Faslg (Fas ligand) - Rat Genome Database

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Gene: Faslg (Fas ligand) Rattus norvegicus
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Symbol: Faslg
Name: Fas ligand
RGD ID: 3880
Description: Exhibits death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular ion homeostasis; cellular response to interferon-gamma; and extrinsic apoptotic signaling pathway via death domain receptors. Localizes to caveola; cytoplasmic vesicle; and perinuclear region of cytoplasm. Used to study brain glioma; substance-related disorder; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); chronic obstructive pulmonary disease; gastric ulcer; liver disease (multiple); and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand); Apt1Lg1; CD95 ligand; CD95-L; CD95L protein; Fas antigen ligand; Fas ligand (TNF superfamily, member 6); Fasl; Tnfsf6; Tnlg1a; Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); tumor necrosis factor (ligand) superfamily, member 6; Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); tumor necrosis factor ligand 1a; tumor necrosis factor ligand superfamily member 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: FaslgTn(sb-T2/Bart3)2.325Mcwi  
Genetic Models: F344-FaslgTn(sb-T2/Bart3)2.325Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21374,151,519 - 74,172,760 (-)NCBI
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01379,696,811 - 79,717,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01384,590,119 - 84,605,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,472,950 - 77,480,210 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11377,487,137 - 77,494,398 (-)NCBI
Celera1373,908,438 - 73,915,703 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (ISO)
abdominal aortic aneurysm  (IEP)
Acute Hepatitis  (IEP,ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
aplastic anemia  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type IB  (ISO)
biliary tract benign neoplasm  (ISO)
brain glioma  (IDA)
brain ischemia  (IEP)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholangiocarcinoma  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (IEP)
clonorchiasis  (IEP)
congestive heart failure  (IEP)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Allergic Asthma  (IEP)
Experimental Arthritis  (IMP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Pancreatitis, Acute  (ISO)
familial combined hyperlipidemia  (ISO)
Fetal Growth Retardation  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IEP)
gastrointestinal stromal tumor  (ISO)
Graft vs Host Disease  (IEP,ISO)
HELLP syndrome  (IEP,ISO)
hepatitis  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hypothermia  (IEP)
idiopathic pulmonary fibrosis  (ISO)
infectious mononucleosis  (ISO)
Intestinal Reperfusion Injury  (IEP)
intrahepatic cholangiocarcinoma  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Reperfusion Injury  (IEP)
leiomyoma  (ISO)
limited scleroderma  (ISO)
liver disease  (IEP)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IMP)
lung cancer  (ISS)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (IEP,ISO)
pre-eclampsia  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
seminoma  (ISO)
Sepsis  (IEP)
Spinal Cord Compression  (ISO)
substance-related disorder  (IDA)
testicular disease  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (IDA,ISO,ISS)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (IEP)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(E)-roxithromycin  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (EXP)
2,6-dichloroindophenol  (ISO)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP)
adenosine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
andrographolide  (ISO)
androst-4-ene-3,17-dione  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP,ISO)
bafilomycin A1  (EXP,ISO)
benazepril  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bufalin  (ISO)
busulfan  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (EXP)
capsaicin  (EXP)
capsazepine  (ISO)
carbachol  (ISO)
carbamazepine  (ISO)
carbon disulfide  (EXP)
carbon nanotube  (ISO)
carvedilol  (ISO)
casticin  (ISO)
catechol  (ISO)
CCCP  (EXP)
celastrol  (ISO)
celecoxib  (EXP)
chloramphenicol  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (ISO)
chrysazin  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
coformycin  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (EXP)
DDE  (EXP)
DDT  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
dibromoacetic acid  (ISO)
dichlorvos  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioscin  (ISO)
dioxygen  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
enalapril  (EXP)
esculetin  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fenvalerate  (EXP)
fisetin  (ISO)
flavanone  (ISO)
flavonoids  (EXP,ISO)
flucloxacillin  (ISO)
flutamide  (EXP)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gefitinib  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
hexachlorobenzene  (EXP)
hydralazine  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyurea  (ISO)
hyperforin  (ISO)
idelalisib  (ISO)
ifosfamide  (ISO)
inosine  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP)
L-methionine  (ISO)
lansoprazole  (EXP)
lenalidomide  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
lovastatin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
magnesium oxide  (ISO)
mancozeb  (ISO)
manganese(II) chloride  (EXP)
Manumycin A  (ISO)
masoprocol  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
mifepristone  (ISO)
mitogen  (ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naproxen  (EXP)
nickel atom  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nimustine  (ISO)
nitric oxide  (ISO)
nitrobenzene  (ISO)
nocodazole  (ISO)
Nodularin  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
octreotide  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
pentobarbital  (EXP)
pepstatin A  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (ISO)
platycodin D  (ISO)
probenecid  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
regorafenib  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
Roridin A  (ISO)
ryanodine  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
swainsonine  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrazolium violet  (ISO)
thalidomide  (ISO)
thiosalicylic acid  (EXP)
thymidine  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimethylarsine oxide  (EXP)
trimethyltin  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
uranium atom  (EXP)
uridine  (ISO)
usnic acid  (ISO)
valsartan  (EXP)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vinorelbine  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zearalenone  (EXP)
zidovudine  (EXP,ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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81. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:7511063   PMID:10588860   PMID:11101870   PMID:12201652   PMID:12477972   PMID:12761501   PMID:14517994   PMID:14576824   PMID:14679192   PMID:14749367   PMID:15039234   PMID:15379972  
PMID:15507796   PMID:15555619   PMID:15629131   PMID:15799720   PMID:16033886   PMID:16226958   PMID:16318909   PMID:16831245   PMID:16921742   PMID:16973387   PMID:17045251   PMID:17053043  
PMID:17076679   PMID:17098047   PMID:17105443   PMID:17241545   PMID:17557115   PMID:17615270   PMID:17658509   PMID:17684774   PMID:18204739   PMID:18246871   PMID:18292530   PMID:18293083  
PMID:18392917   PMID:18726999   PMID:18835034   PMID:19005073   PMID:19239001   PMID:19304523   PMID:19364818   PMID:19407976   PMID:19567205   PMID:20404348   PMID:20406899   PMID:20620473  
PMID:20840605   PMID:21586345   PMID:21625644   PMID:21792649   PMID:22325471   PMID:22609371   PMID:22664023   PMID:22891283   PMID:22892327   PMID:22904205   PMID:22907769   PMID:23711477  
PMID:23806367   PMID:23934924   PMID:23940767   PMID:23949220   PMID:24297385   PMID:24631528   PMID:25294749   PMID:25428397   PMID:25439027   PMID:26519036   PMID:26582200   PMID:26646413  
PMID:27606894   PMID:28722192   PMID:29738767   PMID:29891925   PMID:31416448   PMID:31782491  


Genomics

Comparative Map Data
Faslg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21374,151,519 - 74,172,760 (-)NCBI
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01379,696,811 - 79,717,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01384,590,119 - 84,605,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,472,950 - 77,480,210 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11377,487,137 - 77,494,398 (-)NCBI
Celera1373,908,438 - 73,915,703 (-)NCBICelera
Cytogenetic Map13q22NCBI
FASLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBI
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,459 - 174,058,323 (+)NCBICHM1_1
Fasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,608,260 - 161,616,064 (-)NCBIGRCm39mm39
GRCm39 Ensembl1161,608,258 - 161,616,064 (-)Ensembl
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBImm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
Faslg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,098,662 - 13,107,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,098,479 - 13,107,045 (+)NCBIChiLan1.0ChiLan1.0
FASLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11151,868,430 - 151,876,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1151,868,430 - 151,876,281 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01148,159,826 - 148,167,785 (+)NCBIMhudiblu_PPA_v0panPan3
FASLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,335,837 - 26,344,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,335,846 - 26,344,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,866,683 - 25,875,068 (-)NCBI
ROS_Cfam_1.0726,086,377 - 26,094,750 (-)NCBI
UMICH_Zoey_3.1725,997,538 - 26,005,908 (-)NCBI
UNSW_CanFamBas_1.0726,067,461 - 26,075,850 (-)NCBI
UU_Cfam_GSD_1.0726,217,995 - 26,226,386 (-)NCBI
Faslg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,942,494 - 96,949,833 (-)NCBI
SpeTri2.0NW_00493648114,789,547 - 14,795,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,068,090 - 115,076,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,641,066 - 126,647,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASLG
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12556,488,572 - 56,496,469 (-)NCBI
ChlSab1.1 Ensembl2556,489,417 - 56,496,251 (-)Ensembl
Faslg
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247719,031,978 - 9,038,760 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)136450135182995671Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136500824591629354Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)137456837882995671Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137456837892916783Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137456837892916783Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137456837892916783Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137956708186833540Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat


Genetic Models
This gene Faslg is modified in the following models/strains
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir21rno-miR-21-5pMirtarbaseexternal_infoImmunofluorescence//In situ hybridization//LuciferFunctional MTI20840605

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:81
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000003998
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 3 2
Low 2 19 32 20 16 20 72 17 31 9
Below cutoff 1 21 23 20 20 8 8 2 18 9 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003998   ⟹   ENSRNOP00000003998
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)Ensembl
RefSeq Acc Id: NM_012908   ⟹   NP_037040
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21374,154,954 - 74,162,215 (-)NCBI
Rnor_6.01379,698,445 - 79,705,705 (-)NCBI
Rnor_5.01384,590,119 - 84,605,900 (-)NCBI
RGSC_v3.41377,472,950 - 77,480,210 (-)RGD
Celera1373,908,438 - 73,915,703 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250148   ⟹   XP_006250210
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01379,696,811 - 79,717,581 (-)NCBI
Rnor_5.01384,590,119 - 84,605,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769607   ⟹   XP_008767829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01379,696,811 - 79,717,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598675   ⟹   XP_017454164
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21374,151,519 - 74,172,760 (-)NCBI
Rnor_6.01379,696,811 - 79,716,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598676   ⟹   XP_017454165
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01379,699,469 - 79,717,581 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037040 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454164 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52129 (Get FASTA)   NCBI Sequence Viewer  
  CTQ86170 (Get FASTA)   NCBI Sequence Viewer  
  EDM09413 (Get FASTA)   NCBI Sequence Viewer  
  P36940 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037040   ⟸   NM_012908
- UniProtKB: P36940 (UniProtKB/Swiss-Prot),   A0A0U5J7X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250210   ⟸   XM_006250148
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008767829   ⟸   XM_008769607
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454164   ⟸   XM_017598675
- Peptide Label: isoform X1
- UniProtKB: P36940 (UniProtKB/Swiss-Prot),   A0A0U5J7X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454165   ⟸   XM_017598676
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000003998   ⟸   ENSRNOT00000003998
Protein Domains
TNF_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3880 AgrOrtholog
Ensembl Genes ENSRNOG00000002978 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003998 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003998 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FASL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25385 ENTREZGENE
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Faslg PhenoGen
PRINTS FASLIGAND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U5J7X8 ENTREZGENE, UniProtKB/TrEMBL
  P36940 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Faslg  Fas ligand (TNF superfamily, member 6)  Fasl  Fas ligand (TNF superfamily, member 6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Fasl  Fas ligand (TNF superfamily, member 6)  Faslg  Fas ligand (TNF superfamily, member 6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Faslg  Fas ligand (TNF superfamily, member 6)  Tnfsf6  tumor necrosis factor (ligand) superfamily, member 6  Symbol and Name updated 1299863 APPROVED
2002-06-10 Tnfsf6  tumor necrosis factor (ligand) superfamily, member 6      Name updated 70584 APPROVED
2002-02-06 Fasl  Fas antigen ligand      Fasl withdrawn and merged with Tnfsf6 (RGD:3880) 68913 WITHDRAWN
2001-06-22 Tnfsf6  Tumor necrosis factor (ligand) superfamily, member 6      Name updated, removed withdrawn gene name text 67952 APPROVED
2001-06-22 Apt1Lg1  Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)      Symbol withdrawn, duplicate of Tnfsf6 (RGD:3880) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression increases in response to hydrogen peroxide 730260