Fasl (Fas ligand) - Rat Genome Database

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Gene: Fasl (Fas ligand) Mus musculus
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Symbol: Fasl
Name: Fas ligand
RGD ID: 1553064
MGI Page MGI
Description: Predicted to enable cytokine activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APT1; APT1LG1; CD178; CD95; CD95 ligand; CD95-L; CD95L; F; Fa; Fas antigen ligand; Fas ligand (TNF superfamily, member 6); Fas-L; Fas-Ligand; Faslg; generalized lymphoproliferative disease; gld; Tnfs; Tnfsf6; Tnlg1a; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand 1a; tumor necrosis factor ligand superfamily member 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,608,260 - 161,616,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,608,258 - 161,616,064 (-)EnsemblGRCm39 Ensembl
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBIMGSCv36mm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (ISO)
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (IEP,IMP)
Acute Hepatitis  (ISO)
Acute Liver Failure  (IEP,ISO)
Acute Lung Injury  (ISO)
aplastic anemia  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
autoimmune hepatitis  (IEP)
autoimmune lymphoproliferative syndrome  (IAGP,ISO)
Autoimmune Lymphoproliferative Syndrome, Type IB  (ISO)
biliary tract benign neoplasm  (ISO)
brain glioma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (EXP,ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholangiocarcinoma  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clonorchiasis  (ISO)
congestive heart failure  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
Fetal Growth Retardation  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (ISO)
graft-versus-host disease  (ISO)
HELLP syndrome  (ISO)
hepatitis  (IMP,ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (IMP)
Immunodeficiency 98 with Autoinflammation, X-Linked  (ISO)
infectious mononucleosis  (ISO)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Reperfusion Injury  (ISO)
leiomyoma  (ISO)
limited scleroderma  (IMP)
liver disease  (ISO)
Liver Injury  (IEP)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
Necrosis  (EXP)
Neoplasm Metastasis  (ISO)
Oxygen-Induced Retinopathy  (IMP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
pre-eclampsia  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (IAGP,IDA)
rheumatoid arthritis  (ISO)
seminoma  (ISO)
Sepsis  (ISO)
Spinal Cord Compression  (IMP,ISO)
substance-related disorder  (ISO)
testicular disease  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IAGP,ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-roxithromycin  (ISO)
(R)-adrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (ISO)
2,6-dichloroindophenol  (ISO)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitro-m-cresol  (EXP,ISO)
4-nonylphenol  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (EXP)
8-Br-cAMP  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
adenosine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
andrographolide  (ISO)
androst-4-ene-3,17-dione  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
bafilomycin A1  (EXP,ISO)
benazepril  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
bufalin  (ISO)
busulfan  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
candesartan  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
capsazepine  (EXP)
carbachol  (ISO)
carbamazepine  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
casticin  (ISO)
catechol  (ISO)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chloramphenicol  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (EXP)
chrysazin  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (EXP)
clozapine  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
coformycin  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibromoacetic acid  (EXP)
Dibutyl phosphate  (ISO)
dichlorvos  (EXP)
diclofenac  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydroxyacetone  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioscin  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
elemental selenium  (ISO)
emodin  (ISO)
enalapril  (ISO)
esculetin  (ISO)
ethanol  (ISO)
etoposide  (EXP,ISO)
Evodiamine  (ISO)
fenvalerate  (ISO)
fisetin  (ISO)
flavanone  (ISO)
flavonoids  (EXP,ISO)
flucloxacillin  (EXP)
flutamide  (ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
furosemide  (ISO)
Fusarenone X  (EXP)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycidol  (ISO)
glyphosate  (EXP)
hexachlorobenzene  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyurea  (EXP)
hyperforin  (ISO)
idelalisib  (ISO)
ifosfamide  (ISO)
inosine  (ISO)
ionomycin  (ISO)
irinotecan  (EXP,ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
L-methionine  (EXP)
lansoprazole  (ISO)
lenalidomide  (EXP)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
lovastatin  (ISO)
lupulone  (ISO)
LY294002  (ISO)
lycopene  (ISO)
magnesium oxide  (ISO)
manganese(II) chloride  (ISO)
manumycin A  (EXP)
masoprocol  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
mifepristone  (ISO)
mitogen  (ISO)
mitomycin C  (ISO)
Mitotane  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
morin  (ISO)
morphine  (EXP)
Myrtucommulone A  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naproxen  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (EXP)
nimustine  (ISO)
nitric oxide  (ISO)
nitrobenzene  (EXP)
nocodazole  (ISO)
Nodularin  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octreotide  (ISO)
ouabain  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
pentobarbital  (ISO)
pepstatin A  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (ISO)
platycodin D  (ISO)
probenecid  (EXP)
propanal  (ISO)
prostaglandin E2  (EXP)
pterostilbene  (EXP)
puerarin  (ISO)
pyrethrins  (ISO)
pyruvic acid  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
ritonavir  (ISO)
Roridin A  (EXP)
ryanodine  (EXP)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (ISO)
sanguinarine  (ISO)
SB 203580  (EXP,ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sumatriptan  (ISO)
swainsonine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrazolium violet  (EXP)
thalidomide  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
thiosalicylic acid  (ISO)
thymidine  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trimethylarsine oxide  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
Tungsten carbide  (ISO)
uranium atom  (ISO)
uridine  (ISO)
usnic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vinorelbine  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cytotoxic T cell physiology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal double-negative T cell morphology  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal humoral immune response  (IEA)
abnormal interleukin level  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal male germ cell apoptosis  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retina ganglion cell morphology  (IAGP)
abnormal retina nerve fiber layer morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal thymus cell ratio  (IAGP)
anemia  (IAGP)
atherosclerotic lesions  (IAGP)
autoimmune response  (IAGP)
blood vessel inflammation  (IAGP)
brain inflammation  (IAGP)
CNS inflammation  (IAGP)
decreased B cell number  (IEA)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased granulocyte number  (IAGP)
decreased hepatocyte apoptosis  (IAGP)
decreased IgG level  (IEA)
decreased neuron apoptosis  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased susceptibility to injury  (IAGP)
demyelination  (IAGP)
dermatitis  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
eye inflammation  (IAGP)
focal hepatic necrosis  (IAGP)
glomerular crescent  (IAGP)
glomerulonephritis  (IAGP)
impaired humoral immune response  (IEA)
impaired macrophage phagocytosis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased apoptosis  (IAGP)
increased autoantibody level  (IAGP)
increased B cell proliferation  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased germinal center B cell number  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver tumor incidence  (IAGP)
increased lymphocyte cell number  (IAGP)
increased lymphoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased neutrophil cell number  (IAGP)
increased plasma cell number  (IAGP)
increased retina apoptosis  (IAGP)
increased sperm number  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to Picornaviridae infection  (IAGP)
increased susceptibility to systemic lupus erythematosus  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
increased urine protein level  (IAGP)
interstitial pneumonia  (IAGP)
kidney inflammation  (IAGP)
liver inflammation  (IAGP)
lymphoid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
renal cast  (IAGP)
retina ganglion cell degeneration  (IAGP)
skin edema  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4-induced hepatitis. null
2. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
3. Expression of Fas and Fas ligand in human testicular germ cell tumours. Baldini E, etal., Int J Androl. 2007 Oct 3;.
4. Fas/Fas-ligand expressions in primary breast cancer are significant predictors of its skeletal spread. Bebenek M, etal., Anticancer Res. 2007 Jan-Feb;27(1A):215-8.
5. Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression. Chopin D, etal., Am J Pathol. 2003 Apr;162(4):1139-49.
6. Fas/Fas-Ligand pathway is impaired in patients with type 2 diabetes. Influence of hypertension and insulin resistance. Cosson E, etal., Diabetes Metab. 2005 Feb;31(1):47-54.
7. Fas and Fas ligand expression in cystic fibrosis airway epithelium. Durieu I, etal., Thorax. 1999 Dec;54(12):1093-8.
8. Association of promoter polymorphisms of Fas -FasL genes with development of Chronic Myeloid Leukemia. Edathara PM, etal., Tumour Biol. 2015 Nov 13.
9. Human pancreatic cancer cells express non-functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape. Elnemr A, etal., Int J Oncol. 2001 Jan;18(1):33-9.
10. Serum levels of soluble molecules associated with evasion of immune surveillance: a study in biliary disease. Enjoji M, etal., Liver Int. 2004 Aug;24(4):330-4.
11. IL-18-binding protein protects against lipopolysaccharide- induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice. Faggioni R, etal., J Immunol. 2001 Nov 15;167(10):5913-20.
12. Fas and Fas-L expression in Huntington's disease and Parkinson's disease. Ferrer I, etal., Neuropathol Appl Neurobiol. 2000 Oct;26(5):424-33.
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PMID:21819958   PMID:21873635   PMID:21918502   PMID:21964609   PMID:21966366   PMID:21978769   PMID:22022540   PMID:22075702   PMID:22099756   PMID:22156346   PMID:22175699   PMID:22183068  
PMID:22197557   PMID:22205032   PMID:22212899   PMID:22312128   PMID:22327073   PMID:22403281   PMID:22438562   PMID:22461695   PMID:22509080   PMID:22535954   PMID:22542159   PMID:22573809  
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Genomics

Comparative Map Data
Fasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,608,260 - 161,616,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,608,258 - 161,616,064 (-)EnsemblGRCm39 Ensembl
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBIMGSCv36mm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
FASLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36Build 36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,496 - 174,058,323 (+)NCBICHM1_1
T2T-CHM13v2.01172,016,214 - 172,023,987 (+)NCBIT2T-CHM13v2.0
Faslg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,680,885 - 76,706,042 (-)NCBIGRCr8
mRatBN7.21374,151,519 - 74,172,760 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,154,954 - 74,162,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,724,620 - 76,731,883 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,031,667 - 78,038,929 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,291,523 - 75,298,787 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,696,811 - 79,717,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01384,590,119 - 84,605,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,472,950 - 77,480,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11377,487,137 - 77,494,398 (-)NCBI
Celera1373,908,438 - 73,915,703 (-)NCBICelera
Cytogenetic Map13q22NCBI
Faslg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,098,662 - 13,107,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,098,479 - 13,107,045 (+)NCBIChiLan1.0ChiLan1.0
FASLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2177,076,483 - 77,084,478 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1176,756,472 - 76,764,434 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,159,826 - 148,167,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11151,868,430 - 151,876,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1151,868,430 - 151,876,281 (+)Ensemblpanpan1.1panPan2
FASLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,335,837 - 26,344,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,335,846 - 26,344,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,866,683 - 25,875,068 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0726,086,377 - 26,094,750 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl726,086,386 - 26,094,750 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,997,538 - 26,005,908 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0726,067,461 - 26,075,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0726,217,995 - 26,226,386 (-)NCBIUU_Cfam_GSD_1.0
Faslg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,942,494 - 96,949,833 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648114,789,547 - 14,795,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,068,090 - 115,076,464 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,641,066 - 126,647,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12556,488,572 - 56,496,469 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2556,489,417 - 56,496,251 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605558,094,483 - 58,102,557 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Faslg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)So