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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDNicotine affects the expression of FASLG mRNA

PMID:20426880
increases expressionEXP 6480464CTDNicotine results in increased expression of FASLG protein alternative form

PMID:18203686
increases expressionISORGD:16063426480464CTDNicotine results in increased expression of FASLG mRNA, Nicotine results in increased expression of FASLG protein

PMID:18247414, PMID:19896492, PMID:20383341
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.