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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDQuercetin results in decreased expression of FASLG mRNA

PMID:10925121
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of FASLG mRNA], Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of FASLG protein]

PMID:24316378
increases expressionISORGD:16063426480464CTDQuercetin results in increased expression of FASLG mRNA, Quercetin results in increased expression of FASLG protein

PMID:21165570, PMID:24299158, PMID:25293876, PMID:30152185
multiple interactionsISORGD:16063426480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of FASLG protein], pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of FASLG protein]

PMID:21165570
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.