Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Fasl (Fas ligand (TNF superfamily, member 6)) Mus musculus
Symbol: Fasl
Name: Fas ligand (TNF superfamily, member 6)
RGD ID: 1553064
Description: Predicted to have death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Localizes to external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: APT1; APT1LG1; CD178; CD95; CD95 ligand; CD95-L; CD95L; F; Fa; Fas antigen ligand; Fas-L; Fas-Ligand; Faslg; generalized lymphoproliferative disease; gld; Tnfs; Tnfsf6; Tnlg1a; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand 1a; tumor necrosis factor ligand superfamily member 6
Homo sapiens (human) : FASLG (Fas ligand)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Faslg (Fas ligand)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Faslg (Fas ligand)
Pan paniscus (bonobo/pygmy chimpanzee) : FASLG (Fas ligand)
Canis lupus familiaris (dog) : FASLG (Fas ligand)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Faslg (Fas ligand)
Sus scrofa (pig) : FASLG (Fas ligand (TNF superfamily, member 6))
Chlorocebus sabaeus (African green monkey) : FASLG (Fas ligand)
Heterocephalus glaber (naked mole-rat) : Faslg (Fas ligand)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391161,608,260 - 161,616,064 (-)NCBI
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBImm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fasl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553064
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.