FASLG (Fas ligand) - Rat Genome Database

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Gene: FASLG (Fas ligand) Homo sapiens
Analyze
Symbol: FASLG
Name: Fas ligand
RGD ID: 1606342
HGNC Page HGNC
Description: Predicted to enable signaling receptor binding activity. Involved in several processes, including necroptotic signaling pathway; positive regulation of endothelial cell apoptotic process; and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of apoptotic process; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Located in extracellular exosome; nucleus; and plasma membrane. Implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; pancreatic cancer (multiple); pre-eclampsia (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including bone marrow cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; clonorchiasis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS1B; apoptosis (APO-1) antigen ligand 1; apoptosis antigen ligand; APT1LG1; APTL; CD178; CD95 ligand; CD95-L; CD95L; fas antigen ligand; Fas ligand (TNF superfamily, member 6); FASL; mutant tumor necrosis factor family member 6; TNFSF6; TNLG1A; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand 1A; tumor necrosis factor ligand superfamily member 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBI
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,496 - 174,058,323 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (IAGP)
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (IEP,ISO)
Acute Liver Failure  (EXP,IEP,ISO)
Acute Lung Injury  (EXP)
atherosclerosis  (EXP)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (IAGP)
Autoimmune Lymphoproliferative Syndrome, Type IB  (IAGP)
biliary tract benign neoplasm  (IEP)
brain glioma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (IAGP,IEP)
cardiomyopathy  (EXP)
carotid artery disease  (EXP)
cervix uteri carcinoma in situ  (IEP)
cholangiocarcinoma  (IDA)
chronic myeloid leukemia  (IAGP)
chronic obstructive pulmonary disease  (ISO)
clonorchiasis  (IEP)
congestive heart failure  (ISO)
cystic fibrosis  (IEP)
diabetic angiopathy  (EXP,IEP)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (EXP)
drug allergy  (EXP)
Esophageal Neoplasms  (IEP)
Experimental Allergic Asthma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (EXP)
Fetal Growth Retardation  (IEP)
Gallbladder Neoplasms  (IEP)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (IAGP)
Graft vs Host Disease  (IEP,ISO)
HELLP syndrome  (IAGP,ISO)
hepatitis  (EXP,ISO)
hepatitis B  (IEP)
hepatocellular carcinoma  (IEP)
Huntington's disease  (IEP)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
infectious mononucleosis  (IEP)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (IEP)
invasive lobular carcinoma  (IEP)
Kidney Reperfusion Injury  (ISO)
leiomyoma  (IEP)
limited scleroderma  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (IEA)
Lung Neoplasms  (IAGP)
lung non-small cell carcinoma  (EXP)
melanoma  (EXP,IAGP)
multiple myeloma  (IEP)
multiple sclerosis  (EXP,IAGP)
myelodysplastic syndrome  (IEP)
Necrosis  (ISO)
Neoplasm Metastasis  (IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (IAGP,IDA,IEP)
pancreatic ductal carcinoma  (IDA,IEP)
parathyroid carcinoma  (IAGP)
Parkinson's disease  (IEP,ISO)
pre-eclampsia  (IAGP)
Prostatic Neoplasms  (EXP)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (EXP)
seminoma  (IEP)
Sepsis  (ISO)
Spinal Cord Compression  (IEP,ISO)
substance-related disorder  (ISO)
testicular disease  (EXP)
transitional cell carcinoma  (IEP)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IEP,ISO,ISS)
type 2 diabetes mellitus  (IAGP)
ulcerative colitis  (ISO)
urinary bladder cancer  (IAGP)
Uterine Cervical Neoplasms  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-roxithromycin  (EXP)
(R)-adrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (ISO)
2,6-dichloroindophenol  (EXP)
2-naphthylamine  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-nitro-m-cresol  (EXP,ISO)
4-nonylphenol  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (EXP)
[6]-Shogaol  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
adenosine  (EXP,ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-acitretin  (EXP)
all-trans-retinoic acid  (EXP)
Aloe emodin  (EXP)
alpha-naphthoflavone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
andrographolide  (EXP)
androst-4-ene-3,17-dione  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
arecoline  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
atenolol  (EXP)
atorvastatin calcium  (EXP,ISO)
bafilomycin A1  (ISO)
benazepril  (ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP)
Benzo[k]fluoranthene  (ISO)
berberine  (EXP)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
bufalin  (EXP)
busulfan  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbachol  (EXP)
carbamazepine  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
casticin  (EXP)
catechol  (EXP)
CCCP  (ISO)
celastrol  (EXP)
celecoxib  (ISO)
chloramphenicol  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chrysazin  (EXP)
chrysin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP)
coenzyme Q10  (ISO)
coformycin  (ISO)
copper(II) sulfate  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibromoacetic acid  (ISO)
dichlorvos  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dihydroxyacetone  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (EXP)
dioxygen  (EXP)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental selenium  (EXP)
emodin  (EXP)
enalapril  (ISO)
esculetin  (EXP)
ethanol  (EXP,ISO)
etoposide  (EXP,ISO)
Evodiamine  (EXP)
fenvalerate  (ISO)
fisetin  (EXP)
flavanone  (EXP)
flavonoids  (ISO)
flucloxacillin  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (EXP)
furan  (ISO)
furosemide  (ISO)
Fusarenone X  (ISO)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (EXP)
Geniposide pentaacetate  (ISO)
genistein  (EXP)
glucose  (EXP)
glutathione  (EXP,ISO)
glycidol  (ISO)
hexachlorobenzene  (ISO)
hydralazine  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxyurea  (ISO)
hyperforin  (EXP)
idelalisib  (EXP)
ifosfamide  (EXP)
inosine  (EXP)
ionomycin  (EXP)
irinotecan  (EXP,ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lenalidomide  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
lovastatin  (EXP)
LY294002  (EXP)
lycopene  (EXP)
magnesium oxide  (EXP)
mancozeb  (EXP)
manganese(II) chloride  (ISO)
manumycin A  (ISO)
masoprocol  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
methamphetamine  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
mifepristone  (EXP)
mitogen  (EXP)
mitomycin C  (EXP)
Mitotane  (ISO)
MK 571  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
morphine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naproxen  (ISO)
nickel atom  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nimustine  (EXP)
nitric oxide  (EXP)
nitrobenzene  (ISO)
nocodazole  (EXP)
Nodularin  (EXP)
NS-398  (EXP)
Nutlin-3  (EXP)
ochratoxin A  (ISO)
octreotide  (EXP)
ouabain  (EXP)
ozone  (ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
pentobarbital  (ISO)
pepstatin A  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenol  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phylloquinone  (EXP)
platycodin D  (EXP)
probenecid  (ISO)
propanal  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
rebaudioside A  (EXP)
regorafenib  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
ritonavir  (EXP)
Roridin A  (ISO)
ryanodine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
S-nitrosoglutathione  (EXP)
sanguinarine  (EXP)
SB 203580  (EXP,ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
sorafenib  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP)
sumatriptan  (ISO)
swainsonine  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
telmisartan  (ISO)
temozolomide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetrazolium violet  (ISO)
thalidomide  (EXP,ISO)
thiosalicylic acid  (ISO)
thymidine  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trimethylarsine oxide  (ISO)
trimethyltin  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
Tungsten carbide  (EXP)
uranium atom  (ISO)
uridine  (EXP)
usnic acid  (EXP)
valsartan  (ISO)
vemurafenib  (EXP)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vinorelbine  (ISO)
vorinostat  (EXP)
wortmannin  (EXP)
Y-27632  (EXP)
zearalenone  (ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal CNS myelination  (IAGP)
Abnormal proportion of CD8-positive T cells  (IAGP)
Abnormal serum interleukin level  (IAGP)
Abnormal vitamin B12 level  (IAGP)
Alveolar cell carcinoma  (IAGP)
Antineutrophil antibody positivity  (IAGP)
Antinuclear antibody positivity  (IAGP)
Antiphospholipid antibody positivity  (IAGP)
Arthritis  (IAGP)
Autoimmune hemolytic anemia  (IAGP)
Autoimmune thrombocytopenia  (IAGP)
Autosomal dominant inheritance  (IAGP)
B-cell lymphoma  (IAGP)
Basal cell carcinoma  (IAGP)
Bone marrow hypercellularity  (IAGP)
Bone marrow hypocellularity  (IAGP)
Bruising susceptibility  (IAGP)
Burkitt lymphoma  (IAGP)
Chronic noninfectious lymphadenopathy  (IAGP)
Colitis  (IAGP)
Coombs-positive hemolytic anemia  (IAGP)
Decreased circulating IgG level  (IAGP)
Decreased circulating total IgM  (IAGP)
Decreased lymphocyte apoptosis  (IAGP)
Decreased proportion of CD4-positive helper T cells  (IAGP)
Decreased specific anti-polysaccharide antibody level  (IAGP)
Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells  (IAGP)
Eosinophilia  (IAGP)
Fibroadenoma of the breast  (IAGP)
Follicular hyperplasia  (IAGP)
Gastritis  (IAGP)
Gastrointestinal stroma tumor  (IAGP)
Glomerulonephritis  (IAGP)
Headache  (IAGP)
Hepatitis  (IAGP)
Hepatocellular carcinoma  (IAGP)
Hepatomegaly  (IAGP)
Hodgkin lymphoma  (IAGP)
Hydrops fetalis  (IAGP)
Hypersplenism  (IAGP)
Increased B cell count  (IAGP)
Increased circulating IgA level  (IAGP)
Increased circulating IgE level  (IAGP)
Increased circulating IgG level  (IAGP)
Increased circulating IgM level  (IAGP)
Increased proportion of HLA DR+ T cells  (IAGP)
Iron deficiency anemia  (IAGP)
Lung adenocarcinoma  (IAGP)
Neoplasm of the lung  (IAGP)
Neoplasm of the tongue  (IAGP)
Neutropenia in presence of anti-neutropil antibodies  (IAGP)
Panniculitis  (IAGP)
Parathyroid carcinoma  (IAGP)
Platelet antibody positive  (IAGP)
Premature ovarian insufficiency  (IAGP)
Pulmonary fibrosis  (IAGP)
Pulmonary infiltrates  (IAGP)
Recurrent aphthous stomatitis  (IAGP)
Reduced delayed hypersensitivity  (IAGP)
Renal insufficiency  (IAGP)
Reticulocytosis  (IAGP)
Rheumatoid factor positive  (IAGP)
Seizure  (IAGP)
Smooth muscle antibody positivity  (IAGP)
Somatic mutation  (IAGP)
Splenomegaly  (IAGP)
Systemic lupus erythematosus  (IAGP)
T-cell lymphoma  (IAGP)
Thyroid adenoma  (IAGP)
Thyroid carcinoma  (IAGP)
Thyroiditis  (IAGP)
Urticaria  (IAGP)
Uveitis  (IAGP)
Vasculitis  (IAGP)
References

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Additional References at PubMed
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PMID:12137598   PMID:12161534   PMID:12198154   PMID:12201652   PMID:12208869   PMID:12220636   PMID:12372468   PMID:12393889   PMID:12414525   PMID:12414956   PMID:12421989   PMID:12454289  
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Genomics

Comparative Map Data
FASLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBI
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,496 - 174,058,323 (+)NCBICHM1_1
Fasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,608,260 - 161,616,064 (-)NCBIGRCm39mm39
GRCm39 Ensembl1161,608,258 - 161,616,064 (-)Ensembl
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBImm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
Faslg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21374,151,519 - 74,172,760 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1374,154,954 - 74,162,215 (-)Ensembl
Rnor_6.01379,696,811 - 79,717,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01384,590,119 - 84,605,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,472,950 - 77,480,210 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11377,487,137 - 77,494,398 (-)NCBI
Celera1373,908,438 - 73,915,703 (-)NCBICelera
Cytogenetic Map13q22NCBI
Faslg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,098,662 - 13,107,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,098,479 - 13,107,045 (+)NCBIChiLan1.0ChiLan1.0
FASLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11151,868,430 - 151,876,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1151,868,430 - 151,876,281 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01148,159,826 - 148,167,785 (+)NCBIMhudiblu_PPA_v0panPan3
FASLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,335,837 - 26,344,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,335,846 - 26,344,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,866,683 - 25,875,068 (-)NCBI
ROS_Cfam_1.0726,086,377 - 26,094,750 (-)NCBI
UMICH_Zoey_3.1725,997,538 - 26,005,908 (-)NCBI
UNSW_CanFamBas_1.0726,067,461 - 26,075,850 (-)NCBI
UU_Cfam_GSD_1.0726,217,995 - 26,226,386 (-)NCBI
Faslg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,942,494 - 96,949,833 (-)NCBI
SpeTri2.0NW_00493648114,789,547 - 14,795,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,068,090 - 115,076,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,641,066 - 126,647,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12556,488,572 - 56,496,469 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2556,489,417 - 56,496,251 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605558,094,483 - 58,102,557 (-)NCBIVero_WHO_p1.0
Faslg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247719,031,978 - 9,038,760 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D1S3209  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,635,327 - 172,635,529UniSTSGRCh37
Build 361170,901,950 - 170,902,152RGDNCBI36
Celera1145,744,834 - 145,745,036RGD
Cytogenetic Map1q23UniSTS
HuRef1143,859,936 - 143,860,138UniSTS
TNG Radiation Hybrid Map179644.0UniSTS
GeneMap99-GB4 RH Map1623.3UniSTS
GeneMap99-G3 RH Map16749.0UniSTS
G42266  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,630,446 - 172,630,659UniSTSGRCh37
Build 361170,897,069 - 170,897,282RGDNCBI36
Celera1145,739,954 - 145,740,167RGD
Cytogenetic Map1q23UniSTS
HuRef1143,855,056 - 143,855,269UniSTS
D1S3717  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,635,627 - 172,635,864UniSTSGRCh37
Build 361170,902,250 - 170,902,487RGDNCBI36
Celera1145,745,134 - 145,745,371RGD
Cytogenetic Map1q23UniSTS
HuRef1143,860,236 - 143,860,473UniSTS
PMC135646P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,627,892 - 172,628,239UniSTSGRCh37
Build 361170,894,515 - 170,894,862RGDNCBI36
Celera1145,737,400 - 145,737,747RGD
Cytogenetic Map1q23UniSTS
HuRef1143,852,502 - 143,852,849UniSTS
PMC86001P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,634,777 - 172,635,026UniSTSGRCh37
Build 361170,901,400 - 170,901,649RGDNCBI36
Celera1145,744,284 - 145,744,533RGD
Cytogenetic Map1q23UniSTS
HuRef1143,859,386 - 143,859,635UniSTS
PMC86001P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,634,947 - 172,635,026UniSTSGRCh37
Build 361170,901,570 - 170,901,649RGDNCBI36
Celera1145,744,454 - 145,744,533RGD
Cytogenetic Map1q23UniSTS
HuRef1143,859,556 - 143,859,635UniSTS
TNFSF6_2403  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,635,315 - 172,636,071UniSTSGRCh37
Build 361170,901,938 - 170,902,694RGDNCBI36
Celera1145,744,822 - 145,745,578RGD
HuRef1143,859,924 - 143,860,680UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23177026
MIR21hsa-miR-21-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI20371612

Predicted Target Of
Summary Value
Count of predictions:755
Count of miRNA genes:397
Interacting mature miRNAs:427
Transcripts:ENST00000340030, ENST00000367721
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 6 68 2 2 154 2 1 5 12 4
Low 466 702 608 277 940 244 162 24 129 148 307 850 33 237 73 1
Below cutoff 1542 1634 1001 308 324 190 2606 1425 2375 196 865 532 122 835 1640 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB013303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF027385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF044583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY225406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY858799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA916336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN083421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA362609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ948655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN874312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z96050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000340030   ⟹   ENSP00000344739
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,659,144 - 172,666,075 (+)Ensembl
RefSeq Acc Id: ENST00000367721   ⟹   ENSP00000356694
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,659,103 - 172,666,876 (+)Ensembl
RefSeq Acc Id: NM_000639   ⟹   NP_000630
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,659,103 - 172,666,876 (+)NCBI
GRCh371172,628,185 - 172,636,013 (+)ENTREZGENE
Build 361170,894,808 - 170,902,636 (+)NCBI Archive
HuRef1143,852,795 - 143,860,622 (+)ENTREZGENE
CHM1_11174,050,459 - 174,058,323 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302746   ⟹   NP_001289675
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,659,103 - 172,666,876 (+)NCBI
CHM1_11174,050,459 - 174,058,323 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000630   ⟸   NM_000639
- Peptide Label: isoform 1
- UniProtKB: P48023 (UniProtKB/Swiss-Prot),   Q53ZZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289675   ⟸   NM_001302746
- Peptide Label: isoform 2
- UniProtKB: P48023 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000356694   ⟸   ENST00000367721
RefSeq Acc Id: ENSP00000344739   ⟸   ENST00000340030
Protein Domains
TNF_2

Promoters
RGD ID:6785557
Promoter ID:HG_KWN:6210
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:ENST00000340030,   ENST00000367721
Position:
Human AssemblyChrPosition (strand)Source
Build 361170,894,721 - 170,895,221 (+)MPROMDB
RGD ID:6858136
Promoter ID:EPDNEW_H2232
Type:initiation region
Name:FASLG_1
Description:Fas ligand
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,659,103 - 172,659,163EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000639.3(FASLG):c.473_556del (p.Met158_Glu185del) deletion Autoimmune lymphoproliferative syndrome, type 1b [RCV000017959] Chr1:172665642..172665725 [GRCh38]
Chr1:172634782..172634865 [GRCh37]
Chr1:1q24.3
pathogenic
NM_000639.2(FASLG):c.-157-687C= single nucleotide variant LUNG CANCER, SUSCEPTIBILITY TO [RCV000017960] Chr1:172658358 [GRCh38]
Chr1:172627498 [GRCh37]
Chr1:1q24.3
pathogenic|risk factor
NM_000639.3(FASLG):c.466A>G (p.Arg156Gly) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000020369]|Autoimmune lymphoproliferative syndrome [RCV000763770] Chr1:172665636 [GRCh38]
Chr1:172634776 [GRCh37]
Chr1:1q24.3
pathogenic|uncertain significance
NM_000639.1(FASLG):c.740C>A (p.Ala247Glu) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000020371] Chr1:172665910 [GRCh38]
Chr1:172635050 [GRCh37]
Chr1:1q24.3
pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1
pathogenic
GRCh38/hg38 1q23.3-25.2(chr1:164922655-180061589)x3 copy number gain See cases [RCV000051856] Chr1:164922655..180061589 [GRCh38]
Chr1:164891892..180030724 [GRCh37]
Chr1:163158516..178297347 [NCBI36]
Chr1:1q23.3-25.2
pathogenic
GRCh38/hg38 1q24.2-25.1(chr1:168314822-175299299)x1 copy number loss See cases [RCV000053918] Chr1:168314822..175299299 [GRCh38]
Chr1:168284060..175268435 [GRCh37]
Chr1:166550684..173535058 [NCBI36]
Chr1:1q24.2-25.1
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q24.1-25.1(chr1:166762832-175327423)x1 copy number loss See cases [RCV000053917] Chr1:166762832..175327423 [GRCh38]
Chr1:166732069..175296559 [GRCh37]
Chr1:164998693..173563182 [NCBI36]
Chr1:1q24.1-25.1
pathogenic
NM_000639.3(FASLG):c.204G>A (p.Leu68=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001412309] Chr1:172659405 [GRCh38]
Chr1:172628545 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.263del (p.Phe88fs) deletion Autoimmune lymphoproliferative syndrome [RCV000144151] Chr1:172659460 [GRCh38]
Chr1:172628600 [GRCh37]
Chr1:1q24.3
pathogenic
GRCh38/hg38 1q24.3-31.1(chr1:171039975-186875957)x3 copy number gain See cases [RCV000134876] Chr1:171039975..186875957 [GRCh38]
Chr1:171009116..186845089 [GRCh37]
Chr1:169275740..185111712 [NCBI36]
Chr1:1q24.3-31.1
pathogenic
GRCh38/hg38 1q24.2-25.2(chr1:169218236-178075834)x1 copy number loss See cases [RCV000137128] Chr1:169218236..178075834 [GRCh38]
Chr1:169187474..178044969 [GRCh37]
Chr1:167454098..176311592 [NCBI36]
Chr1:1q24.2-25.2
pathogenic
GRCh38/hg38 1q24.3-31.2(chr1:170929720-191065409)x1 copy number loss See cases [RCV000142369] Chr1:170929720..191065409 [GRCh38]
Chr1:170898861..191034539 [GRCh37]
Chr1:169165485..189301162 [NCBI36]
Chr1:1q24.3-31.2
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:163382523-175877022)x1 copy number loss See cases [RCV000143292] Chr1:163382523..175877022 [GRCh38]
Chr1:163352313..175846158 [GRCh37]
Chr1:161618937..174112781 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q24.2-31.1(chr1:170036068-187555148)x1 copy number loss See cases [RCV000143688] Chr1:170036068..187555148 [GRCh38]
Chr1:170005209..187524280 [GRCh37]
Chr1:168271833..185790903 [NCBI36]
Chr1:1q24.2-31.1
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
NM_000639.3(FASLG):c.395-15C>G single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000389079] Chr1:172664319 [GRCh38]
Chr1:172633459 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_002055.5(GFAP):c.469G>A (p.Asp157Asn) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000395174]|not provided [RCV001668643] Chr1:172659348 [GRCh38]
Chr1:172628488 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.177G>A (p.Pro59=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000301343]|not provided [RCV001699287] Chr1:172659378 [GRCh38]
Chr1:172628518 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.280T>G (p.Leu94Val) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000275447] Chr1:172659481 [GRCh38]
Chr1:172628621 [GRCh37]
Chr1:1q24.3
likely benign|conflicting interpretations of pathogenicity
NM_000639.3(FASLG):c.451+7A>G single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000275976]|Autoimmune lymphoproliferative syndrome [RCV001281011] Chr1:172664397 [GRCh38]
Chr1:172633537 [GRCh37]
Chr1:1q24.3
benign|likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_000639.3(FASLG):c.176C>T (p.Pro59Leu) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000260218] Chr1:172659377 [GRCh38]
Chr1:172628517 [GRCh37]
Chr1:1q24.3
likely benign|conflicting interpretations of pathogenicity
NM_000639.3(FASLG):c.364C>A (p.His122Asn) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000329844] Chr1:172660110 [GRCh38]
Chr1:172629250 [GRCh37]
Chr1:1q24.3
likely benign|conflicting interpretations of pathogenicity
NM_000639.3(FASLG):c.108G>A (p.Val36=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000339567]|not provided [RCV001200373] Chr1:172659309 [GRCh38]
Chr1:172628449 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.174G>A (p.Pro58=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000354762] Chr1:172659375 [GRCh38]
Chr1:172628515 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.278C>T (p.Ala93Val) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000356098] Chr1:172659479 [GRCh38]
Chr1:172628619 [GRCh37]
Chr1:1q24.3
conflicting interpretations of pathogenicity|uncertain significance
NM_000639.3(FASLG):c.*725A>G single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000269118] Chr1:172666741 [GRCh38]
Chr1:172635881 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.*606T>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000313886] Chr1:172666622 [GRCh38]
Chr1:172635762 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.*32T>C single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000380723] Chr1:172666048 [GRCh38]
Chr1:172635188 [GRCh37]
Chr1:1q24.3
likely benign|uncertain significance
NM_000639.3(FASLG):c.*406G>T single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000402514] Chr1:172666422 [GRCh38]
Chr1:172635562 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.-16T>C single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000406319] Chr1:172659186 [GRCh38]
Chr1:172628326 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.*54A>T single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000290985] Chr1:172666070 [GRCh38]
Chr1:172635210 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*306A>C single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000342779] Chr1:172666322 [GRCh38]
Chr1:172635462 [GRCh37]
Chr1:1q24.3
likely benign|uncertain significance
NM_000639.3(FASLG):c.*612T>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000363923] Chr1:172666628 [GRCh38]
Chr1:172635768 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*817A>G single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000364805] Chr1:172666833 [GRCh38]
Chr1:172635973 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.749A>T (p.Asn250Ile) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000326288] Chr1:172665919 [GRCh38]
Chr1:172635059 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*119G>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000345970] Chr1:172666135 [GRCh38]
Chr1:172635275 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*754G>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000328792] Chr1:172666770 [GRCh38]
Chr1:172635910 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_001302746.1(FASLG):c.-136G>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000348226] Chr1:172659066 [GRCh38]
Chr1:172628206 [GRCh37]
Chr1:1q24.3
likely benign|uncertain significance
NM_000639.3(FASLG):c.*203C>T single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000283133] Chr1:172666219 [GRCh38]
Chr1:172635359 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*601_*602GT[17] microsatellite Autoimmune lymphoproliferative syndrome [RCV000279559] Chr1:172666616..172666617 [GRCh38]
Chr1:172635756..172635757 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.42G>C (p.Trp14Cys) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000303818] Chr1:172659243 [GRCh38]
Chr1:172628383 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.171GCC[2] (p.Pro61_Pro62del) microsatellite Autoimmune lymphoproliferative syndrome [RCV000304577] Chr1:172659370..172659375 [GRCh38]
Chr1:172628510..172628515 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*601_*602GT[18] microsatellite Autoimmune lymphoproliferative syndrome [RCV000334783] Chr1:172666616..172666617 [GRCh38]
Chr1:172635756..172635757 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*601GT[14] microsatellite Autoimmune lymphoproliferative syndrome [RCV000368459] Chr1:172666617..172666620 [GRCh38]
Chr1:172635757..172635760 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*600G>T single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000299773] Chr1:172666616 [GRCh38]
Chr1:172635756 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*601_*602GT[13] microsatellite Autoimmune lymphoproliferative syndrome [RCV000394439] Chr1:172666617..172666622 [GRCh38]
Chr1:172635757..172635762 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.*601_*602GT[19] microsatellite Autoimmune lymphoproliferative syndrome [RCV000394442] Chr1:172666616..172666617 [GRCh38]
Chr1:172635756..172635757 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*120G>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000377319] Chr1:172666136 [GRCh38]
Chr1:172635276 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.426G>C (p.Glu142Asp) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000638911] Chr1:172664365 [GRCh38]
Chr1:172633505 [GRCh37]
Chr1:1q24.3
likely benign
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1
pathogenic
GRCh37/hg19 1q24.2-25.3(chr1:169423492-180367623) copy number gain not provided [RCV000767621] Chr1:169423492..180367623 [GRCh37]
Chr1:1q24.2-25.3
pathogenic
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3
pathogenic
GRCh37/hg19 1q24.2-25.3(chr1:169873155-181823980)x1 copy number loss See cases [RCV000447593] Chr1:169873155..181823980 [GRCh37]
Chr1:1q24.2-25.3
pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758)x1 copy number loss See cases [RCV000448686] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_000639.3(FASLG):c.109C>G (p.Pro37Ala) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000638903] Chr1:172659310 [GRCh38]
Chr1:172628450 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.147GCCACC[3] (p.Pro52_Pro53dup) microsatellite Autoimmune lymphoproliferative syndrome [RCV000638904] Chr1:172659342..172659343 [GRCh38]
Chr1:172628482..172628483 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.144_152del (p.Pro51_Pro53del) deletion Autoimmune lymphoproliferative syndrome [RCV000638908] Chr1:172659340..172659348 [GRCh38]
Chr1:172628480..172628488 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.749A>G (p.Asn250Ser) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000539265] Chr1:172665919 [GRCh38]
Chr1:172635059 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.828C>T (p.Phe276=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000638910] Chr1:172665998 [GRCh38]
Chr1:172635138 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.349-45G>T single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000661936]|Autoimmune lymphoproliferative syndrome, type 1b [RCV000661935] Chr1:172660050 [GRCh38]
Chr1:172629190 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.394+3G>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000695821] Chr1:172660143 [GRCh38]
Chr1:172629283 [GRCh37]
Chr1:1q24.3
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2
pathogenic
NM_000085.5(CLCNKB):c.101-50G>C single nucleotide variant not provided [RCV001679116] Chr1:172664210 [GRCh38]
Chr1:172633350 [GRCh37]
Chr1:1q24.3
benign
Single allele deletion 1q24q25 microdeletion syndrome [RCV000754969] Chr1:169095250..175778910 [GRCh37]
Chr1:1q24.2-25.1
pathogenic
NM_000639.3(FASLG):c.497A>G (p.Tyr166Cys) single nucleotide variant not provided [RCV000994194] Chr1:172665667 [GRCh38]
Chr1:172634807 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.451+8T>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001098807]|not provided [RCV000937923] Chr1:172664398 [GRCh38]
Chr1:172633538 [GRCh37]
Chr1:1q24.3
benign|likely benign
NM_000639.3(FASLG):c.147GCCACC[1] (p.Pro52_Pro53del) microsatellite Autoimmune lymphoproliferative syndrome [RCV001038608] Chr1:172659343..172659348 [GRCh38]
Chr1:172628483..172628488 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.659A>G (p.Gln220Arg) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001038680] Chr1:172665829 [GRCh38]
Chr1:172634969 [GRCh37]
Chr1:1q24.3
uncertain significance
NC_000001.11:g.(?_172658358)_(172666036_?)dup duplication Autoimmune lymphoproliferative syndrome [RCV001031038] Chr1:172627498..172635176 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.743T>C (p.Val248Ala) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000814558] Chr1:172665913 [GRCh38]
Chr1:172635053 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.822G>T (p.Thr274=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001501007]|not provided [RCV000936200] Chr1:172665992 [GRCh38]
Chr1:172635132 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.209C>G (p.Pro70Arg) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000986460] Chr1:172659410 [GRCh38]
Chr1:172628550 [GRCh37]
Chr1:1q24.3
likely benign
GRCh37/hg19 1q24.2-25.1(chr1:167430471-174635618)x1 copy number loss not provided [RCV001005149] Chr1:167430471..174635618 [GRCh37]
Chr1:1q24.2-25.1
pathogenic
NM_000639.3(FASLG):c.319C>A (p.Leu107Ile) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000817664] Chr1:172659520 [GRCh38]
Chr1:172628660 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.503T>A (p.Ile168Asn) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000805632] Chr1:172665673 [GRCh38]
Chr1:172634813 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.412C>T (p.Pro138Ser) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001098806] Chr1:172664351 [GRCh38]
Chr1:172633491 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.452-12G>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001098808] Chr1:172665610 [GRCh38]
Chr1:172634750 [GRCh37]
Chr1:1q24.3
uncertain significance
NC_000001.11:g.172658929A>G single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000986458] Chr1:172658929 [GRCh38]
Chr1:172628069 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.834A>T (p.Leu278Phe) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000986461] Chr1:172666004 [GRCh38]
Chr1:172635144 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.173C>T (p.Pro58Leu) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001203159] Chr1:172659374 [GRCh38]
Chr1:172628514 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.256A>G (p.Met86Val) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001215332] Chr1:172659457 [GRCh38]
Chr1:172628597 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.170C>T (p.Pro57Leu) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001212483] Chr1:172659371 [GRCh38]
Chr1:172628511 [GRCh37]
Chr1:1q24.3
uncertain significance
null single nucleotide variant not provided [RCV001708374] Chr1:172659757 [GRCh38]
Chr1:172628897 [GRCh37]
Chr1:1q24.3
benign
NM_007294.4(BRCA1):c.3362A>G (p.Asn1121Ser) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001702325]|not provided [RCV001707922] Chr1:172665594 [GRCh38]
Chr1:172634734 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.72C>A (p.Ala24=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001455188]|not provided [RCV000975827] Chr1:172659273 [GRCh38]
Chr1:172628413 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.144A>G (p.Pro48=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000937307] Chr1:172659345 [GRCh38]
Chr1:172628485 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.474G>C (p.Met158Ile) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001210493] Chr1:172665644 [GRCh38]
Chr1:172634784 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.153G>A (p.Pro51=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV000911431] Chr1:172659354 [GRCh38]
Chr1:172628494 [GRCh37]
Chr1:1q24.3
likely benign
NM_001302746.1(FASLG):c.-187_-186GA[4] microsatellite Autoimmune lymphoproliferative syndrome [RCV000986459] Chr1:172659014..172659017 [GRCh38]
Chr1:172628154..172628157 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.49A>C (p.Ser17Arg) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001054880] Chr1:172659250 [GRCh38]
Chr1:172628390 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_004837.4(GGPS1):c.782G>A (p.Arg261His) AND MUSCULAR DYSTROPHY, CONGENITAL HEARING LOSS, single nucleotide variant not provided [RCV001638291] Chr1:172658724 [GRCh38]
Chr1:172627864 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.360G>C (p.Gln120His) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001097063] Chr1:172660106 [GRCh38]
Chr1:172629246 [GRCh37]
Chr1:1q24.3
benign|conflicting interpretations of pathogenicity
NM_000639.3(FASLG):c.137C>T (p.Pro46Leu) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001056349] Chr1:172659338 [GRCh38]
Chr1:172628478 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*608T>A single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001100630] Chr1:172666624 [GRCh38]
Chr1:172635764 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.95G>C (p.Cys32Ser) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001062915] Chr1:172659296 [GRCh38]
Chr1:172628436 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.*3G>T single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001098809] Chr1:172666019 [GRCh38]
Chr1:172635159 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.301A>G (p.Met101Val) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001233572] Chr1:172659502 [GRCh38]
Chr1:172628642 [GRCh37]
Chr1:1q24.3
uncertain significance
NC_000001.11:g.(?_172658358)_(172909884_?)dup duplication Autoimmune lymphoproliferative syndrome [RCV001032299] Chr1:172627498..172879024 [GRCh37]
Chr1:1q24.3
uncertain significance
null deletion not provided [RCV001662905] Chr1:172665450 [GRCh38]
Chr1:172634590 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.355A>T (p.Ser119Cys) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001297208] Chr1:172660101 [GRCh38]
Chr1:172629241 [GRCh37]
Chr1:1q24.3
uncertain significance
NC_000001.10:g.(?_172627498)_(172635176_?)dup duplication Autoimmune lymphoproliferative syndrome [RCV001318977] Chr1:172627498..172635176 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.135ACC[3] (p.Pro53del) microsatellite Autoimmune lymphoproliferative syndrome [RCV001339237] Chr1:172659334..172659336 [GRCh38]
Chr1:172628474..172628476 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.781G>A (p.Val261Ile) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001361240] Chr1:172665951 [GRCh38]
Chr1:172635091 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.397C>T (p.His133Tyr) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001319308] Chr1:172664336 [GRCh38]
Chr1:172633476 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.179C>T (p.Pro60Leu) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001343780] Chr1:172659380 [GRCh38]
Chr1:172628520 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.323A>G (p.Gln108Arg) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001339428] Chr1:172659524 [GRCh38]
Chr1:172628664 [GRCh37]
Chr1:1q24.3
uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
NM_000639.3(FASLG):c.54T>A (p.Ser18Arg) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001350065] Chr1:172659255 [GRCh38]
Chr1:172628395 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_000639.3(FASLG):c.796C>T (p.Leu266=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001461309] Chr1:172665966 [GRCh38]
Chr1:172635106 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.624C>T (p.Ser208=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001491457] Chr1:172665794 [GRCh38]
Chr1:172634934 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.561G>A (p.Gly187=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001488732] Chr1:172665731 [GRCh38]
Chr1:172634871 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.678G>A (p.Glu226=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001437457] Chr1:172665848 [GRCh38]
Chr1:172634988 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.579C>T (p.Ser193=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001417270] Chr1:172665749 [GRCh38]
Chr1:172634889 [GRCh37]
Chr1:1q24.3
likely benign
NM_000639.3(FASLG):c.537T>C (p.Gly179=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001410118] Chr1:172665707 [GRCh38]
Chr1:172634847 [GRCh37]
Chr1:1q24.3
likely benign
NC_000001.10:g.172627498C>T single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001511738] Chr1:172658358 [GRCh38]
Chr1:172627498 [GRCh37]
Chr1:1q24.3
benign
NM_000085.5(CLCNKB):c.101-50G>C single nucleotide variant not provided [RCV001686763] Chr1:172658997 [GRCh38]
Chr1:172628137 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.259T>C (p.Phe87Leu) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001522939] Chr1:172659460 [GRCh38]
Chr1:172628600 [GRCh37]
Chr1:1q24.3
benign
NM_000639.3(FASLG):c.225G>A (p.Gly75=) single nucleotide variant Autoimmune lymphoproliferative syndrome [RCV001502639] Chr1:172659426 [GRCh38]
Chr1:172628566 [GRCh37]
Chr1:1q24.3
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11936 AgrOrtholog
COSMIC FASLG COSMIC
Ensembl Genes ENSG00000117560 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000344739 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000356694 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000340030 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000367721 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000117560 GTEx
HGNC ID HGNC:11936 ENTREZGENE
Human Proteome Map FASLG Human Proteome Map
InterPro FASL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 356 ENTREZGENE
OMIM 134638 OMIM
  211980 OMIM
  601859 OMIM
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA56 PharmGKB
PRINTS FASLIGAND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNECROSISFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H3VB22_HUMAN UniProtKB/TrEMBL
  P48023 ENTREZGENE
  Q0VHD7_HUMAN UniProtKB/TrEMBL
  Q53ZZ1 ENTREZGENE, UniProtKB/TrEMBL
  TNFL6_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q9BZP9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-05 FASLG  Fas ligand    Fas ligand (TNF superfamily, member 6)  Symbol and/or name change 5135510 APPROVED
2011-08-16 FASLG  Fas ligand (TNF superfamily, member 6)  FASLG  Fas ligand (TNF superfamily, member 6)  Symbol and/or name change 5135510 APPROVED