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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCurcumin results in decreased expression of FASLG mRNA

PMID:10925121
decreases expressionISORGD:16063426480464CTDCurcumin results in decreased expression of FASLG mRNA

PMID:16101141
multiple interactionsISORGD:16063426480464CTD[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein, Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein], Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]

PMID:17351739, PMID:23452621, PMID:27430728
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.