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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCisplatin results in increased expression of FASLG mRNA

PMID:12684229
multiple interactionsEXP 6480464CTD1, 3-dimethylthiourea inhibits the reaction [Cisplatin results in increased expression of FASLG mRNA]

PMID:12684229
increases expressionISORGD:16063426480464CTDCisplatin results in increased expression of FASLG mRNA, Cisplatin results in increased expression of FASLG protein

PMID:16957513, PMID:20878077, PMID:21216935
increases response to substanceISORGD:15530646480464CTDFASL protein results in increased susceptibility to Cisplatin

PMID:9182976
multiple interactionsISORGD:15530646480464CTD[Cisplatin co-treated with vinorelbine] results in decreased expression of FASL mRNA

PMID:21544650
multiple interactionsISORGD:16063426480464CTD[andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein], [andrographolide co-treated with Cisplatin] results in increased expression of FASLG mRNA, [andrographolide co-treated with Cisplatin] results in increased expression of FASLG protein, [Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein, [Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein, [Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein, [Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein, [Cisplatin co-treated with fisetin] results in increased expression of FASLG protein, [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin, Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein], Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein], Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein], Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein], BCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein], BCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein], BCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein], benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein], benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein], benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein], Y 27632 inhibits the reaction [Cisplatin results in increased expression of FASLG mRNA]

PMID:17574045, PMID:20878077, PMID:21216935, PMID:21509038, PMID:24563380
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.