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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:16063426480464CTDBenzo(a)pyrene results in increased expression of FASLG mRNA, Benzo(a)pyrene results in increased expression of FASLG protein

PMID:16041517, PMID:18247414
multiple interactionsISORGD:16063426480464CTDAHR mutant form inhibits the reaction [Benzo(a)pyrene promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]], AHR mutant form inhibits the reaction [Benzo(a)pyrene results in increased activity of [FASLG protein binds to FASLG protein]], Benzo(a)pyrene promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein], Benzo(a)pyrene results in increased activity of [FASLG protein binds to FASLG protein], Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of FASLG protein]

PMID:16041517, PMID:22951985
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.