Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageISORGD:16063426480464CTDresveratrol results in increased cleavage of FASLG protein

PMID:22644961
increases expressionISORGD:15530646480464CTDresveratrol results in increased expression of FASL protein

PMID:17872969
increases expressionISORGD:16063426480464CTDresveratrol analog results in increased expression of FASLG mRNA, resveratrol results in increased expression of FASLG mRNA, resveratrol results in increased expression of FASLG protein

PMID:15217905, PMID:20717957, PMID:24044363, PMID:24299158, PMID:9680369
multiple interactionsISORGD:16063426480464CTDresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA], resveratrol promotes the reaction [FOXO3 protein binds to FASLG promoter], SB 203580 promotes the reaction [resveratrol results in increased cleavage of FASLG protein]

PMID:17513867, PMID:22644961, PMID:23452621
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.