FASLG (Fas ligand) - Rat Genome Database

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Gene: FASLG (Fas ligand) Sus scrofa
Analyze
Symbol: FASLG
Name: Fas ligand
RGD ID: 14241291
Description: ENCODES a protein that exhibits death receptor binding (ortholog); tumor necrosis factor receptor binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); apoptotic signaling pathway (ortholog); cellular chloride ion homeostasis (ortholog); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); cytoplasmic vesicle (ortholog); INTERACTS WITH cilastatin; cisplatin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CD95 ligand; CD95-L; fas antigen ligand; Fas ligand (TNF superfamily, member 6); FASL; TNFSF6; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,068,090 - 115,076,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,641,066 - 126,647,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (ISO)
abdominal aortic aneurysm  (ISO)
Acute Hepatitis  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
atherosclerosis  (ISO)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type IB  (ISO)
biliary tract benign neoplasm  (ISO)
brain glioma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholangiocarcinoma  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clonorchiasis  (ISO)
congestive heart failure  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Pancreatitis, Acute  (ISO)
familial combined hyperlipidemia  (ISO)
Fetal Growth Retardation  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (ISO)
Graft vs Host Disease  (ISO)
HELLP syndrome  (ISO)
hepatitis  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
infectious mononucleosis  (ISO)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Reperfusion Injury  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
pre-eclampsia  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
seminoma  (ISO)
Sepsis  (ISO)
Spinal Cord Compression  (ISO)
substance-related disorder  (ISO)
testicular disease  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cilastatin  (EXP)
cisplatin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11429161   PMID:11792426   PMID:12371937   PMID:15303979   PMID:16365405   PMID:17321702   PMID:18503890   PMID:25177944  


Genomics

Comparative Map Data
FASLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,068,090 - 115,076,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,641,066 - 126,647,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBI
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,459 - 174,058,323 (+)NCBICHM1_1
Fasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,608,260 - 161,616,064 (-)NCBIGRCm39mm39
GRCm39 Ensembl1161,608,258 - 161,616,064 (-)Ensembl
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBImm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
Faslg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21374,151,519 - 74,172,760 (-)NCBI
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01379,696,811 - 79,717,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01384,590,119 - 84,605,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,472,950 - 77,480,210 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11377,487,137 - 77,494,398 (-)NCBI
Celera1373,908,438 - 73,915,703 (-)NCBICelera
Cytogenetic Map13q22NCBI
Faslg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,098,662 - 13,107,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,098,479 - 13,107,045 (+)NCBIChiLan1.0ChiLan1.0
FASLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11151,868,430 - 151,876,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1151,868,430 - 151,876,281 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01148,159,826 - 148,167,785 (+)NCBIMhudiblu_PPA_v0panPan3
FASLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,335,837 - 26,344,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,335,846 - 26,344,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,866,683 - 25,875,068 (-)NCBI
ROS_Cfam_1.0726,086,377 - 26,094,750 (-)NCBI
UMICH_Zoey_3.1725,997,538 - 26,005,908 (-)NCBI
UNSW_CanFamBas_1.0726,067,461 - 26,075,850 (-)NCBI
UU_Cfam_GSD_1.0726,217,995 - 26,226,386 (-)NCBI
Faslg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,942,494 - 96,949,833 (-)NCBI
SpeTri2.0NW_00493648114,789,547 - 14,795,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASLG
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12556,488,572 - 56,496,469 (-)NCBI
ChlSab1.1 Ensembl2556,489,417 - 56,496,251 (-)Ensembl
Faslg
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247719,031,978 - 9,038,760 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 5 1 2 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026331   ⟹   ENSSSCP00000019767
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9115,068,090 - 115,076,475 (+)Ensembl
RefSeq Acc Id: NM_213806   ⟹   NP_998971
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_998971   ⟸   NM_213806
- UniProtKB: Q9BEA8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000019767   ⟸   ENSSSCT00000026331
Protein Domains
TNF_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000019767 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026331 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FASL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396726 UniProtKB/Swiss-Prot
NCBI Gene FASLG ENTREZGENE
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FASLIGAND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNECROSISFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt I3L6W5_PIG UniProtKB/TrEMBL
  Q9BEA8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q95M04 UniProtKB/Swiss-Prot
  Q95N10 UniProtKB/Swiss-Prot
VGNC ID VGNC:103942 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-18 FASLG  Fas ligand  FASLG  Fas ligand (TNF superfamily, member 6)  Symbol and/or name change 19259463 PROVISIONAL