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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTestosterone deficiency results in decreased expression of FASLG protein

PMID:20850791
increases expressionEXP 6480464CTDTestosterone results in increased expression of FASLG mRNA

PMID:24658017
multiple interactionsEXP 6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased expression of FASLG mRNA], Flutamide inhibits the reaction [Testosterone results in increased expression of FASLG mRNA], Testosterone inhibits the reaction [Diethylstilbestrol results in increased expression of FASLG protein], tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Testosterone results in increased expression of FASLG mRNA]

PMID:12477725, PMID:24658017
multiple interactionsISORGD:16063426480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with Testosterone] results in increased expression of FASLG mRNA, [Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with Testosterone] results in increased expression of FASLG protein

PMID:20529085
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.