO)
hydrogen peroxide  (EXP)
icariin  (ISO)
isoprenaline  (ISO)
lamotrigine  (EXP)
lipoic acid  (ISO)
LY294002  (EXP)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP)
mercaptopurine  (ISO)
methapyrilene  (ISO)
methyl beta-cyclodextrin  (EXP)
methylmercury chloride  (EXP)
morphine  (EXP)
myo-inositol hexakisphosphate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nitrofen  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
PhIP  (EXP)
piperacillin  (EXP)
potassium bromate  (EXP)
progesterone  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
SB 431542  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
solasodine  (EXP)
sporidesmin A  (EXP)
stattic  (EXP)
sulfamethoxazole  (EXP)
sulfur dioxide  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
Tungsten carbide  (ISO)
tyrphostin AG 1478  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP)
wortmannin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IMP)
blood vessel development  (ISS)
BMP signaling pathway  (IMP)
cellular response to angiotensin  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to gamma radiation  (IMP)
cellular response to glucose stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IDA,IMP,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to resveratrol  (ISS)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen metabolic process  (ISS)
embryo implantation  (NAS)
endothelial tube morphogenesis  (IMP)
epithelial to mesenchymal transition involved in cardiac fibroblast development  (IDA)
female pregnancy  (ISO)
inflammatory response to antigenic stimulus  (ISO)
miRNA-mediated gene silencing  (IDA,IMP,ISO)
miRNA-mediated gene silencing by inhibition of translation  (IDA,IMP)
negative regulation of angiogenesis  (IC,ISO,ISS)
negative regulation of aortic smooth muscle cell differentiation  (IDA)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of arginine catabolic process  (ISS)
negative regulation of cardiac muscle cell apoptotic process  (ISO,ISS)
negative regulation of cardiac muscle hypertrophy  (ISS)
negative regulation of cartilage development  (IDA)
negative regulation of cell migration  (IDA)
negative regulation of cell population proliferation  (IDA)
negative regulation of chondrocyte proliferation  (IDA)
negative regulation of cytokine-mediated signaling pathway  (IDA)
negative regulation of endothelial cell migration  (IDA)
negative regulation of endothelial cell proliferation  (IDA)
negative regulation of endothelial tube morphogenesis  (ISS)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (IDA,IGI,IMP,ISO)
negative regulation of GTPase activity  (IDA)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (ISO,ISS)
negative regulation of hydrogen sulfide biosynthetic process  (IDA)
negative regulation of innate immune response  (IMP)
negative regulation of interleukin-1-mediated signaling pathway  (IGI)
negative regulation of interleukin-12 production  (IDA)
negative regulation of interleukin-21 production  (IDA)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (IDA)
negative regulation of MAPK cascade  (ISS)
negative regulation of mitotic cell cycle  (IMP)
negative regulation of myofibroblast cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (IGI)
negative regulation of NIK/NF-kappaB signaling  (IMP,ISS)
negative regulation of reactive oxygen species biosynthetic process  (ISS)
negative regulation of regulatory T cell differentiation  (IGI)
negative regulation of smooth muscle cell apoptotic process  (ISS)
negative regulation of stress fiber assembly  (IDA)
negative regulation of superoxide dismutase activity  (IDA)
negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
negative regulation of type I interferon production  (IDA)
negative regulation of type I interferon-mediated signaling pathway  (IDA)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IDA)
negative regulation of vascular associated smooth muscle cell migration  (IDA)
phenotypic switching  (IDA)
positive regulation of activated T cell proliferation  (IGI)
positive regulation of angiogenesis  (IDA)
positive regulation of apoptotic process  (IDA)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA)
positive regulation of cardiac muscle hypertrophy  (ISS)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (IDA,IMP)
positive regulation of cell population proliferation  (IDA,IMP)
positive regulation of cell projection organization  (ISS)
positive regulation of cellular response to hypoxia  (ISS)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cytokine production  (IDA)
positive regulation of cytokine production involved in inflammatory response  (ISS)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (IDA)
positive regulation of endothelial cell migration  (IDA)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of epithelial to mesenchymal transition  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISS)
positive regulation of fat cell differentiation  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of inflammatory response  (IMP,ISS)
positive regulation of inflammatory response to wounding  (ISS)
positive regulation of interferon-gamma production  (ISO)
positive regulation of keratinocyte proliferation  (IDA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IMP)
positive regulation of metalloendopeptidase activity  (IDA)
positive regulation of myofibroblast differentiation  (IMP,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IMP,ISO)
positive regulation of potassium ion export across plasma membrane  (IDA)
positive regulation of protein kinase B signaling  (IDA,IMP)
positive regulation of protein phosphorylation  (IDA,ISS)
positive regulation of replicative senescence  (IDA)
positive regulation of T-helper 17 cell differentiation  (ISS)
positive regulation of T-helper 17 type immune response  (ISS)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP)
positive regulation of vascular associated smooth muscle cell differentiation  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (IMP,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA,IMP,ISS)
positive regulation of vascular associated smooth muscle contraction  (IDA)
positive regulation of vascular endothelial cell proliferation  (IDA)
positive regulation of vascular endothelial growth factor signaling pathway  (IDA)
positive regulation of wound healing  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (IDA)
regulation of cell migration  (IGI)
regulation of cell shape  (IMP)
regulation of epidermal growth factor receptor signaling pathway  (IMP)
regulation of gene expression  (ISO)
regulation of mesenchymal stem cell differentiation  (ISO)
regulation of protein kinase B signaling  (ISS)
regulation of reactive oxygen species metabolic process  (ISS)
response to bacterium  (ISO)
response to hypoxia  (ISO)
response to muscle activity  (ISO)
response to oxygen levels  (ISO)
retinal cell apoptotic process  (ISS)
transforming growth factor beta receptor signaling pathway  (ISS)
wound healing  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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Additional References at PubMed
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PMID:29892003   PMID:29902577   PMID:29905364   PMID:29905365   PMID:29928882   PMID:29976637   PMID:29981499   PMID:30015844   PMID:30024605   PMID:30030592   PMID:30074182   PMID:30092298  
PMID:30106099   PMID:30118248   PMID:30132571   PMID:30134003   PMID:30134821   PMID:30154401   PMID:30179296   PMID:30184526   PMID:30194772   PMID:30212710   PMID:30212824   PMID:30215459  
PMID:30221692   PMID:30226598   PMID:30232913   PMID:30246355   PMID:30256067   PMID:30267810   PMID:30291880   PMID:30310053   PMID:30317621   PMID:30332981   PMID:30338782   PMID:30338786  
PMID:30338794   PMID:30338850   PMID:30352127   PMID:30357530   PMID:30372890   PMID:30375257   PMID:30389444   PMID:30398001   PMID:30401711   PMID:30447706   PMID:30453448   PMID:30454026  
PMID:30457256   PMID:30463012   PMID:30464258   PMID:30468492   PMID:30481073   PMID:30518009   PMID:30520131   PMID:30526047   PMID:30531928   PMID:30536317   PMID:30536328   PMID:30551437  
PMID:30555555   PMID:30556872   PMID:30556877   PMID:30565043   PMID:30569149   PMID:30569605   PMID:30575905   PMID:30576678   PMID:30591064   PMID:30595567   PMID:30636774   PMID:30644017  
PMID:30664688   PMID:30681889   PMID:30700111   PMID:30711569   PMID:30781615   PMID:30803440   PMID:30808234   PMID:30820789   PMID:30825229   PMID:30840273   PMID:30849539   PMID:30870812  
PMID:30880765   PMID:30887933   PMID:30905898   PMID:30925941   PMID:30931980   PMID:30950039   PMID:30967746   PMID:30982052   PMID:30997628   PMID:30997863   PMID:30999696   PMID:31002820  
PMID:31017473   PMID:31030498   PMID:31033015   PMID:31033484   PMID:31035975   PMID:31037150   PMID:31038023   PMID:31042008   PMID:31045265   PMID:31053148   PMID:31054160   PMID:31066165  
PMID:31069831   PMID:31070482   PMID:31084400   PMID:31095782   PMID:31101191   PMID:31115569   PMID:31128066   PMID:31129247   PMID:31136988   PMID:31140328   PMID:31155965   PMID:31161410  
PMID:31163082   PMID:31173285   PMID:31176779   PMID:31184708   PMID:31211819   PMID:31225740   PMID:31235478   PMID:31257538   PMID:31263200   PMID:31276668   PMID:31302227   PMID:31307177  
PMID:31308028   PMID:31326400   PMID:31330059   PMID:31344049   PMID:31351450   PMID:31358876   PMID:31368531   PMID:31389582   PMID:31413212   PMID:31416448   PMID:31450909   PMID:31469974  
PMID:31482406   PMID:31500623   PMID:31505885   PMID:31506038   PMID:31513959   PMID:31535570   PMID:31554487   PMID:31556140   PMID:31558368   PMID:31558773   PMID:31574853   PMID:31575846  
PMID:31583718   PMID:31585536   PMID:31586768   PMID:31599663   PMID:31600098   PMID:31602161   PMID:31603116   PMID:31611175   PMID:31621912   PMID:31655383   PMID:31660696   PMID:31660891  
PMID:31699948   PMID:31722341   PMID:31726271   PMID:31727077   PMID:31733640   PMID:31763811   PMID:31764830   PMID:31778243   PMID:31789394   PMID:31814034   PMID:31815762   PMID:31823412  
PMID:31837336   PMID:31863364   PMID:31866421   PMID:31872268   PMID:31872875   PMID:31907972   PMID:31909885   PMID:31910411   PMID:31913198   PMID:31926164   PMID:31926946   PMID:31945658  
PMID:31948396   PMID:31950510   PMID:31985389   PMID:31986951   PMID:32013579   PMID:32016465   PMID:32019988   PMID:32020207   PMID:32020707   PMID:32028672   PMID:32033332   PMID:32060074  
PMID:32069387   PMID:32081769   PMID:32090490   PMID:32091667   PMID:32102516   PMID:32108968   PMID:32127037   PMID:32141536   PMID:32144351   PMID:32147308   PMID:32160412   PMID:32176569  
PMID:32191117   PMID:32196704   PMID:32204765   PMID:32236579   PMID:32256450   PMID:32271438   PMID:32279740   PMID:32293319   PMID:32319558   PMID:32319564   PMID:32319566   PMID:32323738  
PMID:32327705   PMID:32333014   PMID:32352018   PMID:32356483   PMID:32388866   PMID:32401035   PMID:32412786   PMID:32427870   PMID:32432671   PMID:32468043   PMID:32521885   PMID:32527354  
PMID:32542340   PMID:32557866   PMID:32572900   PMID:32598698   PMID:32623387   PMID:32632096   PMID:32669469   PMID:32675386   PMID:32717421   PMID:32727244   PMID:32746985   PMID:32749107  
PMID:32791063   PMID:32794418   PMID:32862588   PMID:32871166   PMID:32871962   PMID:32888967   PMID:32911844   PMID:32941675   PMID:32949355   PMID:32996748   PMID:33015156   PMID:33054296  
PMID:33075314   PMID:33081752   PMID:33096778   PMID:33106660   PMID:33112535   PMID:33112562   PMID:33114482   PMID:33119045   PMID:33120918   PMID:33123586   PMID:33139818   PMID:33176966  
PMID:33185898   PMID:33200798   PMID:33206331   PMID:33253708   PMID:33268675   PMID:33287921   PMID:33288677   PMID:33290159   PMID:33318473   PMID:33332708   PMID:33378024   PMID:33382770  
PMID:33414439   PMID:33415165   PMID:33429194   PMID:33434077   PMID:33463918   PMID:33467964   PMID:33480702   PMID:33481270   PMID:33495842   PMID:33499700   PMID:33533513   PMID:33537096  
PMID:33569850   PMID:33596145   PMID:33601096   PMID:33606670   PMID:33664454   PMID:33739023   PMID:33776993   PMID:33785715   PMID:33804639   PMID:33813478   PMID:33813728   PMID:33834978  
PMID:33837901   PMID:33869627   PMID:33876465   PMID:33877895   PMID:33888045   PMID:33902001   PMID:33904674   PMID:33936025   PMID:33940234   PMID:33948855   PMID:33975532   PMID:33976355  
PMID:34020163   PMID:34024034   PMID:34086554   PMID:34088891   PMID:34101224   PMID:34208765   PMID:34225531   PMID:34226680   PMID:34233454   PMID:34233673   PMID:34244602   PMID:34258959  
PMID:34266326   PMID:34270831   PMID:34288231   PMID:34331128   PMID:34337857   PMID:34358482   PMID:34366325   PMID:34424813   PMID:34464226   PMID:34473845   PMID:34492742   PMID:34506963  
PMID:34518132   PMID:34558644   PMID:34571048   PMID:34590501   PMID:34610416   PMID:34628789   PMID:34644206   PMID:34681754   PMID:34687038   PMID:34698413   PMID:34699621   PMID:34708894  
PMID:34741385   PMID:34796728   PMID:34797887   PMID:34799871   PMID:34818876   PMID:34873417   PMID:34887868   PMID:34889164   PMID:34905503   PMID:34906045   PMID:34911834   PMID:34950438  
PMID:34954475   PMID:34956174   PMID:34957910   PMID:34972164   PMID:34979378   PMID:35016439   PMID:35027490   PMID:35033900   PMID:35035839   PMID:35068324   PMID:35137654   PMID:35141939  
PMID:35157721   PMID:35159373   PMID:35163198   PMID:35163436   PMID:35169355   PMID:35184427   PMID:35191804   PMID:35203389   PMID:35271888   PMID:35312228   PMID:35328425   PMID:35328750  
PMID:35329083   PMID:35341975   PMID:35346324   PMID:35399150   PMID:35421166   PMID:35441676   PMID:35501921   PMID:35525840  


Genomics

Comparative Map Data
MIR21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1759,841,266 - 59,841,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBINCBI36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBI
Mir21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,474,893 - 86,474,984 (-)NCBIGRCm39mm39
GRCm39 Ensembl1186,474,893 - 86,474,984 (-)Ensembl
GRCm381186,584,067 - 86,584,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,584,067 - 86,584,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,397,569 - 86,397,660 (-)NCBIGRCm37mm9NCBIm37
Celera1196,199,974 - 96,200,065 (-)NCBICelera
Cytogenetic Map11CNCBI
Mir21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21071,405,257 - 71,405,348 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1071,405,257 - 71,405,348 (-)Ensembl
Rnor_6.01073,902,210 - 73,902,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,902,210 - 73,902,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,197,081 - 76,197,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1070,326,375 - 70,326,466 (-)NCBICelera
Cytogenetic Map10q26NCBI
MIR21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,340,550 - 34,340,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,340,533 - 34,340,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha933,572,293 - 33,572,352 (+)NCBI
ROS_Cfam_1.0935,150,885 - 35,150,944 (+)NCBI
ROS_Cfam_1.0 Ensembl935,150,868 - 35,150,959 (+)Ensembl
UMICH_Zoey_3.1933,934,637 - 33,934,696 (+)NCBI
UNSW_CanFamBas_1.0934,220,122 - 34,220,181 (+)NCBI
UU_Cfam_GSD_1.0934,306,261 - 34,306,320 (+)NCBI
MIR21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,065,267 - 36,065,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,065,267 - 36,065,358 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,340,385 - 37,340,476 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
SHGC-64257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,735 - 57,917,824UniSTSGRCh37
Build 361755,272,517 - 55,272,606RGDNCBI36
Celera1754,381,248 - 54,381,337RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,224 - 53,290,313UniSTS
TNG Radiation Hybrid Map1726111.0UniSTS
RH91780  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,788 - 57,917,888UniSTSGRCh37
Build 361755,272,570 - 55,272,670RGDNCBI36
Celera1754,381,301 - 54,381,401RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,277 - 53,290,377UniSTS
GeneMap99-GB4 RH Map17372.1UniSTS
RH102091  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,919,341 - 57,919,465UniSTSGRCh37
GRCh37994,913,462 - 94,913,586UniSTSGRCh37
Build 36993,953,283 - 93,953,407RGDNCBI36
Celera1754,382,854 - 54,382,978UniSTS
Celera965,349,755 - 65,349,879RGD
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map17q23.1UniSTS
HuRef1753,291,830 - 53,291,954UniSTS
HuRef964,591,395 - 64,591,519UniSTS
D17F294S2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37994,913,534 - 94,913,699UniSTSGRCh37
GRCh371757,919,413 - 57,919,578UniSTSGRCh37
Build 36993,953,355 - 93,953,520RGDNCBI36
Celera965,349,827 - 65,349,992RGD
Celera1754,382,926 - 54,383,091UniSTS
Cytogenetic Map17q23.1UniSTS
Cytogenetic Map9q22.31UniSTS
HuRef1753,291,902 - 53,292,067UniSTS
HuRef964,591,467 - 64,591,632UniSTS
RH46129  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,918,157 - 57,918,341UniSTSGRCh37
Build 361755,272,939 - 55,273,123RGDNCBI36
Celera1754,381,670 - 54,381,854RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,646 - 53,290,830UniSTS
GeneMap99-GB4 RH Map17377.81UniSTS
NCBI RH Map17665.5UniSTS

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
LRRFIP1hsa-miR-21-5pMirtarbaseexternal_infosemi-qRT-PCR//Luciferase reporter assay//Western bFunctional MTI19559015
MARCKShsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19302977
SP1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22034194
CCL20hsa-miR-21-5pMirtarbaseexternal_infoELISA//Immunofluorescence//Luciferase reporter assFunctional MTI22001440
TPM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18270520
TPM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot;qRT-PCRFunctional MTI17363372
NFIBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18384814
CDK6hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
BTG2hsa-miR-21-5pMirtarbaseexternal_infosemi-qRT-PCR//GFP reporter assay//Western blot//LuFunctional MTI19546886
FAShsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20048743
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Westren blot//Reporter Functional MTI17968323
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19509156
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19682430
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI18270520
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20143188
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19836969
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19419954
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI18372920
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19133651
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19264808
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20056717
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI20831814
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Quantitative pFunctional MTI19253296
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19276261
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI18829576
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunofluorescence//Luciferase reporteFunctional MTI20533548
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)16966691
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21469086
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistryFunctional MTI (WeaK)19473551
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20219857
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI17991735
PTENhsa-miR-21-5pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCR//WesternFunctional MTI19167416
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20460403
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21347332
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21872591
RHOBhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23313253
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18270520
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI21636785
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI20693317
BMPR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19578724
ERBB2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19419954
PTENhsa-miR-21-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI20827319
TGFBR3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19253296
MSH2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21078976
MSH2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21047769
TIAM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI20826792
TIAM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23442323
ISCUhsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//Luciferase reporFunctional MTI20480266
MEF2Chsa-miR-21-5pMirtarbaseexternal_infoImmunofluorescence//In situ hybridization//LuciferFunctional MTI21170291
EIF4A2hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//Luciferase reporFunctional MTI21219636
EGFRhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
NFKB1hsa-miR-21-5pMirtarbaseexternal_infoChIP-seqFunctional MTI (Weak)21081469
IL1Bhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCRFunctional MTI21131358
CDK2AP1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21191961
PTX3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI21131358
CDK2AP1hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI21328460
PPARAhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Flow//ImmunoprecipitaioFunctional MTI21636785
FASLGhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23177026
FASLGhsa-miR-21-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI20371612
SOD3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22836756
TCF21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23206776
SMAD7hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23292313
MMP2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19435867
VEGFAhsa-miR-21-5pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI21544242
ELAVL4hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986
AKAP9hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19242418
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17072344
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21826097
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17478730
WNK3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21544242
NSD3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19398721
DCP1Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18372920
DCP1Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17968323
RDH11hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17363372
BCL6hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23416424
OTUD1hsa-miR-21-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TPM1hsa-miR-21-5pTarbaseexternal_infoWesternblitPOSITIVE
PDCD4hsa-miR-21-5pTarbaseexternal_infoReporter GenePOSITIVE
TPM1hsa-miR-21-5pTarbaseexternal_infoqPCRNEGATIVE
AGO4hsa-miR-21-5pTarbaseexternal_infoMicroarrayPOSITIVE
RECKhsa-miR-21-5pTarbaseexternal_infoqPCRPOSITIVE
EGFRhsa-miR-21-5pTarbaseexternal_infoOtherPOSITIVE
TIMP3hsa-miR-21-5pTarbaseexternal_infoMicroarrayNEGATIVE
GRPEL2hsa-miR-21-5pTarbaseexternal_infoSequencingPOSITIVE
TPM1hsa-miR-21-5pMirecordsexternal_infoNANA17363372
NFIBhsa-miR-21-5pMirecordsexternal_info{unchanged}NA18384814
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}NA18372920
PDCD4hsa-miR-21-5pMirecordsexternal_infoNANA18270520
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}{unchanged}NA17968323
CDKN1Ahsa-miR-21-5pMirecordsexternal_info{changed}NA17991735
PDCD4hsa-miR-21-5pMirecordsexternal_info{changed}{changed}NA17991735
RECKhsa-miR-21-5pMirecordsexternal_infoNANA18794849
TIMP3hsa-miR-21-5pMirecordsexternal_info{changed}NA18591254
MTAPhsa-miR-21-5pMirecordsexternal_infoNANA19013014
JMYhsa-miR-21-5pMirecordsexternal_infoNANA18829576
TGFBR3hsa-miR-21-5pMirecordsexternal_infoNANA11829576
PDCD4hsa-miR-21-5pMirecordsexternal_infoNANA18850008
RB1hsa-miR-21-5pMirecordsexternal_infoNANA19175831
TGFB1hsa-miR-21-5pMirecordsexternal_infoNANA19264808
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}NA19276261
PTENhsa-miR-21-5pMirecordsexternal_info{changed}NA19906824
CDC25Ahsa-miR-21-5pMirecordsexternal_info{changed}NA19826040
BMPR2hsa-miR-21-5pMirecordsexternal_infoNANA19578724
LRRFIP1hsa-miR-21-5pMirecordsexternal_infoNANA19559015
BTG2hsa-miR-21-5pMirecordsexternal_info{changed}NA19546886
JAG1hsa-miR-21-5pMirecordsexternal_infoNANA19398721
MARCKShsa-miR-21-5pMirecordsexternal_infoNANA19302977
PELI1hsa-miR-21-5pMirecordsexternal_infoNANA20167875
RECKhsa-miR-21-5pMirecordsexternal_info{unchanged}NA20154725
PPARAhsa-miR-21-5pMirecordsexternal_infoNANA20693317
STAT3hsa-miR-21-5pMirecordsexternal_info{changed}NA21381024
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23466500
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23226804
TCF21hsa-miR-21-5pOncomiRDBexternal_infoNANA23206776
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23174819
CASP3hsa-miR-21-5pOncomiRDBexternal_infoNANA22964638
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22956424
SOD3hsa-miR-21-5pOncomiRDBexternal_infoNANA22836756
MSH2hsa-miR-21-5pOncomiRDBexternal_infoNANA22806311
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22770403
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA22761427
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22685542
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22678116
BTG2hsa-miR-21-5pOncomiRDBexternal_infoNANA22614007
SERPINI1hsa-miR-21-5pOncomiRDBexternal_infoNANA22464652
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22335905
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22322403
PIAS3hsa-miR-21-5pOncomiRDBexternal_infoNANA22316494
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22267008
CCL20hsa-miR-21-5pOncomiRDBexternal_infoNANA22099878
JAG1hsa-miR-21-5pOncomiRDBexternal_infoNANA22618231
GRHL3hsa-miR-21-5pOncomiRDBexternal_infoNANA22094257
TGFBR2hsa-miR-21-5pOncomiRDBexternal_infoNANA22072622
CCL20hsa-miR-21-5pOncomiRDBexternal_infoNANA22001440
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21940630
RHOBhsa-miR-21-5pOncomiRDBexternal_infoNANA21872591
TIMP3hsa-miR-21-5pOncomiRDBexternal_infoNANA21820586
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21806946
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21471222
CDK2AP1hsa-miR-21-5pOncomiRDBexternal_infoNANA21328460
ANP32Ahsa-miR-21-5pOncomiRDBexternal_infoNANA21317927
SPRY2hsa-miR-21-5pOncomiRDBexternal_infoNANA21278789
ANKRD46hsa-miR-21-5pOncomiRDBexternal_infoNANA21219636
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21820606
THRBhsa-miR-21-5pOncomiRDBexternal_infoNANA21159845
PLAThsa-miR-21-5pOncomiRDBexternal_infoNANA21131358
MSH2hsa-miR-21-5pOncomiRDBexternal_infoNANA21078976
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20831814
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20581857
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA20480266
TIAM1hsa-miR-21-5pOncomiRDBexternal_infoNANA20826792
RHOBhsa-miR-21-5pOncomiRDBexternal_infoNANA20460403
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA20447717
TIMP3hsa-miR-21-5pOncomiRDBexternal_infoNANA20346171
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA20223231
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20148895
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20143188
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20141427
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20670480
CDC25Ahsa-miR-21-5pOncomiRDBexternal_infoNANA19826040
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19682430
BMPR2hsa-miR-21-5pOncomiRDBexternal_infoNANA19578724
LRRFIP1hsa-miR-21-5pOncomiRDBexternal_infoNANA19559015
BTG2hsa-miR-21-5pOncomiRDBexternal_infoNANA19546886
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19308091
MARCKShsa-miR-21-5pOncomiRDBexternal_infoNANA19302977
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19276261
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19264808
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19013014
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA18850008
HNRNPKhsa-miR-21-5pOncomiRDBexternal_infoNANA18829576
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA18794849
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA18591254
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA18372920
TPM1hsa-miR-21-5pOncomiRDBexternal_infoNANA18270520
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA17991735
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA17968323
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA17681183
TPM1hsa-miR-21-5pOncomiRDBexternal_infoNANA17363372
BCL2hsa-miR-21-5pOncomiRDBexternal_infoNANA17072344
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA16762633
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19296468
KMT5Bhsa-miR-21-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
RASGRP1hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20483747
RASGRP1hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18591254
CDC25Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Northern blot//qRT-PCRFunctional MTI (Weak)19826040
CDC25Ahsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23496142
BCL2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17072344
BCL2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotNon-Functional MTI22528454
BCL2hsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI21468550
BCL2hsa-miR-21-5pMirtarbaseexternal_infoWestern blot;OtherFunctional MTI20048743
PYM1hsa-miR-21-5pMirtarbaseexternal_infoQuantitative proteomic approachFunctional MTI (Weak)19253296
TM9SF3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19253296
RTN4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Quantitative proteomic Functional MTI19253296
RPS7hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Quantitative proteomic approachFunctional MTI (Weak)19253296
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20371350
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Western blotFunctional MTI17968323
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17991735
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19682430
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19276261
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19419954
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18850008
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16966691
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19672202
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19342589
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21069438
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18270520
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19836969
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19133651
RPS7hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)18372920
RPS7hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)18591254
JAG1hsa-miR-21-5pMirtarbaseexternal_infoFlow//Immunoblot//Luciferase reporter assay//MicroFunctional MTI19398721
JAG1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22618231
RESThsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19242418
SMARCA4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21317927
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18508928
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI21278789
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23239100
DUSP10hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22387553
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//qRT-PCR//Functional MTI18591254
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20346171
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21820586
SOX5hsa-miR-21-5pMirtarbaseexternal_infoWestern blot//Northern blot//qRT-PCR//Luciferase rFunctional MTI19013014
DOCK7hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22158624
RECKhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20480266
RECKhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI18794849
RECKhsa-miR-21-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assay//Functional MTI18591254
RECKhsa-miR-21-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assayFunctional MTI20154725
RECKhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22630347
PIAS3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22316494
E2F2hsa-miR-21-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//ChIPFunctional MTI (Weak)19528081
FMODhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19906824
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19906824
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI19816956
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18829576
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22072622
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19672202
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19072831
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18850008
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI20216554
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20223231
PTENhsa-miR-21-5pMirtarbaseexternal_infoMicroarray//immunohistochemistryFunctional MTI (Weak)19175831
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI20048743
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20813833
PTENhsa-miR-21-5pMirtarbaseexternal_infoGFP reporter assay//Northern blot//qRT-PCR//WesterFunctional MTI19641183
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//NoFunctional MTI17681183
PTENhsa-miR-21-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blot//Reporter assFunctional MTI16762633
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI20797623
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI20978511
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22267008
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistryNon-Functional MTI (Weak)19473551
PTENhsa-miR-21-5pMirtarbaseexternal_infoELISA//Immunoblot//qRT-PCRFunctional MTI (Weak)22678116
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22956424
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22761812
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI22770403
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22879939
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23226804
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI21544242
E2F1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI19528081
TGFBIhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19136465

Predicted Targets
Summary Value
Count of predictions:19209
Count of gene targets:7868
Count of transcripts:15128
Interacting mature miRNAs:hsa-miR-21-3p, hsa-miR-21-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 20 20 14 2 15 1 19 2 29 1 9 24 1 19 12
Below cutoff 12 20 9 16 12 5 17 2 7 9 11 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000362134
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,841,266 - 59,841,337 (+)Ensembl
RefSeq Acc Id: NR_029493
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,841,266 - 59,841,337 (+)NCBI
GRCh371757,918,627 - 57,918,698 (+)ENTREZGENE
HuRef1753,291,116 - 53,291,187 (+)ENTREZGENE
CHM1_11757,982,648 - 57,982,719 (+)NCBI
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
Chr17:17q22-23.3
pathogenic
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
Chr17:17q21.33-23.2
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q22-23.2(chr17:56623275-60285107)x1 copy number loss See cases [RCV000511292] Chr17:56623275..60285107 [GRCh37]
Chr17:17q22-23.2
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q23.1(chr17:57817697-57955754)x3 copy number gain not provided [RCV000739625] Chr17:57817697..57955754 [GRCh37]
Chr17:17q23.1
benign
GRCh37/hg19 17q22-23.1(chr17:57582867-58080569)x3 copy number gain not provided [RCV000752157] Chr17:57582867..58080569 [GRCh37]
Chr17:17q22-23.1
benign
GRCh37/hg19 17q23.1(chr17:57616400-57986918)x1 copy number loss not provided [RCV001006908] Chr17:57616400..57986918 [GRCh37]
Chr17:17q23.1
likely pathogenic
GRCh37/hg19 17q22-24.2(chr17:57357088-66306668) copy number gain not provided [RCV000767764] Chr17:57357088..66306668 [GRCh37]
Chr17:17q22-24.2
pathogenic
GRCh37/hg19 17q23.1-24.2(chr17:57869604-67078443)x3 copy number gain not provided [RCV000845965] Chr17:57869604..67078443 [GRCh37]
Chr17:17q23.1-24.2
pathogenic
GRCh37/hg19 17q23.1-23.2(chr17:57605300-59389547)x1 copy number loss not provided [RCV001827980] Chr17:57605300..59389547 [GRCh37]
Chr17:17q23.1-23.2
pathogenic
NC_000017.10:g.(?_54671585)_(59938900_?)dup duplication Joubert syndrome [RCV001923071] Chr17:54671585..59938900 [GRCh37]
Chr17:17q22-23.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31586 AgrOrtholog
COSMIC MIR21 COSMIC
Ensembl Genes ENSG00000284190 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362134 ENTREZGENE
GTEx ENSG00000284190 GTEx
HGNC ID HGNC:31586 ENTREZGENE
Human Proteome Map MIR21 Human Proteome Map
miRBase MI0000077 ENTREZGENE
NCBI Gene 406991 ENTREZGENE
OMIM 611020 OMIM
PharmGKB PA164722590 PharmGKB
RNAcentral URS000009262D RNACentral
  URS00000AF93C RNACentral
  URS000039ED8D RNACentral