MIR21 (microRNA 21) - Rat Genome Database

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Gene: MIR21 (microRNA 21) Homo sapiens
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Symbol: MIR21
Name: microRNA 21
RGD ID: 1349265
HGNC Page HGNC:31586
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and regulation of signal transduction. Acts upstream of or within negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm and extracellular exosome. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); liver disease (multiple); lung cancer (multiple); and uterine disease (multiple).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-21; miR-21; MIRN21; miRNA21
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,841,266 - 59,841,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBINCBI36Build 36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute myocardial infarction  (IEP)
allergic contact dermatitis  (ISO)
anaplastic thyroid carcinoma  (IEP)
Angina Pectoris  (IEP)
atherosclerosis  (IEP)
Atrial Remodeling  (ISO)
autoimmune uveitis  (ISO)
brain glioma  (IEP)
breast cancer  (HEP,IEP,ISO)
Burkitt lymphoma  (IEP)
Cardio-Renal Syndrome  (ISO)
Cardiomegaly  (EXP,ISO)
cerebral infarction  (ISO)
cervical cancer  (IEP)
cervical squamous cell carcinoma  (IEP)
cervicitis  (IEP)
cervix uteri carcinoma in situ  (IEP)
Chemical and Drug Induced Liver Injury  (EXP)
chlamydia  (ISO)
cholangiocarcinoma  (IEP)
Cholangiofibrosis  (IEP)
Chronic Hepatitis  (IEP)
chronic lymphocytic leukemia  (IEP)
colon cancer  (IEP)
colorectal cancer  (IEP,ISO)
congestive heart failure  (EXP,IEP,ISO)
coronary artery disease  (IEP)
Crohn's disease  (IEP)
cryptosporidiosis  (ISO)
dengue disease  (IEP)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (EXP)
endometrial cancer  (IEP)
endometriosis  (EXP)
esophageal cancer  (IEP)
Esophageal Neoplasms  (EXP)
esophagus adenocarcinoma  (IEP)
Experimental Colitis  (ISO)
Fibrosis  (EXP)
Fusobacterium Infections  (IEP)
glioblastoma  (ISO)
Haemophilus Infections  (ISO)
heart disease  (EXP)
hepatitis C  (IEP)
hepatoblastoma  (IEP)
hepatocellular carcinoma  (IEP)
Hyperoxic Lung Injury  (ISO)
hypertensive heart disease  (IEP)
Inflammation  (EXP)
influenza  (ISO)
intermediate coronary syndrome  (IEP)
intestinal obstruction  (IEP)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (IEP)
irritable bowel syndrome  (IEP)
Joubert syndrome 1  (IAGP)
kidney disease  (EXP)
laryngeal squamous cell carcinoma  (HEP)
listeriosis  (ISO)
liver cirrhosis  (IEP,ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (IEP,ISO)
lung adenoma  (ISO)
lung cancer  (IEP,ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IEP)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
Microsatellite Instability  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP,IMP)
Neoplastic Cell Transformation  (EXP)
obesity  (EXP)
papillomavirus infectious disease  (IEP)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (ISO)
peritonitis  (ISO)
primary biliary cholangitis  (IEP)
Prostatic Neoplasms  (EXP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (ISO)
skin melanoma  (IEP)
skin papilloma  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (IEP)
thyroid cancer  (ISO)
toxic shock syndrome  (ISO)
Varicose Ulcer  (IEP)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (EXP)
(R)-lipoic acid  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,5-hexanedione  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
acetic acid  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
Allylamine  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antigen  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
baicalein  (EXP)
Bandrowski's base  (EXP)
benomyl  (ISO)
berberine  (EXP)
bicalutamide  (EXP)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (EXP)
bortezomib  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon atom  (EXP)
carbon monoxide  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (EXP)
curcumin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dapagliflozin  (ISO)
daunorubicin  (EXP)
DDT  (EXP,ISO)
dehydroepiandrosterone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental carbon  (EXP)
Enterolactone  (EXP)
fenhexamid  (EXP)
ferulic acid  (ISO)
fludioxonil  (EXP)
formaldehyde  (EXP)
fulvestrant  (EXP)
gallic acid  (ISO)
geldanamycin  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
graphene oxide  (EXP)
halothane  (ISO)
hydrogen peroxide  (EXP)
icariin  (ISO)
isoprenaline  (ISO)
lamotrigine  (EXP)
lipoic acid  (ISO)
LY294002  (EXP)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
mercaptopurine  (ISO)
methanol  (ISO)
methapyrilene  (ISO)
methyl beta-cyclodextrin  (EXP)
methylmercury chloride  (EXP)
morphine  (EXP)
myo-inositol hexakisphosphate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nitrofen  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
PhIP  (EXP)
piperacillin  (EXP)
potassium bromate  (EXP)
progesterone  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
SB 431542  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
solasodine  (EXP)
sporidesmin A  (EXP)
stattic  (EXP)
streptozocin  (ISO)
sulfamethoxazole  (EXP)
sulfur dioxide  (EXP)
tacrolimus hydrate  (ISO)
Tanshinone I  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
Tungsten carbide  (ISO)
tyrphostin AG 1478  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP)
wortmannin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (ISS)
BMP signaling pathway  (IMP)
cellular response to angiotensin  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to gamma radiation  (IMP)
cellular response to glucose stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to ionizing radiation  (IDA)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IDA,IMP,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to resveratrol  (ISS)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen metabolic process  (ISS)
embryo implantation  (NAS)
endothelial tube morphogenesis  (IMP)
epithelial to mesenchymal transition involved in cardiac fibroblast development  (IDA)
female pregnancy  (ISO)
inflammatory response to antigenic stimulus  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (IDA,IMP)
miRNA-mediated post-transcriptional gene silencing  (IDA,IMP,ISO)
negative regulation of angiogenesis  (IC,ISO,ISS)
negative regulation of aortic smooth muscle cell differentiation  (IDA)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of arginine catabolic process  (ISS)
negative regulation of cardiac muscle cell apoptotic process  (ISO,ISS)
negative regulation of cardiac muscle hypertrophy  (ISS)
negative regulation of cartilage development  (IDA)
negative regulation of cell migration  (IDA)
negative regulation of cell population proliferation  (IDA)
negative regulation of chondrocyte proliferation  (IDA)
negative regulation of cytokine-mediated signaling pathway  (IDA)
negative regulation of endothelial cell migration  (IDA)
negative regulation of endothelial cell proliferation  (IDA)
negative regulation of endothelial tube morphogenesis  (ISS)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (IDA,IGI,IMP,ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (ISO,ISS)
negative regulation of hydrogen sulfide biosynthetic process  (IDA)
negative regulation of innate immune response  (IMP)
negative regulation of interleukin-1-mediated signaling pathway  (IGI)
negative regulation of interleukin-12 production  (IDA)
negative regulation of interleukin-21 production  (IDA)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (IDA)
negative regulation of MAPK cascade  (ISS)
negative regulation of mitotic cell cycle  (IMP)
negative regulation of myofibroblast cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (IGI)
negative regulation of non-canonical NF-kappaB signal transduction  (IMP,ISS)
negative regulation of Rac protein signal transduction  (IDA)
negative regulation of reactive oxygen species biosynthetic process  (ISS)
negative regulation of regulatory T cell differentiation  (IGI)
negative regulation of Rho protein signal transduction  (IDA)
negative regulation of smooth muscle cell apoptotic process  (ISS)
negative regulation of stress fiber assembly  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type I interferon production  (IDA)
negative regulation of type I interferon-mediated signaling pathway  (IDA)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IDA)
negative regulation of vascular associated smooth muscle cell migration  (IDA)
phenotypic switching  (IDA)
positive regulation of activated T cell proliferation  (IGI)
positive regulation of angiogenesis  (IDA)
positive regulation of apoptotic process  (IDA)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA)
positive regulation of cardiac muscle hypertrophy  (ISS)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (IDA,IMP)
positive regulation of cell population proliferation  (IDA,IMP)
positive regulation of cell projection organization  (ISS)
positive regulation of cellular response to hypoxia  (ISS)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cytokine production  (IDA)
positive regulation of cytokine production involved in inflammatory response  (ISS)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (IDA)
positive regulation of endothelial cell migration  (IDA)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of epithelial to mesenchymal transition  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISS)
positive regulation of fat cell differentiation  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of inflammatory response  (IMP,ISS)
positive regulation of inflammatory response to wounding  (ISS)
positive regulation of keratinocyte proliferation  (IDA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IMP)
positive regulation of myofibroblast differentiation  (IMP,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IMP,ISO)
positive regulation of potassium ion export across plasma membrane  (IDA)
positive regulation of protein phosphorylation  (IDA,ISS)
positive regulation of replicative senescence  (IDA)
positive regulation of T-helper 17 cell differentiation  (ISS)
positive regulation of T-helper 17 type immune response  (ISS)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP,ISS)
positive regulation of type II interferon production  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (IMP,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA,IMP,ISS)
positive regulation of vascular associated smooth muscle contraction  (IDA)
positive regulation of vascular endothelial cell proliferation  (IDA)
positive regulation of vascular endothelial growth factor signaling pathway  (IDA)
positive regulation of wound healing  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (IDA)
regulation of cell migration  (IGI)
regulation of cell shape  (IMP)
regulation of epidermal growth factor receptor signaling pathway  (IMP)
regulation of extracellular matrix organization  (IDA)
regulation of gene expression  (ISO)
regulation of mesenchymal stem cell differentiation  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISS)
regulation of reactive oxygen species metabolic process  (IDA,ISS)
response to bacterium  (ISO)
response to hypoxia  (ISO)
response to muscle activity  (ISO)
response to oxygen levels  (ISO)
retinal cell apoptotic process  (ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Adams AT, etal., Inflamm Bowel Dis. 2014 Oct;20(10):1784-93. doi: 10.1097/MIB.0000000000000179.
2. Anti-inflammatory effects of miR-21 in the macrophage response to peritonitis. Barnett RE, etal., J Leukoc Biol. 2016 Feb;99(2):361-71. doi: 10.1189/jlb.4A1014-489R. Epub 2015 Sep 17.
3. MicroRNA-21 protects neurons from ischemic death. Buller B, etal., FEBS J. 2010 Oct;277(20):4299-307. doi: 10.1111/j.1742-4658.2010.07818.x. Epub 2010 Sep 14.
4. Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. Bumrungthai S, etal., PLoS One. 2015 May 26;10(5):e0127109. doi: 10.1371/journal.pone.0127109. eCollection 2015.
5. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
6. Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia. Chen N, etal., Oncol Rep. 2018 Jun;39(6):3064-3072. doi: 10.3892/or.2018.6367. Epub 2018 Apr 12.
7. MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Chuppa S, etal., Kidney Int. 2018 Feb;93(2):375-389. doi: 10.1016/j.kint.2017.05.014. Epub 2017 Jul 29.
8. Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein. Clément S, etal., Liver Int. 2019 Jul;39(7):1226-1236. doi: 10.1111/liv.14112. Epub 2019 Apr 16.
9. Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. Correa-Gallego C, etal., PLoS One. 2016 Sep 29;11(9):e0163699. doi: 10.1371/journal.pone.0163699. eCollection 2016.
10. Upregulation of miR-21 by Ras in vivo and its role in tumor growth. Frezzetti D, etal., Oncogene. 2011 Jan 20;30(3):275-86. doi: 10.1038/onc.2010.416. Epub 2010 Oct 18.
11. miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen-/- Immunization. Gannavaram S, etal., Front Immunol. 2019 Sep 24;10:2273. doi: 10.3389/fimmu.2019.02273. eCollection 2019.
12. MicroRNA-21 contributes to high glucose-induced fibrosis in peritoneal mesothelial cells in rat models by activation of the Ras-MAPK signaling pathway via Sprouty-1. Gao Q, etal., J Cell Physiol. 2019 May;234(5):5915-5925. doi: 10.1002/jcp.26941. Epub 2018 Dec 4.
13. Serum levels of microRNA-21 and microRNA-10a can predict long-term prognosis in laryngeal cancer patients: a multicenter study. Gao S, etal., Transl Cancer Res. 2020 May;9(5):3680-3690. doi: 10.21037/tcr-20-1758.
14. CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice. Guesdon W, etal., J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.
15. MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis. He J, etal., Clin Invest Med. 2013 Apr 1;36(2):E103-11. doi: 10.25011/cim.v36i2.19573.
16. Methyl helicterte ameliorates liver fibrosis by regulating miR-21-mediated ERK and TGF-β1/Smads pathways. Huang Q, etal., Int Immunopharmacol. 2019 Jan;66:41-51. doi: 10.1016/j.intimp.2018.11.006. Epub 2018 Nov 9.
17. Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer. Iseki Y, etal., Anticancer Res. 2016 Oct;36(10):5145-5151. doi: 10.21873/anticanres.11084.
18. MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis. Jia P, etal., Crit Care Med. 2017 Jul;45(7):e703-e710. doi: 10.1097/CCM.0000000000002363.
19. Serum miR-21 and miR-26a Levels Negatively Correlate with Severity of Cirrhosis in Patients with Chronic Hepatitis B. Jiang S, etal., Microrna. 2019;8(1):86-92. doi: 10.2174/2211536607666180821162850.
20. Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. Jiao J, etal., J Int Med Res. 2015 Oct;43(5):672-8. doi: 10.1177/0300060515583707. Epub 2015 Jul 6.
21. MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection. Johnston DGW, etal., Front Cell Infect Microbiol. 2017 May 23;7:201. doi: 10.3389/fcimb.2017.00201. eCollection 2017.
22. Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer. Kabakov AV, etal., Bull Exp Biol Med. 2020 Feb;168(4):500-502. doi: 10.1007/s10517-020-04740-w. Epub 2020 Mar 10.
23. Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes. Kim G, etal., J Control Release. 2020 Jan 10;317:273-281. doi: 10.1016/j.jconrel.2019.11.009. Epub 2019 Nov 12.
24. Therapeutic efficacy of modified anti-miR21 in metastatic prostate cancer. Kim K, etal., Biochem Biophys Res Commun. 2020 Aug 27;529(3):707-713. doi: 10.1016/j.bbrc.2020.05.215. Epub 2020 Jul 18.
25. MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2. Kim RY, etal., J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10.
26. Associations Between miRNAs and Two Different Cancers: Breast and Colon. Kundaktepe BP, etal., Cancer Manag Res. 2020 Feb 7;12:871-879. doi: 10.2147/CMAR.S227628. eCollection 2020.
27. MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression. Kunita A, etal., Sci Rep. 2018 Jun 11;8(1):8838. doi: 10.1038/s41598-018-27128-3.
28. Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children. Li J, etal., Med Sci Monit. 2016 Dec 19;22:4992-5002. doi: 10.12659/msm.897417.
29. MicroRNA-21-Mediated Inhibition of Mast Cell Degranulation Involved in the Protective Effect of Berberine on 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Rats via p38 Pathway. Li W, etal., Inflammation. 2018 Mar;41(2):689-699. doi: 10.1007/s10753-017-0723-1.
30. LncRNA RUNX1-IT1 is Downregulated in Endometrial Cancer and Binds to miR-21 Precursor to Suppress Its Maturation. Liang M, etal., Cancer Manag Res. 2020 Dec 30;12:13451-13459. doi: 10.2147/CMAR.S272165. eCollection 2020.
31. Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome. Ling H, etal., Front Physiol. 2020 Jun 11;11:654. doi: 10.3389/fphys.2020.00654. eCollection 2020.
32. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. Liu C, etal., J Hepatol. 2010 Jul;53(1):98-107. doi: 10.1016/j.jhep.2010.02.021. Epub 2010 Apr 4.
33. Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer. Liu Q, etal., J BUON. 2018 Jan-Feb;23(1):29-35.
34. Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study. Liu W, etal., Pediatr Surg Int. 2016 Nov;32(11):1059-1065. doi: 10.1007/s00383-016-3960-8. Epub 2016 Sep 6.
35. MicroRNA-21 and -146b are involved in the pathogenesis of murine viral myocarditis by regulating TH-17 differentiation. Liu YL, etal., Arch Virol. 2013 Sep;158(9):1953-63. doi: 10.1007/s00705-013-1695-6. Epub 2013 Apr 16.
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PMID:25543261   PMID:25544502   PMID:25544773   PMID:25564252   PMID:25569638   PMID:25571964   PMID:25575817   PMID:25579119   PMID:25587717   PMID:25589783   PMID:25591761   PMID:25603978  
PMID:25605429   PMID:25623117   PMID:25633921   PMID:25647415   PMID:25656574   PMID:25656948   PMID:25660363   PMID:25661333   PMID:25663768   PMID:25687183   PMID:25706383   PMID:25706647  
PMID:25707810   PMID:25725128   PMID:25728838   PMID:25735723   PMID:25755729   PMID:25758165   PMID:25769454   PMID:25771986   PMID:25784377   PMID:25790954   PMID:25797200   PMID:25803229  
PMID:25814440   PMID:25825239   PMID:25826292   PMID:25831148   PMID:25845681   PMID:25846727   PMID:25869329   PMID:25873777   PMID:25882990   PMID:25885877   PMID:25908274   PMID:25909227  
PMID:25910568   PMID:25928282   PMID:25928322   PMID:25950115   PMID:25950983   PMID:25953218   PMID:25963606   PMID:25969534   PMID:25972604   PMID:25973032   PMID:25979949   PMID:25981603  
PMID:25991372   PMID:25991676   PMID:25994220   PMID:26007293   PMID:26026961   PMID:26038573   PMID:26051842   PMID:26063582   PMID:26063956   PMID:26073083   PMID:26082192   PMID:26095457  
PMID:26097555   PMID:26101800   PMID:26114349   PMID:26116834   PMID:26119078   PMID:26125864   PMID:26142886   PMID:26149640   PMID:26151427   PMID:26156753   PMID:26160841   PMID:26189797  
PMID:26191145   PMID:26191156   PMID:26191158   PMID:26191167   PMID:26193421   PMID:26208095   PMID:26208314   PMID:26208390   PMID:26209976   PMID:26210448   PMID:26212010   PMID:26230405  
PMID:26242334   PMID:26247873   PMID:26248946   PMID:26250493   PMID:26252635   PMID:26261606   PMID:26261620   PMID:26262588   PMID:26276131   PMID:26284486   PMID:26289851   PMID:26296971  
PMID:26302379   PMID:26302751   PMID:26311740   PMID:26314961   PMID:26320576   PMID:26337652   PMID:26342497   PMID:26345812   PMID:26349663   PMID:26363493   PMID:26367487   PMID:26376826  
PMID:26383248   PMID:26415649   PMID:26418978   PMID:26427146   PMID:26436398   PMID:26439034   PMID:26452030   PMID:26453197   PMID:26455824   PMID:26496100   PMID:26496641   PMID:26498351  
PMID:26498464   PMID:26500110   PMID:26516113   PMID:26525579   PMID:26549725   PMID:26558781   PMID:26565986   PMID:26568302   PMID:26572589   PMID:26574780   PMID:26575977   PMID:26595526  
PMID:26646696   PMID:26646931   PMID:26651881   PMID:26660281   PMID:26666820   PMID:26676464   PMID:26690371   PMID:26701969   PMID:26720919   PMID:26731559   PMID:26733162   PMID:26769851  
PMID:26772615   PMID:26779632   PMID:26784015   PMID:26787105   PMID:26802234   PMID:26806656   PMID:26823838   PMID:26824898   PMID:26826461   PMID:26827795   PMID:26841045   PMID:26842377  
PMID:26845148   PMID:26847279   PMID:26847601   PMID:26847916   PMID:26853468   PMID:26864640   PMID:26867589   PMID:26872030   PMID:26874829   PMID:26884851   PMID:26891730   PMID:26909911  
PMID:26911854   PMID:26915797   PMID:26940124   PMID:26943153   PMID:26968172   PMID:26969625   PMID:26975392   PMID:26977002   PMID:27009461   PMID:27010367   PMID:27014996   PMID:27021436  
PMID:27030384   PMID:27035337   PMID:27035555   PMID:27035745   PMID:27039296   PMID:27040772   PMID:27040946   PMID:27050372   PMID:27055844   PMID:27060458   PMID:27064390   PMID:27067271  
PMID:27075111   PMID:27084907   PMID:27086919   PMID:27101583   PMID:27107063   PMID:27107786   PMID:27122240   PMID:27153564   PMID:27159391   PMID:27166186   PMID:27166999   PMID:27171163  
PMID:27179559   PMID:27185036   PMID:27207585   PMID:27220494   PMID:27222255   PMID:27226339   PMID:27250636   PMID:27264483   PMID:27278606   PMID:27279796   PMID:27285119   PMID:27286259  
PMID:27288814   PMID:27293316   PMID:27329723   PMID:27350731   PMID:27351379   PMID:27353714   PMID:27370645   PMID:27376830   PMID:27383043   PMID:27385533   PMID:27420617   PMID:27422033  
PMID:27427222   PMID:27432735   PMID:27434290   PMID:27495250   PMID:27509989   PMID:27510174   PMID:27510529   PMID:27521993   PMID:27531352   PMID:27531746   PMID:27542229   PMID:27550546  
PMID:27554193   PMID:27561985   PMID:27565378   PMID:27567668   PMID:27571873   PMID:27586871   PMID:27590242   PMID:27596120   PMID:27596748   PMID:27600360   PMID:27610006   PMID:27611950  
PMID:27644439   PMID:27655698   PMID:27663503   PMID:27671240   PMID:27672217   PMID:27684463   PMID:27696295   PMID:27708252   PMID:27712594   PMID:27717618   PMID:27739364   PMID:27752128  
PMID:27765464   PMID:27771712   PMID:27775690   PMID:27785570   PMID:27793160   PMID:27798914   PMID:27811366   PMID:27814278   PMID:27816459   PMID:27824649   PMID:27825521   PMID:27864711  
PMID:27867039   PMID:27885434   PMID:27895788   PMID:27910062   PMID:27922432   PMID:27922982   PMID:27959491   PMID:27993628   PMID:28006751   PMID:28039018   PMID:28039483   PMID:28040201  
PMID:28042781   PMID:28061868   PMID:28067096   PMID:28069514   PMID:28075055   PMID:28078851   PMID:28108673   PMID:28109960   PMID:28121625   PMID:28125734   PMID:28127562   PMID:28128744  
PMID:28159509   PMID:28160564   PMID:28170197   PMID:28177881   PMID:28184919   PMID:28192117   PMID:28197636   PMID:28207045   PMID:28208259   PMID:28224282   PMID:28253825   PMID:28254348  
PMID:28270521   PMID:28314265   PMID:28335740   PMID:28347230   PMID:28347692   PMID:28363193   PMID:28398611   PMID:28410224   PMID:28412211   PMID:28415652   PMID:28431233   PMID:28447761  
PMID:28448534   PMID:28472815   PMID:28477010   PMID:28477403   PMID:28477839   PMID:28489839   PMID:28490741   PMID:28495464   PMID:28495592   PMID:28497421   PMID:28506791   PMID:28522568  
PMID:28529243   PMID:28534371   PMID:28545454   PMID:28614272   PMID:28624440   PMID:28628833   PMID:28641313   PMID:28642869   PMID:28652429   PMID:28656135   PMID:28669725   PMID:28677800  
PMID:28677811   PMID:28686971   PMID:28705115   PMID:28709088   PMID:28714373   PMID:28726006   PMID:28727188   PMID:28727276   PMID:28732437   PMID:28734015   PMID:28742209   PMID:28744338  
PMID:28765959   PMID:28766461   PMID:28798470   PMID:28799568   PMID:28802862   PMID:28824293   PMID:28826000   PMID:28870579   PMID:28901491   PMID:28910982   PMID:28911139   PMID:28935174  
PMID:28944900   PMID:28945212   PMID:28946056   PMID:28947822   PMID:28951521   PMID:28957811   PMID:28971974   PMID:29023075   PMID:29039542   PMID:29048648   PMID:29082244   PMID:29091291  
PMID:29101039   PMID:29103767   PMID:29107050   PMID:29113498   PMID:29113809   PMID:29113828   PMID:29117538   PMID:29131259   PMID:29149687   PMID:29177591   PMID:29178290   PMID:29185784  
PMID:29192241   PMID:29197221   PMID:29197999   PMID:29198131   PMID:29198701   PMID:29228450   PMID:29229992   PMID:29253196   PMID:29274560   PMID:29283887   PMID:29286167   PMID:29292183  
PMID:29298734   PMID:29301499   PMID:29308505   PMID:29320977   PMID:29328455   PMID:29329959   PMID:29331036   PMID:29355387   PMID:29385987   PMID:29393355   PMID:29445851   PMID:29484416  
PMID:29487007   PMID:29490650   PMID:29501572   PMID:29516946   PMID:29516989   PMID:29527928   PMID:29540832   PMID:29542167   PMID:29543496   PMID:29549908   PMID:29620442   PMID:29635890  
PMID:29635981   PMID:29637273   PMID:29659130   PMID:29663730   PMID:29668922   PMID:29669316   PMID:29679553   PMID:29679565   PMID:29680210   PMID:29682517   PMID:29687845   PMID:29696468  
PMID:29699056   PMID:29703843   PMID:29710470   PMID:29721089   PMID:29730429   PMID:29731265   PMID:29739972   PMID:29747655   PMID:29772439   PMID:29777792   PMID:29788092   PMID:29807978  
PMID:29808800   PMID:29848477   PMID:29848733   PMID:29854071   PMID:29856242   PMID:29857185   PMID:29859516   PMID:29884447   PMID:29902577   PMID:29905364   PMID:29905365   PMID:29976637  
PMID:29981499   PMID:30015844   PMID:30024605   PMID:30030592   PMID:30074182   PMID:30092298   PMID:30106099   PMID:30118248   PMID:30132571   PMID:30134003   PMID:30134821   PMID:30154401  
PMID:30179296   PMID:30184526   PMID:30194772   PMID:30212824   PMID:30215459   PMID:30221692   PMID:30226598   PMID:30232913   PMID:30246355   PMID:30256067   PMID:30267810   PMID:30291880  
PMID:30317621   PMID:30332981   PMID:30338782   PMID:30338786   PMID:30338794   PMID:30338850   PMID:30352127   PMID:30357530   PMID:30372890   PMID:30375257   PMID:30389444   PMID:30398001  
PMID:30401711   PMID:30447706   PMID:30453448   PMID:30454026   PMID:30457256   PMID:30463012   PMID:30464258   PMID:30468492   PMID:30481073   PMID:30518009   PMID:30520131   PMID:30526047  
PMID:30531928   PMID:30536317   PMID:30536328   PMID:30555555   PMID:30556872   PMID:30556877   PMID:30565043   PMID:30569149   PMID:30569605   PMID:30575905   PMID:30576678   PMID:30591064  
PMID:30595567   PMID:30636774   PMID:30664688   PMID:30681889   PMID:30700111   PMID:30711569   PMID:30781615   PMID:30803440   PMID:30808234   PMID:30820789   PMID:30825229   PMID:30840273  
PMID:30849539   PMID:30870812   PMID:30880765   PMID:30887933   PMID:30905898   PMID:30925941   PMID:30931980   PMID:30950039   PMID:30967746   PMID:30982052   PMID:30997628   PMID:30997863  
PMID:30999696   PMID:31002820   PMID:31017473   PMID:31030498   PMID:31033015   PMID:31033484   PMID:31035975   PMID:31037150   PMID:31038023   PMID:31042008   PMID:31045265   PMID:31053148  
PMID:31054160   PMID:31066165   PMID:31069831   PMID:31070482   PMID:31084400   PMID:31095782   PMID:31101191   PMID:31115569   PMID:31128066   PMID:31129247   PMID:31136988   PMID:31140328  
PMID:31155965   PMID:31161410   PMID:31163082   PMID:31173285   PMID:31176779   PMID:31184708   PMID:31211819   PMID:31225740   PMID:31235478   PMID:31257538   PMID:31263200   PMID:31276668  
PMID:31302227   PMID:31307177   PMID:31308028   PMID:31326400   PMID:31330059   PMID:31344049   PMID:31351450   PMID:31358876   PMID:31368531   PMID:31389582   PMID:31413212   PMID:31416448  
PMID:31450909   PMID:31469974   PMID:31482406   PMID:31500623   PMID:31505885   PMID:31506038   PMID:31513959   PMID:31535570   PMID:31554487   PMID:31556140   PMID:31558368   PMID:31558773  
PMID:31574853   PMID:31575846   PMID:31583718   PMID:31585536   PMID:31586768   PMID:31599663   PMID:31600098   PMID:31602161   PMID:31603116   PMID:31611175   PMID:31621912   PMID:31655383  
PMID:31660696   PMID:31660891   PMID:31699948   PMID:31722341   PMID:31726271   PMID:31727077   PMID:31733640   PMID:31763811   PMID:31764830   PMID:31778243   PMID:31789394   PMID:31814034  
PMID:31815762   PMID:31823412   PMID:31837336   PMID:31863364   PMID:31866421   PMID:31872268   PMID:31872875   PMID:31907972   PMID:31909885   PMID:31910411   PMID:31913198   PMID:31926164  
PMID:31926946   PMID:31945658   PMID:31948396   PMID:31950510   PMID:31985389   PMID:31986951   PMID:32013579   PMID:32016465   PMID:32019988   PMID:32020207   PMID:32020707   PMID:32028672  
PMID:32033332   PMID:32060074   PMID:32069387   PMID:32081769   PMID:32090490   PMID:32091667   PMID:32102516   PMID:32108968   PMID:32127037   PMID:32141536   PMID:32144351   PMID:32147308  
PMID:32160412   PMID:32176569   PMID:32191117   PMID:32196704   PMID:32204765   PMID:32236579   PMID:32256450   PMID:32271438   PMID:32279740   PMID:32293319   PMID:32316783   PMID:32319558  
PMID:32319564   PMID:32319566   PMID:32323738   PMID:32327705   PMID:32333014   PMID:32352018   PMID:32356483   PMID:32388866   PMID:32401035   PMID:32412349   PMID:32412786   PMID:32427870  
PMID:32432671   PMID:32468043   PMID:32521885   PMID:32527354   PMID:32542340   PMID:32557866   PMID:32572900   PMID:32598698   PMID:32623387   PMID:32632096   PMID:32669469   PMID:32675386  
PMID:32717421   PMID:32727244   PMID:32746985   PMID:32749107   PMID:32791063   PMID:32794418   PMID:32862588   PMID:32871166   PMID:32871962   PMID:32881598   PMID:32888967   PMID:32911844  
PMID:32941675   PMID:32949355   PMID:32996748   PMID:33015156   PMID:33054296   PMID:33075314   PMID:33081752   PMID:33096778   PMID:33106660   PMID:33112535   PMID:33112562   PMID:33114482  
PMID:33119045   PMID:33120918   PMID:33123586   PMID:33139818   PMID:33176966   PMID:33185898   PMID:33200798   PMID:33206331   PMID:33253708   PMID:33268675   PMID:33287921   PMID:33288677  
PMID:33290159   PMID:33318473   PMID:33332708   PMID:33378024   PMID:33382770   PMID:33414439   PMID:33415165   PMID:33429194   PMID:33434077   PMID:33463918   PMID:33480702   PMID:33481270  
PMID:33495842   PMID:33499700   PMID:33533513   PMID:33537096   PMID:33569850   PMID:33596145   PMID:33601096   PMID:33606670   PMID:33664454   PMID:33728488   PMID:33739023   PMID:33776993  
PMID:33785715   PMID:33804639   PMID:33813478   PMID:33813728   PMID:33834978   PMID:33837901   PMID:33869627   PMID:33876465   PMID:33877895   PMID:33888045   PMID:33902001   PMID:33904674  
PMID:33936025   PMID:33940234   PMID:33942238   PMID:33948855   PMID:33975532   PMID:33976355   PMID:34020163   PMID:34024034   PMID:34086554   PMID:34088891   PMID:34101224   PMID:34208765  
PMID:34225531   PMID:34226680   PMID:34233454   PMID:34233673   PMID:34244602   PMID:34258959   PMID:34266326   PMID:34270831   PMID:34288231   PMID:34314629   PMID:34331128   PMID:34337857  
PMID:34358482   PMID:34366325   PMID:34424813   PMID:34464226   PMID:34473845   PMID:34492742   PMID:34506963   PMID:34518132   PMID:34558644   PMID:34571048   PMID:34590501   PMID:34610416  
PMID:34611295   PMID:34628789   PMID:34644206   PMID:34681754   PMID:34687038   PMID:34698413   PMID:34699621   PMID:34708894   PMID:34741385   PMID:34796728   PMID:34797887   PMID:34799871  
PMID:34818876   PMID:34887868   PMID:34889164   PMID:34905503   PMID:34906045   PMID:34911834   PMID:34950438   PMID:34954475   PMID:34956174   PMID:34957910   PMID:34958006   PMID:34972164  
PMID:34979378   PMID:35016439   PMID:35027490   PMID:35033900   PMID:35068324   PMID:35112252   PMID:35137654   PMID:35141939   PMID:35157721   PMID:35159373   PMID:35163198   PMID:35163436  
PMID:35169355   PMID:35184427   PMID:35191804   PMID:35203389   PMID:35271888   PMID:35276697   PMID:35302299   PMID:35312228   PMID:35328425   PMID:35328750   PMID:35329083   PMID:35341975  
PMID:35346324   PMID:35399150   PMID:35421166   PMID:35440807   PMID:35441676   PMID:35501921   PMID:35504804   PMID:35511493   PMID:35525840   PMID:35549815   PMID:35606305   PMID:35660458  
PMID:35691029   PMID:35707883   PMID:35716075   PMID:35761154   PMID:35809289   PMID:35835254   PMID:35883438   PMID:35892150   PMID:35895593   PMID:35897096   PMID:35907209   PMID:35975534  
PMID:35976169   PMID:35980523   PMID:35988268   PMID:36002186   PMID:36017911   PMID:36035369   PMID:36058441   PMID:36074324   PMID:36082081   PMID:36139366   PMID:36180486   PMID:36197244  
PMID:36208253   PMID:36244909   PMID:36253358   PMID:36303271   PMID:36359774   PMID:36359921   PMID:36423787   PMID:36586571   PMID:36690226   PMID:36694219   PMID:36697494   PMID:36756790  
PMID:36765486   PMID:36789695   PMID:36825546   PMID:36869070   PMID:36902024   PMID:36941810   PMID:36945942   PMID:37005877   PMID:37088278   PMID:37094852   PMID:37164915   PMID:37187452  
PMID:37230199   PMID:37283359   PMID:37312615   PMID:37373259   PMID:37378942   PMID:37393665   PMID:37418993   PMID:37419429   PMID:37481646   PMID:37506155   PMID:37507808   PMID:37511090  
PMID:37639012   PMID:37683274   PMID:37715430   PMID:37726969   PMID:37824392   PMID:37851645   PMID:37864733   PMID:37865291   PMID:37865350   PMID:37883102   PMID:37898451   PMID:37904010  
PMID:37950500   PMID:37960842   PMID:37976292   PMID:37993769   PMID:38015343   PMID:38019229   PMID:38041730   PMID:38043193   PMID:38062969   PMID:38063121   PMID:38081950   PMID:38126112  
PMID:38129923   PMID:38131475   PMID:38139440   PMID:38155071   PMID:38192185   PMID:38218039   PMID:38262269   PMID:38277748   PMID:38287200   PMID:38299392   PMID:38302783   PMID:38409136  
PMID:38446251   PMID:38457157   PMID:38470169   PMID:38516774   PMID:38530760   PMID:38542098   PMID:38602536   PMID:38612895   PMID:38708494   PMID:38742566   PMID:38750066   PMID:38766781  
PMID:38817823   PMID:38874783   PMID:38926950   PMID:39042337   PMID:39201680  


Genomics

Comparative Map Data
MIR21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,841,266 - 59,841,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBINCBI36Build 36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBIT2T-CHM13v2.0
Mir21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,474,893 - 86,474,984 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,474,893 - 86,474,984 (-)EnsemblGRCm39 Ensembl
GRCm381186,584,067 - 86,584,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,584,067 - 86,584,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,397,569 - 86,397,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1196,199,974 - 96,200,065 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.82NCBI
Mir21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,902,600 - 71,902,691 (-)NCBIGRCr8
mRatBN7.21071,405,257 - 71,405,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1071,405,257 - 71,405,348 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,026,707 - 76,026,798 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01075,531,582 - 75,531,673 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01070,996,132 - 70,996,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01073,902,210 - 73,902,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,902,210 - 73,902,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,197,081 - 76,197,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1070,326,375 - 70,326,466 (-)NCBICelera
Cytogenetic Map10q26NCBI
MIR21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,340,550 - 34,340,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,340,533 - 34,340,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha933,572,293 - 33,572,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0935,150,885 - 35,150,944 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,150,868 - 35,150,959 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1933,934,637 - 33,934,696 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,220,122 - 34,220,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,306,261 - 34,306,320 (+)NCBIUU_Cfam_GSD_1.0
MIR21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,065,267 - 36,065,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,065,267 - 36,065,358 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,340,385 - 37,340,476 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
Chr17:17q22-23.3
pathogenic
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
Chr17:17q21.33-23.2
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q22-23.2(chr17:56623275-60285107)x1 copy number loss See cases [RCV000511292] Chr17:56623275..60285107 [GRCh37]
Chr17:17q22-23.2
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q23.1(chr17:57817697-57955754)x3 copy number gain not provided [RCV000739625] Chr17:57817697..57955754 [GRCh37]
Chr17:17q23.1
benign
GRCh37/hg19 17q22-23.1(chr17:57582867-58080569)x3 copy number gain not provided [RCV000752157] Chr17:57582867..58080569 [GRCh37]
Chr17:17q22-23.1
benign
GRCh37/hg19 17q23.1(chr17:57616400-57986918)x1 copy number loss not provided [RCV001006908] Chr17:57616400..57986918 [GRCh37]
Chr17:17q23.1
likely pathogenic
GRCh37/hg19 17q22-24.2(chr17:57357088-66306668) copy number gain not provided [RCV000767764] Chr17:57357088..66306668 [GRCh37]
Chr17:17q22-24.2
pathogenic
GRCh37/hg19 17q23.1-24.2(chr17:57869604-67078443)x3 copy number gain not provided [RCV000845965] Chr17:57869604..67078443 [GRCh37]
Chr17:17q23.1-24.2
pathogenic
GRCh37/hg19 17q23.1-23.2(chr17:57605300-59389547)x1 copy number loss not provided [RCV001827980] Chr17:57605300..59389547 [GRCh37]
Chr17:17q23.1-23.2
pathogenic
NC_000017.10:g.(?_54671585)_(59938900_?)dup duplication Familial aplasia of the vermis [RCV001923071] Chr17:54671585..59938900 [GRCh37]
Chr17:17q22-23.2
uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
LRRFIP1hsa-miR-21-5pMirtarbaseexternal_infosemi-qRT-PCR//Luciferase reporter assay//Western bFunctional MTI19559015
MARCKShsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19302977
SP1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22034194
CCL20hsa-miR-21-5pMirtarbaseexternal_infoELISA//Immunofluorescence//Luciferase reporter assFunctional MTI22001440
TPM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18270520
TPM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot;qRT-PCRFunctional MTI17363372
NFIBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18384814
CDK6hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
BTG2hsa-miR-21-5pMirtarbaseexternal_infosemi-qRT-PCR//GFP reporter assay//Western blot//LuFunctional MTI19546886
FAShsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20048743
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Westren blot//Reporter Functional MTI17968323
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19509156
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19682430
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI18270520
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20143188
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19836969
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19419954
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI18372920
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19133651
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19264808
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20056717
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI20831814
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Quantitative pFunctional MTI19253296
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19276261
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI18829576
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunofluorescence//Luciferase reporteFunctional MTI20533548
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)16966691
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21469086
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistryFunctional MTI (WeaK)19473551
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20219857
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI17991735
PTENhsa-miR-21-5pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCR//WesternFunctional MTI19167416
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20460403
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21347332
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21872591
RHOBhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23313253
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18270520
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI21636785
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI20693317
BMPR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19578724
ERBB2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19419954
PTENhsa-miR-21-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI20827319
TGFBR3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19253296
MSH2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21078976
MSH2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21047769
TIAM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI20826792
TIAM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23442323
ISCUhsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//Luciferase reporFunctional MTI20480266
MEF2Chsa-miR-21-5pMirtarbaseexternal_infoImmunofluorescence//In situ hybridization//LuciferFunctional MTI21170291
EIF4A2hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//Luciferase reporFunctional MTI21219636
EGFRhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
NFKB1hsa-miR-21-5pMirtarbaseexternal_infoChIP-seqFunctional MTI (Weak)21081469
IL1Bhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCRFunctional MTI21131358
CDK2AP1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21191961
PTX3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI21131358
CDK2AP1hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI21328460
PPARAhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Flow//ImmunoprecipitaioFunctional MTI21636785
FASLGhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23177026
FASLGhsa-miR-21-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI20371612
SOD3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22836756
TCF21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23206776
SMAD7hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23292313
MMP2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19435867
VEGFAhsa-miR-21-5pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI21544242
ELAVL4hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986
AKAP9hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19242418
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17072344
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21826097
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17478730
WNK3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21544242
NSD3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19398721
DCP1Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18372920
DCP1Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17968323
RDH11hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17363372
BCL6hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23416424
OTUD1hsa-miR-21-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TPM1hsa-miR-21-5pTarbaseexternal_infoWesternblitPOSITIVE
PDCD4hsa-miR-21-5pTarbaseexternal_infoReporter GenePOSITIVE
TPM1hsa-miR-21-5pTarbaseexternal_infoqPCRNEGATIVE
AGO4hsa-miR-21-5pTarbaseexternal_infoMicroarrayPOSITIVE
RECKhsa-miR-21-5pTarbaseexternal_infoqPCRPOSITIVE
EGFRhsa-miR-21-5pTarbaseexternal_infoOtherPOSITIVE
TIMP3hsa-miR-21-5pTarbaseexternal_infoMicroarrayNEGATIVE
GRPEL2hsa-miR-21-5pTarbaseexternal_infoSequencingPOSITIVE
TPM1hsa-miR-21-5pMirecordsexternal_infoNANA17363372
NFIBhsa-miR-21-5pMirecordsexternal_info{unchanged}NA18384814
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}NA18372920
PDCD4hsa-miR-21-5pMirecordsexternal_infoNANA18270520
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}{unchanged}NA17968323
CDKN1Ahsa-miR-21-5pMirecordsexternal_info{changed}NA17991735
PDCD4hsa-miR-21-5pMirecordsexternal_info{changed}{changed}NA17991735
RECKhsa-miR-21-5pMirecordsexternal_infoNANA18794849
TIMP3hsa-miR-21-5pMirecordsexternal_info{changed}NA18591254
MTAPhsa-miR-21-5pMirecordsexternal_infoNANA19013014
JMYhsa-miR-21-5pMirecordsexternal_infoNANA18829576
TGFBR3hsa-miR-21-5pMirecordsexternal_infoNANA11829576
PDCD4hsa-miR-21-5pMirecordsexternal_infoNANA18850008
RB1hsa-miR-21-5pMirecordsexternal_infoNANA19175831
TGFB1hsa-miR-21-5pMirecordsexternal_infoNANA19264808
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}NA19276261
PTENhsa-miR-21-5pMirecordsexternal_info{changed}NA19906824
CDC25Ahsa-miR-21-5pMirecordsexternal_info{changed}NA19826040
BMPR2hsa-miR-21-5pMirecordsexternal_infoNANA19578724
LRRFIP1hsa-miR-21-5pMirecordsexternal_infoNANA19559015
BTG2hsa-miR-21-5pMirecordsexternal_info{changed}NA19546886
JAG1hsa-miR-21-5pMirecordsexternal_infoNANA19398721
MARCKShsa-miR-21-5pMirecordsexternal_infoNANA19302977
PELI1hsa-miR-21-5pMirecordsexternal_infoNANA20167875
RECKhsa-miR-21-5pMirecordsexternal_info{unchanged}NA20154725
PPARAhsa-miR-21-5pMirecordsexternal_infoNANA20693317
STAT3hsa-miR-21-5pMirecordsexternal_info{changed}NA21381024
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23466500
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23226804
TCF21hsa-miR-21-5pOncomiRDBexternal_infoNANA23206776
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23174819
CASP3hsa-miR-21-5pOncomiRDBexternal_infoNANA22964638
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22956424
SOD3hsa-miR-21-5pOncomiRDBexternal_infoNANA22836756
MSH2hsa-miR-21-5pOncomiRDBexternal_infoNANA22806311
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22770403
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA22761427
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22685542
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22678116
BTG2hsa-miR-21-5pOncomiRDBexternal_infoNANA22614007
SERPINI1hsa-miR-21-5pOncomiRDBexternal_infoNANA22464652
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22335905
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22322403
PIAS3hsa-miR-21-5pOncomiRDBexternal_infoNANA22316494
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22267008
CCL20hsa-miR-21-5pOncomiRDBexternal_infoNANA22099878
JAG1hsa-miR-21-5pOncomiRDBexternal_infoNANA22618231
GRHL3hsa-miR-21-5pOncomiRDBexternal_infoNANA22094257
TGFBR2hsa-miR-21-5pOncomiRDBexternal_infoNANA22072622
CCL20hsa-miR-21-5pOncomiRDBexternal_infoNANA22001440
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21940630
RHOBhsa-miR-21-5pOncomiRDBexternal_infoNANA21872591
TIMP3hsa-miR-21-5pOncomiRDBexternal_infoNANA21820586
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21806946
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21471222
CDK2AP1hsa-miR-21-5pOncomiRDBexternal_infoNANA21328460
ANP32Ahsa-miR-21-5pOncomiRDBexternal_infoNANA21317927
SPRY2hsa-miR-21-5pOncomiRDBexternal_infoNANA21278789
ANKRD46hsa-miR-21-5pOncomiRDBexternal_infoNANA21219636
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21820606
THRBhsa-miR-21-5pOncomiRDBexternal_infoNANA21159845
PLAThsa-miR-21-5pOncomiRDBexternal_infoNANA21131358
MSH2hsa-miR-21-5pOncomiRDBexternal_infoNANA21078976
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20831814
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20581857
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA20480266
TIAM1hsa-miR-21-5pOncomiRDBexternal_infoNANA20826792
RHOBhsa-miR-21-5pOncomiRDBexternal_infoNANA20460403
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA20447717
TIMP3hsa-miR-21-5pOncomiRDBexternal_infoNANA20346171
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA20223231
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20148895
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20143188
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20141427
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20670480
CDC25Ahsa-miR-21-5pOncomiRDBexternal_infoNANA19826040
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19682430
BMPR2hsa-miR-21-5pOncomiRDBexternal_infoNANA19578724
LRRFIP1hsa-miR-21-5pOncomiRDBexternal_infoNANA19559015
BTG2hsa-miR-21-5pOncomiRDBexternal_infoNANA19546886
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19308091
MARCKShsa-miR-21-5pOncomiRDBexternal_infoNANA19302977
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19276261
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19264808
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19013014
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA18850008
HNRNPKhsa-miR-21-5pOncomiRDBexternal_infoNANA18829576
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA18794849
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA18591254
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA18372920
TPM1hsa-miR-21-5pOncomiRDBexternal_infoNANA18270520
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA17991735
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA17968323
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA17681183
TPM1hsa-miR-21-5pOncomiRDBexternal_infoNANA17363372
BCL2hsa-miR-21-5pOncomiRDBexternal_infoNANA17072344
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA16762633
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19296468
KMT5Bhsa-miR-21-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
RASGRP1hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20483747
RASGRP1hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18591254
CDC25Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Northern blot//qRT-PCRFunctional MTI (Weak)19826040
CDC25Ahsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23496142
BCL2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17072344
BCL2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotNon-Functional MTI22528454
BCL2hsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI21468550
BCL2hsa-miR-21-5pMirtarbaseexternal_infoWestern blot;OtherFunctional MTI20048743
PYM1hsa-miR-21-5pMirtarbaseexternal_infoQuantitative proteomic approachFunctional MTI (Weak)19253296
TM9SF3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19253296
RTN4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Quantitative proteomic Functional MTI19253296
RPS7hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Quantitative proteomic approachFunctional MTI (Weak)19253296
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20371350
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Western blotFunctional MTI17968323
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17991735
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19682430
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19276261
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19419954
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18850008
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16966691
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19672202
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19342589
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21069438
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18270520
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19836969
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19133651
RPS7hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)18372920
RPS7hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)18591254
JAG1hsa-miR-21-5pMirtarbaseexternal_infoFlow//Immunoblot//Luciferase reporter assay//MicroFunctional MTI19398721
JAG1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22618231
RESThsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19242418
SMARCA4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21317927
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18508928
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI21278789
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23239100
DUSP10hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22387553
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//qRT-PCR//Functional MTI18591254
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20346171
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21820586
SOX5hsa-miR-21-5pMirtarbaseexternal_infoWestern blot//Northern blot//qRT-PCR//Luciferase rFunctional MTI19013014
DOCK7hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22158624
RECKhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20480266
RECKhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI18794849
RECKhsa-miR-21-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assay//Functional MTI18591254
RECKhsa-miR-21-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assayFunctional MTI20154725
RECKhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22630347
PIAS3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22316494
E2F2hsa-miR-21-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//ChIPFunctional MTI (Weak)19528081
FMODhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19906824
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19906824
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI19816956
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18829576
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22072622
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19672202
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19072831
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18850008
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI20216554
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20223231
PTENhsa-miR-21-5pMirtarbaseexternal_infoMicroarray//immunohistochemistryFunctional MTI (Weak)19175831
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI20048743
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20813833
PTENhsa-miR-21-5pMirtarbaseexternal_infoGFP reporter assay//Northern blot//qRT-PCR//WesterFunctional MTI19641183
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//NoFunctional MTI17681183
PTENhsa-miR-21-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blot//Reporter assFunctional MTI16762633
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI20797623
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI20978511
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22267008
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistryNon-Functional MTI (Weak)19473551
PTENhsa-miR-21-5pMirtarbaseexternal_infoELISA//Immunoblot//qRT-PCRFunctional MTI (Weak)22678116
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22956424
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22761812
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI22770403
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22879939
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23226804
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI21544242
E2F1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI19528081
TGFBIhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19136465

Predicted Targets
Summary Value
Count of predictions:19209
Count of gene targets:7868
Count of transcripts:15128
Interacting mature miRNAs:hsa-miR-21-3p, hsa-miR-21-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-64257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,735 - 57,917,824UniSTSGRCh37
Build 361755,272,517 - 55,272,606RGDNCBI36
Celera1754,381,248 - 54,381,337RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,224 - 53,290,313UniSTS
TNG Radiation Hybrid Map1726111.0UniSTS
RH91780  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,788 - 57,917,888UniSTSGRCh37
Build 361755,272,570 - 55,272,670RGDNCBI36
Celera1754,381,301 - 54,381,401RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,277 - 53,290,377UniSTS
GeneMap99-GB4 RH Map17372.1UniSTS
RH102091  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,919,341 - 57,919,465UniSTSGRCh37
GRCh37994,913,462 - 94,913,586UniSTSGRCh37
Build 36993,953,283 - 93,953,407RGDNCBI36
Celera1754,382,854 - 54,382,978UniSTS
Celera965,349,755 - 65,349,879RGD
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map17q23.1UniSTS
HuRef1753,291,830 - 53,291,954UniSTS
HuRef964,591,395 - 64,591,519UniSTS
D17F294S2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37994,913,534 - 94,913,699UniSTSGRCh37
GRCh371757,919,413 - 57,919,578UniSTSGRCh37
Build 36993,953,355 - 93,953,520RGDNCBI36
Celera965,349,827 - 65,349,992RGD
Celera1754,382,926 - 54,383,091UniSTS
Cytogenetic Map17q23.1UniSTS
Cytogenetic Map9q22.31UniSTS
HuRef1753,291,902 - 53,292,067UniSTS
HuRef964,591,467 - 64,591,632UniSTS
RH46129  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,918,157 - 57,918,341UniSTSGRCh37
Build 361755,272,939 - 55,273,123RGDNCBI36
Celera1754,381,670 - 54,381,854RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,646 - 53,290,830UniSTS
GeneMap99-GB4 RH Map17377.81UniSTS
NCBI RH Map17665.5UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
30 32 16 21 61 23 40 2 31 1 21 77 94 46 11 20 33 1

Sequence


Ensembl Acc Id: ENST00000362134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1759,841,266 - 59,841,337 (+)Ensembl
RefSeq Acc Id: NR_029493
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,841,266 - 59,841,337 (+)NCBI
GRCh371757,918,627 - 57,918,698 (+)ENTREZGENE
HuRef1753,291,116 - 53,291,187 (+)ENTREZGENE
CHM1_11757,982,648 - 57,982,719 (+)NCBI
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31586 AgrOrtholog
COSMIC MIR21 COSMIC
Ensembl Genes ENSG00000284190 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362134 ENTREZGENE
GTEx ENSG00000284190 GTEx
HGNC ID HGNC:31586 ENTREZGENE
Human Proteome Map MIR21 Human Proteome Map
miRBase MI0000077 ENTREZGENE
NCBI Gene 406991 ENTREZGENE
OMIM 611020 OMIM
PharmGKB PA164722590 PharmGKB
RNAcentral URS000009262D RNACentral
  URS00000AF93C RNACentral
  URS000039ED8D RNACentral