RGD Reference Report - FAS A-670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre-eclampsia and may contribute to HELLP syndrome: a case-controlled study. - Rat Genome Database

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FAS A-670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre-eclampsia and may contribute to HELLP syndrome: a case-controlled study.

Authors: Raguema, N  Zitouni, H  Ben Ali Gannoun, M  Benletaifa, D  Almawi, W Y  Mahjoub, T  Lavoie, J L 
Citation: Raguema N, etal., BJOG. 2018 Dec;125(13):1758-1764. doi: 10.1111/1471-0528.15412. Epub 2018 Sep 3.
RGD ID: 14700669
Pubmed: (View Article at PubMed) PMID:30066360
DOI: Full-text: DOI:10.1111/1471-0528.15412


OBJECTIVE: We evaluated the association between the Fas-670A/G and the Fas ligand FasL IVS2nt 124 A/G polymorphisms and the risk of pre-eclampsia and its complications.
DESIGN: A case-controlled study.
SETTING: University Hospitals in most areas of Tunisia.
POPULATION: We recruited 300 pregnant women who developed pre-eclampsia and 300 age-matched healthy pregnant women from the same hospital.
METHODS: Genotyping of Fas-670A/G and the FasL IVS2nt 124A/G gene polymorphisms were conducted using polymerase chain reaction-restriction fragment length polymorphism among our cohort.
MAIN OUTCOME MEASURES: Fisher's exact test was used to compare the statistical differences between groups for categorical variables and Student t tests were used for continuous variables.
RESULTS: The frequency of the Fas-670G gene variant was significantly increased in women with pre-eclampsia (42%) compared with control women (30%; P < 0.001). Also, a statistically significant difference was obtained in the distribution of the FasL IVS2nt 124G gene variant when comparing women with pre-eclampsia (43%) with controls (30%; P < 0.001). Interestingly, we found that the carriage of Fas-670G was associated with increased liver enzymes, suggesting an increased prevalence of the haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, a pre-eclampsia complication.
CONCLUSION: The Fas-670G and FasL IVS2nt 124G polymorphisms are associated with a higher risk of pre-eclampsia and its complications.
TWEETABLE ABSTRACT: Polymorphisms in the Fas and FasL genes are associated with increased risk of pre-eclampsia and HELLP syndrome.

Annotation

Disease Annotations    
HELLP syndrome  (IAGP,ISO)
pre-eclampsia  (IAGP,ISO)

Phenotype Annotations    

Human Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)
Faslg  (Fas ligand)

Genes (Mus musculus)
Fas  (Fas (TNF receptor superfamily member 6))
Fasl  (Fas ligand (TNF superfamily, member 6))

Genes (Homo sapiens)
FAS  (Fas cell surface death receptor)
FASLG  (Fas ligand)


Additional Information