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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16063426480464CTDRifampin results in decreased expression of FASLG mRNA, Rifampin results in decreased expression of FASLG protein

PMID:11958592, PMID:24552687
multiple interactionsISORGD:15530646480464CTD[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA

PMID:21224054
multiple interactionsISORGD:16063426480464CTDMifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]], Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]

PMID:12645856
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.