FASLG (Fas ligand) - Rat Genome Database

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Gene: FASLG (Fas ligand) Homo sapiens
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Symbol: FASLG
Name: Fas ligand
RGD ID: 1606342
HGNC Page HGNC:11936
Description: Enables cytokine activity. Involved in several processes, including necroptotic signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of endothelial cell apoptotic process. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Located in extracellular exosome; nucleus; and plasma membrane. Is active in extracellular space. Implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; pancreatic cancer (multiple); pre-eclampsia (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including bone marrow cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; clonorchiasis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ALPS1B; apoptosis (APO-1) antigen ligand 1; apoptosis antigen ligand; APT1LG1; APTL; CD178; CD95 ligand; CD95-L; CD95L; fas antigen ligand; Fas ligand (TNF superfamily, member 6); FASL; mutant tumor necrosis factor family member 6; TNFSF6; TNLG1A; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand 1A; tumor necrosis factor ligand superfamily member 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36Build 36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,496 - 174,058,323 (+)NCBICHM1_1
T2T-CHM13v2.01172,016,214 - 172,023,987 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (IAGP)
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (IEP,ISO)
Acute Liver Failure  (EXP,IEP,ISO)
Acute Lung Injury  (EXP)
atherosclerosis  (EXP)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (EXP,IAGP,ISS)
Autoimmune Lymphoproliferative Syndrome, Type IB  (IAGP)
biliary tract benign neoplasm  (IEP)
brain glioma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (IAGP,IEP)
cardiomyopathy  (EXP)
Cardiotoxicity  (EXP,ISO)
carotid artery disease  (EXP)
cervix uteri carcinoma in situ  (IEP)
cholangiocarcinoma  (IDA)
chronic myeloid leukemia  (IAGP)
chronic obstructive pulmonary disease  (ISO)
clonorchiasis  (IEP)
congestive heart failure  (ISO)
cystic fibrosis  (IEP)
diabetic angiopathy  (EXP,IEP)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (EXP)
drug allergy  (EXP)
Esophageal Neoplasms  (IEP)
Experimental Allergic Asthma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (EXP)
Fetal Growth Retardation  (IEP)
Gallbladder Neoplasms  (IEP)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (IAGP)
graft-versus-host disease  (IEP,ISO)
HELLP syndrome  (IAGP,ISO)
hepatitis  (EXP,ISO)
hepatitis B  (IEP)
hepatocellular carcinoma  (IEP)
Huntington's disease  (IEP)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Immunodeficiency 98 with Autoinflammation, X-Linked  (IAGP)
infectious mononucleosis  (IEP)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (IEP)
invasive lobular carcinoma  (IEP)
Kidney Reperfusion Injury  (ISO)
leiomyoma  (IEP)
limited scleroderma  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (IAGP)
Lung Injury  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (EXP)
melanoma  (EXP,IAGP)
multiple myeloma  (IEP)
multiple sclerosis  (EXP,IAGP)
myelodysplastic syndrome  (IEP)
Necrosis  (ISO)
Neoplasm Metastasis  (IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (IAGP,IDA,IEP)
pancreatic ductal carcinoma  (IDA,IEP)
parathyroid carcinoma  (IAGP)
Parkinson's disease  (IEP,ISO)
pre-eclampsia  (IAGP)
Prostatic Neoplasms  (EXP)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (EXP)
seminoma  (IEP)
Sepsis  (ISO)
Spinal Cord Compression  (IEP,ISO)
substance-related disorder  (ISO)
testicular disease  (EXP)
transitional cell carcinoma  (IEP)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IEP,ISO,ISS)
type 2 diabetes mellitus  (IAGP)
ulcerative colitis  (ISO)
urinary bladder cancer  (IAGP)
Uterine Cervical Neoplasms  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-roxithromycin  (EXP)
(R)-adrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (ISO)
2,6-dichloroindophenol  (EXP)
2-naphthylamine  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-nitro-m-cresol  (EXP,ISO)
4-nonylphenol  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (EXP)
9-Methoxycamptothecin  (EXP)
[6]-Shogaol  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
adenosine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-acitretin  (EXP)
all-trans-retinoic acid  (EXP)
Aloe emodin  (EXP)
alpha-naphthoflavone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
andrographolide  (EXP)
androst-4-ene-3,17-dione  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
arecoline  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
atenolol  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
bafilomycin A1  (ISO)
benazepril  (ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP)
Benzo[k]fluoranthene  (ISO)
berberine  (EXP)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
bufalin  (EXP)
busulfan  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbachol  (EXP)
carbamazepine  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
casticin  (EXP)
catechol  (EXP)
CCCP  (ISO)
celastrol  (EXP)
celecoxib  (ISO)
chloramphenicol  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chrysazin  (EXP)
chrysin  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
clozapine  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP)
coenzyme Q10  (ISO)
coformycin  (ISO)
copper(II) sulfate  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibromoacetic acid  (ISO)
Dibutyl phosphate  (EXP)
dichlorvos  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dihydroxyacetone  (EXP)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (EXP)
dioxygen  (EXP)
disulfiram  (EXP)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental selenium  (EXP)
emodin  (EXP)
enalapril  (ISO)
esculetin  (EXP)
ethanol  (EXP,ISO)
etoposide  (EXP,ISO)
Evodiamine  (EXP)
fenpropathrin  (ISO)
fenvalerate  (ISO)
fisetin  (EXP)
flavanone  (EXP)
flavonoids  (ISO)
flucloxacillin  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP)
furan  (ISO)
furosemide  (ISO)
Fusarenone X  (ISO)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (EXP)
Geniposide pentaacetate  (ISO)
genistein  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycidol  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (ISO)
hydralazine  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxyurea  (ISO)
hyperforin  (EXP)
idelalisib  (EXP)
ifosfamide  (EXP)
inosine  (EXP)
ionomycin  (EXP)
irinotecan  (EXP,ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lenalidomide  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
lovastatin  (EXP)
lupulone  (EXP)
LY294002  (EXP)
lycopene  (EXP)
magnesium oxide  (EXP)
manganese(II) chloride  (ISO)
manumycin A  (ISO)
masoprocol  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
mifepristone  (EXP)
mitogen  (EXP)
mitomycin C  (EXP)
Mitotane  (ISO)
MK 571  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
morphine  (ISO)
Myrtucommulone A  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naproxen  (ISO)
nickel atom  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nimustine  (EXP)
nitric oxide  (EXP)
nitrobenzene  (ISO)
nocodazole  (EXP)
Nodularin  (EXP)
NS-398  (EXP)
Nutlin-3  (EXP)
ochratoxin A  (ISO)
octreotide  (EXP)
ouabain  (EXP)
ozone  (ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
pentobarbital  (ISO)
pepstatin A  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenol  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phylloquinone  (EXP)
platycodin D  (EXP)
probenecid  (ISO)
propanal  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyrethrins  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
rebaudioside A  (EXP)
regorafenib  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
ritonavir  (EXP)
Roridin A  (ISO)
ryanodine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
S-nitrosoglutathione  (EXP)
sanguinarine  (EXP)
SB 203580  (EXP,ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
sorafenib  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP)
sumatriptan  (ISO)
swainsonine  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
telmisartan  (ISO)
temozolomide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetrazolium violet  (ISO)
thalidomide  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
thioacetamide  (ISO)
thiosalicylic acid  (ISO)
thymidine  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trimethylarsine oxide  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
Tungsten carbide  (EXP)
uranium atom  (ISO)
uridine  (EXP)
usnic acid  (EXP)
valsartan  (ISO)
vanadyl sulfate  (EXP)
vanillin  (ISO)
vemurafenib  (EXP)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vinorelbine  (ISO)
vorinostat  (EXP)
wortmannin  (EXP)
Y-27632  (EXP)
zearalenone  (ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,TAS)
apoptotic signaling pathway  (IDA,IEA,IMP,ISO)
cell communication  (IEA)
cell-cell signaling  (TAS)
cellular response to type II interferon  (IEA,ISO)
endosomal lumen acidification  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IDA)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA,IDA,IEA,ISO)
immune response  (IEA)
inflammatory cell apoptotic process  (IEA,ISO)
intracellular chloride ion homeostasis  (IEA,ISO)
necroptotic process  (IDA)
necroptotic signaling pathway  (IDA)
negative regulation of angiogenesis  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA)
positive regulation of apoptotic process  (IDA)
positive regulation of canonical NF-kappaB signal transduction  (IBA,IEP)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cysteine-type endopeptidase activity  (IGI)
positive regulation of endothelial cell apoptotic process  (IDA)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IBA)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of phosphatidylserine exposure on apoptotic cell surface  (IDA)
release of sequestered calcium ion into cytosol by endoplasmic reticulum  (IDA)
response to growth factor  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
retinal cell programmed cell death  (IEA,ISO)
signal transduction  (IEA,TAS)
signaling  (IEA)
T cell apoptotic process  (IDA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal bleeding  (IAGP)
Abnormal circulating interleukin concentration  (IAGP)
Abnormal circulating vitamin B12 concentration  (IAGP)
Abnormal CNS myelination  (IAGP)
Abnormal lymphocyte apoptosis  (IAGP)
Abnormal proportion of CD4-positive T cells  (IAGP)
Abnormal proportion of CD8-positive T cells  (IAGP)
Alveolar cell carcinoma  (IAGP)
Anti-smooth muscle antibody positivity  (IAGP)
Antineutrophil antibody positivity  (IAGP)
Antinuclear antibody positivity  (IAGP)
Antiphospholipid antibody positivity  (IAGP)
Arthritis  (IAGP)
Autoimmune hemolytic anemia  (IAGP)
Autoimmune thrombocytopenia  (IAGP)
Autoimmunity  (IAGP)
Autosomal dominant inheritance  (IAGP)
B-cell lymphoma  (IAGP)
Basal cell carcinoma  (IAGP)
Bone marrow hypercellularity  (IAGP)
Bone marrow hypocellularity  (IAGP)
Bruising susceptibility  (IAGP)
Burkitt lymphoma  (IAGP)
Chronic noninfectious lymphadenopathy  (IAGP)
Colitis  (IAGP)
Coombs-positive hemolytic anemia  (IAGP)
Decreased circulating IgG concentration  (IAGP)
Decreased circulating total IgM  (IAGP)
Decreased lymphocyte apoptosis  (IAGP)
Decreased proportion of CD4-positive helper T cells  (IAGP)
Decreased specific anti-polysaccharide antibody level  (IAGP)
Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells  (IAGP)
Eosinophilia  (IAGP)
Fibroadenoma of the breast  (IAGP)
Follicular hyperplasia  (IAGP)
Gastritis  (IAGP)
Gastrointestinal stroma tumor  (IAGP)
Glomerulonephritis  (IAGP)
Headache  (IAGP)
Hepatitis  (IAGP)
Hepatocellular carcinoma  (IAGP)
Hepatomegaly  (IAGP)
Hodgkin lymphoma  (IAGP)
Hydrops fetalis  (IAGP)
Hypersplenism  (IAGP)
Increased B cell count  (IAGP)
Increased circulating antibody concentration  (IAGP)
Increased circulating IgA concentration  (IAGP)
Increased circulating IgE concentration  (IAGP)
Increased circulating IgG concentration  (IAGP)
Increased circulating IgM level  (IAGP)
Increased circulating interleukin 10 concentration  (IAGP)
Increased circulating interleukin 18 concentration  (IAGP)
Increased proportion of HLA DR+ T cells  (IAGP)
Iron deficiency anemia  (IAGP)
Lung adenocarcinoma  (IAGP)
Lymphadenopathy  (IAGP)
Lymphocytosis  (IAGP)
Lymphopenia  (IAGP)
Neoplasm of the lung  (IAGP)
Neoplasm of the skin  (IAGP)
Neoplasm of the tongue  (IAGP)
Neutropenia in presence of anti-neutropil antibodies  (IAGP)
Non-Hodgkin lymphoma  (IAGP)
Non-small cell lung carcinoma  (IAGP)
Panniculitis  (IAGP)
Parathyroid carcinoma  (IAGP)
Platelet antibody positive  (IAGP)
Premature ovarian insufficiency  (IAGP)
Pulmonary fibrosis  (IAGP)
Pulmonary infiltrates  (IAGP)
Recurrent aphthous stomatitis  (IAGP)
Reduced delayed hypersensitivity  (IAGP)
Renal insufficiency  (IAGP)
Reticulocytosis  (IAGP)
Rheumatoid factor positive  (IAGP)
Seizure  (IAGP)
Splenomegaly  (IAGP)
Systemic lupus erythematosus  (IAGP)
T-cell lymphoma  (IAGP)
Thyroid adenoma  (IAGP)
Thyroid carcinoma  (IAGP)
Thyroiditis  (IAGP)
Typified by somatic mosaicism  (IAGP)
Urticaria  (IAGP)
Uveitis  (IAGP)
Vasculitis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4-induced hepatitis. null
2. Lung injury after ischemia-reperfusion of small intestine in rats involves apoptosis of type II alveolar epithelial cells mediated by TNF-alpha and activation of Bid pathway. An S, etal., Apoptosis. 2007 Nov;12(11):1989-2001. doi: 10.1007/s10495-007-0125-1.
3. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
4. Expression of Fas and Fas ligand in human testicular germ cell tumours. Baldini E, etal., Int J Androl. 2007 Oct 3;.
5. Fas/Fas-ligand expressions in primary breast cancer are significant predictors of its skeletal spread. Bebenek M, etal., Anticancer Res. 2007 Jan-Feb;27(1A):215-8.
6. Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression. Chopin D, etal., Am J Pathol. 2003 Apr;162(4):1139-49.
7. Fas/Fas-Ligand pathway is impaired in patients with type 2 diabetes. Influence of hypertension and insulin resistance. Cosson E, etal., Diabetes Metab. 2005 Feb;31(1):47-54.
8. Fas and Fas ligand expression in cystic fibrosis airway epithelium. Durieu I, etal., Thorax. 1999 Dec;54(12):1093-8.
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PMID:23847689   PMID:23850805   PMID:23923075   PMID:23986795   PMID:23991192   PMID:24025841   PMID:24072745   PMID:24086353   PMID:24094130   PMID:24178789   PMID:24184557   PMID:24228099  
PMID:24248546   PMID:24265545   PMID:24289581   PMID:24291222   PMID:24335017   PMID:24347794   PMID:24375196   PMID:24408012   PMID:24424626   PMID:24473454   PMID:24518159   PMID:24534457  
PMID:24561085   PMID:24598538   PMID:24619598   PMID:24634493   PMID:24665877   PMID:24690069   PMID:24729186   PMID:24802849   PMID:24815844   PMID:24821435   PMID:24899502   PMID:24904167  
PMID:24924176   PMID:24999842   PMID:25056888   PMID:25059065   PMID:25078097   PMID:25169582   PMID:25225287   PMID:25241761   PMID:25333257   PMID:25366259   PMID:25378591   PMID:25394756  
PMID:25404054   PMID:25416956   PMID:25437350   PMID:25464339   PMID:25510486   PMID:25529148   PMID:25596086   PMID:25745808   PMID:25944167   PMID:25950471   PMID:25976983   PMID:25990938  
PMID:26102031   PMID:26156853   PMID:26186194   PMID:26211005   PMID:26232171   PMID:26334989   PMID:26345794   PMID:26359460   PMID:26374830   PMID:26400345   PMID:26429326   PMID:26467838  
PMID:26479732   PMID:26582200   PMID:26617708   PMID:26617948   PMID:26646413   PMID:26690594   PMID:26819081   PMID:26826505   PMID:26858129   PMID:26871637   PMID:26922070   PMID:27089864  
PMID:27117663   PMID:27277758   PMID:27302366   PMID:27572459   PMID:27608763   PMID:27628319   PMID:27682872   PMID:27790710   PMID:27806260   PMID:27857173   PMID:28013316   PMID:28127562  
PMID:28326325   PMID:28378099   PMID:28442396   PMID:28468172   PMID:28514442   PMID:28514658   PMID:28587866   PMID:28609212   PMID:28785150   PMID:28942044   PMID:29083508   PMID:29187439  
PMID:29207034   PMID:29358576   PMID:29419701   PMID:29453645   PMID:29509956   PMID:29527928   PMID:29566277   PMID:29611722   PMID:29642281   PMID:29652777   PMID:29719304   PMID:29734947  
PMID:29781316   PMID:29891848   PMID:29952767   PMID:30103900   PMID:30132510   PMID:30324908   PMID:30385692   PMID:30718366   PMID:30942389   PMID:31195645   PMID:31225740   PMID:31416448  
PMID:31425784   PMID:31467122   PMID:31537619   PMID:31566051   PMID:31582729   PMID:31741398   PMID:31825106   PMID:32053892   PMID:32105000   PMID:32109550   PMID:32209020   PMID:32212814  
PMID:32296183   PMID:32555150   PMID:32628088   PMID:32785835   PMID:32945711   PMID:33093334   PMID:33168041   PMID:33247994   PMID:33410302   PMID:33513976   PMID:33639675   PMID:33671651  
PMID:33862353   PMID:33879403   PMID:33961781   PMID:34127318   PMID:34366198   PMID:34697371   PMID:34753694   PMID:34889164   PMID:35240289   PMID:35870695   PMID:35988104   PMID:36124496  
PMID:36671466   PMID:37431614   PMID:37837385   PMID:38363216  


Genomics

Comparative Map Data
FASLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36Build 36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,496 - 174,058,323 (+)NCBICHM1_1
T2T-CHM13v2.01172,016,214 - 172,023,987 (+)NCBIT2T-CHM13v2.0
Fasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,608,260 - 161,616,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,608,258 - 161,616,064 (-)EnsemblGRCm39 Ensembl
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBIMGSCv36mm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
Faslg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,680,885 - 76,706,042 (-)NCBIGRCr8
mRatBN7.21374,151,519 - 74,172,760 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,154,954 - 74,162,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,724,620 - 76,731,883 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,031,667 - 78,038,929 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,291,523 - 75,298,787 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,696,811 - 79,717,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01384,590,119 - 84,605,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,472,950 - 77,480,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11377,487,137 - 77,494,398 (-)NCBI
Celera1373,908,438 - 73,915,703 (-)NCBICelera
Cytogenetic Map13q22NCBI
Faslg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,098,662 - 13,107,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,098,479 - 13,107,045 (+)NCBIChiLan1.0ChiLan1.0
FASLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2177,076,483 - 77,084,478 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1176,756,472 - 76,764,434 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,159,826 - 148,167,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11151,868,430 - 151,876,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1151,868,430 - 151,876,281 (+)Ensemblpanpan1.1panPan2
FASLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,335,837 - 26,344,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,335,846 - 26,344,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,866,683 - 25,875,068 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0726,086,377 - 26,094,750 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl726,086,386 - 26,094,750 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,997,538 - 26,005,908 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0726,067,461 - 26,075,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0726,217,995 - 26,226,386 (-)NCBIUU_Cfam_GSD_1.0
Faslg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,942,494 - 96,949,833 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648114,789,547 - 14,795,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,068,090 - 115,076,464 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,641,066 - 126,647,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12556,488,572 - 56,496,469 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2556,489,417 - 56,496,251 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605558,094,483 - 58,102,557 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Faslg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247719,032,016 - 9,038,825 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247719,031,978 - 9,038,760 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FASLG
166 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000639.3(FASLG):c.473_556del (p.Met158_Glu185del) deletion Autoimmune lymphoproliferative syndrome type 1 [RCV001789750]|Autoimmune lymphoproliferative syndrome, type 1b [RCV000017959] Chr1:172665642..172665725 [GRCh38]
Chr1:172634782..172634865 [GRCh37]
Chr1:1q24.3
pathogenic|not provided
NC_000001.11:g.172658358= single nucleotide variant LUNG CANCER, SUSCEPTIBILITY TO [RCV000017960] Chr1:172658358 [GRCh38]
Chr1:172627498 [GRCh37]
Chr1:1q24.3
pathogenic|risk factor
NM_000639.3(FASLG):c.466A>G (p.Arg156Gly) single nucleotide variant Autoimmune lymphoproliferative syndrome type 1 [RCV000020369]|Autoimmune lymphoproliferative syndrome type 1 [RCV002476995]|FASLG-related disorder [RCV004755745] Chr1:172665636 [GRCh38]
Chr1:172634776 [GRCh37]
Chr1:1q24.3
pathogenic|uncertain significance
NM_000639.3(FASLG):c.740C>A (p.Ala247Glu) single nucleotide variant Autoimmune lymphoproliferative syndrome type 1 [RCV001789805] Chr1:172665910 [GRCh38]
Chr1:172635050 [GRCh37]
Chr1:1q24.3
pathogenic|uncertain significance|not provided
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1
pathogenic
GRCh38/hg38 1q23.3-25.2(chr1:164922655-180061589)x3 copy number gain See cases [RCV000051856] Chr1:164922655..180061589 [GRCh38]
Chr1:164891892..180030724 [GRCh37]
Chr1:163158516..178297347 [NCBI36]
Chr1:1q23.3-25.2
pathogenic
GRCh38/hg38 1q24.2-25.1(chr1:168314822-175299299)x1 copy number loss See cases [RCV000053918] Chr1:168314822..175299299 [GRCh38]
Chr1:168284060..175268435 [GRCh37]
Chr1:166550684..173535058 [NCBI36]
Chr1:1q24.2-25.1
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q24.1-25.1(chr1:166762832-175327423)x1 copy number loss See cases [RCV000053917] Chr1:166762832..175327423 [GRCh38]
Chr1:166732069..175296559 [GRCh37]
Chr1:164998693..173563182 [NCBI36]
Chr1:1q24.1-25.1
pathogenic
NM_000639.3(FASLG):c.204G>A (p.Leu68=) single nucleotide variant Autoimmune lymphoproliferative syndrome type 1 [RCV001412309] Chr1:172659405 [GRCh38]
Chr1:172628545 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.263del (p.Phe88fs) deletion Autoimmune lymphoproliferative syndrome type 1 [RCV000144151] Chr1:172659460 [GRCh38]
Chr1:172628600 [GRCh37]
Chr1:1q24.3
pathogenic|not provided
GRCh38/hg38 1q24.3-31.1(chr1:171039975-186875957)x3 copy number gain See cases [RCV000134876] Chr1:171039975..186875957 [GRCh38]
Chr1:171009116..186845089 [GRCh37]
Chr1:169275740..185111712 [NCBI36]
Chr1:1q24.3-31.1
pathogenic
GRCh38/hg38 1q24.2-25.2(chr1:169218236-178075834)x1 copy number loss See cases [RCV000137128] Chr1:169218236..178075834 [GRCh38]
Chr1:169187474..178044969 [GRCh37]
Chr1:167454098..176311592 [NCBI36]
Chr1:1q24.2-25.2
pathogenic
GRCh38/hg38 1q24.3-31.2(chr1:170929720-191065409)x1 copy number loss See cases [RCV000142369] Chr1:170929720..191065409 [GRCh38]
Chr1:170898861..191034539 [GRCh37]
Chr1:169165485..189301162 [NCBI36]
Chr1:1q24.3-31.2
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:163382523-175877022)x1 copy number loss See cases [RCV000143292] Chr1:163382523..175877022 [GRCh38]
Chr1:163352313..175846158 [GRCh37]
Chr1:161618937..174112781 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q24.2-31.1(chr1:170036068-187555148)x1 copy number loss See cases [RCV000143688] Chr1:170036068..187555148 [GRCh38]
Chr1:170005209..187524280 [GRCh37]
Chr1:168271833..185790903 [NCBI36]
Chr1:1q24.2-31.1
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
NM_000639.3(FASLG):c.395-15C>G single nucleotide variant Autoimmune lymphoproliferative syndrome type 1 [RCV000389079] Chr1:172664319 [GRCh38]
Chr1:172633459 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.147G>A (p.Pro49=) single nucleotide variant Autoimmune lymphoproliferative syndrome type 1 [RCV000395174]|not provided [RCV001668643] Chr1:172659348 [GRCh38]
Chr1:172628488 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.177G>A (p.Pro59=) single nucleotide variant Autoimmune lymphoproliferative syndrome type 1 [RCV000301343]|not provided [RCV001699287] Chr1:172659378 [GRCh38]
Chr1:172628518 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.280T>G (p.Leu94Val) single nucleotide variant Autoimmune lymphoproliferative syndrome type 1 [RCV000275447]|not provided [RCV001764258] Chr1:172659481 [GRCh38]